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141. Comparison of Total Intravenous Anesthesia vs. Inhalational Anesthesia in Acute Subdural Hematoma Patients

, standard monitors including non invasive blood pressure (NIBP), electrocardiogram (ECG), heart rate (HR), pulse oximetry, SPO2 probe will be connected. Pre-oxygenation will be done with 100% O2 for 3 minutes. In both the groups induction will be done using 3 mcg/kg fentanyl, 2 mg/kg propofol and muscle relaxation will be achieved with 0.1mg/kg vecuronium. Post induction patients will be intubated with appropriate size endotracheal tube (male with 8.0 and female with 7.0) and radial artery

2017 Clinical Trials

142. Compare the Oncological Benefit of Deep Neuromuscular Block in Gastric Cancer Obesity Patient

group Sugammadex sodium 4mg/kg/IV after operation Drug: Sugammadex Sodium INDICATIONS AND USAGE BRIDION® is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery. BRIDION (sugammadex) injection is a sterile, clear, colorless to slightly yellow-brown, non-pyrogenic aqueous solution intended for intravenous infusion. DOSAGE AND ADMINISTRATION BRIDION (sugammadex) injection, for intravenous use, should be administered (...) by trained healthcare providers familiar with the use, actions, characteristics, and complications of neuromuscular blocking agents (NMBA) and neuromuscular block reversal agents. Other Name: Bridion®, MSD Experimental: Moderate neuromuscular group Sugammadex sodium 2mg/kg/IV after operation Drug: Sugammadex Sodium INDICATIONS AND USAGE BRIDION® is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery. BRIDION (sugammadex

2017 Clinical Trials

143. Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements?

Collaborators: Maine Medical Center Spectrum Medical Group Anesthesiology Information provided by (Responsible Party): Craig Curry, Maine Medical Center Study Details Study Description Go to Brief Summary: During many surgeries, increased muscle tension makes it harder for the surgeon to expose the site of surgery and work within the incision. Neuromuscular blockade (NMB) drugs such as Vecuronium bind to neurotransmitter (acetyl choline) receptors at the neuromuscular junction, blocking their action (...) conditions during total hip replacement (THR). Condition or disease Intervention/treatment Phase Arthropathy of Hip Drug: Vecuronium 0.1 mg/kg Drug: Vecuronium 0.2mg/kg Phase 4 Detailed Description: Specific Aims Assess difference in surgical conditions between moderate and deep NMB groups. Enrolled patients will be randomized to receive moderate (n=58) or deep (n=58) NMB. Difference in surgical conditions will be evaluated by: The number of requests from the surgeon for additional relaxation (NMB

2017 Clinical Trials

144. The Effect of Chronic Opioid Use on End-Tidal Concentration of Sevoflurane Necessary to Maintain a Bispectral Index Below 50: A Prospective, Single-Blind Study. (Abstract)

(BIS) <50 (SEVOBIS50) in patients with chronic opioid use compared with those naïve to opioid use.We included chronic opioid users who received a stable dose of oral morphine of at least 60 mg/d according to the morphine equivalent daily dose for at least 4 weeks and opioid-naïve patients. General anesthesia that included thiopental, vecuronium, and sevoflurane in oxygen was administered to all patients. Anesthesia was maintained using predetermined end-tidal sevoflurane concentrations. Fifteen

2017 Anesthesia and Analgesia

148. [Neuromuscular monitoring during anesthesia.]. (Abstract)

prolapse given muscle relaxants during anesthesia were studied, randomly allocated to four groups. Fourty of these patients were monitored with neuromuscular monitor (TOF-guard") during anesthesia and the set point was a TOF-ratio of at least 70% before extubating the patients. Fourty patients were monitored by usual clinical signs (spontaneus breathing, cough and muscle movement). Twenty patients in each group were given vecuronium as muscle relaxant and 20 patients recieved pancuronium, again

2015 Laeknabladid Controlled trial quality: uncertain

150. Dexdor - dexmedetomidine

, etomidate, vecuronium bromide, pancuronium bromide, succinylcholine, atracurium besylate, mivacurium chloride, rocuronium bromide, glycopyrrolate bromide, phenylephrine HCl, atropine sulphate, dopamine, noradrenaline, dobutamine, midazolam, morphine sulphate, fentanyl citrate, and a plasma-substitute. 2.2.2. Active Substance The chemical names of dexmedetomidine are 1H-imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, (S)-, hydrochloride, or (+)-4-[(S)- a,2,3-trimethylbenzyl]-imidazole hydrochloride

2011 European Medicines Agency - EPARs

151. Bridion (sugammadex sodium)

in the reversal of neuromuscular blockade induced by rocuronium bromide or vecuronium bromide have been demonstrated. However, the efficacy and safety of the proposed product have been evaluated using foreign clinical data, based on the results from 2 bridging studies for routine reversal of shallow (at the reappearance of T 2 [the second twitch in response to train-of-four (TOF) stimulation], as detected with a neuromuscular monitor) and profound (at 1-2 PTCs [1-2 post-tetanic counts] [1-2 responses to post (...) with impaired renal or hepatic function, geriatric patients, children, and pregnant women/nursing mothers. It is also necessary to investigate the influences of the neuromuscular blocking agent used (rocuronium bromide or vecuronium bromide), the level of neuromuscular blockade to be reversed by the proposed product, and the use of a neuromuscular monitor on the efficacy and safety of the proposed product, and the details of administration and the safety of the proposed product when it had to be re

2010 Pharmaceuticals and Medical Devices Agency, Japan

152. What, besides large anterior STEMI, is so ominous about this ECG?

is the ominous finding: Right Bundle Branch Block (RBBB) + LAFB (left anterior fascicular block) . I have seen a dozen cases of STEMI with RBBB and LAFB . All were close to death. : See these cases: Treatments : 1. Aspirin 325 mg 2. Ticagrelor 180 mg 3. Atorvastatin 80 mg (small studies support this) 4. Heparin bolus 5. Fluid challenge 6. Because cardiogenic shock is likely to get worse, even after reperfusion (because myocardial stunning lasts many days), we intubated the patient. 7. Vecuronium paralysis 8

2016 Dr Smith's ECG Blog

153. Use of Neuromuscular Blockers During Therapeutic Hypothermia After Cardiac Arrest: A Nursing Protocol. Full Text available with Trip Pro

in a 24-bed cardiac arrest center. During the before period, paralysis was maintained by continuous infusion of vecuronium during therapeutic hypothermia. During the after period, a nurse-implemented protocol was used to strictly control use of neuromuscular blockers. The primary outcome measure was duration of infusion of neuromuscular blockers; secondary end points included rates of ventilator-associated pneumonia and intensive care unit mortality.Among the 22 patients in the before group and the 23

2016 Critical care nurse

154. [Clinical observation on controlling antihypertension with the general anesthesia of TEAS and anesthetics in endoscopic endonasal surgery]. (Abstract)

of surgery. The BP and HR were observed and recorded at the end of monitoring in operation room, 10 min after tranquilization (T0), 30 min after intervention (Tj, after induction~of general anestiesa (T2), 30 min after surgery start (T3), 60 min after surgery start (T4) and 30 min after extubation (T5). The doses of vecuronium bromide, propofol and nitroglycerin were recorded statistically in surgery, as well as the operative bleeding volume, the operative time, the resuscitation time and the visual (...) was different at T2 to Ts in the sham-TEAS group statistically (all P < 0.01). The doses of vecuronium bromide, propofol and nitroglycerin, the operative bleeding volume, the operative time, the resuscitation time and VAS after resuscitation were not different significantly between the two groups (all P > 0.05).The general anesthesia with TEAS and anesthetics involved for controlling antihypertension contributes to the control of BP and HR in the patients in endoscopic endonasal surgery. The impacts

2016 Zhongguo zhen jiu = Chinese acupuncture & moxibustion Controlled trial quality: uncertain

155. Target Controlled Infusion versus Sevoflurane/Desflurane Anesthesia for Laparoscopic Cholecystectomy: Comparison Postoperative Nausea/Vomiting and Extubation Time. (Abstract)

in terms of postoperative nausea and vomiting (PONV) and extubation times.The present study was prospective with informed consent from 75 patients, ASA 1-3 scheduled for laparoscopic cholecystectomy, and classified by anesthetic technique into three groups. The patients were induced by propofol target plasma concentration 6 µg/ml in Group P, or 1-2 mg/kg in Group S and Group D, fentanyl 2 µg/kg and vecuronium 0.1 mg/kg followed by propofol 2 to 5 µg/mI in group P, sevoflurane 0.5 to 3% in Group S

2016 Journal of the Medical Association of Thailand = Chotmaihet thangphaet Controlled trial quality: uncertain

156. Do we really need sugammadex as an antagonist of muscle relaxants in anesthesia? (Abstract)

Do we really need sugammadex as an antagonist of muscle relaxants in anesthesia? Sugammadex is a selective relaxant-binding agent that is designed to encapsulate rocuronium and chemically similar steroidal muscle relaxants such as vecuronium. This review summarizes recent information on the use of sugammadex in clinical practice.The main advantages of sugammadex when compared with conventional anticholinesterase agents are a much faster recovery time and its unique ability to reverse rapidly

2016 Current Opinion in Anaesthesiology

157. Comparison of intravenous labetalol and bupivacaine scalp block on the hemodynamic and entropy changes following skull pin application: A randomized, open label clinical trial. Full Text available with Trip Pro

procedures were randomized into two groups, L (labetalol) and B (bupivacaine) of 33 each. After a standard induction sequence using fentanyl, propofol and vecuronium, patients were intubated. Baseline hemodynamic parameters and entropy levels were noted. Five minutes before, application of the pins, group L patients received IV labetalol 0.25 mg/kg and group B patients received scalp block with 30 ml of 0.25% bupivacaine. Following application of the pins, heart rate (HR), systolic arterial pressure (SAP

2016 Asian journal of neurosurgery Controlled trial quality: uncertain

158. Sugammadex at both high and low doses does not affect the depth of anesthesia or hemodynamics: a randomized double blind trial. (Abstract)

Sugammadex at both high and low doses does not affect the depth of anesthesia or hemodynamics: a randomized double blind trial. Previous studies have shown that sugammadex decreases the anesthetic depth when administered to reverse the neuromuscular blockade produced by rocuronium/vecuronium. The aim of the present study was to investigate the effect of sugammadex alone on anesthetic depth and hemodynamics. Sixty patients scheduled for abdominal surgery participated in the study. Anesthesia

2016 Journal of clinical monitoring and computing Controlled trial quality: predicted high

159. Voxel-Based Morphometry in Epileptic Baboons: Parallels to Human Juvenile Myoclonic Epilepsy Full Text available with Trip Pro

scans using a 3T Siemens TIM Trio (Siemens, Erlangen, Germany) were available in 107 baboons (67 females; mean age 16±6years) with documented clinical histories and scalp-electroencephalography (EEG) results. For neuroimaging, baboons were anesthetized with isoflurane 1% (1-1.5 MAC) and paralyzed with vecuronium (0.1-0.3mg/kg). Data processing and analysis were performed using FSL's VBM toolbox. GMC was compared between CTL and SZ+ baboons, epileptic baboons with interictal epileptic discharges

2016 Epilepsy research

160. Postoperative Respiratory Failure in a Patient with Undiagnosed Myastenia Gravis Full Text available with Trip Pro

Postoperative Respiratory Failure in a Patient with Undiagnosed Myastenia Gravis Myasthenia gravis (MG) is an autoimmune disease caused by the development of antibodies against the nicotinic acetylcholine receptor. There is hypersensitivity against non-depolarizing muscle relaxants in these patients. Sugammadex eliminates the effects of steroid non-depolarizing muscle relaxants, such as rocuronium and vecuronium, by selectively encapsulating their molecules. In this case report, we present

2016 Turkish journal of anaesthesiology and reanimation

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