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141. Is rocuronium as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation?

20 adult patients ASA 1-3, MAL 1-2 requiring RSI. Received 1.2mg/kg rocuronium or succinylcholine 1mg/kg. (30 other patients with lower doses of rocuronium or vecuronium also studied but not reviewed here) Double blind RCT (1) Time to onset muscle relaxant (nerve stimulator on adductor pollicis). (2) Intubating conditions at 60seconds (jaw relaxation, vocal cord postion and movement, diaphragm movement) (1) Time to onset; no significant difference (rocuronium = 55s (SD14 range 36-84) vs (...) in the emergency department Acad Emerg Med 2011 Jan;18(1):10-4 Andrews JI, Kumar N, van den Brom RH et al. A large simple randomized trial of rocuronium versus succinylcholine in rapid-sequence induction of anaesthesia along with propofol Acta Anaesthesiol Scand 1999 Jan;43(1):4-8. Magorian T, Flannery KB, Miller RD Comparison of rocuronium, succinylcholine, and vecuronium for rapid-sequence induction of anesthesia in adult patients Anesthesiology 1993 Nov;79(5):913-8 Perry JJ, Lee JS, Sillberg VA et al

2012 BestBETS

142. Suxamethonium (succinylcholine) for RSI and intubation in head injury

) was administered to all subjects. Group 1a and 1b then received vecuronium (0.14mg/kg) and a second suxamethonium dose (1m/kg). Fisher’s exact test was used to determine significant increases in ICP. Poor quality cohort study; level IV Changes in parameters (cardiovascular, ICP) within individuals pre-and post-intervention. Peripheral radial arterial catheter and subarachnoid ICP bolt to gather data. Group 1: mean ICP rise from 15±1mmHg to 20±2mmHg after first suxamethonium dose (P Non-random group allocation (...) (vecuronium or metocurine). While this effect may be valid and of clinical importance, the use of these agents necessitated active ventilation in both study groups prior to suxamethonium administration - a measure which the principle of rapid sequence induction injured adult population may be inappropriate. It is worth noting that subjects in the Barrington paper (Barrington, Finer et al, 1989) were also manually ventilated, though in this case after suxamethonium administration. If the purpose

2012 BestBETS

143. Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension

will be given by inj fentanyl 2µg/kg body weight. Lower limbs will be neither elevated or wrapped. Vitals will be recorded again. 3 minutes of pre-oxygenation will be done. Anaesthesia will be induced with inj. propofol 2mg/kg body weight injected over 30 seconds. Muscle relaxation will be achieved by inj. vecuronium 0.1mg/kg body weight. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Other: control no intervention has (...) . vecuronium 0.1mg/kg body weight. Patient will be ventilated with oxygen for 5 minutes. Orotracheal intubation will be performed with appropriate sized endotracheal tube. Stand will be removed and legs will be brought to horizontal position 10 minutes after intubation. Other: leg elevation A stand making an angle of 30 degree to the horizontal is used to elevate both the legs Experimental: Group W Leg wrapping Patient will be shifted to operation theatre. Crystalloids at 100ml/hr will be given. Analgesia

2016 Clinical Trials

144. Cognitive Dysfunction Following Cardiac Surgery

were randomized into two groups to receive either intravenous dexamethasone 0.1 mg/kg or the same volume of normal saline i.v. 10 hours before the surgery. Random sequence generator was used to determine participant allocation. Anesthesia in all patients was based on fentanyl, midazolam, vecuronium and sevoflurane. The depth of anesthesia was monitored using bispectral index (BIS). During cardiopulmonary bypass alpha-stat technique was used with the maintenance of normothermia (35.5-36.5°C

2016 Clinical Trials

145. A Unique Device for Independent Lung Ventilation

for neuromuscular blockade, and bronchial intubation with a Robertshow double lumen tube was performed. The left bronchus was intubated for right lung surgery, and the right bronchus was intubated for left lung surgery. Tube placement was checked via auscultation and fiberscope. Anaesthesia was maintained with sevoflurane, additional fentanyl doses were used if needed, and neuromuscular blockade was obtained with vecuronium 0.1 mg kg-1. Additionally, 0.1 mg kg-1 dose of morphine was given subcutaneously

2016 Clinical Trials

146. Effect of Acetazolamide on Optic Nerve Sheath Diameter in Laparoscopic Donor Nephrectomies

: Normal Saline Not Applicable Detailed Description: this study was done on 40 American Society of Anaesthesiologist(ASA) I & II live donors of either sex in adult age group undergoing laparoscopic live donor nephrectomy. After getting approval from institutes ethical committee and written informed consent, Donors were randomly allocated to either of two group. Anaesthesia was induced with injection morphine 0.1 mg/kg, injection propofol 1-2 mg/kg and vecuronium 0.1 mg/kg. Maintenance of anaesthesia

2016 Clinical Trials

147. Rapid Sequence Induction Czech Republic: Survey

for induction (order with the number in the row) - propofol, etomidate, ketamine, thiopental, midazolam, suxamethonium, rocuronium, cisatracurium, atracurium, vecuronium Manual hand-bag ventilation after induction: with limited pressure/contraindicated Airway: tracheal tube with the cuff/without cuff/laryngeal mask Comments Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 164 participants Observational Model: Other Time Perspective: Prospective Official

2016 Clinical Trials

148. Transversus Abdominis Plane Block in Iliac Crest harvest-is it Beneficial?

excluded from the study. Patients undergoing revision surgeries were also excluded from the study. All the candidates were randomly alloted to either of the two groups, using a computer - generated number. All the patients were premedicated with Midazolam 0.15mg kg-1 and Glycopyrolate 0.01mg kg-1 Anaesthesia was induced with Propofol 2 mg kg -1 and Fentanyl 2 mcg kg-1 .Vecuronium 0.1 mg kg-1 was given to facilitate orotracheal intubation with a cuffed tube.Anaesthesia was maintained with oxygen

2016 Clinical Trials

149. Comparison of Two Methods of Strain by Perioperative Transesophageal Echo in CABG : An Observational Study

anaesthesia technique will be used for all the patients. Inside the operating room, electrocardiography (ECG), pulse oximetry and noninvasive blood pressure (NIBP) will be applied. Anaesthesia will be induced with fentanyl 5 - 10 µg/kg/ body weight and propofol titrated to loss of response to verbal commands followed by endotracheal intubation facilitated by vecuronium 0.1mg/kg. A 20 gauge arterial catheter will be inserted in left radial artery and right internal jugular vein will be cannulated (...) with triple lumen catheter for central venous access and pulmonary artery catheter for haemodynamic assessment. A baseline transthoracic echocardiogram will be performed after induction of general anaesthesia. After induction of general anaesthesia , a TEE probe (GE Medical Systems, Horten, Norway) will be introduced. Anaesthesia will be maintained by isoflurane, intravenous morphine (intermittent boluses; total 0.5 mg/kg during surgery) and vecuronium boluses. All patients will undergo CABG under

2016 Clinical Trials

150. Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG

of anesthesia; Fast channel anesthesia • Induction use Sufentanil 0.5~1ug/kg, Vecuronium for Injection 0.15mg/kg and Etomidate 0.2~0.6mg/kg; ②. Maintain use Sufentanil Hydrochloride for Injection 0.01~0.04ug/kg•min, Sevoflurane 0.5~1.5MAC(minimum alveolar concentration) and Infusing Dexmedetomidine which load dose 0.5μg/kg in 10min then changed into 0.5-1.0μg/kg•h,Vecuronium 0.06~0.12mg/kg•h; ③. Intravenous hydromorphone Hydrochloride Injection 0.15mg/kg before surgery over. Experimental: TPVB T3/4+GA (...) : Lung protection measure during the surgery(Dräger Primus) Protective ventilation strategy(Low tidal volume about 6~7ml/kg, joint use of PEEP) Drug: Anesthesia drugs during the surgery Bilateral thoracic paravertebral block before induction of anesthesia; Fast channel anesthesia • Induction use Sufentanil 0.5~1ug/kg, Vecuronium for Injection 0.15mg/kg and Etomidate 0.2~0.6mg/kg; ②. Maintain use Sufentanil Hydrochloride for Injection 0.01~0.04ug/kg•min, Sevoflurane 0.5~1.5MAC(minimum alveolar

2016 Clinical Trials

151. Magnesium Sulfate Effect Following the Reversal of Neuromuscular Blockade Induced by Rocuronium With Sugammadex

Neuromuscular Blockade Drug: Magnesium Sulfate Drug: Saline Phase 4 Detailed Description: Sugammadex is a novel neuromuscular blocking reversal agent. Its mechanism of action is the encapsulation of rocuronium and vecuronium molecules. Numerous studies show a potential role of magnesium in reducing anesthetic requirements, sympathetic response to surgical trauma, antinociceptive action and neuroprotective effects. However, its use is limited because magnesium potentiates non-depolarizing neuromuscular

2016 Clinical Trials

152. Comparison of Onset and Duration of Rocuronium Between 2nd Trimester Pregnant and Non-pregnant Women

to the following factors; Increase in plasma volume, heart rate and cardiac output; decrease in blood pressure due to decrease of systemic resistance and relative decrease of hepatic circulation and the aggravation of hepatic dysfunction. These changes intensify as pregnancy progresses into the 3rd trimester and take their effect on the onset time and duration of muscle relaxants. Rocuronium and the steroidal non-depolarizing muscle relaxant like vecuronium is mostly excreted with bile by hepatic metabolism (...) and classified as the FDA pregnancy category B, and is widely used in general anesthesia of pregnant women. Previous studies reported onset time of rocuronium is affected by cardiac output, blood circulation time of the whole body, and muscle perfusion. Accordingly, many researches were conducted under the assumption of onset time and duration being affected by physiologic changes during pregnancy. For example, in the research where vecuronium was used as muscle relaxant for pregnant woman undergoing C-sec

2016 Clinical Trials

153. Sugammadex/Neostigmine and Liver Transplantation

at the neuromuscular junction. The administration of neostigmine may however cause bronchospasm, abdominal pain, nausea, cardiac arrhythmias and can not be used if the neuromuscular blockade is deep. Recently the use of sugammadex, a new drug that can act as an antidote to a comparison of non-depolarizing muscle relaxants amino-steroidal (rocuronium, vecuronium) showed good clinical impact. This drug works by encapsulating the muscle relaxant molecule in the plasma with a high affinity and binding to the complex

2016 Clinical Trials

154. Use of Neuromuscular Blockers During Therapeutic Hypothermia After Cardiac Arrest: A Nursing Protocol. (PubMed)

in a 24-bed cardiac arrest center. During the before period, paralysis was maintained by continuous infusion of vecuronium during therapeutic hypothermia. During the after period, a nurse-implemented protocol was used to strictly control use of neuromuscular blockers. The primary outcome measure was duration of infusion of neuromuscular blockers; secondary end points included rates of ventilator-associated pneumonia and intensive care unit mortality.Among the 22 patients in the before group and the 23

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2016 Critical care nurse

155. Efficacy and safety of sugammadex compared to neostigmine for reversal of neuromuscular blockade: a meta-analysis of randomized controlled trials. (PubMed)

Efficacy and safety of sugammadex compared to neostigmine for reversal of neuromuscular blockade: a meta-analysis of randomized controlled trials. Sugammadex has been introduced for reversal of rocuronium (or vecuronium)-induced neuromuscular blockade (NMB). Although its efficacy has been established, data are conflicting whether it is safer than neostigmine traditionally used for reversing NMB.Meta-analysis of data about effectiveness and safety of sugammadex compared to neostigmine

2016 Journal of clinical anesthesia

156. Feasibility of monitoring stress using skin conduction measurements during intubation of newborns. (PubMed)

Feasibility of monitoring stress using skin conduction measurements during intubation of newborns. The objective of this study was to assess the feasibility of monitoring stress responses in newborns during naso-tracheal intubation after two different premedication regimens, using skin conductance measurements (SCM). Twenty-two newborns were randomised and premedicated with morphine + vecuronium or propofol. SCM (peaks/s) were collected prior to, during and after the procedure. Threshold (...) for interpreting responses as stressful was 0.21 peaks/s. Intubation conditions and physiological parameters were registered. Intubation conditions were good in all newborns. Administration of morphine (range 1.4-10.3 min) before administration of vecuronium did not affect SCM when a stressful stimulus was applied. Within 1.6 min (range 0.8-3 min) after administration of vecuronium, SCM disappeared in 10 of 11 newborns. Propofol reduced SCM in 10 of 11 newborns at the first attempt. Further attempts were

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2016 European journal of pediatrics

157. Incidence of postoperative nausea and vomiting following gynecological laparoscopy: A comparison of standard anesthetic technique and propofol infusion. (PubMed)

) controlled trial.Operation theater, postanesthesia recovery room, teaching hospital.Sixty ASA (American Society of Anesthesiologists) I and II female patients (aged 20-60 years) scheduled for gynecological laparoscopy were included in the study.Patients in Group A received standard anesthesia with thiopentone for induction and maintenance with isoflurane-fentanyl, and those in Group B received propofol for induction and maintenance along with fentanyl. All patients received nitrous oxide, vecuronium

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2016 Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists

158. [Clinical observation on controlling antihypertension with the general anesthesia of TEAS and anesthetics in endoscopic endonasal surgery]. (PubMed)

of surgery. The BP and HR were observed and recorded at the end of monitoring in operation room, 10 min after tranquilization (T0), 30 min after intervention (Tj, after induction~of general anestiesa (T2), 30 min after surgery start (T3), 60 min after surgery start (T4) and 30 min after extubation (T5). The doses of vecuronium bromide, propofol and nitroglycerin were recorded statistically in surgery, as well as the operative bleeding volume, the operative time, the resuscitation time and the visual (...) was different at T2 to Ts in the sham-TEAS group statistically (all P < 0.01). The doses of vecuronium bromide, propofol and nitroglycerin, the operative bleeding volume, the operative time, the resuscitation time and VAS after resuscitation were not different significantly between the two groups (all P > 0.05).The general anesthesia with TEAS and anesthetics involved for controlling antihypertension contributes to the control of BP and HR in the patients in endoscopic endonasal surgery. The impacts

2016 Zhongguo zhen jiu = Chinese acupuncture & moxibustion

159. Target Controlled Infusion versus Sevoflurane/Desflurane Anesthesia for Laparoscopic Cholecystectomy: Comparison Postoperative Nausea/Vomiting and Extubation Time. (PubMed)

in terms of postoperative nausea and vomiting (PONV) and extubation times.The present study was prospective with informed consent from 75 patients, ASA 1-3 scheduled for laparoscopic cholecystectomy, and classified by anesthetic technique into three groups. The patients were induced by propofol target plasma concentration 6 µg/ml in Group P, or 1-2 mg/kg in Group S and Group D, fentanyl 2 µg/kg and vecuronium 0.1 mg/kg followed by propofol 2 to 5 µg/mI in group P, sevoflurane 0.5 to 3% in Group S

2016 Journal of the Medical Association of Thailand = Chotmaihet thangphaet

160. Do we really need sugammadex as an antagonist of muscle relaxants in anesthesia? (PubMed)

Do we really need sugammadex as an antagonist of muscle relaxants in anesthesia? Sugammadex is a selective relaxant-binding agent that is designed to encapsulate rocuronium and chemically similar steroidal muscle relaxants such as vecuronium. This review summarizes recent information on the use of sugammadex in clinical practice.The main advantages of sugammadex when compared with conventional anticholinesterase agents are a much faster recovery time and its unique ability to reverse rapidly

2016 Current Opinion in Anaesthesiology

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