How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,411 results for

Vecuronium

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1401. [Rocuronium or vecuronium for intubation for short operations in the preschool age? Effects on time in the operating room and postoperative phase]. (Abstract)

[Rocuronium or vecuronium for intubation for short operations in the preschool age? Effects on time in the operating room and postoperative phase]. This prospective randomized study compares the effects of rocuronium (R) and vecuronium (V) on the early postoperative period in infants. Forty-eight infants between the ages of three and six, scheduled for elective ENT procedures, were studied after prior approval of local ethics committee and informed parental consent. All children were (...) premedicated with chlorprotixene and belladonna. Anaesthesia was induced with 5 mg/kg thiopentone and 1 vol.-% halothane. Subsequently, 0.4 mg/kg rocuronium or 0.075 mg/kg vecuronium were administered, respectively. Anaesthesia and post-operative care were conducted by independent anaesthetists, who were unaware of the drug used and of the relaxometric data obtained. All children were monitored in the recovery room by pulse oximetry until they reached a Steward Score of 6. Demographic data did not differ

2001 Anaesthesiologie und Reanimation Controlled trial quality: uncertain

1402. Infusion of amino acid enriched solution hastens recovery from neuromuscular block caused by vecuronium. (Abstract)

Infusion of amino acid enriched solution hastens recovery from neuromuscular block caused by vecuronium. We investigated the effect of an amino acid infusion on neuromuscular block produced by vecuronium, and on rectal temperature and surface temperature over the adductor pollicis muscle. Sixty adult patients undergoing general anaesthesia were randomly divided into four groups of 15 patients each: amino acid (AA)-post-tetanic count (PTC); AA-train-of-four (TOF); control (C)-PTC; or C-TOF group (...) . In the AA-PTC and AA-TOF groups, after a bolus of vecuronium 0.1 mg kg(-1), a continuous infusion of an 18 amino acid enriched solution (AMIPAREN) was started at a rate of 166 kJ h(-1). In the C-PTC and C-TOF groups, normal saline was administered. Time from vecuronium to the return of the PTC in the AA-PTC group was significantly shorter than in the C-PTC group (mean (SD), 13.3 (4.5) versus 18.0 (5.6) min, P<0.05). Times to return of T1, T2, T3, and T4 (first, second, third, and fourth twitch of TOF

2001 British Journal of Anaesthesia Controlled trial quality: uncertain

1403. Neuromuscular block with vecuronium reduces the rapidly extracted auditory evoked potentials index during steady state anesthesia. Full Text available with Trip Pro

Neuromuscular block with vecuronium reduces the rapidly extracted auditory evoked potentials index during steady state anesthesia. During clinical monitoring, vecuronium appeared to reduce the rapidly extracted auditory evoked potentials index (A-line ARX index or AAI) to some extent. A prospective and randomized study was designed to analyze this phenomenon.Forty adult patients undergoing elective surgery were studied. After tracheal intubation, anesthesia was maintained with an end-tidal (...) isoflurane concentration (F(ET)ISO) of 1.0% for 20 min, then a 10-mL dose of either vecuronium 0.05 mg*kg(-1), 0.1 mg*kg(-1), 0.2 mg*kg(-1) or saline was administered in a randomized, double-blind design. The AAI and bispectral index (BI(hx)) were monitored throughout the study and analyzed off-line.BI(hx) was unaltered after the administration of saline or vecuronium. The mean of the averaged (per patient) AAI values recorded from two minutes to ten minutes after the administration of saline

2003 Canadian journal of anaesthesia = Journal canadien d'anesthesie Controlled trial quality: uncertain

1404. Respiratory acidosis prolongs, while alkalosis shortens, the duration and recovery time of vecuronium in humans. (Abstract)

Respiratory acidosis prolongs, while alkalosis shortens, the duration and recovery time of vecuronium in humans. To determine the effects of respiratory acidosis and alkalosis by mechanical ventilation on the onset, duration, and recovery times of vecuronium.Randomized, prospective study.Operating rooms in the Sapporo Medical University Hospital and Kitami Red Cross Hospital.90 ASA physical status I and II patients undergoing lower abdominal surgery.Patients were randomly allocated to one (...) of three groups by arterial carbon dioxide tension level (PaCO2; mmHg) after induction: hyperventilation group (PaCO2 = 25-35), normoventilation group (PaCO2 = 35-45), and hypoventilation group (PaCO2 = 45-55). Anesthesia was maintained by spinal block with inhalation of 50% to 66% nitrous oxide in oxygen and intermittent intravenous administration of fentanyl and midazolam with tracheal intubation.After vecuronium 0.08 mg/kg was given, onset, duration, and recovery time were measured

2002 Journal of clinical anesthesia Controlled trial quality: uncertain

1405. Double-blind comparison of the variability in spontaneous recovery of cisatracurium- and vecuronium-induced neuromuscular block in adult and elderly patients. (Abstract)

Double-blind comparison of the variability in spontaneous recovery of cisatracurium- and vecuronium-induced neuromuscular block in adult and elderly patients. This study was designed to compare variability in the offset of two neuromuscular blocking agents with different elimination pathways.The spontaneous recovery profiles of cisatracurium and vecuronium were compared in adult (18-64 years) and elderly (> or =65 years) patients receiving N2O/O2/fentanyl/propofol anaesthesia. Patients were (...) randomised to receive an initial bolus dose and maintenance doses of 3xED95, respectively, 0.6xED95 for cisatracurium (0.15 and 0.03 mg.kg-1) or 2xED95, respectively, and 0.4xED95 for vecuronium (0.1 and 0.02 mg.kg(-1)), as recommended in their prescribing information. Administration of the study drugs was double-blinded, and neuromuscular transmission was monitored using mechanomyography of the evoked response of the adductor pollicis, following ulnar nerve stimulation.The clinically effective duration

2002 Acta Anaesthesiologica Scandinavica Controlled trial quality: uncertain

1406. Injection pain of rocuronium and vecuronium is evoked by direct activation of nociceptive nerve endings. (Abstract)

Injection pain of rocuronium and vecuronium is evoked by direct activation of nociceptive nerve endings. Rocuronium and, to a lesser extent, vecuronium can induce burning sensations associated with withdrawal reactions during administration. Dermal microdialysis in human and electrophysiological recordings of nociceptors in mouse skin were used to elucidate the underlying mechanisms of pain induction.Microdialysis catheters were inserted intradermally into the forearm of 10 volunteers and were (...) perfused with two different concentrations of rocuronium and vecuronium (1 and 10 mg mL(-1)) or a control. Dialysis samples were taken every 15 min and analysed for protein, histamine, tryptase and bradykinin content. Pain intensity was rated on a numerical scale of 0-10. In a parallel design, activation of cutaneous nociceptors was assessed directly in a skin-nerve in vitro preparation of the mouse hind paw. The receptive fields of identified single C-nociceptors (n = 12) were superfused

2003 European Journal of Anaesthesiology

1407. Residual paralysis induced by either vecuronium or rocuronium after reversal with pyridostigmine. (Abstract)

Residual paralysis induced by either vecuronium or rocuronium after reversal with pyridostigmine. We investigated postoperative residual curarization after administration of either vecuronium or rocuronium with reversal by pyridostigmine in 602 consecutive patients without perioperative neuromuscular monitoring. On arrival in the recovery room, neuromuscular function was assessed both by acceleromyography in a train-of-four (TOF) pattern and also clinically by the ability to sustain a head-lift (...) for >5 s and the tongue-depressor test. Postoperative residual curarization was defined as a TOF ratio <0.7. One fifth of 602 patients (vecuronium, 24.7%; rocuronium, 14.7%) had a TOF <0.7 in the recovery room. There were no significant differences in the TOF ratios between 10 mg and 20 mg of pyridostigmine. The patients with residual block had several associated factors: the absence of perioperative neuromuscular monitoring, the use of pyridostigmine, which is less potent than neostigmine, a larger

2002 Anesthesia and Analgesia

1408. Comparison between the continuous infusion of vecuronium and the intermittent administration of pancuronium and vecuronium. (Abstract)

Comparison between the continuous infusion of vecuronium and the intermittent administration of pancuronium and vecuronium. The neuromuscular blocking effects of repeated bolus injections of pancuronium, or vecuronium, and of the continuous infusion of vecuronium have been compared in 36 patients by means of evoked twitch tension. Groups I and II received a loading dose (0.075 mg kg-1) of pancuronium or vecuronium, respectively, followed by 0.015-mg kg-1 maintenance doses when twitch tension (...) had recovered to 25% of control. Group III received a 0.075-mg kg-1 loading dose of vecuronium plus a continuous infusion (commenced simultaneously) delivering 0.075 mg kg-1 h-1. With repeated injections of pancuronium (group I) or vecuronium (group II), the durations of blockade to 25% recovery were 64 and 25 min, respectively. Maintenance doses had to be injected every 42 min with pancuronium and every 12 min with vecuronium. The recovery times from 25% to 75% of control twitch tension were 44 v

1984 British Journal of Anaesthesia Controlled trial quality: uncertain

1409. Quantifying the interaction of vecuronium with enflurane using closed-loop feedback control of vecuronium infusion. (Abstract)

Quantifying the interaction of vecuronium with enflurane using closed-loop feedback control of vecuronium infusion. The influence of different levels of enflurane anaesthesia on infusion requirements of vecuronium was studied in 40 adult surgical patients. Ninety percent neuromuscular block was maintained by computer controlled infusion of vecuronium. During the first 90 min study period all patients received fentanyl-nitrous oxide-oxygen (2:1) anaesthesia. For the following 90 min the patients (...) were randomly assigned to receive enflurane at different end-tidal concentrations: group I, control, fentanyl-nitrous oxide anaesthesia; group II, enflurane 0.3%-nitrous oxide; group III, enflurane 0.6%-nitrous oxide; group IV, enflurane 0.9%-nitrous oxide. Every patient served as his/her own control and the changes of vecuronium infusion requirements were determined individually. When the administration of enflurane was started, vecuronium infusion requirements decreased progressively until 90 min

1995 Acta Anaesthesiologica Scandinavica Controlled trial quality: uncertain

1410. A double-blind comparison of vecuronium administered by the Springfusor infusion device to vecuronium by intermittent bolus injection in critically ill adult patients. Full Text available with Trip Pro

A double-blind comparison of vecuronium administered by the Springfusor infusion device to vecuronium by intermittent bolus injection in critically ill adult patients. To evaluate the Springfusor infusion device for clinical use in an Intensive Care Unit and to compare the technique of intermittent bolus and constant infusion of muscle relaxants, we undertook a prospective double-blind randomized placebo-controlled study. Twenty critically ill ventilated patients requiring muscle paralysis were (...) investigated. Although we could show no clinical advantage in infusing vecuronium, the Springfusor provided a more constant level of paralysis compared with hourly bolus doses. The device is robust, easy to use and reduces nursing workload. This may translate into cost-saving improvement in patient care if the Springfusor is used to provide muscle relaxation, sedation and analgesia.

1994 Anaesthesia and intensive care Controlled trial quality: uncertain

1411. Duration of action of vecuronium after an intubating dose of rapacuronium, vecuronium, or succinylcholine. (Abstract)

Duration of action of vecuronium after an intubating dose of rapacuronium, vecuronium, or succinylcholine. Rapacuronium (RAP) is a new, rapid-onset, short-duration, nondepolarizing neuromuscular blocker. If RAP is used to facilitate endotracheal intubation, what will the duration of a subsequent maintenance dose of vecuronium (VEC) be? We investigated the duration of action of a maintenance dose of VEC after intubation with RAP, VEC, or succinylcholine (SUC). Adult surgical patients under (...) % after VEC for the RAP, VEC, and SUC groups were 18.9 +/- 11.5, 21.5 +/- 8.03, and 12.8 +/- 8.4 min, and at T1 50% they were 21.5 +/- 9.1, 30.8 +/- 9.5, and 15.5 +/- 9.7 min (mean +/- SD), respectively (P < 0.001, RAP and VEC versus SUC). The duration of action of a maintenance dose of VEC was similar after an intubating dose of RAP or VEC but was shortened when preceded by an intubating dose of SUC.The duration of action of a maintenance dose of vecuronium was longer after an endotracheal intubating

2001 Anesthesia and analgesia Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>