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81. Guidelines on Smoking as Related to the Perioperative Period Background Paper

Ethylene oxide 7mcg 1 Cigarette smoke induces liver enzymes in the cytochrome P450 system, which performs such (Phase 1) reactions as drug oxidation/hydroxylation. 75 Polycyclic aromatic hydrocarbons in smoke are principally involved in induction the isoenzymes CYP1A1, CYP1A2 and CYP2E1. 75 Some anaesthetic drugs are also metabolised via these enzymes so this in part may explain some of the literature such as the increased requirements for vecuronium and rocuronium in smokers. 75 Smokers also have

2014 Australian and New Zealand College of Anaesthetists

82. Anesthesia Among Patients Undergoing Knee Arthroplasty

arthroplasty Knee group: 20 (10/10) Continuous epidural (bupivacaine plus morphine) for 48 hours post-surgery and oral piroxacam General anesthesia and intramuscular opioid (midazolam, fentanyl, and pancuronium) and acetaminophen Williams- Russo et al, 1995 (7) Knee arthroplasty 262 (134/128) Epidural (lidocaine or bupivicaine, and midazolam or fentanyl) and post-surgery epidural analgesia as requested General anesthesia (thiopental sodium, fentanyl, vecuronium, and nitrous oxide) and post-surgery (...) intravenous analgesia Williams- Russo et al, 1996 a (8) Knee arthroplasty 178 (97/81) Epidural (lidocaine or bupivicaine, and midazolam or fentanyl) and post-surgery epidural analgesia as requested General anesthesia (thiopental sodium, fentanyl, vecuronium, and nitrous oxide) and post-surgery intravenous analgesia a Subgroup of Williams-Russo et al, 1995 study (7) of patients who received thromboembolic prophylaxis. Anesthesia Among Patients Undergoing Knee Arthroplasty: A Rapid Review. November 2013; pp

2013 Health Quality Ontario

83. Guidelines on Smoking as Related to the Perioperative Period

) reactions as drug oxidation/hydroxylation. 21 Polycyclic aromatic hydrocarbons in smoke are principally involved in induction the isoenzymes CYP1A1, CYP1A2 and CYP2E1.21 Some anaesthetic drugs are also metabolised via these enzymes so this may explain some of the literature such as the increased requirements for vecuronium and rocuronium in smokers. 21 Smokers also have higher opioid requirements after surgery and experience more postoperative pain, although pharmacokinetic explanations via enzyme

2014 Australian and New Zealand College of Anaesthetists

86. [Effect of perioperative multi-day low dose ketamine infusion on prevention of postmastectomy pain syndrome]. (PubMed)

) and ketamine group (group K). Patients in group K were infused with 0.5 mg/kg of ketamine mixed in 250 ml of 0.9% normal saline in 1 h daily for 7 days. Patients in group C were infused the same dose of 0.9% normal saline. Anesthesia induction in both groups were given intravenous midazolam, sufentanil, propofol, vecuronium and intermittent positive pressure ventilation after tracheal intubation, anesthesia was maintained with propofol and remifentanil. After awakening, all patients were monitored

2018 Zhonghua yi xue za zhi

87. Effects of neostigmine or edrophonium on force of contraction when administered at a train-of-four ratio of 0.9 in anesthetized dogs. (PubMed)

study.A total of 12 Beagle dogs.Each dog was anesthetized twice with propofol and maintained with isoflurane and dexmedetomidine. Intravenous (IV) vecuronium (0.1 mg kg-1) was administered. When the mechanographic train-of-four (TOF) ratio had spontaneously recovered to ≥0.9, either neostigmine (0.04 mg kg-1) or edrophonium (0.5 mg kg-1) was administered IV, preceeded by atropine. Changes in twitch height or TOF ratio were measured for the next 10 minutes. Recurarization was considered to be present

2018 Veterinary anaesthesia and analgesia

88. Hemodynamic responses and plasma phenylephrine concentrations associated with intranasal phenylephrine in children. (PubMed)

% phenylephrine in children.After Institutional Review Board and parental approval, 77 children between the ages of 2 and 12 years were studied in a prospective, double-blind manner and randomized into three groups. Group 1 received intranasal saline, while groups 2 and 3 received 0.1 mL/kg of 0.25% or 0.5% phenylephrine, respectively. All received the same anesthetic of halothane, N2 O, O2 , and vecuronium. After inhalation induction, endtidal halothane and PaCO2 were maintained at 1.5% and 35 mm Hg

2018 Paediatric anaesthesia

89. Effect of Type II Diabetes Mellitus With Neuropathy on the Clinical Use of Rocuronium

during anesthesia maintenance. In a series of studies, vecuronium has been the only agent investigated in patients with diabetes mellitus and other diseases characterized by neuromuscular dysfunction. Delayed recovery from the neuromuscular block after vecuronium administration was shown in patients with diabetes mellitus. Currently, rocuronium, with its rapid onset of action, rapid recovery profile and inactive metabolites, is generally known as a safe agent for anesthesia under normal conditions

2018 Clinical Trials

90. Practice Change From Intermittent Medication Boluses to Bolusing From a Continuous Infusion in Pediatric Critical Care: A Quality Improvement Project. (PubMed)

hospital.Patients less than 18 years old admitted to the PICU or pediatric cardiac ICU receiving a continuous infusion of dexmedetomidine, midazolam, fentanyl, morphine, vecuronium, or cisatracurium from May 2015 to May 2016, excluding November 2015 (washout period), were eligible for inclusion.Change in practice from administering bolus doses from an automated dispensing machine to administering bolus medications from continuous infusion in PICUs.Timing studies were conducted pre- and post implementation in 29

2018 Pediatric Critical Care Medicine

91. Rapid Sequence Intubation in Traumatic Brain-injured Adults (PubMed)

Rapid Sequence Intubation in Traumatic Brain-injured Adults Deciding on proper medication administration for the traumatic brain injury (TBI) patient undergoing intubation can be daunting and confusing. Pretreatment with lidocaine and/or vecuronium is no longer recommended; however, high-dose fentanyl can be utilized to help blunt the sympathetic stimulation of intubation. Induction with etomidate is recommended; however, ketamine can be considered in the proper patient population

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2018 Cureus

92. Estimation of the effect-site equilibration rate constant using the time-to-peak effect of muscle relaxants measured by train-of-four stimulation during general anesthesia induction (PubMed)

practice by applying a priming dose and train-of-four (TOF) during general anesthesia induction, and ke0 can be calculated from the tpe of the four muscle relaxants that are commonly used in general anesthesia.Eighty patients who received general anesthesia were divided into the succinylcholine, rocuronium, atracurium, or vecuronium groups. Priming doses of muscle relaxants were administered. The effects of muscle relaxants were quantified by recording the twitch response of the adductor pollicis (...) muscle after stimulating the ulnar nerve. The tpe was measured at the lowest TOF value. ke0 was calculated from the measured tpe .The ke0 values of the succinylcholine, rocuronium, atracurium, and vecuronium groups were 0.076 (0.030)/min, 0.228 (0.122)/min, 0.062 (0.011)/min, and 0.077 (0.019)/min, respectively.It is possible to estimate ke0 from the tpe of muscle relaxants using a priming dose and TOF during general anesthesia induction.

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2018 Korean journal of anesthesiology

93. Characterization of mouse neuro‐urological dynamics in a novel decerebrate arterially perfused mouse (DAPM) preparation (PubMed)

(>400 pM) caused dyssynergy of the LUT resulting in retention in DAPM as it increased tonic EUS activity and basal bladder pressure in a dose-dependent manner (basal pressure increase also noted in pithed DAPM). Both neuromuscular blockade (vecuronium) and autonomic ganglion blockade (hexamethonium), initially caused incomplete voiding, and both drugs eventually stopped voiding in DAPM. Intravesical acetic acid (0.2%) decreased the micturition interval. Recordings from the pelvic nerve in the pithed

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2018 Neurourology and urodynamics

94. Use of Sugammadex in a Patient With Myotonic Dystrophy (PubMed)

Use of Sugammadex in a Patient With Myotonic Dystrophy One of the challenges during the perioperative care of patients with myotonic dystrophy is the reversal of neuromuscular blocking agents. Agents that inhibit acetylcholinesterase, such as neostigmine, may precipitate myotonia, and are therefore relatively contraindicated. Sugammadex is a novel pharmacologic agent, which encapsulates rocuronium or vecuronium, thereby reversing their effect. We report anecdotal experience with the use

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2018 Cardiology Research

95. Midazolam Versus Dexamethasone-ondansetron in Preventing Postoperative Nausea-vomiting for Laparoscopic Surgeries

will be recruited for the study if they satisfy the inclusion and exclusion criteria as mentioned later. Consent will be obtained from the patients themselves. Standard protocol for administration of anaesthesia will be followed in all patients which is briefly described. All patients will receive general anaesthesia and will be induced with Propofol titrated to effect. Intraoperatively, isoflurane will be used as maintenance agent and vecuronium as non depolarizing muscle relaxant. For analgesia, patients

2018 Clinical Trials

96. The Effect of Pressure-controlled Ventilation-volume Guaranteed Mode

of Anesthesiologists physical status I-III who underwent lumbar spine surgery in prone position were enrolled. All patients fasted for 8 hours before the surgery and were premedicated with intramuscular glycopyrrolate 0.2 mg. Anesthesia was induced with remifentanil (0.1-0.2 ug/kg/min), propofol (1.5-2 mg/kg) and rocuronium (0.6 and maintained with sevoflurane (2.0-2.5 vol%) in inspired oxygen fraction with 0.5, remifentanil (0.05-0.3 ug/kg/min) and vecuronium (0.03-0.05 mg/kg/hr). A 20 G catheter

2018 Clinical Trials

97. Effects of Hypotensive Anesthesia on Thiol Disulphide Balance

Faculty Training and Research Hospital. Participants with uncontrolled hypertension, diabetes mellitus, cerebrovascular disease, cogulopathy, morbid obesity (BMI ≥35) and renal disease will not be taken. Participants were first pre-medicated with an infusion of midazolam 0.05 mg/kg, fentanyl 1 µg/kg, lidocaine 1 mg/kg. Induction of anesthesia was achieved with an infusion of propofol 1-2 mg/kg and vecuronium bromide 0.6 mg/kg and after 2 to 3 minutes participants were intubated with the appropriate

2018 Clinical Trials

98. Opioid-Free Shoulder Arthroplasty

: To identify and provide a safe, opioid-free treatment pathway for shoulder arthroplasty with a focus on perioperative pain control and postoperative symptoms from treatment Condition or disease Intervention/treatment Phase Opioid Use Shoulder Osteoarthritis Avascular Necrosis Rotator Cuff Tear Arthritis;Inflammatory Drug: Gabapentin Drug: Celecoxib Drug: toradol Drug: acetaminophen Drug: regional block Drug: propofol Drug: IV lidocaine Drug: rocuronium Drug: vecuronium Drug: sevoflurane Drug: desflurane (...) without the aid of opioid co-medication. Intra-op management by anesthesia with non-opioid modalities but should include one dose of IV acetaminophen during the procedure. Anesthetic modalities will include, but not limited to, regional block, propofol, IV lidocaine, rocuronium/vecuronium, and sevoflurane/desflurane. If the attending anesthesiologist deems it necessary to dose with opioids during procedure, it will be recorded and reported. Liposomal bupivacaine will be injected into the peri

2018 Clinical Trials

99. Validation of the REPS Prediction Tool

Healthy Volunteers: Yes Sampling Method: Non-Probability Sample Study Population Adult patients who underwent non-cardiac surgery under general anesthesia with intermediate-acting NMBAs and are admitted to the Post-Anaesthesia Care Unit (PACU) after surgery. Criteria Inclusion Criteria: 18 years or older Non-cardiac surgery General anesthesia with intermediate-acting NMBAs (atracurium, cisatracurium, vecuronium, or rocuronium) PACU after surgery Exclusion Criteria: American Society of Anesthesiology

2018 Clinical Trials

100. Anesthetic Methods and Gene Expression Profile

in the GA-group received general anesthesia. GA was induced by intravenous fentanyl (1 mcg/kg) and propofol (2 mg/kg), followed by vecuronium bromide (0.1 mg/kg) to facilitate tracheal intubation, then GA was maintained using a 50% air/oxygen mixture and sevoflurane.The end-tidal concentration of sevoflurane was adjusted to maintain heart rate and blood pressure values within 20% of baseline. Mechanical ventilation was regulated to maintain the end-tidal carbon dioxide partial pressure ranging between

2018 Clinical Trials

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