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Vecuronium

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41. Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia

Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01379352 Recruitment Status : Completed First Posted : June 23, 2011

2011 Clinical Trials

42. [Rocuronium vs vecuronium for neuromuscular block during transsternal thymectomy in the patient with myasthenia gravis]. (PubMed)

[Rocuronium vs vecuronium for neuromuscular block during transsternal thymectomy in the patient with myasthenia gravis]. Myasthenia gravis is an autoimmune disease marked by high titers of immunoglobulin G antibodies, which accelerate destruction of cholinergic receptors and interfere with neuromuscular transmission. This study aimed to determine whether neuromuscular function under a rocuronium block is different from function under a vecuronium block patients with myasthenia gravis (...) and to describe extubation conditions in the operating room or the intensive care unit.Randomized, single-blind clinical trial enrolling patients with myasthenia gravis type IIa and IIb according to the classification of Osserman. The patients were randomized to groups receiving a vecuronium or rocuronium block. We recorded arterial oxygen saturation, capnogram, heart rate, noninvasive blood pressure, electrocardiogram, and neuromuscular function by accelerometry. During surgery 25% of the total dose

2011 Revista española de anestesiología y reanimación

43. Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial (PubMed)

Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial Sugammadex, a specifically designed gamma-cyclodextrin, is a selective relaxant binding drug that rapidly reverses rocuronium-induced and, to a lesser extent, vecuronium-induced neuromuscular blockade. In this study, we compared the efficacy of sugammadex and neostigmine for the reversal of vecuronium-induced neuromuscular blockade in patients (...) scheduled for elective surgery.Patients aged > or = 18 yr, ASA Class I-III, and scheduled for a surgical procedure under sevoflurane/opioid anesthesia received an intubating dose of vecuronium (0.1 mg/kg) and maintenance doses of 0.02-0.03 mg/kg at reappearance of the second twitch (T(2)) of train-of-four (TOF) if required. Neuromuscular blockade was monitored using acceleromyography (TOF-Watch SX, Schering-Plough Ireland, Dublin, Ireland). At end of surgery, at reappearance of T(2) after the last dose

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2010 EvidenceUpdates

44. A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia (PubMed)

A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia Sugammadex is the first of a new class of selective muscle relaxant binding drugs developed for the rapid and complete reversal of neuromuscular blockade induced by rocuronium and vecuronium. Many studies have demonstrated a dose-response relationship with sugammadex for reversal of neuromuscular blockade in patients induced (...) and maintained under propofol anesthesia. However, sevoflurane anesthesia, unlike propofol, can prolong the effect of neuromuscular blocking drugs (NMBDs) such as rocuronium and vecuronium.We designed this randomized, open-label, dose-response trial to explore the dose-response relationship of sugammadex for the reversal of deep neuromuscular blockade induced by rocuronium or vecuronium under propofol-induced and sevoflurane-maintained anesthesia. As a secondary objective, the safety variables of sugammadex

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2010 EvidenceUpdates

45. [Efficacy of vecuronium in the elimination of human-machine confrontation resulting from mechanical ventilation in newborns]. (PubMed)

[Efficacy of vecuronium in the elimination of human-machine confrontation resulting from mechanical ventilation in newborns]. 20416229 2010 08 03 2013 11 21 1008-8830 12 4 2010 Apr Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics Zhongguo Dang Dai Er Ke Za Zhi [Efficacy of vecuronium in the elimination of human-machine confrontation resulting from mechanical ventilation in newborns]. 303-5 Wang Zhao-Kang ZK Department of Pediatrics, People's Hospital of Binyang County (...) , Nanning 530405, China. Wu Bao-Zhen BZ chi Journal Article Randomized Controlled Trial China Zhongguo Dang Dai Er Ke Za Zhi 100909956 1008-8830 0 Neuromuscular Nondepolarizing Agents 7E4PHP5N1D Vecuronium Bromide IM Blood Gas Analysis Humans Infant, Newborn Neuromuscular Nondepolarizing Agents therapeutic use Respiration, Artificial adverse effects Vecuronium Bromide therapeutic use 2010 4 27 6 0 2010 4 27 6 0 2010 8 4 6 0 ppublish 20416229 1008-8830(2010)04-0303-03

2010 Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

46. Effects of sugammadex doses up to 32 mg/kg alone or in combination with rocuronium or vecuronium on QTc prolongation: a thorough QTc study. (PubMed)

Effects of sugammadex doses up to 32 mg/kg alone or in combination with rocuronium or vecuronium on QTc prolongation: a thorough QTc study. Sugammadex reverses the effects of rocuronium- and vecuronium-induced neuromuscular blockade, which are achieved by encapsulation. It is known that some non-antiarrhythmic drugs have the potential to delay cardiac repolarization and it is therefore recommended that the effects of all new drugs on the QT interval are assessed.This thorough corrected QT (QTc (...) ) study evaluated the effect of sugammadex alone and in combination with rocuronium or vecuronium on the individually corrected QTc interval (QTcI).This was a randomized, double-blind, six-period crossover, placebo-controlled study, with an open-label active-controlled component (moxifloxacin). The study was designed according to International Conference on Harmonization (ICH) E14 guidelines. The study was conducted in a clinical research unit from November 2006 to April 2007. Healthy male and female

2010 Clinical drug investigation

47. Sugammadex rapidly reverses moderate rocuronium- or vecuronium-induced neuromuscular block during sevoflurane anaesthesia: a dose-response relationship. (PubMed)

Sugammadex rapidly reverses moderate rocuronium- or vecuronium-induced neuromuscular block during sevoflurane anaesthesia: a dose-response relationship. Sugammadex shows a dose-response relationship for reversal of neuromuscular block (NMB) during propofol anaesthesia. Sevoflurane, unlike propofol, can prolong the effect of neuromuscular blocking agents (NMBAs), increasing recovery time. This open-label, randomized, dose-finding trial explored sugammadex dose-response relationships, safety (...) , and pharmacokinetics when administered for reversal of moderate rocuronium- or vecuronium-induced NMB during sevoflurane maintenance anaesthesia.After anaesthesia induction with propofol, adult patients were randomized to receive single-dose rocuronium 0.9 mg kg⁻¹ or vecuronium 0.1 mg kg⁻¹, with maintenance doses as needed. Anaesthesia was maintained with sevoflurane. NMB was monitored using acceleromyography. After the last dose of NMBA, at reappearance of T(2), single-dose sugammadex 0.5, 1.0, 2.0, or 4.0 mg kg

2010 British Journal of Anaesthesia

48. Acceleromyographic monitoring of neuromuscular block over the orbicularis oris muscle in anesthetized patients receiving vecuronium. (PubMed)

Acceleromyographic monitoring of neuromuscular block over the orbicularis oris muscle in anesthetized patients receiving vecuronium. To evaluate the level of neuromuscular block acceleromyographically over the orbicularis oris muscle.Prospective, randomized, controlled study.Operating room of a university-affiliated hospital.36 adult, ASA physical status I and II women scheduled for mastectomy with air-oxygen-isoflurane-fentanyl anesthesia.Patients were randomized to two groups (...) . In the orbicularis oris group (n=18), the facial nerve was stimulated and movement of the orbicularis oris muscle was measured acceleromyographically. In the control group (n=18), adduction of the thumb was quantified mechanically.Onset and recovery of neuromuscular block caused by vecuronium 0.1 mg/kg were compared between the groups.Time to onset of neuromuscular block in the orbicularis oris group was significantly shorter than in the control group (176 + or - 52 vs. 220 + or - 34 sec, mean + or - SD; P

2010 Journal of clinical anesthesia

49. Neuromuscular blockade by vecuronium during induction with 5% sevoflurane or propofol. (PubMed)

Neuromuscular blockade by vecuronium during induction with 5% sevoflurane or propofol. This randomized trial investigated whether 5% sevoflurane potentiated neuromuscular blockade by vecuronium. General anaesthesia was induced with 5% sevoflurane in oxygen in 16 patients or with propofol in 16 patients. After loss of consciousness, vecuronium was administered to all participants at randomly assigned doses of 25, 30, 35 or 40 μg/kg. Neuromuscular blockade was assessed by use of acceleromyography

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2010 The Journal of international medical research

50. Reversal of profound vecuronium-induced neuromuscular block under sevoflurane anesthesia: sugammadex versus neostigmine. (PubMed)

Reversal of profound vecuronium-induced neuromuscular block under sevoflurane anesthesia: sugammadex versus neostigmine. Acetylcholinesterase inhibitors cannot rapidly reverse profound neuromuscular block. Sugammadex, a selective relaxant binding agent, reverses the effects of rocuronium and vecuronium by encapsulation. This study assessed the efficacy of sugammadex compared with neostigmine in reversal of profound vecuronium-induced neuromuscular block under sevoflurane anesthesia.Patients (...) aged ≥18 years, American Society of Anesthesiologists class 1-4, scheduled to undergo surgery under general anesthesia were enrolled in this phase III, multicenter, randomized, safety-assessor blinded study. Sevoflurane anesthetized patients received vecuronium 0.1 mg/kg for intubation, with maintenance doses of 0.015 mg/kg as required. Patients were randomized to receive sugammadex 4 mg/kg or neostigmine 70 μg/kg with glycopyrrolate 14 μg/kg at 1-2 post-tetanic counts. The primary efficacy

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2010 BMC anesthesiology

51. Guidelines for the Administration of Electroconvulsive Therapy

. Careful monitoring is essential. The isolated limb technique can be very helpful. The patient is asked to ‘move your right foot!’ immediately prior to the delivery of the stimulus enabling the anaesthetist to administer a further dose of the induction agent before treatment is administered if required. Adequate muscle relaxant should be used – usually sux- amethonium. A small dose of rocuronium, or vecuronium, may be administered before suxamethonium to minimise the suxamethonium-induced myalgia

2019 American Psychiatric Association

52. Update: Does Rocuronium Create Better Intubating Conditions Than Succinylcholine for Rapid Sequence Intubation?

snapshot is: Tran DT, Newton EK, Mount VA, et al. Rocuronium versus succinylcholine for rapid sequence induction intubation. Cochrane Database Syst Rev. 2015;(10):CD002788. http://dx. doi.org/10.1002/14651858. CD002788.pub3. 1. Magorian T, Flannery KB, Miller RD. Comparison of rocuronium, succinylcholine, and vecuronium for rapid-sequence induction of anesthesia in adult patients. Anesthesiology. 1993;79:913-918. 2. Martyn JA, Richtsfeld M. Succinylcholine- induced hyperkalemia in acquired pathologic

2017 Annals of Emergency Medicine Systematic Review Snapshots

54. Comparative effectiveness of sugammadex versus neostigmine for reversal of neuromuscular blockade following surgery in adult patients

assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Comparative effectiveness of sugammadex versus neostigmine for reversal of neuromuscular blockade following surgery in adult patients . Lansdale: HAYES, Inc.. Directory Publication. 2016 Authors' objectives Sugammadex (SUG) is indicated for the reversal of neuromuscular blockade (NMB) induced by rocuronium bromide and vecuronium bromide during surgery. SUG selectively binds

2017 Health Technology Assessment (HTA) Database.

55. Sugammadex for the Reversal of Neuromuscular Blockade in Adult Patients: A Review of Clinical Effectiveness and Cost-Effectiveness

for the recovery of neuromuscular blockade in adult patients, as compared with other pharmacological reversal agents or spontaneous recovery. Based on the identified published literature, sugammadex is associated with a quicker recovery from rocuronium or vecuronium-induced muscle relaxation, results in a shorter time to extubation, and is associated with a reduced likelihood of residual postoperative paralysis in comparison with neostigmine or spontaneous recovery. Similarly, safety data suggest

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

57. Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient

in November 2012 and included the timeframe of 2001 to November 22, 2012 (to capture literature published since the previous guidelines were created) using the following terms: neuromuscular blocking agents , neuromuscular blockers, cisatracurium, atracurium, rocuronium, vecuronium, pancuronium, succinylcholine , and sugammadex , each alone and in combination with sedation , analgesia, monitoring, electroencephalogram (EEG), Bispectral Index (BIS), shock, oxygen delivery, oxygen consumption, pregnancy (...) nervous system and at presynaptic muscarinic receptors in the peripheral sympathetic nervous system, with the former resulting in vagolytic action and the latter increasing norepinephrine release, both of which cause tachycardia. Rocuronium, more so than vecuronium, has affinity for muscarinic receptors at other sites within the parasympathetic nervous system. The remaining nondepolarizing agents have even weaker affinities for the muscarinic receptor ( ). The most significant manifestation

2016 Society of Critical Care Medicine

58. Syringe labelling in critical care areas review

/ml. mg/ml. Vecuronium mg/ml. Morphine mg/ml. Fentanyl micrograms/ml. micrograms/ml. Ephedrine mg/ml. Atropine micrograms/ml. Glycopyrronium micrograms/ml. Ondansetron mg/ml. Diazepam mg/ml. Midazolam mg/ml. Neostigmine micrograms/ml. Naloxone micrograms/ml. Labetalol mg/ml. Lidocaine %. Bupivacaine %. Heparin units/ml. Protamine mg/ml. STANDARD BACKGROUND COLOURS FOR USER-APPLIED SYRINGE DRUG LABELS Drug class Examples Pantone ® colour (uncoated) Anti-emetics Metoclopramide, Ondansetron Pantone ® (...) 156 (salmon) Induction agents Thiopental, etomidate, ketamine, propofol Yellow Hypnotics Diazepam, lorazepam, midazolam Pantone ® 151 (orange) Hypnotic antagonists Flumazenil Pantone ® 151 (orange with white diagonal stripes) Depolarising neuromuscular blocking drugs Suxamethonium Pantone ® 805 (fluorescent or warm red lettering out of black above, red below) Non-depolarising neuromuscular blocking drugs Atracurium, Vecuronium Pantone ® 805 (fluorescent or warm red) Neuromuscular blocking drug

2016 Association of Anaesthetists of GB and Ireland

59. Nitrous oxide added at the end of isoflurane anesthesia hastens early recovery without increasing the risk for postoperative nausea and vomiting: a randomized clinical trial

with thiopental 5 mg·kg-1, vecuronium 0.1 mg·kg-1, and fentanyl 1-2 μg·kg-1 iv and maintained with isoflurane. Indicators of early recovery (time to extubation, eye opening, following commands, orientation) were assessed by an anesthesiologist unaware of the group assignment. The incidence and severity of PONV was measured at two and 24 hr postoperatively.Altogether, 82 participants completed the study (42 in GO2, 40 in GN2O) and were analyzed. The mean (SD) time of N2O administration in GN2O patients

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2018 EvidenceUpdates

60. Perioperative management of people with inherited salt-wasting alkaloses (Gitelman?s syndrome and Bartter?s syndrome) undergoing non-urgent surgical procedure

with Bartter’s/Gitelman’s syndromes. Clin Nephrol. 2007 Mar;67(3):193–7. 4. Abston PA, Priano LL. Bartter’s syndrome: anesthetic implications based on pathophysiology and treatment. Anesth Analg. 1981 Oct;60(10):764–6. 5. Nishikawa T, Dohi S. Baroreflex function in a patient with Bartter’s syndrome. Can Anaesth Soc J. 1985 Nov;32(6):646–50. 6. Chenoweth D. Successful use of isoflurane and vecuronium in a patient with Bartter’s syndrome: a case study. AANA J. 1987 Nov;55(5):434–6. 7. Higa K, Ishino H, Sato S

2015 Renal Association

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