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Vecuronium

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41. Comparison of intubating conditions of rocuronium bromide and vecuronium bromide with succinylcholine using "timing principle". (Abstract)

Comparison of intubating conditions of rocuronium bromide and vecuronium bromide with succinylcholine using "timing principle". Rapid and safe endotracheal intubation is of paramount importance in general anaesthesia. The aim of this study was to compare the intubating conditions of succinylcholine with rocuronium bromide and vecuronium bromide using "Timing principle". The timing principle entails administration of a single bolus dose of nondepolarizing muscle relaxant, followed (...) by an induction drug at the onset of clinical weakness. PATIENTS #ENTITYSTARTX00026;75 patients were divided into three groups of 25 each. Patients allocated to Groups A and B received rocuronium 0.6 mg kg(-1) and vecuronium 0.12 mg kg(-1) respectively. At the onset of clinical weakness (ptosis), anesthesia was induced with propofol 2.5 mg kg(-1); intubation was accomplished after 60 seconds of induction agent in both groups. Patients in Group C received propofol 2.5mg kg(-1) followed by succinylcholine 2mg

2011 Journal of anaesthesiology, clinical pharmacology Controlled trial quality: uncertain

42. Continuous Infusion versus Intermittent Bolus Dosing of Vecuronium in Patients Receiving Therapeutic Hypothermia After Sudden Cardiac Arrest. (Abstract)

Continuous Infusion versus Intermittent Bolus Dosing of Vecuronium in Patients Receiving Therapeutic Hypothermia After Sudden Cardiac Arrest. To compare the effects of vecuronium administered as an intravenous continuous infusion versus intermittent bolus doses in patients treated with therapeutic hypothermia after sudden cardiac arrest (SCA). Design. Retrospective medical record review.Cardiac care unit of a university-affiliated, level I trauma center.Of 123 adults treated with therapeutic (...) hypothermia after SCA, 80 received continuous-infusion vecuronium 0.8 μg/kg/minute started 2 hours after cooling began or if shivering occurred (January 1, 2004-December 31, 2007), and 43 received intermittent boluses of vecuronium 0.05 mg/kg every 2 hours (January 1, 2008-September 30, 2009).The degree of neuromuscular blockade was measured with a train-of-four (TOF) test. Primary outcomes evaluated were time to achieve goal TOF response and percentage of time the TOF response was maintained at goal

2011 Pharmacotherapy

43. [Rocuronium vs vecuronium for neuromuscular block during transsternal thymectomy in the patient with myasthenia gravis]. (Abstract)

[Rocuronium vs vecuronium for neuromuscular block during transsternal thymectomy in the patient with myasthenia gravis]. Myasthenia gravis is an autoimmune disease marked by high titers of immunoglobulin G antibodies, which accelerate destruction of cholinergic receptors and interfere with neuromuscular transmission. This study aimed to determine whether neuromuscular function under a rocuronium block is different from function under a vecuronium block patients with myasthenia gravis (...) and to describe extubation conditions in the operating room or the intensive care unit.Randomized, single-blind clinical trial enrolling patients with myasthenia gravis type IIa and IIb according to the classification of Osserman. The patients were randomized to groups receiving a vecuronium or rocuronium block. We recorded arterial oxygen saturation, capnogram, heart rate, noninvasive blood pressure, electrocardiogram, and neuromuscular function by accelerometry. During surgery 25% of the total dose

2011 Revista española de anestesiología y reanimación Controlled trial quality: uncertain

44. Effect of epidural levobupivacaine on recovery from vecuronium-induced neuromuscular block in patients undergoing lower abdominal surgery. Full Text available with Trip Pro

Effect of epidural levobupivacaine on recovery from vecuronium-induced neuromuscular block in patients undergoing lower abdominal surgery. The aim of this study was to evaluate the effect of epidural levobupivacaine on recovery from vecuronium-induced neuromuscular block. Ninety patients undergoing lower abdominal surgery were randomised into two groups after an epidural test dose: the epidural group (n = 45) received a bolus of 15 ml of 0.5% levobupivacaine whereas the control group (n = 45 (...) ) did not. Anaesthesia was induced and maintained with propofol, fentanyl, vecuronium and nitrous oxide. Neuromuscular block was induced with vecuronium 0.1 mg/kg and monitored with acceleromyographic train-of-four at the adductor pollicis. Patients in each group received neostigmine at 25% recovery of the first twitch of train-of-four during recovery from anaesthesia. The effect of epidural levobupivacaine on the speed of recovery of neuromuscular function was evaluated. The lag time, onset time

2011 Anaesthesia and intensive care Controlled trial quality: uncertain

45. Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia

Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01379352 Recruitment Status : Completed First Posted : June 23, 2011

2011 Clinical Trials

46. [Comparison of atracurium, cisatracurium and vecuronium during anaesthesia for laparoscopic surgery]. (Abstract)

[Comparison of atracurium, cisatracurium and vecuronium during anaesthesia for laparoscopic surgery]. The aim of the study was to compare the intubating conditions, onset time, and duration of action of atracurium, cisatracurium, and vecuronium, when used for muscle relaxation in laparoscopic surgery with carbon dioxide inflation. In trying to find an "ideal" relaxant we compared the relative potency of these drugs, and also measured pH, PaCO2 and skin temperature.Ninety-five ASA I and II (...) patients were randomly allocated to three groups, to receive atracurium (I), cisatracurium (II), or vecuronium (III), during propofol/fentanyl anaesthesia. Neuromuscular transmission was monitored using accelerography (TOF GUARD). Patients were intubated after the injection of 0.5 mg kg-1 atracurium (I), 0.1 mg kg(-1) cisatracurium (II), or 0.1 mg kg(-1) vecuronium (III). Muscle relaxation was maintained with incremental doses of 0.1 0.2 mg kg(-1) and 0.03 mg kg(-1) of the relaxants respectively, given

2011 Anestezjologia intensywna terapia Controlled trial quality: uncertain

47. Covid-19: Guidance on potential changes to anaesthetic drug usage and administration during pandemic emergency pressures

Alternative drugs / techniques Induction propofol # thiopental sodium / etomidate ketamine # propofol / thiopental sodium / midazolam Neuromuscular blockade - RSI rocuronium # suxamethonium # Neuromuscular blockade – routine rocuronium vecuronium / atracurium*# / cisatracurium*# / pancuronium Maintenance of anaesthesia propofol (TIVA) * sevoflurane / isoflurane / desflurane sevoflurane Isoflurane / desflurane Analgesia – short acting opioid fentanyl*# alfentanil *#/ remifentanil remifentanil # none

2020 ICM Anaesthesia COVID-19

49. COVID-19 potential anaesthetic drug list

on injection • 1 MAC = 1.2% in adults • Potentiates action of non- depolarising neuromuscular blocking drugs • Avoid for inhalational induction • Saddle block: 10-20 mg (0.5-1 mls) • T10 block: 40-60 mg (2-3mls) • No need for additional opioids • Reduced risk of urinary retention and ongoing motor block • Surgery for up approximately 60 minutes • Relatively contraindicated in sickle cell disease due to methaemoglobinaemia risk VECURONIUM VECURONIUM • Dose: 0.08-0.1 mg/kg IV • Onset: 3-5 min • Duration: 20

2020 ICM Anaesthesia COVID-19

50. Guidelines for the Administration of Electroconvulsive Therapy

. Careful monitoring is essential. The isolated limb technique can be very helpful. The patient is asked to ‘move your right foot!’ immediately prior to the delivery of the stimulus enabling the anaesthetist to administer a further dose of the induction agent before treatment is administered if required. Adequate muscle relaxant should be used – usually sux- amethonium. A small dose of rocuronium, or vecuronium, may be administered before suxamethonium to minimise the suxamethonium-induced myalgia

2019 American Psychiatric Association

52. Forms for the Diagnosis of Death using neurological criteria

Yes / No Guidance The patient should not have received any drugs that might be contributing to the unconsciousness, apnoea and loss of brain-stem reflexes (narcotics, hypnotics, sedatives or tranquillisers); nor should they have any residual effect from any neuromuscular blocking agents (atracurium, vecuronium or suxamethonium). It remains the duty of the two doctors carrying out the testing to be satisfied that sufficient time has elapsed to ensure that any remaining drug effect is non

2019 Faculty of Intensive Care Medicine

53. Intubation of the Critically Ill Child

(Etomidate 0.3mg/kg) Rocuronium 1mg/kg Suxamethonium 1-2mg/kg Atracurium 0.5mg/kg Vecuronium 0.1mg/kg Pancuronium 0.1mg/kg Difficult airway: refer to algorithm and involve ENT Cardiovascular instability: appropriate induction agent and prepare inotrope(s) + fluid bolus Aspiration risk: rapid sequence induction Assessment Induction agent Choices Neuromuscular blockade Choices Ongoing sedation Morphine infusion 5-40mcg/kg/hr +/- boluses 50-100mcg/kg Midazolam infusion 1-4mcg/kg/min +/- boluses 50-100mcg/kg (...) Ongoing NMB (if necessary) Vecuronium infusion 1-6mcg/kg/min +/- boluses 100mcg/kg Flowchart for induction of anaesthesia for non-elective intubation *Please read all notes below* Printed copies of this document may not be up to date, obtain the most recent version from www.cats.nhs.uk Children’s Acute Transport Service provides paediatric intensive care retrieval for Great Ormond Street, The Royal Brompton and St Mary’s NHS Trusts. Funded and accountable to the North Thames Paediatric Intensive Care

2018 Children's Acute Transport Service

54. Acute Severe Asthma

). • Sedate and paralyse for ventilation. A combination of midazolam and ketamine, or fentanyl and midazolam can be used for sedation. Vecuronium can be used for paralysis. Inhalational agents such as sevoflurane (have bronchodilatory properties) may also be used for ongoing sedation. • Pursue a pressure limited permissive hypercapnia strategy (pH = 7.2) o Aim PIP < 35 cm H 2O (to minimise risk of barotrauma) o Keep tidal volume 5-7 ml/kg o Low rate (10 - 15 bpm) o I: E ratio of at least 1:2 • PEEP of 5-7

2018 Children's Acute Transport Service

55. Burns

pressures and early chest escharotomy. 4.3 Regular ETT suctioning may be required. 4.4 Analgesia, sedation and paralysis: morphine, midazolam and vecuronium infusions, plus ketamine if necessary. 4.5 Examine CXR for signs of pneumonitis and ARDS. 4.6 Place nasogastric (or orogastric if nasogastric contraindicated) tube if not already placed. 5. Transport considerations 5.1 Consider cervical spine and spinal immobilisation in all patients (as per current guidelines) 5.2 Maintain circulation: maintenance

2018 Children's Acute Transport Service

56. Vein of Galen malformation

Street NHS Trust. Page 2 of 3 Printed copies of this document may not be up to date, obtain the most recent version from www.cats.nhs.uk • Neuroprotective strategies - sedate and paralyse with morphine and vecuronium infusions, regular pupillary observations, 30 degrees head up tilt. • If signs of raised ICP, consider osmotherapy (3ml/kg of 2.7% saline aiming for Na 145- 150mmol/L or 0.25g/kg mannitol). • Aim for normothermia – to minimise further peripheral vasodilation and tachycardia. • If any

2018 Children's Acute Transport Service

57. Update: Does Rocuronium Create Better Intubating Conditions Than Succinylcholine for Rapid Sequence Intubation?

snapshot is: Tran DT, Newton EK, Mount VA, et al. Rocuronium versus succinylcholine for rapid sequence induction intubation. Cochrane Database Syst Rev. 2015;(10):CD002788. http://dx. doi.org/10.1002/14651858. CD002788.pub3. 1. Magorian T, Flannery KB, Miller RD. Comparison of rocuronium, succinylcholine, and vecuronium for rapid-sequence induction of anesthesia in adult patients. Anesthesiology. 1993;79:913-918. 2. Martyn JA, Richtsfeld M. Succinylcholine- induced hyperkalemia in acquired pathologic

2017 Annals of Emergency Medicine Systematic Review Snapshots

59. Comparative effectiveness of sugammadex versus neostigmine for reversal of neuromuscular blockade following surgery in adult patients

assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Comparative effectiveness of sugammadex versus neostigmine for reversal of neuromuscular blockade following surgery in adult patients . Lansdale: HAYES, Inc.. Directory Publication. 2016 Authors' objectives Sugammadex (SUG) is indicated for the reversal of neuromuscular blockade (NMB) induced by rocuronium bromide and vecuronium bromide during surgery. SUG selectively binds

2017 Health Technology Assessment (HTA) Database.

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