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Vecuronium

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181. [Effect of intraoperative esmolol infusion on anesthetic, analgesic requirements and postoperative nausea-vomitting in a group of laparoscopic cholecystectomy patients]. Full Text available with Trip Pro

, postoperative pain and PNV.Sixty patients have been included. Propofol, remifentanil and vecuronium were used for induction. Study groups were as follows; I - Esmolol infusion was added to maintenance anesthetics (propofol and remifentanil), II - Only propofol and remifentanil was used during maintenance, III - Esmolol infusion was added to maintenance anesthetics (desflurane and remifentanil), IV - Only desflurane and remifentanil was used during maintenance. They have been followed up for 24h for PNV

2015 Revista brasileira de anestesiologia Controlled trial quality: uncertain

182. Atracurium Besylate and other neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cells Full Text available with Trip Pro

astroglial but not neuronal differentiation of GSCs. Functionally, Atracurium Besylate treatment significantly inhibited the clonogenic capacity of several independent patient-derived GSC neurosphere lines, a phenomenon which was largely irreversible. A second NNMB, Vecuronium, also induced GSC astrocytic differentiation while Dimethylphenylpiperazinium (DMPP), a nicotinic acetylcholine receptor (nAChR) agonist, significantly blocked Atracurium Besylate pro-differentiation activity. To investigate

2015 Oncotarget

183. Sugammadex and rocuronium-induced anaphylaxis Full Text available with Trip Pro

) is associated with a relatively high rate of IgE-mediated anaphylaxis compared with other muscle relaxant agents. Sugammadex is widely used for reversal of the effects of steroidal neuromuscular blocking agents, such as rocuronium and vecuronium. Confirmed cases of allergic reactions to clinical doses of sugammadex have also been recently reported. Given these circumstances, the number of cases of hypersensitivity to either sugammadex or rocuronium is likely to increase. Thus, anesthesiologists should

2015 Journal of anesthesia

184. Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents. Full Text available with Trip Pro

Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents. The authors evaluated the comparative effectiveness of calabadion 2 to reverse non-depolarizing neuromuscular-blocking agents (NMBAs) by binding and inactivation.The dose-response relationship of drugs to reverse vecuronium-, rocuronium-, and cisatracurium-induced neuromuscular block (NMB) was evaluated in vitro (competition binding assays and urine analysis), ex vivo (n = 34 (...) times the affinity of sugammadex (Ka = 3.4 × 10 M and Ka = 3.8 × 10 M-). The results of urine analysis (proton nuclear magnetic resonance), competition binding assays, and ex vivo study obtained in the absence of metabolic deactivation are in accordance with an 1:1 binding ratio of sugammadex and calabadion 2 toward rocuronium. In living rats, calabadion 2 dose-dependently and rapidly reversed all NMBAs tested. The molar potency of calabadion 2 to reverse vecuronium and rocuronium was higher

2015 Anesthesiology

185. Sedation after airway reconstruction in children: A protocol to reduce withdrawal and length of stay. (Abstract)

. eng Journal Article 2015 07 07 United States Laryngoscope 8607378 0023-852X 0 Analgesics, Opioid 0 Hypnotics and Sedatives 0 Neuromuscular Nondepolarizing Agents 76I7G6D29C Morphine 7E4PHP5N1D Vecuronium Bromide O26FZP769L Lorazepam IM Analgesics, Opioid administration & dosage Child, Preschool Conscious Sedation methods Drug Therapy, Combination Female Follow-Up Studies Humans Hypnotics and Sedatives administration & dosage Infant Infusions, Intravenous Laryngoplasty Laryngostenosis surgery (...) Length of Stay trends Lorazepam administration & dosage Male Morphine administration & dosage Neuromuscular Nondepolarizing Agents administration & dosage Pain, Postoperative therapy Postoperative Care methods Retrospective Studies Tracheal Stenosis surgery Treatment Outcome Vecuronium Bromide administration & dosage Laryngotracheal reconstruction clinical pathway mandibular distraction osteogenesis pediatric airway reconstruction pediatric sedation 2014 11 19 2015 01 05 2015 7 9 6 0 2015 7 15 6 0

2015 Laryngoscope

186. Comparison of train-of-four count by anesthesia providers versus TOF-Watch<sup>®</sup> SX: a prospective cohort study. Full Text available with Trip Pro

of Anesthesiologists physical status III or less and undergoing elective surgery. During recovery from an intubating dose of rocuronium or vecuronium, the TOF count was measured every 15 sec using TOF-Watch SX. Anesthesia providers assessed the TOF count twice at each level of TOF-count, 15 sec after the TOF-Watch SX count increased to the next level and then two to five minutes later.In 75 patients, 687 observations were collected. There was agreement between the TOF-Watch SX and the subjective assessment

2015 Canadian Journal Of Anaesthesia

187. Myocardial Protection and Anesthetic Agents

catheter were inserted under local anesthesia. Central venous catheter (jugular or subclavian) and esophageal heat probe were inserted after tracheal intubation. Anesthesia induction was standardized in all patients and included 1 mg/kg propofol, 1 μg/kg fentanyl and 0.1 mg/kg vecuronium bromus to facilitate endotracheal intubation. The patients were divided into two groups by computer randomization method. Group R (n=25), remifentanil group and Group D (n=25) dexmedetomidine group. In the remifentanil

2015 Clinical Trials

188. Evaluation of Periop Biochemical Stress Factors in Craniotomy Neurosurgical Procedure With Respect to Preop Hypertension

(and the patient's radial artery (non-dominant arm) will be cannulated for further blood sampling and blood pressure monitoring (Agilent Technologies, MA, USA). Anaesthesia will beinduced with thiopental (4-5 mg.kg-1) and fentanyl, (1-2μg.kg-1). Vecuronium, (0.06-0.1 mgkg-1) will be administered to facilitate tracheal intubation and to maintain neuromuscular blockade. Isoflurane (0.7 - 1.2 MAC) will be administered to maintain the Bispectral Index (BIS) (Aspect Medical System Inc, MA, USA), within the range (...) of 35 - 45. End tidal CO2 partial pressure will be maintained between 4-4.6 kPa (IntelliVue Anesthetic Gas Modules-G1, Redmond, WA, USA). During the surgery, intravenous fentanyl and vecuronium will be administered at the discretion of the anaesthetist for pain control and muscle relaxation respectively. An increase in mean arterial pressure (MAP) in excess of 20% of the pre-operative value will be treated either by increasing the inspired isoflurane concentration or by administering metoprolol

2015 Clinical Trials

189. Assessment of Cognitive Functions and Quality of Life in Patients Undergoing Surgery for Supratentorial Brain Tumor

of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: intravenous anesthesia propofol infusion @ 100-200 mcg/kg/min for maintenance of anesthesia Drug: Propofol Propofol infusion @100-200 mcg/kg/min Fentanyl 1mcg/kg Vecuronium 0.1mg/kg Mannitol 1 gm/kg Other Name: 2,6-di(propan-2-yl)phenol Active Comparator: inhalational anesthesia sevoflurane MAC between 0.8-1.2 for maintenance of anesthesia Drug: Sevoflurane MAC of Sevoflurane will be maintained (...) between 0.8-1.2 Fentanyl 1mcg/kg Vecuronium 0.1mg/kg Mannitol 1 gm/kg Other Name: fluoromethyl hexafluoroisopropyl ether Outcome Measures Go to Primary Outcome Measures : Cognitive functions [ Time Frame: Six month. ] Secondary Outcome Measures : Adverse events [ Time Frame: 24 hours ] Number of patients suffering delay in emergence, hemodynamic instability, nausea, vomiting, pneumocephalus. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study

2015 Clinical Trials

190. Dexmedetomidine Affect Diabetic Patient's Glucose Metabolism

in 10 minutes, the speed in maintenance phase is 0.4μg/Kg.h Drug: Dexmedetomidine During anesthesia induction, all patients will be given propofol,fentanyl,vecuronium bromide.But before induction start in Dexmedetomidine(D) group, patient will be given dexmedetomidine 1μg/Kg for 10 minutes In anesthesia maintenance, D group will be given dexmedetomidine 0.4μg/Kg.h until 40 minutes before the end of surgery Other Name: Yi Si Placebo Comparator: placebo Patients in group P will be given normal saline (...) during anesthesia induction and maintenance phase Drug: placebo During anesthesia induction, all patients will be given propofol,fentanyl,vecuronium bromide.But before induction start in Placebo(P) group, patient will be given placebo for 10 minutes In anesthesia maintenance, D group will be given placebo until 40 minutes before the end of surgery Other Name: normal saline Outcome Measures Go to Primary Outcome Measures : sedation level [ Time Frame: from 5 minutes before medication to 10 minutes

2015 Clinical Trials

191. The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass

during the surgery Procedure: ERAS group Protective ventilation strategy:Low tidal volume about 6~8ml/kg and positive end expiratory pressure(PEEP) combined with lung recruitment maneuver Other Name: Lung protection measure during the surgery(Dräger Primus) Procedure: ERAS group Bilateral thoracic paravertebral block before induction of anesthesia; Fast channel anesthesia: Induction use Sufentanil 0.5~1ug/kg, Vecuronium for Injection 0.15mg/kg and Etomidate 0.2~0.6mg/kg; ②. Maintain use Remifentanil (...) Hydrochloride for Injection 0.1~0.4ug/kg·min, Propofol Injection 2~6mg/kg·h, Sevoflurane 0.5~1.5(minimum alveolar concentration) and Infusing Dexmedetomidine which load dose 0.5μg/kg in 10min then changed into 0.5-1.0μg/kg·h,Vecuronium 0.06~0.12mg/kg·h; ③. Intravenous hydromorphone Hydrochloride Injection 0.15mg/kg before surgery over. Other Name: Anesthesia drugs during the surgery Procedure: ERAS group Drink water after 6h, 200ml once, 2~3 times / day, early ambulation,mobilization within 48 h

2015 Clinical Trials

192. Topical Salve for Skin Oxygenation and Blood Flow

): acetylcholine, atropine, bethanechol (Urecholine®), donepezil (Aricept®), ipratropium bromide (Atrovent®), neostigmine (Prostigmine®), nicotine (Nicoderm®, Nicotrol®), oxybutynin (Ditropan®), physostigmine, pilocarpine (Salagen®), pralidoxime (Protopam®), succinylcholine (Anectine®), tiotropium bromide (Spiriva®, Tiova®), tolterodine (Detrol®), vecuronium (Norcuron®). Allergy to any ingredient found in the study products: pine resin, balsam fir resin, elder (Sambucus) flower and bark, marigold (Calendula

2015 Clinical Trials

193. Influence of Cardiopulmonary Bypass, and Sevoflurane or Propofol Anesthesia, on Tissue Oxygen Saturation.

weaning of CPB. Procedure: General anaesthesia with propofol use Premedication: lorazepam 50 μg kg-1, omeprazole 40 mg, and metoprolol 12.5 mg one hour before transport to the operating theatre. Anaesthesia induction: 0.2 mg fentanyl, 0.3 mg/kg, etomidate, and vecuronium bromide 0.1 mg/kg for muscle relaxation, followed by a continuous infusion at the rate of 0.05 mg/kg/h until the sternum closure. Intraoperative analgesia: fentanyl in fractions, up to the total dose of 20-30 μg/kg. Maintenance (...) -clamp, 45 minutes after weaning of CPB. Procedure: General anaesthesia with sevoflurane use Premedication: lorazepam 50 μg kg-1, omeprazole 40 mg, and metoprolol 12.5 mg one hour before transport to the operating theatre. Anaesthesia induction: 0.2 mg fentanyl, 0.3 mg/kg, etomidate, and vecuronium bromide 0.1 mg/kg for muscle relaxation, followed by a continuous infusion at the rate of 0.05 mg/kg/h until the sternum closure. Intraoperative analgesia: fentanyl in fractions, up to the total dose of 20

2015 Clinical Trials

194. Impact of iv Dexamethasone on Reversal of Rocuronium-induced Neuromuscular Block by Sugammadex

Posted : July 21, 2017 Sponsor: Centre Hospitalier Universitaire Vaudois Information provided by (Responsible Party): Eric Albrecht, Centre Hospitalier Universitaire Vaudois Study Details Study Description Go to Brief Summary: Sugammadex is used as a reversal drug for rocuronium- or vecuronium-induced neuromuscular block during general anaesthesia. IV dexamethasone is injected as a prophylactic measure against postoperative nausea and vomiting. Recent animal data have shown that dexamethasone may

2015 Clinical Trials

195. The Effect of TEAS on the Quality of Early Recovery

) on the quality of early recovery in the patients undergoing gynecological laparoscopic surgery. Condition or disease Intervention/treatment Phase C.Delivery; Surgery (Previous), Gynecological Inappropriate Device Stimulation of Tissue Delayed Emergence From Anesthesia Other: TEAS Other: Con Drug: propofol, remifentanil, vecuronium Other: mechanical ventilation Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 60 participants (...) by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment TEAS Group TEAS consisted of 30 min of stimulation (12-15 mA, 2/100 Hz) at the Hegu (L14) and Neiguan (PC6) before anesthesia. Anesthesia was induced i.v. with propofol (2 mg kg-1) and remifentanil (1 μg kg-1) using a target-controlled infusion (TCI) system. After loss of consciousness, vecuronium (0.1 mg kg-1) was administered i.v. Patients' lungs were mechanically ventilated in a volume-controlled mode

2015 Clinical Trials

196. [Lidocaine in endotracheal intubation]. (Abstract)

[Lidocaine in endotracheal intubation]. To evaluate the effect of lidocaîne use by IV during endotracheal intubation.Our study was simple insu randomized prospective and comparative. It was done at the teaching hospital Gabriel Touré of Bamako from march to September 2005. Patients were distributed in 3 groups. The first group I: got fentanyl 2 nmg /kg+penthotal 5mg/kg+vecuronium 0.1mg/kg and intubation 3 mn later. The group II: lodocaîne 1,5mg +fentanyl 2nmg/kg+penthotal 5mg /kg + vecuronium (...) 0.1mg/kg and intubation 3mn later. The group III: lodocaïne 1.5 mg/kg+pentothal 5mg/kg+vecuronium 0.1mg/kg and intubation 3 mn later.The mean arterial pression to intubation has been 105.88±13.82 mmhg in the groupI, 96.60±15.01mmhg in the group II and 96.44±12.09mmhg in the group III with P = 0.008. To incision it has been 99.12±11.82 in the group I, 94.90 ±6.67 mmhg in the group II and 92.26±8.81 mmhg in the groupIII with P = 0.017.Lidocaïne, used alone in Iv or associated to fentanyl 3 mn before

2015 Le Mali medical Controlled trial quality: uncertain

197. Attenuation of sympathoadrenal responses and anesthetic requirement by dexmedetomidine. Full Text available with Trip Pro

and propofol was given until loss of verbal contact. Intubation was facilitated with vecuronium 0.1 mg/kg i.v. Anesthesia was maintained with oxygen (O2) and nitrous oxide (N2O) 33%: 67% and isoflurane. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) was noted at 1 min, 2 min and 5 min after intubation.For statistical analysis of the clinical data obtained, the analysis of variances (ANOVA) with paired t-test was used.Pretreatment with dexmedetomidine 1 ug/kg attenuated

2015 Anesthesia, essays and researches Controlled trial quality: uncertain

198. Comparison of esmolol and lidocaine for attenuation of cardiovascular stress response to laryngoscopy and endotracheal intubation in a Ghanaian population. Full Text available with Trip Pro

) and rate-pressure product (RPP) were measured before induction as baseline and after tracheal intubation at minute 1, 3, and 5. The patients were randomly allocated to receive either saline (Group C), lidocaine 1.5 mg/kg (Group L), or esmolol 2 mg/kg (Group E) (n = 40, each group). After induction of general anesthesia with thiopental 6 mg/kg and vecuronium 0.12 mg/kg, the test solution was infused 2 min before tracheal intubation. Changes in heart rate (HR), systolic blood pressure (SBP), diastolic

2015 Anesthesia, essays and researches Controlled trial quality: uncertain

199. A comparison of effects of oral premedication with clonidine and metoprolol on intraoperative hemodynamics and surgical conditions during functional endoscopic sinus surgery. Full Text available with Trip Pro

with propofol 2 mg/kg. Intubation was done following vecuronium 1 mg/kg. Anesthesia was maintained with 66% N2O, 33% O2 and 1% isoflurane. The heart rate (HR) and blood pressure (BP) were measured before induction and thereafter every 15 min up to 2 h. The surgeons were asked to estimate the quality of the operative field using a pre-defined category scale with scores 1-5.Difference within the groups was analyzed using analysis of variance and post-hoc test was used to test the difference between individual

2015 Anesthesia, essays and researches Controlled trial quality: uncertain

200. Comparison of hemodynamic effects of intravenous etomidate versus propofol during induction and intubation using entropy guided hypnosis levels. Full Text available with Trip Pro

intravenous midazolam 0.03 mg kg(-1) and fentanyl 2 μg kg(-1) as premedication. After induction with the desired agent titrated to entropy 40, vecuronium 0.1 mg kg(-1) was administered for neuromuscular blockade. Heart rate, systolic, diastolic and mean arterial pressures, response entropy [RE] and state entropy [SE] were recorded at baseline, induction and upto three minutes post intubation. Data was subject to statistical analysis SPSS (version 12.0) the paired and the unpaired Student's T-tests

2015 Journal of anaesthesiology, clinical pharmacology Controlled trial quality: uncertain

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