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Vasospastic Angina

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1. Association of statin therapy with clinical outcomes in patients with vasospastic angina: Data from Korean health insurance review and assessment service. (PubMed)

Association of statin therapy with clinical outcomes in patients with vasospastic angina: Data from Korean health insurance review and assessment service. There is conflicting evidence for the clinical benefit of statin therapy in patients with vasospastic angina (VSA). We investigated the association of statin therapy with clinical outcomes in relatively large populations with clinically suspected VSA from a nationwide population-based database. Data were collected from the Health Insurance

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2019 PLoS ONE

2. Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports (PubMed)

Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports It is well known that calcium channel blockers (CCBs) are the first line of therapy for vasospastic angina (VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from a brand-name to a generic CCB. In both cases, angina recurred upon switching from a brand-name CCB to a generic CCB (...) during follow-up. The patients' condition improved upon switching back to the original CCB. Both cases involved a high severity of VSA, based on the results of spasm provocation testing. These findings suggest that, in some patients with severe VSA, the frequency of angina attacks increases when switching from a brand-name CCB to a generic CCB. Cardiologists should consider this factor when prescribing drugs for angina.

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2018 World journal of cardiology

3. Clinical characteristics and long-term prognosis of contemporary patients with vasospastic angina: Ethnic differences detected in an international comparative study. (PubMed)

Clinical characteristics and long-term prognosis of contemporary patients with vasospastic angina: Ethnic differences detected in an international comparative study. Possible ethnic differences in clinical characteristics and long-term prognosis of contemporary patients with vasospastic angina (VSA) remain to be elucidated.The Japanese Coronary Spasm Association (JCSA) conducted an international, prospective, and multicenter registry study for VSA patients. A total of 1457 VSA patients (...) (Japanese/Caucasians, 1339/118) were enrolled based on the same diagnostic criteria. Compared with Caucasian patients, Japanese patients were characterized by higher proportions of males (68 vs. 51%) and smoking history (60 vs. 49%). Japanese patients more often had angina especially during the night and early morning hours, compared with Caucasians. Ninety-five percent of Japanese and 84% of Caucasian patients underwent pharmacological provocation test. Importantly, no significant differences

2019 International journal of cardiology

4. Coronary Adventitial and Perivascular Adipose Tissue Inflammation in Patients With Vasospastic Angina. (PubMed)

Coronary Adventitial and Perivascular Adipose Tissue Inflammation in Patients With Vasospastic Angina. Recent studies suggested that perivascular components, such as perivascular adipose tissue (PVAT) and adventitial vasa vasorum (VV), play an important role as a source of various inflammatory mediators in cardiovascular disease.The authors tested their hypothesis that coronary artery spasm is associated with perivascular inflammation in patients with vasospastic angina (VSA) using 18F (...) Tissue in Vasospastic Angina [ADIPO-VSA Trial]; UMIN000016675).Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

2018 Journal of the American College of Cardiology

5. Impact of different nitrate therapies on long-term clinical outcomes of patients with vasospastic angina: A propensity score-matched analysis. (PubMed)

Impact of different nitrate therapies on long-term clinical outcomes of patients with vasospastic angina: A propensity score-matched analysis. Despite the short-term vasodilatory effects of nitrates, the prognostic effects of long-term nitrate therapy in patients with vasospastic angina (VSA) remains unclear. We investigated the prognostic impact of chronic nitrate therapy in VSA patients.Between January 2003 and December 2014, a total of 1154 VSA patients proven by ergonovine provocation tests

2018 International journal of cardiology

6. Ergonovine Stress Echocardiography for the Diagnosis of Vasospastic Angina and Its Prognostic Implications in 3,094 Consecutive Patients (PubMed)

Ergonovine Stress Echocardiography for the Diagnosis of Vasospastic Angina and Its Prognostic Implications in 3,094 Consecutive Patients Ergonovine stress echocardiography (ErgECHO) has been proposed as a noninvasive tool for the diagnosis of coronary vasospasm. However, concern over the safety of ErgECHO remains. This study was undertaken to investigate the safety and prognostic value of ErgECHO in a large population.We studied 3,094 consecutive patients from a single-center registry who (...) ergonovine-provoked coronary angiography for the diagnosis of vasospastic angina.Copyright © 2018. The Korean Society of Cardiology.

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2018 Korean circulation journal

7. Ergonovine Provocation Echocardiography for Detection and Prognostication in Patients with Vasospastic Angina (PubMed)

Ergonovine Provocation Echocardiography for Detection and Prognostication in Patients with Vasospastic Angina 30238708 2018 11 14 1738-5520 48 10 2018 Oct Korean circulation journal Korean Circ J Ergonovine Provocation Echocardiography for Detection and Prognostication in Patients with Vasospastic Angina. 917-919 10.4070/kcj.2018.0139 Park Jae Hyeong JH https://orcid.org/0000-0001-7035-286X Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam

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2018 Korean circulation journal

8. Recurrent ST segment elevations in a patient with asymptomatic early repolarization during head and neck surgery: implications of vasospastic angina (PubMed)

Recurrent ST segment elevations in a patient with asymptomatic early repolarization during head and neck surgery: implications of vasospastic angina A 57-year-old woman scheduled for cochlear implant removal exhibited preoperative electrocardiographic findings of early repolarization (ER). Four episodes of transient ST segment elevations during surgery raised suspicion for vasospastic angina (VA). In the post-anesthetic care unit, the patient complained of chest discomfort and received

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2018 Journal of Dental Anesthesia and Pain Medicine

9. Noninvasive Cardiac Imaging in Vasospastic Angina Korean Registry (NAVIGATOR)

Noninvasive Cardiac Imaging in Vasospastic Angina Korean Registry (NAVIGATOR) Noninvasive Cardiac Imaging in Vasospastic Angina Korean Registry (NAVIGATOR) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Noninvasive Cardiac Imaging in Vasospastic Angina Korean Registry (NAVIGATOR) (NAVIGATOR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03570671 Recruitment Status : Recruiting First Posted : June 27, 2018 Last Update Posted

2018 Clinical Trials

10. Systemic microvascular dysfunction in microvascular and vasospastic angina. (PubMed)

Systemic microvascular dysfunction in microvascular and vasospastic angina. Coronary microvascular dysfunction and/or vasospasm are potential causes of ischaemia in patients with no obstructive coronary artery disease (INOCA). We tested the hypothesis that these patients also have functional abnormalities in peripheral small arteries.Patients were prospectively enrolled and categorised as having microvascular angina (MVA), vasospastic angina (VSA) or normal control based on invasive coronary

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2018 European Heart Journal

11. Efficacy of Corticosteroid Treatment for Refractory Multivessel Vasospastic Coronary Angina with Hypereosinophilia (PubMed)

Efficacy of Corticosteroid Treatment for Refractory Multivessel Vasospastic Coronary Angina with Hypereosinophilia A 43-year-old man was diagnosed with acute myocardial infarction (AMI) due to multivessel coronary vasospasm. Accordingly, two coronary vasodilators were administered, and he was discharged without an angina attack. However, from the following day, he reported frequent chest pain and was re-hospitalized. Despite adding multiple coronary vasodilators, it was difficult to completely (...) suppress the angina attack. He also demonstrated hypereosinophilia from the onset of AMI, and his eosinophil count gradually increased up to 6,238/μL. After corticosteroid administration was started, the vasospasm was completely controlled, and his eosinophil count normalized. He remained free from angina attacks for two years with corticosteroid therapy.

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2018 Internal Medicine

12. Differential prognosis of vasospastic angina according to presentation with sudden cardiac arrest or not: Analysis of the Korean Health Insurance Review and Assessment Service. (PubMed)

Differential prognosis of vasospastic angina according to presentation with sudden cardiac arrest or not: Analysis of the Korean Health Insurance Review and Assessment Service. The long-term prognosis of vasospastic angina (VSA) patients presenting with aborted sudden cardiac death (ASCD) is still unknown. We sought to compare the long-term clinical outcomes between VSA patients presenting with and without ASCD by retrospective analysis of a nationwide population-based database.A total of 6972

2018 International journal of cardiology

13. Impact of multi-vessel vasospastic angina on cardiovascular outcome. (PubMed)

Impact of multi-vessel vasospastic angina on cardiovascular outcome. Since clinical characteristics and prognosis of patients with multi-vessel vasospastic angina (VSA) are not clear, we investigated the nature and prognosis of multi-vessel VSA in Koreans.Among 2960 patients enrolled in the VA-KOREA (Vasospastic Angina in Korea) registry, 104 definite multi-vessel VSA patients, 163 single vessel VSA patients and 737 non-VSA patients were identified using the intracoronary ergonovine provocation

2018 Atherosclerosis

14. Effect of Amlodipine Versus Amlodipine Combined With Atorvastatin on the Coronary Vasospastic Angina

Effect of Amlodipine Versus Amlodipine Combined With Atorvastatin on the Coronary Vasospastic Angina Effect of Amlodipine Versus Amlodipine Combined With Atorvastatin on the Coronary Vasospastic Angina - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Effect of Amlodipine Versus Amlodipine Combined With Atorvastatin on the Coronary Vasospastic Angina (SCARLET) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03054467

2017 Clinical Trials

15. Prognostic impacts of Rho-kinase activity in circulating leucocytes in patients with vasospastic angina. (PubMed)

Prognostic impacts of Rho-kinase activity in circulating leucocytes in patients with vasospastic angina. Rho-kinase activity in circulating leucocytes is a useful biomarker for diagnosis and disease activity assessment of vasospastic angina (VSA). The present study aimed to examine the long-term prognostic impact of Rho-kinase activity in circulating leucocytes in VSA patients.We prospectively enrolled 174 consecutive patients with VSA and 50 non-VSA patients, in whom we measured Rho-kinase (...) activity in circulating leucocytes, and they were followed for a median of 16 months. The primary endpoint was cardiac events including cardiac death, non-fatal myocardial infarction, and hospitalization for unstable angina. During the follow-up period, cardiac events occurred in 10 VSA patients (5.7%) but in none of the non-VSA patients. When we divided VSA patients into two groups by a median value of their Rho-kinase activity, the Kaplan-Meier survival analysis showed a significantly worse prognosis

2017 European Heart Journal

16. Tpeak-Tend dispersion as a predictor for malignant arrhythmia events in patients with vasospastic angina. (PubMed)

Tpeak-Tend dispersion as a predictor for malignant arrhythmia events in patients with vasospastic angina. Tpeak-Tend interval (Tp-e interval) in electrocardiogram (ECG) has been reported to predict malignant arrhythmia events (MAE) in ST-segment elevation myocardial infarction and ion channelopathy. Tp-e interval and other ECG parameters as predictors for MAE was evaluated in patients with vasospastic angina (VA).Sixty-two patients with VA (Non-MAE group) and 20 patients with VA complicated

2017 International journal of cardiology

17. Gender differences in long-term clinical outcomes and prognostic factors in patients with vasospastic angina. (PubMed)

Gender differences in long-term clinical outcomes and prognostic factors in patients with vasospastic angina. Men are more likely to suffer from vasospastic angina (VSA) than women; however, gender differences in the long-term prognosis of VSA patients have not been fully elucidated. We sought to investigate clinical outcomes and predictive factors of VSA patients according to gender.A total of 986 patients (838 men and 148 women) with a positive result on intracoronary ergonovine provocation

2017 International journal of cardiology

18. Fluctuations in the amplitude of ST-segment elevation in vasospastic angina: Two case reports. (PubMed)

Fluctuations in the amplitude of ST-segment elevation in vasospastic angina: Two case reports. ST-segment elevation localizes an ischemic lesion to the coronary artery supplying the area of the myocardium reflected by the electrocardiographic leads. Dynamic ST-segment elevation can be due to severe transmural ischemia secondary to a thrombus, vasospasm, or a tightly fixed coronary artery lesion or a combination of these situations.In this study, we report on two patients with angina who had (...) fluctuations in ST-segment amplitude on serial electrocardiograms. The amplitude of ST-segment elevation varied between 1-20 mm.Vasospastic angina (VSA) was diagnosed based on electrocardiography and coronary angiography.Calcium antagonists were prescribed for both patients.No recurrent VSA was noted during outpatient follow-up.VSA can be associated with fluctuations in the amplitude of ST-segment elevation, indicating dynamic coronary vasospasm in different locations and extensions in patients with VSA.

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2017 Medicine

19. Exuberant Vasospastic Angina Simulating Severe Three-Vessel Disease (PubMed)

Exuberant Vasospastic Angina Simulating Severe Three-Vessel Disease 28699981 2017 12 18 2017 12 18 1678-4170 108 6 2017 Jun Arquivos brasileiros de cardiologia Arq. Bras. Cardiol. Exuberant Vasospastic Angina Simulating Severe Three-Vessel Disease. 576-577 S0066-782X2017000600576 10.5935/abc.20170071 Marmelo Bruno B Centro Hospitalar Tondela-Viseu. Abreu Luís L Centro Hospitalar Tondela-Viseu. Gil Júlio J Centro Hospitalar Tondela-Viseu. Ferreira Pedro P Centro Hospitalar Tondela-Viseu. Cabral (...) José J Centro Hospitalar Tondela-Viseu. eng por Case Reports Brazil Arq Bras Cardiol 0421031 0066-782X SY7Q814VUP Calcium WXR179L51S Isosorbide IM Angina Pectoris, Variant diagnostic imaging drug therapy physiopathology Angiography Calcium agonists Coronary Vasospasm diagnostic imaging physiopathology Diagnosis, Differential Humans Isosorbide therapeutic use Male Middle Aged 2016 09 26 2016 10 24 2017 7 13 6 0 2017 7 13 6 0 2017 12 19 6 0 ppublish 28699981 S0066-782X2017000600576 10.5935/abc

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2017 Arquivos brasileiros de cardiologia

20. Uric Acid Level Has a U-shaped Association with Clinical Outcomes in Patients with Vasospastic Angina (PubMed)

Uric Acid Level Has a U-shaped Association with Clinical Outcomes in Patients with Vasospastic Angina No data are available on the association of serum uric acid and vasospastic angina (VSA) which has endothelial dysfunction as a possible pathophysiologic mechanism. Low uric acid level might cause adverse outcomes in VSA in connection with endothelial dysfunction. We enrolled 818 VSA patients whose uric acid level was measured at admission. Patients were categorized according to tertiles (...) of uric acid level: group I, ≤ 4.8 mg/dL; group II, 4.9-5.9 mg/dL; and group III, ≥ 6.0 mg/dL. Primary outcome was major adverse cardiac events (MACEs), defined as a composite of cardiac death, acute myocardial infarction (MI), ischemic stroke, coronary revascularization, and rehospitalization for angina. Median follow-up duration was 49.2 months. Median uric acid values were 4.1 mg/dL for group I, 5.4 mg/dL for group II, and 6.7 mg/dL for group III. In the overall population, group II had

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2017 Journal of Korean medical science

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