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803 results for

Valproic Acid Toxicity

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801. The Effects of Valproic Acid on Zidovudine Glucuronidation and Pharmacokinetics in HIV-Infected Patients.

The Effects of Valproic Acid on Zidovudine Glucuronidation and Pharmacokinetics in HIV-Infected Patients. The Effects of Valproic Acid on Zidovudine Glucuronidation and Pharmacokinetics in HIV-Infected Patients. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. The Effects of Valproic Acid on Zidovudine Glucuronidation and Pharmacokinetics in HIV-Infected Patients. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00000629 Recruitment Status : Completed First Posted : August 31, 2001 Last Update Posted

1999 Clinical Trials

802. Case files of the Children’s Hospital of Michigan Regional Poison Control Center: The use of carnitine for the management of acute valproic acid toxicity Full Text available with Trip Pro

Case files of the Children’s Hospital of Michigan Regional Poison Control Center: The use of carnitine for the management of acute valproic acid toxicity 18072149 2008 01 08 2018 11 13 1556-9039 3 3 2007 Sep Journal of medical toxicology : official journal of the American College of Medical Toxicology J Med Toxicol Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity. 129-38 Katiyar Abhishek (...) A Children's Hospital of Michigan Regional Poison Control Center, Detroit, MI, USA. akatiyar2@dmc.org Aaron Cynthia C eng Case Reports Journal Article United States J Med Toxicol 101284598 1556-9039 0 Anticonvulsants 0 Antidotes 12001-76-2 Vitamin B Complex 16291-96-6 Charcoal 614OI1Z5WI Valproic Acid S7UI8SM58A Carnitine IM Adult Anticonvulsants pharmacokinetics poisoning Antidotes therapeutic use Carnitine therapeutic use Charcoal therapeutic use Humans Male Michigan Poison Control

2007 Journal of Medical Toxicology

803. Inactivation of beef brain alpha-ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites. Possible mechanism of anticonvulsant and toxic actions. Full Text available with Trip Pro

Inactivation of beef brain alpha-ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites. Possible mechanism of anticonvulsant and toxic actions. The anticonvulsant valproic acid (VPA, 2-n-propylpentanoic acid) causes inhibition of the citric acid cycle and elevations of central nervous system (CNS) gamma-aminobutyric acid (GABA) levels, which correlates with anticonvulsant action. No unifying mechanism for these actions of VPA has won general acceptance. alpha (...) -Ketoglutarate dehydrogenase complex (KDHC) is a critical control enzyme in the CNS. We hypothesized that VPA may be an inhibitor of this enzyme since decreased KDHC activity would reduce substrate flux through the citric acid cycle and may increase flux into GABA synthesis. To test this hypothesis, inhibition of purified beef brain KDHC by VPA and its metabolites 2-n-propylpent-2-enoic acid (delta 2,3 VPE) and their coenzyme A (CoA) derivatives were studied. Preincubation of the NADH-reduced enzyme

1990 Journal of Clinical Investigation

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