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Valproic Acid Toxicity

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41. Prospective Study of Stereotactic Body Radiation Therapy for Thymoma Inoma: Therapeutic Effect and Toxicity Assessment

, or menopause, or attenuated by use of an approved contraceptive method (intrauterine device [IUD], birth control pills, or barrier device) during and for 2 months after trial. If male, use of an approved contraceptive method during the study and 2 months afterwards. Females with childbearing potential must have a urine negative HCG test within 7 days prior to the study enrollment. No concomitant prescriptions including cyclosporin A, valproic acid, phenobarbital, phenytoin, ketoconazole. Exclusion Criteria (...) Prospective Study of Stereotactic Body Radiation Therapy for Thymoma Inoma: Therapeutic Effect and Toxicity Assessment Prospective Study of Stereotactic Body Radiation Therapy for Thymoma Inoma: Therapeutic Effect and Toxicity Assessment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2017 Clinical Trials

42. Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration Full Text available with Trip Pro

compounds in addition to known environmental toxicants. The hits included the HSP90 inhibitor geldanamycin, the chemotherapeutic arsenic trioxide, the flame-retardant PBDE-99, the pesticide triadimefon and the histone deacetylase inhibitors valproic acid and trichostatin A. Transcriptome changes triggered by these substances in human neural crest cells were recorded and analysed here to answer three questions: (1) can toxicants be individually identified based on their transcript profile; (2) how can (...) Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration The in vitro test battery of the European research consortium ESNATS ('novel stem cell-based test systems') has been used to screen for potential human developmental toxicants. As part of this effort, the migration of neural crest (MINC) assay has been used to evaluate chemical effects on neural crest function. It identified some drug-like

2015 Archives of toxicology

43. The Effect of Combination Therapy Amino Acid L-CARNITINE and Magnesium on Fatty Liver

who received TPN in the past 6 months. Patients with chronic liver disease, A1AT, Hemochromatosis, Wilson, Autoimmune, Toxic injury. Patients on anticoagulation therapy - Coumadin. Patients who use valproic acid therapy. Children, Pregnancy. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its (...) The Effect of Combination Therapy Amino Acid L-CARNITINE and Magnesium on Fatty Liver The Effect of Combination Therapy Amino Acid L-CARNITINE and Magnesium on Fatty Liver - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2017 Clinical Trials

44. Chronotolerance study of the antiepileptic drug valproic acid in mice Full Text available with Trip Pro

Chronotolerance study of the antiepileptic drug valproic acid in mice Valproic acid (VPA) is an antiepileptic drug widely used for the treatment of absence seizures and generalized tonic-clonic seizures. The present work aims to study whether VPA-induced toxicity varies according to the dosing-time in the 24 hour-scale.The influence of dosing-time on tolerance to VPA was investigated in 120 male Swiss mice synchronized under a light-dark cycle (12:12). The mean VPA lethal dose was first (...) dosing at 9 HALO resulted in -9 % weight loss whereas drug dosing at 17 HALO was -15 % (Ø = 20.3 HALO ± 1.1 h, p ≤ 0.0001). Lethal toxicity also varied according to circadian dosing-time (χ2 = 42.1, p < 0.0001). The highest (60 %) and the lowest (6.67 %) survival rates were observed at 9 HALO and 17 HALO respectively. Cosinor analyses validated a significant circadian rhythm in survival duration with an acrophase at 8.4 HALO ± 0.75 h (p < 0.001).With regards to these data the optimal tolerance to VPA

2012 Journal of Circadian Rhythms

45. Bevacizumab, Temsirolimus, Valproic Acid, Cetuximab

Thyroid Gland Neoplasm Biological: Bevacizumab Biological: Cetuximab Other: Laboratory Biomarker Analysis Other: Pharmacological Study Drug: Temsirolimus Drug: Valproic Acid Phase 1 Detailed Description: PRIMARY OBJECTIVES: I. To determine the maximum tolerated doses (MTDs) and dose-limiting toxicities (DLTs) of treatment with bevacizumab and temsirolimus in combination and plus valproic acid or cetuximab. SECONDARY OBJECTIVES: I. Preliminary descriptive assessment of anti-tumor efficacy of each (...) receive temsirolimus and bevacizumab as in Group I and valproic acid orally (PO) daily on days 1-7 and 15-21. GROUP III: Patients receive temsirolimus and bevacizumab as in Group I. In all groups, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 216 participants Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking

2012 Clinical Trials

46. Valproic Acid in Subjects With Intact Cognition

Valproic Acid in Subjects With Intact Cognition Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Valproic Acid in Subjects With Intact (...) by (Responsible Party): Gregory Jicha, 323-5550, University of Kentucky Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the safety of administration and effects of valproic acid on clusterin expression in cognitively-intact, healthy, elderly subjects. Clusterin mutations have recently been identified as a risk factor for the development of Alzheimer's Disease and changes in clusterin expression are seen in the elderly who develop Alzheimer's disease irrespective

2012 Clinical Trials

47. Toxic Epidermal Necrolysis (Overview)

include the following: Sulfonamides (4.5 cases per million users per week) Chloramphenicol Macrolides (eg, erythromycin) Penicillins Quinolones (eg, ciprofloxacin, [ ] trovafloxacin [ ] ) Anticonvulsants associated with TEN include the following: Phenobarbital Phenytoin [ ] Carbamazepine Valproic acid Lamotrigine TEN in patients taking anticonvulsants has most often been reported within 2 months of starting the drug. However, some cases associated with long-term use have been reported. NSAIDs (...) Toxic Epidermal Necrolysis (Overview) Toxic Epidermal Necrolysis (TEN): Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjI5Njk4LW92ZXJ2aWV3 processing > Toxic Epidermal

2014 eMedicine.com

48. Toxic Epidermal Necrolysis (Diagnosis)

include the following: Sulfonamides (4.5 cases per million users per week) Chloramphenicol Macrolides (eg, erythromycin) Penicillins Quinolones (eg, ciprofloxacin, [ ] trovafloxacin [ ] ) Anticonvulsants associated with TEN include the following: Phenobarbital Phenytoin [ ] Carbamazepine Valproic acid Lamotrigine TEN in patients taking anticonvulsants has most often been reported within 2 months of starting the drug. However, some cases associated with long-term use have been reported. NSAIDs (...) Toxic Epidermal Necrolysis (Diagnosis) Toxic Epidermal Necrolysis (TEN): Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjI5Njk4LW92ZXJ2aWV3 processing > Toxic Epidermal

2014 eMedicine.com

49. Toxicity, Valproate (Overview)

Updated: Jan 03, 2018 Author: Asim A Abbasi, MD, FAAP; Chief Editor: Michael A Miller, MD Share Email Print Feedback Close Sections Sections Valproate Toxicity Overview Practice Essentials Although most cases of valproate (valproic acid [VPA]) overdose are benign, serious toxicity, including death, may occur after acute ingestion. Signs and symptoms Few historical features are specifically suggestive of valproate toxicity. The following information should be elicited if possible: Exact time (...) for mood stabilization, as opposed to its initial use predominantly as an anticonvulsant. In recent years, however, VPA exposures have stabilized at a lower rate, with 3211 single exposures reported in 2010 and 3060 reported in 2016. [ , ] The international frequency of valproic acid toxicity is unknown. Age-, sex-, and race-related demographics Although most acute VPA ingestions occur in persons older than 20 years, age does not influence outcomes after an acute ingestion. Children younger than 3

2014 eMedicine Emergency Medicine

50. Toxicity, Valproate (Treatment)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvODE5MzE1LXRyZWF0bWVudA== processing > Valproate Toxicity Treatment & Management Updated: Jan 03, 2018 Author: Asim A Abbasi, MD, FAAP; Chief Editor: Michael A Miller, MD Share Email Print Feedback Close Sections Sections Valproate Toxicity Treatment Approach Considerations Treatment of patients with valproate (valproic acid [VPA]) toxicity is mainly supportive, commonly including the following: Management of airway, breathing, and circulation (ABCs) Oxygenation Administration of intravenous (IV) fluids Monitoring (...) , Gaillard T, Brisou P, Vest P. Acute overdose of enteric-coated valproic acid and olanzapine: unusual presentation and delayed toxicity. Clin Toxicol (Phila) . 2012 Apr. 50(4):268. . Lai MW, Klein-Schwartz W, Rodgers GC, et al. 2005 Annual Report of the American Association of Poison Control Centers' national poisoning and exposure database. Clin Toxicol (Phila) . 2006. 44(6-7):803-932. . Nanau RM, Neuman MG. Adverse drug reactions induced by valproic acid. Clin Biochem . 2013 Oct. 46(15):1323-38

2014 eMedicine Emergency Medicine

51. Toxic Epidermal Necrolysis (Overview)

include the following: Sulfonamides (4.5 cases per million users per week) Chloramphenicol Macrolides (eg, erythromycin) Penicillins Quinolones (eg, ciprofloxacin, [ ] trovafloxacin [ ] ) Anticonvulsants associated with TEN include the following: Phenobarbital Phenytoin [ ] Carbamazepine Valproic acid Lamotrigine TEN in patients taking anticonvulsants has most often been reported within 2 months of starting the drug. However, some cases associated with long-term use have been reported. NSAIDs (...) Toxic Epidermal Necrolysis (Overview) Toxic Epidermal Necrolysis (TEN): Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjI5Njk4LW92ZXJ2aWV3 processing > Toxic Epidermal

2014 eMedicine Emergency Medicine

52. Toxicity, Valproate (Follow-up)

Toxicity Follow-up Updated: Jan 03, 2018 Author: Asim A Abbasi, MD, FAAP; Chief Editor: Michael A Miller, MD Share Email Print Feedback Close Sections Sections Valproate Toxicity Follow-up Further Outpatient Care After the patient's condition is stabilized and he or she is discharged, an ongoing relationship between the patient and a mental health professional is recommended if the overdose was intentional. Next: Further Inpatient Care Depending on level of toxicity, patients with valproic acid (...) to a psychiatric facility. However, this disposition highly depends on the patient's symptoms and the amount of ingestion. In one multicenter case series of 134 patients with valproic acid ingestions (80 with toxic VPA levels at admission), the mean hospital stay for all patients was 44.7 hours (standard deviation, 28 h). [ ] Previous Next: Complications Valproic acid is used in the treatment of mood disorders in addition to its use as an antiseizure medication. Emergency personnel must consider

2014 eMedicine Emergency Medicine

53. Toxicity, Valproate (Diagnosis)

Updated: Jan 03, 2018 Author: Asim A Abbasi, MD, FAAP; Chief Editor: Michael A Miller, MD Share Email Print Feedback Close Sections Sections Valproate Toxicity Overview Practice Essentials Although most cases of valproate (valproic acid [VPA]) overdose are benign, serious toxicity, including death, may occur after acute ingestion. Signs and symptoms Few historical features are specifically suggestive of valproate toxicity. The following information should be elicited if possible: Exact time (...) for mood stabilization, as opposed to its initial use predominantly as an anticonvulsant. In recent years, however, VPA exposures have stabilized at a lower rate, with 3211 single exposures reported in 2010 and 3060 reported in 2016. [ , ] The international frequency of valproic acid toxicity is unknown. Age-, sex-, and race-related demographics Although most acute VPA ingestions occur in persons older than 20 years, age does not influence outcomes after an acute ingestion. Children younger than 3

2014 eMedicine Emergency Medicine

54. Toxic Epidermal Necrolysis (Diagnosis)

include the following: Sulfonamides (4.5 cases per million users per week) Chloramphenicol Macrolides (eg, erythromycin) Penicillins Quinolones (eg, ciprofloxacin, [ ] trovafloxacin [ ] ) Anticonvulsants associated with TEN include the following: Phenobarbital Phenytoin [ ] Carbamazepine Valproic acid Lamotrigine TEN in patients taking anticonvulsants has most often been reported within 2 months of starting the drug. However, some cases associated with long-term use have been reported. NSAIDs (...) Toxic Epidermal Necrolysis (Diagnosis) Toxic Epidermal Necrolysis (TEN): Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjI5Njk4LW92ZXJ2aWV3 processing > Toxic Epidermal

2014 eMedicine Emergency Medicine

55. Toxicity, Carbamazepine (Diagnosis)

). The autoinduction process takes about 4 weeks. Carbamazepine stimulates the synthesis of many monooxygenase and conjugating enzymes, which leads to the metabolism of many medications. [ ] In terms of drug interactions, carbamazepine induces the metabolism of other anticonvulsant drugs such as phenytoin, clonazepam, primidone, valproic acid, and ethosuximide. This may lead to subtherapeutic levels of these drugs, especially phenytoin. In addition, carbamazepine reduces the duration and action of many therapeutic (...) Toxicity, Carbamazepine (Diagnosis) Pediatric Carbamazepine Toxicity: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTAxMTI0MC1vdmVydmlldw== processing > Pediatric

2014 eMedicine Pediatrics

56. Toxicity, Carbamazepine (Overview)

). The autoinduction process takes about 4 weeks. Carbamazepine stimulates the synthesis of many monooxygenase and conjugating enzymes, which leads to the metabolism of many medications. [ ] In terms of drug interactions, carbamazepine induces the metabolism of other anticonvulsant drugs such as phenytoin, clonazepam, primidone, valproic acid, and ethosuximide. This may lead to subtherapeutic levels of these drugs, especially phenytoin. In addition, carbamazepine reduces the duration and action of many therapeutic (...) Toxicity, Carbamazepine (Overview) Pediatric Carbamazepine Toxicity: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTAxMTI0MC1vdmVydmlldw== processing > Pediatric

2014 eMedicine Pediatrics

57. DuoPlavin - clopidogrel / acetylsalicylic acid

DuoPlavin - clopidogrel / acetylsalicylic acid European Medicines Agency 7 Westferry Circus, Canary Wharf, London E14 4HB, UK Tel. (44-20) 74 18 84 00 Fax (44-20) 74 18 86 13 E-mail: mail@ema.europa.eu http://www.ema.europa.eu London, 17 December 2009 Doc. Ref: EMA/CHMP/196090/2010 CHMP ASSESSMENT REPORT FOR DuoPlavin International Nonproprietary Name: clopidogrel / acetylsalicylic acid Procedure No. EMEA/H/C/001143 TABLE OF CONTENTS 1. BACKGROUND INFORMATION ON THE PROCEDURE 3 1.1 Submission (...) for the following indication: DuoPlavin is indicated for the prevention of atherothrombotic events in adult patients already taking both clopidogrel and acetylsalicylic acid (ASA). DuoPlavin is a fixed-dose combination product for continuation of therapy in: ? Non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction) including patients undergoing a stent placement following percutaneous coronary intervention ? ST segment elevation acute myocardial infarction

2010 European Medicines Agency - EPARs

58. DuoCover - clopidogrel / acetylsalicylic acid

DuoCover - clopidogrel / acetylsalicylic acid European Medicines Agency 7 Westferry Circus, Canary Wharf, London E14 4HB, UK Tel. (44-20) 74 18 84 00 Fax (44-20) 74 18 86 13 E-mail: mail@ema.europa.eu http://www.ema.europa.eu London, 17 December 2009 Doc. Ref: EMA/CHMP/195986/2010 CHMP ASSESSMENT REPORT FOR DuoCover International Nonproprietary Name: clopidogrel / acetylsalicylic acid Procedure No. EMEA/H/C/001144 TABLE OF CONTENTS 1. BACKGROUND INFORMATION ON THE PROCEDURE 3 1.1 Submission (...) indication: DuoCover is indicated for the prevention of atherothrombotic events in adult patients already taking both clopidogrel and acetylsalicylic acid (ASA). DuoCover is a fixed-dose combination product for continuation of therapy in: ? Non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction) including patients undergoing a stent placement following percutaneous coronary intervention ? ST segment elevation acute myocardial infarction in medically treated

2010 European Medicines Agency - EPARs

59. Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line Full Text available with Trip Pro

, amiodarone, diclofenac, metformin, phenformin, and valproic acid) to LD(50) data (mg compound/mg cellular protein) showed that the variation in LD(50) values was generally less than that suggested by the original LC(50) data. Toxicological analysis of these six compounds in 3D spheroid culture (either published or presented here) demonstrated similar LD(50) values. Although in vitro 2D HepG2 data showed a poor correlation, the primary hepatocyte and 3D spheroid data resulted in a much higher degree (...) Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line Numerous publications have documented that the immortal cells grown in three-dimensional (3D) cultures possess physiological behavior, which is more reminiscent of their parental organ than when the same cells are cultivated using classical two-dimensional (2D) culture techniques. The goal of this study was to investigate whether this observation could be extended to the determination of LD

2012 Toxicological Sciences

60. Pregabalin (Lyrica or other brands) and gabapentin (Neurontin or other brands): known dangers and uncertainties during pregnancy

in children Prescrire Int 2020 ; 29 (211) : 13-20. Short-term effects of in utero exposure to antiepileptics other than valproic acid Prescrire Int 2020 ; 29 (211) : 16-17. | | | Prescrire Your change of address has been received and will be processed promptly but will not appear instantaneously Prescrire Your message has been sent (...) malformations. Children exposed in utero to pregabalin or gabapentin in the second and third trimesters of pregnancy were found to have a higher incidence of preterm birth, low birth weight, signs of drug toxicity (drowsiness, difficulty sucking, diarrhoea), withdrawal symptoms and admission to a neonatal intensive care unit. In the long term, mental and behavioural disorders are more frequent after in utero exposure to pregabalin than in unexposed children. The data on gabapentin is too scant to rule out

2020 Prescrire

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