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535 results for

Uterine Inversion

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521. The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix. (Abstract)

hypermethylation. We could not demonstrate an inverse correlation between RASSF1A methylation and HPV 16 infection in AC of the uterine cervix.Hypermethylation of the RASSF1A promoter region is common in AC of the uterine cervix and rare in squamous carcinoma of uterine cervix. HPV infection does not correlate with RASSF1A methylation status in AC of the uterine cervix, but the absence of RASSF1A methylation in SCC of the uterine cervix coupled with the high incidence of HPV 16 infection in this subtype (...) The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix. Development of adenocarcinoma (AC) of the uterine cervix, as well as squamous cell carcinoma (SCC), is strongly linked to infection by high-risk human papillomavirus (HPV) types. Human HPV E6 and E7 proteins inactivate the tumor suppressor genes p53 and retinoblastoma, respectively. However, additional genetic alterations may be required to maintain a malignant phenotype. Allelic loss at the short

2003 Clinical Cancer Research

522. Dexamethasone or interleukin-10 blocks interleukin-1beta-induced uterine contractions in pregnant rhesus monkeys. (Abstract)

reduced by dexamethasone (P <.05), whereas tumor necrosis factor-alpha levels and leukocyte counts were attenuated by interleukin-10 treatment (P <.05). An inverse relationship was noted between amniotic fluid interleukin-10 concentrations and interleukin-1beta-induced uterine activity (r = -0.74, P <.05).Dexamethasone and interleukin-10 exert similar inhibitory effects on interleukin-1beta-induced uterine activity, which appears to be mediated by a decrease in prostaglandin production. Reduced (...) Dexamethasone or interleukin-10 blocks interleukin-1beta-induced uterine contractions in pregnant rhesus monkeys. The purpose of this study was to determine whether treatment with the immune modulators dexamethasone or interleukin-10 prevents interleukin-1beta-induced uterine contractions in a nonhuman primate model.Thirteen chronically instrumented rhesus monkeys at 135 +/- 1 days of gestation (term, 167 days) received one of three interventions: (1) intra-amniotic interleukin-1beta (10 microg

2003 American Journal of Obstetrics and Gynecology

523. Impaired uterine artery blood flow at mid gestation and low levels of maternal plasma corticotropin-releasing factor. (Abstract)

CRF levels were significantly lower in women with a unilateral (168.45 +/- 27.5 pg/mL; P <.01) or bilateral (186.07 +/- 34.5 pg/mL; P <.001) uterine artery notch than in healthy control pregnant women (375.06 +/- 21.77 pg/mL). Although no difference was found in CRF levels between patients with a unilateral or bilateral uterine artery notch, a significant inverse correlation was found between the mean RI and maternal plasma CRF levels (Spearman r = -0.6540; 95% confidence interval, -0.7865 (...) Impaired uterine artery blood flow at mid gestation and low levels of maternal plasma corticotropin-releasing factor. Corticotropin-releasing factor (CRF) is a placental neuropeptide that plays a role in the control of uteroplacental blood flow regulation. Because CRF has a relaxant effect on uterine vasculature in pregnant rats, we aimed to evaluate mid-gestation plasma CRF levels in women with impaired uterine artery blood flow.Maternal plasma CRF was assayed by specific radioimmunoassay

2003 Journal of the Society for Gynecologic Investigation

524. Effect of blood transfusion during radiotherapy on the immune function of patients with cancer of the uterine cervix: role of interleukin-10. (Abstract)

Effect of blood transfusion during radiotherapy on the immune function of patients with cancer of the uterine cervix: role of interleukin-10. To analyze prospectively the effects of blood transfusion administered during radiotherapy (RT) on the immune function of patients with locally advanced cervical cancer.In a total of 15 patients, 7 transfused and 8 untransfused, lymphocyte populations, including CD3+, CD4+, and CD8+ T-cell subsets, B cells (CD19+), and natural killer (NK) cells (CD56 (...) with an inversion of the CD4/CD8 ratio, a significant increase in the number of CD8+ T cells at time 2 and CD3+ T cells, CD8+ T cells, and NK cells at time 3 was found in the transfused patients compared with the untransfused group. The percentages of CD25+/CD3+ T cells and HLA-DR+/CD3+ T cells increased during RT of the untransfused patients, but CD3+ T cells showed decreased CD25 expression and increased HLA-DR expression in the transfused group. An increase of CD8+ IFN-gamma+ T cells with a concomitant

2002 Biology and Physics

525. Delayed uterine re-inversion: a unique symptom complex. (Abstract)

Delayed uterine re-inversion: a unique symptom complex. A case of late recurrence of uterine inversion is presented. Symptoms included constipation and urinary retention without uterine bleeding. Symptoms resolved 3 months after the replacement of the uterus. It is hypothesized that the symptoms were related to stretch injury to the pelvic parasympathetic nerves. Timely intervention may prevent long-term sequelae.

2004 American Journal of Obstetrics and Gynecology

526. Nonpuerperal uterine inversion associated with an immature teratoma of the uterus in an adolescent. (Abstract)

Nonpuerperal uterine inversion associated with an immature teratoma of the uterus in an adolescent. We report a case of nonpuerperal uterine inversion associated with an immature teratoma of the uterus.An adolescent nullipara with prolonged vaginal bleeding, severe abdominal pain, symptomatic anemia, and a presumed diagnosis of retained products of conception was found to have a large mass in the vagina. Uterine inversion was diagnosed and corrected using the Haultain procedure. The inversion (...) catalyst was found to be an immature teratoma of the uterus.Reproductive age women with the rare finding of nonpuerperal uterine inversion are likely to have a malignancy. However, uterine-sparing surgery to correct the inversion should be attempted in young women until final pathology is known.

2007 Obstetrics and Gynecology

527. Chronic uterine inversion at 14 weeks postpartum. (Abstract)

Chronic uterine inversion at 14 weeks postpartum. Uterine inversion is a rare complication of vaginal delivery. When chronic inversion is encountered it is often associated with benign or malignant tumors of the uterus. Management of chronic uterine inversion may require several standard techniques before reversion is accomplished.A woman presented with chronic vaginal bleeding 14 weeks after vaginal delivery complicated by a fourth-degree laceration. Chronic uterine inversion was diagnosed (...) . This diagnosis was unique due to the length of time from delivery to diagnosis and therapeutic modalities implemented.Uterine inversion can occur in the acute (less than 24 hours) or chronic (greater than 1 month) phases. The clinician's clue to chronic uterine inversion, as in this case, may be persistent vaginal bleeding.

2007 Obstetrics and Gynecology

528. B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. (Abstract)

B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. B7-H4 (DD-O110), a member of the B7 family, negatively regulates T cell-mediated immune response. Previous studies have shown that B7-H4 is highly expressed in endometrioid ovarian cancers with relatively low levels of expression in normal ovary which was confirmed by Western blot. The present study was designed to localize B7-H4 expression (...) by immunohistochemistry (IHC) in normal endometrium, endometrial hyperplasia and uterine endometrioid adenocarcinoma. The pattern of B7-H4 localization was compared with the IHC detection of CD3 and CD8-positive T lymphocytes and CD14 positive macrophages to investigate the role of B7-H4 in the regulation of tumor immune surveillance. B7-H4 expression was evaluated in apoptotic tumor cells.The proportion and intensity of B7-H4 staining were increased in the progression from normal, hyperplastic and malignant

2007 Gynecologic Oncology

529. Non-puerperal uterine inversion associated with endometrial carcinoma--a case report. (Abstract)

Non-puerperal uterine inversion associated with endometrial carcinoma--a case report. Non-puerperal uterine inversion is rare, and a case associated with endometrial carcinoma is even rarer. It is difficult to diagnose the condition preoperatively and most cases are diagnosed at surgery.We describe a case of uterine inversion associated with endometrial carcinoma. Initially, the patient was thought to have a cervical adenocarcinoma and treated with chemotherapy; however, a diagnosis of uterine (...) inversion was made with magnetic resonance imaging (MRI) and ultrasonography during pre-surgical chemotherapy. We performed total abdominal hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic lymphadenectomy.MRI and ultrasonography can be extremely useful tools for diagnosing uterine inversion.

2005 Gynecologic Oncology

530. A case report of rhabdomyosarcoma of the uterus associated with uterine inversion. (Abstract)

A case report of rhabdomyosarcoma of the uterus associated with uterine inversion. Alveolar rhabdomyosarcoma is an uncommon malignant soft tissue tumor rarely found in the genital tract. This tumor is associated with a poor prognosis, especially in the adult population. Equally as rare are non-puerperal uterine inversions secondary to sarcomas.A 21-year-old obese woman was initially evaluated with excessive vaginal bleeding. On exam, a large pedunculated mass protruding from the cervix was seen (...) and biopsy of this mass revealed an alveolar rhabdomyosarcoma. The patient was treated with adjuvant chemotherapy consisting of VAC (Vincristine, Actinomycin, and Cyclophosphamide) for a presumed cervical rhabdomyosarcoma. After five cycles of chemotherapy the patient underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy, at which time a complete uterine inversion was noted with the tumor located at the fundus of the uterus. Final pathology showed alveolar rhabdomyosarcoma

2005 Gynecologic Oncology

531. Puerperal uterine inversion and shock. Full Text available with Trip Pro

Puerperal uterine inversion and shock. Uterine inversion is an unusual and potentially life-threatening event occurring in the third stage of labour. It is associated with significant blood loss, and shock, which may be out of proportion to the haemorrhage, although this is questionable. When managed promptly and aggressively, uterine inversion can result in minimal maternal morbidity and mortality. A recent case is described, followed by a short review of the literature.

2004 British Journal of Anaesthesia

532. Uterine Inversion

Uterine Inversion Uterine Inversion. Serious obstetric complication | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Uterine Inversion Authored by , Reviewed by | Last edited 10 Dec 2015 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You (...) may find one of our more useful. In this article In This Article Uterine Inversion In this article Uterine inversion, either partial or complete, is a rare but serious obstetric complication. It usually occurs in the second stage of labour and is a life-threatening complication requiring prompt diagnosis and definitive management. It very rarely occurs in non-pregnant patients, when it is usually associated with prolapsing uterine fibroids or other benign pathologies, although in 15% the cause

2008 Mentor

533. Non-puerperal uterine inversion in association with uterine sarcoma: case report in a 26-year-old and review of the literature. (Abstract)

Non-puerperal uterine inversion in association with uterine sarcoma: case report in a 26-year-old and review of the literature. Inversion of the uterus associated with a uterine sarcoma is extremely rare with only 17 cases reported since 1887, so that its clinical presentation and appearance at laparotomy may be confusing.A 26-year-old woman presented with a vaginal mass and bleeding. At laparotomy, her uterus appeared depressed or concave. The final diagnosis of uterine sarcoma and inversion (...) was unique in her age group.Uterine sarcoma with inversion can occur in the premenopausal age group. It presents as a vaginal mass with bleeding. As a clue to the diagnosis, the uterus per se may not be palpable or it may appear concave on physical exam or at laparotomy.

2005 Gynecologic Oncology

534. Surgical correction of uterine inversion in a mare Full Text available with Trip Pro

Surgical correction of uterine inversion in a mare 17424042 2010 06 28 2018 11 13 0008-5286 33 7 1992 Jul The Canadian veterinary journal = La revue veterinaire canadienne Can. Vet. J. Surgical correction of uterine inversion in a mare. 469-71 Waelchli R O RO Kaegi B B Staub M M eng Journal Article Canada Can Vet J 0004653 0008-5286 1992 7 1 0 0 1992 7 1 0 1 1992 7 1 0 0 ppublish 17424042 PMC1481291 Equine Vet J. 1972 Jul;4(3):105-9 4569567 Can Vet J. 1984 Oct;25(10):389-93 17422462

1992 The Canadian Veterinary Journal

535. Postmenopausal uterine inversion associated with endometrial polyps. (Abstract)

Postmenopausal uterine inversion associated with endometrial polyps. Postmenopausal uterine inversion is an extremely rare gynecologic complication. We report a case of uterine inversion associated with endometrial polyps alone.A postmenopausal nullipara with a history of recurrent postmenopausal bleeding was evaluated for persistent vaginal bleeding. Benign endometrial polyps were found, and the patient's symptoms improved after a therapeutic dilation and curettage. She had acute onset (...) of profuse vaginal bleeding 3 months later and a mass protruded from the cervix. A laparotomy revealed an inverted uterus that was resolved by the Haultain technique and was followed by total abdominal hysterectomy.Nonpuerperal uterine inversion associated with endometrial polyps was successfully treated surgically.

2003 Obstetrics and Gynecology

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