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Uterine Inversion

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501. Myometrial activity in first trimester human pregnancy after Epostane therapy. Effect of intravenous oxytocin. (Abstract)

in the placebo group following oxytocin injection. There was a significant inverse correlation between post treatment progesterone values and uterine activity. Epostane appears to sensitize the myometrium to endogenous oxytocics and this probably results from progesterone 'withdrawal'. This effect may prove useful in potentiating the action of exogenous myometrial stimulants, such as prostaglandins, and may have a role in the termination of early pregnancy. (...) concentrations after 3 days of treatment. The placebo-treated group showed a small but significant decline in serum progesterone concentration. Insertion of an intrauterine balloon catheter for pressure measurements produced significantly greater uterine activity in the Epostane-treated group. The oxytocin response was variable and there was no significant difference between the two groups. A small rise in the peripheral plasma concentration of a prostaglandin F2 alpha metabolite (PGFM) was observed

1985 British journal of obstetrics and gynaecology Controlled trial quality: uncertain

502. Primary and myoma-associated menorrhagia: role of prostaglandins and effects of ibuprofen. (Abstract)

Primary and myoma-associated menorrhagia: role of prostaglandins and effects of ibuprofen. The release of 6-keto-prostaglandin F1 alpha(6-keto-PGF1 alpha), a metabolite of prostacyclin (PGI2) and thromboxane B2 (TxB2), a metabolite of thromboxane A2 (TxA2), was estimated in endometrial biopsies taken from 12 menorrhagic and 12 healthy women during the luteal phase of the cycle. The releases of 6-keto-PGF1 alpha and TxB2 were normal, but the ratio TxB2/6-keto-PGF1 alpha was inversely related (...) to menstrual blood loss in women with measured menstrual blood loss exceeding 70 ml. In the second part of the study, 24 women with excessive menstrual bleeding (13 with primary menorrhagia, 10 with uterine fibromyomas, one with haemostatic factor VIII deficiency) were treated at random with ibuprofen (600 mg/day and 1200 mg/day) and with a placebo. Ibuprofen 1200 mg/day reduced (P less than 0.01) median blood loss from 146 ml (range 71-374 ml) to 110 ml (30-288 ml) in primary menorrhagia but had no effect

1986 British journal of obstetrics and gynaecology Controlled trial quality: uncertain

503. Birthweight and blood pressure among children in Harare, Zimbabwe (Full text)

Birthweight and blood pressure among children in Harare, Zimbabwe To determine whether poor uterine growth may be associated with increased blood pressure and subsequent hypertension in adulthood.A retrospective cohort study of 756 schoolchildren (mean age 6.5 years) was carried out in six low income areas in Harare city, Zimbabwe. Indices of intrauterine growth and blood pressure were assessed.Adjusted for current weight, the children's systolic blood pressure was inversely related (...) to their birthweight; for each decreasing kg of birthweight, systolic blood pressure rose by 1.73 mm Hg (95% CI; 0.181 to 3.28). After adjustment for current weight, systolic blood pressure was also inversely associated with occipito-frontal circumference, but not with birth length or gestational age. Diastolic blood pressure was not associated with any of the intrauterine indices.Fetal size may be inversely related to systolic blood pressure in childhood in an African population.

1998 Archives of Disease in Childhood. Fetal and Neonatal Edition PubMed abstract

504. The sedative effect of intravenous injection of low dose midazolam during spinal anesthesia in cesarean section. (Abstract)

of the mothers in the midazolam group fell asleep smoothly before the operations started. The neonates in the midazolam group were scored similar to saline control group on Apgar score and umbilical venous pH. The incidences of maternal hypotension during operation in both groups were 55%. However, the occurrence of intra-operative maternal discomfort was eleven fold more often in the saline control group. On the other hand, there existed a significant inverse correlation between uterine incision-delivery

1992 Ma zui xue za zhi = Anaesthesiologica Sinica Controlled trial quality: uncertain

505. The addition of epinephrine to subarachnoid administered hyperbaric bupivacaine with fentanyl for cesarean delivery: the effect on onset time. (Abstract)

fentanyl. Group 1 received no epinephrine while Groups 2 and 3 received 100 micrograms and 200 micrograms epinephrine, respectively. Injection of the spinal anesthetic solutions was performed with the patient in the sitting position. Immediately after drug administration, patients were placed supine with their heads elevated on a pillow and 15 degrees of left uterine displacement was maintained. Vital signs and sensory levels were obtained every minute for 10 minutes.In Groups 2 and 3, the mean time (...) is related inversely to patient weight, and epinephrine (100 micrograms and 200 micrograms) delays the onset of sensory block to T4 when administered with subarachnoid hyperbaric bupivacaine-fentanyl.

1992 Regional anesthesia Controlled trial quality: uncertain

506. A prospective, randomized study of endometrial telomerase during the menstrual cycle. (Full text)

detected), and then rose to moderate levels in the late luteal phase beginning on luteal d 10. Serum progesterone levels were inversely related to telomerase activity. In conclusion, endometrial telomerase activity is dynamic: high during the proliferative phase but inhibited during the midsecretory phase of the menstrual cycle. The timing of expression coincides with the rise and fall of progesterone levels and the time period of maximal uterine receptivity for embryo implantation. This supports

2001 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain PubMed abstract

507. Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens in serous ovarian neoplasms. (Abstract)

Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens in serous ovarian neoplasms. The cancer-testis (CT) family of antigens is expressed in a variety of malignant neoplasms and is silent in normal tissues, except for the testis. Expression of two members of this family, MAGE-A4 and NY-ESO-1, has been described in melanomas, germ cell tumors, certain carcinomas and sarcomas, and more recently in uterine neoplasms. The objective of this study was to evaluate the extent and prognostic (...) % of the serous tumors of borderline malignancy. No staining was detected in serous cystadenomas or in the normal ovary. In 8 of 30 positively stained serous carcinomas, >50% of the tumor cells expressed MAGE-A4. NY-ESO-1 expression was seen in 19% of the serous carcinomas, whereas serous tumors of borderline malignancy and cystadenomas were negative. A significant inverse correlation was found between MAGE-A4 expression and patient survival (P = 0.016). Multivariate analysis revealed that both tumor stage

2003 Clinical Cancer Research

508. Soluble adhesion molecules in serum throughout the menstrual cycle. (Abstract)

Soluble adhesion molecules in serum throughout the menstrual cycle. The female reproductive and immune systems are integrally linked with respect to shared cellular and molecular mediators. Cell adhesion molecules (CAMs) involved in leukocyte-endothelial interactions, e.g. intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin, are regulated by sex steroids when expressed by cultured endothelium, while uterine and ovarian CAM expression appears (...) the follicular phase and mid-cycle, but also declined in the late luteal phase (P < 0.01), whereas sE-selectin concentration did not vary markedly across the menstrual cycle. Plasma hormone and urinary hormone metabolite levels confirmed precise cycle tracking and revealed an inverse relationship between sICAM-1 and estradiol (r = -0.38, P < 0.005). A negative correlation was also apparent between sVCAM-1 and circulating monocyte cell numbers (r = -0.47, P < 0.001).The normal cyclic variation in peripheral

2002 Human Reproduction

509. High cyclooxygenase-2 expression in cervical adenocarcinomas. (Abstract)

cervical tissues were obtained as from other patients with uterine myomas treated with a total hysterectomy (n = 16). The immunoreactivity was quantified using an immunohistochemical scoring system that approximates the use of an image analysis-based system.Twenty-two cervical cancer tissues (41.5%), including 10 SCCs and 12 ACs, expressed COX-2 at a moderate to strong level, which significantly, differed from the negligible expression found in the control group of 16 normal cervical tissues (P = 0.001 (...) ). Different cell types showed significantly different expression levels of COX-2 (SCC at 28.6% vs AC at 70.6%, P = 0.004). The presence of deep stromal invasion (n = 40) showed a significant inverse relationship to COX-2 expression (32.5% vs 69.2%, P = 0.02). The expression of COX-2 in well-differentiated carcinomas was significantly increased compared to that in moderately and poorly differentiated carcinomas (72.7% vs 33.3%, respectively, P = 0.018).Overexpression of COX-2 was found in both SCC and AC

2003 Gynecologic Oncology

510. The effects of maternal nutrition and body condition on placental and foetal growth in the ewe. (Abstract)

, placental and foetal parameters were measured. Whilst the placentome number tended to be lower in L than H ewes, the mean placentome weight was significantly greater in L100 than H100 animals. Nutritionally related changes in IGFBP expression within the placentome and intercotyledonary endometrium may explain these findings, with IGFBP-3 expression in the luminal epithelium and caruncular stroma of the placentome villi being inversely correlated to placentome number and the total placentome weight (...) respectively. The foetal CRL was shorter and the ponderal index greater in L than H ewes. The foetal CRL was positively correlated to maternal IGF-I concentrations and the placentome number, although the foetal weight remained unaltered by treatment. This study therefore demonstrates that body condition and ration can alter foetal and placental growth, perhaps by modifying systemic parameters and uterine IGF expression.

2003 Placenta

511. inversion of the uterus

inversion of the uterus inversion of the uterus - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search inversion of the uterus Inversion of the uterus occurs in 1 in 5000 deliveries. Rarely it is a spontaneous event but usually results from mismanagement of the third stage. The Brandt-Andrews method for delivery of the placenta reduces the risk of uterine inversion. Uterine inversion is more common when: cord traction is used

2010 GP Notebook

512. acute inversion of the uterus

acute inversion of the uterus acute inversion of the uterus - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search acute inversion of the uterus Inversion of the uterus occurs in 1 in 5000 deliveries. Rarely it is a spontaneous event but usually results from mismanagement of the third stage. The Brandt-Andrews method for delivery of the placenta reduces the risk of uterine inversion. Uterine inversion is more common when: cord

2010 GP Notebook

513. acute uterine inversion

acute uterine inversion acute uterine inversion - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search acute uterine inversion Inversion of the uterus occurs in 1 in 5000 deliveries. Rarely it is a spontaneous event but usually results from mismanagement of the third stage. The Brandt-Andrews method for delivery of the placenta reduces the risk of uterine inversion. Uterine inversion is more common when: cord traction is used

2010 GP Notebook

514. uterine inversion

uterine inversion uterine inversion - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search uterine inversion Inversion of the uterus occurs in 1 in 5000 deliveries. Rarely it is a spontaneous event but usually results from mismanagement of the third stage. The Brandt-Andrews method for delivery of the placenta reduces the risk of uterine inversion. Uterine inversion is more common when: cord traction is used for delivery

2010 GP Notebook

515. Aspirin for the prevention of preeclampsia in women with abnormal uterine artery Doppler: a meta-analysis

Aspirin for the prevention of preeclampsia in women with abnormal uterine artery Doppler: a meta-analysis Aspirin for the prevention of preeclampsia in women with abnormal uterine artery Doppler: a meta-analysis Aspirin for the prevention of preeclampsia in women with abnormal uterine artery Doppler: a meta-analysis Coomarasamy A, Papaioannou S, Gee H, Khan K S Authors' objectives To assess the effect of aspirin in preventing pre-eclampsia in women identified as being at high risk (...) by an abnormal uterine artery Doppler examination in the second trimester. Searching MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched for trials published between 1966 and November 2000. A combination of search terms were used to generate two subsets of citations: one including studies of 'aspirin' ('aspirin', 'antiplatelet', 'salicyl', 'acetylsalicyl', and 'platelet aggregation inhibitors') and the other including studies of 'Doppler ultrasonography' ('ultrasonography', 'ultraso

2001 DARE.

516. A Pilot Study of Celecoxib in Patients With Grade 2 or 3 Uterine Cancers

of uterine cancers will be put on a selective COX-II inhibitor, Celebrex (Celecoxib) until the day of their surgery. We hypothesize that Celecoxib will downregulate the expression of COX-II in these tumor types as it does in other similar tumors. We also hypothesize that apoptosis, as measured with the TUNEL assay, will be increased in areas with less COX-II expression and should be inversely proportional to cellular p21 expression. We hypothesize COX-related gene expression will be altered thus (...) A Pilot Study of Celecoxib in Patients With Grade 2 or 3 Uterine Cancers A Pilot Study of Celecoxib in Patients With Grade 2 or 3 Uterine Cancers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Pilot

2005 Clinical Trials

517. Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study (Full text)

was inversely associated with age at menarche, parity, and age at first birth and positively associated with years since last birth. Overweight or obesity appeared to attenuate the inverse association between parity and uterine leiomyomata. Current use of progestin-only injectables was inversely associated with risk. No consistent patterns were observed for other forms of hormonal contraception. Reproductive history is an important determinant of leiomyomata risk in premenopausal US Black women. Progestin (...) Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study The authors assessed the risk of uterine leiomyomata in relation to reproductive factors and hormonal contraception in a prospective cohort study of US Black women. From March 1997 through March 2001, the authors followed 22,895 premenopausal women with intact uteri and no prior self-reported diagnosis of uterine leiomyomata. The authors used age- and time-stratified Cox

2004 American Journal of Epidemiology PubMed abstract

518. Prediction of pre-eclampsia by uterine artery Doppler imaging: relationship to gestational age at delivery and small-for-gestational age. (Full text)

pregnancies.In the 30,639 pregnancies examined, the median uterine artery pulsatility index (PI) was 1.0 and the 95(th) centile was 1.58. In 614 (2%) cases the woman developed pre-eclampsia and in this group there was an inverse significant association between the gestational age at delivery and prevalence of SGA (r = - 0.99, P < 0.0001), and between the gestational at delivery and mean uterine artery PI (r = - 0.51, P < 0.0001) and prevalence of mean uterine artery PI above the 95(th) centile (r = - 0.99, P (...) Prediction of pre-eclampsia by uterine artery Doppler imaging: relationship to gestational age at delivery and small-for-gestational age. To determine the relationship between pre-eclampsia, small-for-gestational age (SGA) and gestational age at delivery, and the effect of this relationship on the prediction of pre-eclampsia by uterine artery Doppler imaging.This was a multicenter prospective Doppler study of the uterine artery at 22-24 weeks of gestation in unselected women with singleton

2008 Ultrasound in Obstetrics and Gynecology PubMed abstract

519. Impaired uterine perfusion associated with metabolic disorders in women with polycystic ovary syndrome. (Abstract)

lipoprotein-cholesterol (HDL-C). The uterine arterial pulsatility index (PI) in women with PCOS was significantly higher than that in the control women during the follicular phase. The PI was correlated with BMI, LH/FSH ratio, or LDL-C/HDL-C ratio, whereas it was inversely correlated with the HDL-C level. Women with PCOS had reduced endometrial thickness and elevated uterine arterial PI in the luteal phase, in which implantation occurs.Elevation of uterine arterial blood flow resistance is associated (...) Impaired uterine perfusion associated with metabolic disorders in women with polycystic ovary syndrome. Risk factors for cardiovascular disease, including chronic anovulation, obesity, hyperandrogenism, hyperinsulinemia, and dyslipidemia, are commonly observed in women with polycystic ovary syndrome (PCOS). We evaluated uterine perfusion and its correlation with clinical and biochemical parameters in women with PCOS.We performed a pulsed Doppler study on uterine arterial blood flow in 25 women

2005 Acta Obstetricia et Gynecologica Scandinavica

520. Changes of plasma vascular endothelial growth factor level after uterine artery embolisation for leiomyomata. (Abstract)

arteries before and after UAE. The level of plasma VEGF increased significantly after UAE (on day 1 and day 3) and decreased on day 7, and then increased again on day 30. The level of VEGF reached a peak value within three days after UAE. A significant inverse correlation was found between uterine artery PI and the level of VEGF on day 30, suggesting that VEGF may have negative effect on the efficacy of treatment of uterine leiomyomata by UAE. (...) Changes of plasma vascular endothelial growth factor level after uterine artery embolisation for leiomyomata. Uterine artery embolisation (UAE) has become an alternative treatment for symptomatic uterine leiomyomata. Most reports suggest that it is well tolerated and effective, although there have been no reports of studies of biological parameters after UAE. In this study, we analysed the plasma level of vascular endothelial growth factor (VEGF) and the pulsatility index (PI) of uterine

2005 BJOG

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