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Uterine Inversion

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501. Impaired uterine artery blood flow at mid gestation and low levels of maternal plasma corticotropin-releasing factor. (PubMed)

CRF levels were significantly lower in women with a unilateral (168.45 +/- 27.5 pg/mL; P <.01) or bilateral (186.07 +/- 34.5 pg/mL; P <.001) uterine artery notch than in healthy control pregnant women (375.06 +/- 21.77 pg/mL). Although no difference was found in CRF levels between patients with a unilateral or bilateral uterine artery notch, a significant inverse correlation was found between the mean RI and maternal plasma CRF levels (Spearman r = -0.6540; 95% confidence interval, -0.7865 (...) Impaired uterine artery blood flow at mid gestation and low levels of maternal plasma corticotropin-releasing factor. Corticotropin-releasing factor (CRF) is a placental neuropeptide that plays a role in the control of uteroplacental blood flow regulation. Because CRF has a relaxant effect on uterine vasculature in pregnant rats, we aimed to evaluate mid-gestation plasma CRF levels in women with impaired uterine artery blood flow.Maternal plasma CRF was assayed by specific radioimmunoassay

2003 Journal of the Society for Gynecologic Investigation

502. Saline infusion sonography in women with abnormal uterine bleeding: an update of recent findings. (PubMed)

in the evaluation of the uterine cavity. The use of gel instead of saline as distension medium and the introduction of new three-dimensional inversion rendering techniques enhances the visualization of the endometrium which may improve the diagnostic accuracy of saline infusion sonography. A simple, feasible and seemingly cost-effective method of saline infusion sonography-based guided endometrial biopsy has been developed. The technique may allow saline infusion sonography based polypectomy. A classification (...) Saline infusion sonography in women with abnormal uterine bleeding: an update of recent findings. To inform about new developments concerning saline infusion sonography, especially in women suffering from abnormal uterine bleeding.The diagnostic accuracy of saline infusion sonography has been established before the period of this review; however, recent papers support the high diagnostic accuracy and conclude saline infusion sonography is able to replace diagnostic hysteroscopy

2006 Current Opinion in Obstetrics and Gynecology

503. Power Doppler ultrasound studies of ovarian, uterine, and endometrial blood flow in regularly menstruating women with respect to luteal phase defects. (PubMed)

Power Doppler ultrasound studies of ovarian, uterine, and endometrial blood flow in regularly menstruating women with respect to luteal phase defects. The menstrual cycle outcome of 71 regularly menstruating women was ovulatory in 60.5% of the cases, luteal phase defect in 25.3%, luteinized unruptured follicle in 11.2%, and anovulatory in 2.8%. Significantly lower resistance indices were seen in the uterine, arcuate, radial, and spiral arteries of the ovulatory group in the midluteal phase (...) , which was inversely related to the P level.

2005 Fertility and Sterility

504. The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix. (PubMed)

hypermethylation. We could not demonstrate an inverse correlation between RASSF1A methylation and HPV 16 infection in AC of the uterine cervix.Hypermethylation of the RASSF1A promoter region is common in AC of the uterine cervix and rare in squamous carcinoma of uterine cervix. HPV infection does not correlate with RASSF1A methylation status in AC of the uterine cervix, but the absence of RASSF1A methylation in SCC of the uterine cervix coupled with the high incidence of HPV 16 infection in this subtype (...) The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix. Development of adenocarcinoma (AC) of the uterine cervix, as well as squamous cell carcinoma (SCC), is strongly linked to infection by high-risk human papillomavirus (HPV) types. Human HPV E6 and E7 proteins inactivate the tumor suppressor genes p53 and retinoblastoma, respectively. However, additional genetic alterations may be required to maintain a malignant phenotype. Allelic loss at the short

2003 Clinical Cancer Research

505. Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys. (PubMed)

were detected between the SPI+ and SPI- groups. SPI+ treatment resulted in significantly lower serum concentrations of estrone (P < 0.01) and estradiol (P < 0.05) vs. SPI-. Within the SPI+ group, serum isoflavone concentrations were inversely correlated with serum estrone and mammary glandular area. These findings suggest that high dietary levels of soy isoflavones do not stimulate breast or uterine proliferation in postmenopausal monkeys and may contribute to an estrogen profile associated (...) Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys. In this study we evaluated the long-term effects of soy isoflavones on intermediate markers of cancer risk in the normal postmenopausal monkey breast and uterus. Ovariectomized female cynomolgus monkeys were randomized to receive one of three diets for 36 months: 1) isoflavone-depleted soy protein isolate (SPI-) (n = 57); 2) soy protein isolate with the equivalent of 129 mg/d

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2004 Journal of Clinical Endocrinology and Metabolism

506. Clinical significance of RCAS1 as a biomarker of uterine cancer. (PubMed)

induced K562 cell growth inhibition, but this effect partially recovered after immunodepletion of RCAS1. Peripheral lymphocyte number and serum RCAS1 concentration were inversely related (P=0.0310).RCAS1 may be a biomarker of uterine cancer because of its potential to predict results of uterine cancer treatment and inhibit growth of immune cells. (...) Clinical significance of RCAS1 as a biomarker of uterine cancer. Expression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is associated with prognosis of various malignancies including uterine cancer. Proteolytic cleavage of RCAS1 at extracellular domains (ectodomain shedding) yields soluble RCAS1. Although RCAS1 can induce apoptosis in normal peripheral lymphocytes, its biologic function in cancer patients is unclear. Here, we evaluated serum RCAS1 concentrations

2006 Gynecologic Oncology

507. Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study (PubMed)

was inversely associated with age at menarche, parity, and age at first birth and positively associated with years since last birth. Overweight or obesity appeared to attenuate the inverse association between parity and uterine leiomyomata. Current use of progestin-only injectables was inversely associated with risk. No consistent patterns were observed for other forms of hormonal contraception. Reproductive history is an important determinant of leiomyomata risk in premenopausal US Black women. Progestin (...) Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study The authors assessed the risk of uterine leiomyomata in relation to reproductive factors and hormonal contraception in a prospective cohort study of US Black women. From March 1997 through March 2001, the authors followed 22,895 premenopausal women with intact uteri and no prior self-reported diagnosis of uterine leiomyomata. The authors used age- and time-stratified Cox

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2004 American Journal of Epidemiology

508. Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma. (PubMed)

Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma. Although the incidence of cervical adenocarcinoma is increasing, few genetic and epigenetic changes in its progression have been described. We hypothesized that RASSF1A methylation and KRAS and BRAF mutations may play an important role in cervical adenocarcinoma.Archival primary carcinoma tissues (n=258) in uterine cervix consisting cervical adenocarcinomas (n=115) and squamous cell (...) carcinomas (n=143) were evaluated for activating mutations of BRAF and KRAS and promoter hypermethylation of RASSF1A using methylation specific PCR and specific sequence analysis. HPV E7 Type-specific PCR was used for HPV-16 and -18 status.KRAS mutations were found in 16 adenocarcinomas (13.9%), while BRAF mutations were found in 5 (4.3%). RASSF1A methylation was found in 27 adenocarcinomas (23.5%) and inversely correlated with KRAS and/or BRAF mutation (p=0.002) in cervical adenocarcinoma. In cervical

2007 Gynecologic Oncology

509. Relation between retinoblastoma and p53 proteins in human papilloma viruses 16/18 positive and negative cancers of the uterine cervix. (PubMed)

Relation between retinoblastoma and p53 proteins in human papilloma viruses 16/18 positive and negative cancers of the uterine cervix. To ascertain the extent of retinoblastoma protein (pRB) expression in comparison to p53 protein and human papilloma viruses (HPV) 16/18 status in cervical carcinomas.Fifty cases of invasive cervical carcinoma were HPV typed for genotypes 16 and 18 using consensus primers by polymerase chain reaction (PCR). Immunohistochemistry for pRB and p53 was done (...) for p53 and a further seven were +1 positive. This inverse pattern of staining between pRB and p53 had a p value of < 0.001. No correlation was observed between HPV 16/18 status and p53 and/or pRB staining.pRB is expressed in the majority of cases of cervical cancer (86%), with more than 75% (+4) of the tumour cell population being positive in 16 cases (32%). There appears to be a general inverse pattern of staining between pRB (high) and p53 (low) in cervical cancer. The expression of both pRB

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1997 Journal of Clinical Pathology

510. A Uterine Ultrasonographic Scoring System as a Method for the Prognosis of Embryo Implantation (PubMed)

it reached at least the basal layer of the endometrium; F. Myometrial power Doppler (absent = 0 weakly present 2; strongly present = 3); G. Myometrial echogenicity (homogeneous = 2; inhomogeneous = 0). The patients were divided into 4 groups according to total score: Group I, score < 10: Group II, score 10-14, Group III, score 15-17 and Group IV, score 18-20.The uterine parameters using an ultrasonographic scoring system are inversely correlated with patient age (p < 0.0001). The number of days (...) significantly (p = 0.93) between groups.The ultrasonographic evaluation of uterine parameters on the day of hCG administration using a scoring system is inversely correlated with patient age. In the present study, the use of this ultrasonographic score method could not identify a population with greater uterine receptivity.

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2002 Journal of assisted reproduction and genetics

511. Comparative immunohistochemical and molecular analysis of uterine and extrauterine leiomyosarcomas. (PubMed)

only one retroperitoneal tumor had focal weak positivity. Over 80% of the extrauterine and 50% of the uterine sarcomas showed absence of CD44s immunoreactivity. Percentage of cyclin D1 immunoreactivity was independent of tumor grade and inversely proportional to the percent of bcl2 positivity. An LMS of the male breast contained k-ras-2 exon 1 point mutation (codon 12 aspartate substitution of glycine). P53 allelic imbalance was present in 29% of ULMS and 57% EULMS. Mdm2 amplification was present (...) Comparative immunohistochemical and molecular analysis of uterine and extrauterine leiomyosarcomas. Histologic criteria defining malignancy in smooth muscle tumors are currently site specific. This study was undertaken to determine whether, in leiomyosarcomas (LMS) occurring in different anatomic locations, there were differences in patterns of expression of molecules that have been demonstrated to be associated with biologically aggressive behavior in malignant neoplasms, and also to determine

1999 Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

512. Effect of blood transfusion during radiotherapy on the immune function of patients with cancer of the uterine cervix: role of interleukin-10. (PubMed)

Effect of blood transfusion during radiotherapy on the immune function of patients with cancer of the uterine cervix: role of interleukin-10. To analyze prospectively the effects of blood transfusion administered during radiotherapy (RT) on the immune function of patients with locally advanced cervical cancer.In a total of 15 patients, 7 transfused and 8 untransfused, lymphocyte populations, including CD3+, CD4+, and CD8+ T-cell subsets, B cells (CD19+), and natural killer (NK) cells (CD56 (...) with an inversion of the CD4/CD8 ratio, a significant increase in the number of CD8+ T cells at time 2 and CD3+ T cells, CD8+ T cells, and NK cells at time 3 was found in the transfused patients compared with the untransfused group. The percentages of CD25+/CD3+ T cells and HLA-DR+/CD3+ T cells increased during RT of the untransfused patients, but CD3+ T cells showed decreased CD25 expression and increased HLA-DR expression in the transfused group. An increase of CD8+ IFN-gamma+ T cells with a concomitant

2002 Biology and Physics

513. Delayed uterine re-inversion: a unique symptom complex. (PubMed)

Delayed uterine re-inversion: a unique symptom complex. A case of late recurrence of uterine inversion is presented. Symptoms included constipation and urinary retention without uterine bleeding. Symptoms resolved 3 months after the replacement of the uterus. It is hypothesized that the symptoms were related to stretch injury to the pelvic parasympathetic nerves. Timely intervention may prevent long-term sequelae.

2004 American Journal of Obstetrics and Gynecology

514. Postmenopausal uterine inversion associated with endometrial polyps. (PubMed)

Postmenopausal uterine inversion associated with endometrial polyps. Postmenopausal uterine inversion is an extremely rare gynecologic complication. We report a case of uterine inversion associated with endometrial polyps alone.A postmenopausal nullipara with a history of recurrent postmenopausal bleeding was evaluated for persistent vaginal bleeding. Benign endometrial polyps were found, and the patient's symptoms improved after a therapeutic dilation and curettage. She had acute onset (...) of profuse vaginal bleeding 3 months later and a mass protruded from the cervix. A laparotomy revealed an inverted uterus that was resolved by the Haultain technique and was followed by total abdominal hysterectomy.Nonpuerperal uterine inversion associated with endometrial polyps was successfully treated surgically.

2003 Obstetrics and Gynecology

515. Chronic uterine inversion at 14 weeks postpartum. (PubMed)

Chronic uterine inversion at 14 weeks postpartum. Uterine inversion is a rare complication of vaginal delivery. When chronic inversion is encountered it is often associated with benign or malignant tumors of the uterus. Management of chronic uterine inversion may require several standard techniques before reversion is accomplished.A woman presented with chronic vaginal bleeding 14 weeks after vaginal delivery complicated by a fourth-degree laceration. Chronic uterine inversion was diagnosed (...) . This diagnosis was unique due to the length of time from delivery to diagnosis and therapeutic modalities implemented.Uterine inversion can occur in the acute (less than 24 hours) or chronic (greater than 1 month) phases. The clinician's clue to chronic uterine inversion, as in this case, may be persistent vaginal bleeding.

2007 Obstetrics and Gynecology

516. Nonpuerperal uterine inversion associated with an immature teratoma of the uterus in an adolescent. (PubMed)

Nonpuerperal uterine inversion associated with an immature teratoma of the uterus in an adolescent. We report a case of nonpuerperal uterine inversion associated with an immature teratoma of the uterus.An adolescent nullipara with prolonged vaginal bleeding, severe abdominal pain, symptomatic anemia, and a presumed diagnosis of retained products of conception was found to have a large mass in the vagina. Uterine inversion was diagnosed and corrected using the Haultain procedure. The inversion (...) catalyst was found to be an immature teratoma of the uterus.Reproductive age women with the rare finding of nonpuerperal uterine inversion are likely to have a malignancy. However, uterine-sparing surgery to correct the inversion should be attempted in young women until final pathology is known.

2007 Obstetrics and Gynecology

517. Non-puerperal uterine inversion associated with endometrial carcinoma--a case report. (PubMed)

Non-puerperal uterine inversion associated with endometrial carcinoma--a case report. Non-puerperal uterine inversion is rare, and a case associated with endometrial carcinoma is even rarer. It is difficult to diagnose the condition preoperatively and most cases are diagnosed at surgery.We describe a case of uterine inversion associated with endometrial carcinoma. Initially, the patient was thought to have a cervical adenocarcinoma and treated with chemotherapy; however, a diagnosis of uterine (...) inversion was made with magnetic resonance imaging (MRI) and ultrasonography during pre-surgical chemotherapy. We performed total abdominal hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic lymphadenectomy.MRI and ultrasonography can be extremely useful tools for diagnosing uterine inversion.

2005 Gynecologic Oncology

518. B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. (PubMed)

B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. B7-H4 (DD-O110), a member of the B7 family, negatively regulates T cell-mediated immune response. Previous studies have shown that B7-H4 is highly expressed in endometrioid ovarian cancers with relatively low levels of expression in normal ovary which was confirmed by Western blot. The present study was designed to localize B7-H4 expression (...) by immunohistochemistry (IHC) in normal endometrium, endometrial hyperplasia and uterine endometrioid adenocarcinoma. The pattern of B7-H4 localization was compared with the IHC detection of CD3 and CD8-positive T lymphocytes and CD14 positive macrophages to investigate the role of B7-H4 in the regulation of tumor immune surveillance. B7-H4 expression was evaluated in apoptotic tumor cells.The proportion and intensity of B7-H4 staining were increased in the progression from normal, hyperplastic and malignant

2007 Gynecologic Oncology

519. A case report of rhabdomyosarcoma of the uterus associated with uterine inversion. (PubMed)

A case report of rhabdomyosarcoma of the uterus associated with uterine inversion. Alveolar rhabdomyosarcoma is an uncommon malignant soft tissue tumor rarely found in the genital tract. This tumor is associated with a poor prognosis, especially in the adult population. Equally as rare are non-puerperal uterine inversions secondary to sarcomas.A 21-year-old obese woman was initially evaluated with excessive vaginal bleeding. On exam, a large pedunculated mass protruding from the cervix was seen (...) and biopsy of this mass revealed an alveolar rhabdomyosarcoma. The patient was treated with adjuvant chemotherapy consisting of VAC (Vincristine, Actinomycin, and Cyclophosphamide) for a presumed cervical rhabdomyosarcoma. After five cycles of chemotherapy the patient underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy, at which time a complete uterine inversion was noted with the tumor located at the fundus of the uterus. Final pathology showed alveolar rhabdomyosarcoma

2005 Gynecologic Oncology

520. Puerperal uterine inversion and shock. (PubMed)

Puerperal uterine inversion and shock. Uterine inversion is an unusual and potentially life-threatening event occurring in the third stage of labour. It is associated with significant blood loss, and shock, which may be out of proportion to the haemorrhage, although this is questionable. When managed promptly and aggressively, uterine inversion can result in minimal maternal morbidity and mortality. A recent case is described, followed by a short review of the literature.

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2004 British Journal of Anaesthesia

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