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Uterine Inversion

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21. Uterine Foxl2 regulates the adherence of the Trophectoderm cells to the endometrial epithelium (PubMed)

of the Wnt/Fzd and apoptotic pathways, both of which are involved in uterine receptivity. Furthermore, FOXL2 expression was inversely correlated with G-protein signaling protein 2 (Rgs2) and cytokine expression.These results suggest that FOXL2 interferes with embryo attachment. Better understanding of the function of FOXL2 in the uterus would possibly suggest novel strategies for treatment of infertility attributed to repeated implantation failure. (...) Uterine Foxl2 regulates the adherence of the Trophectoderm cells to the endometrial epithelium Forkhead Transcription Factor L2 (FOXL2) is a member of the forkhead family with important roles in reproduction. Recent studies showed that FOXL2 is expressed in human and bovine endometrium and that its levels fluctuate during pregnancy. In this study, we aimed at evaluating the expression and function of FOXL2 in embryo implantation.Mouse uteri at different days of pregnancy were isolated

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2018 Reproductive biology and endocrinology : RB&E

22. Spontaneous complete regression of large uterine fibroid after the second vaginal delivery: Case report. (PubMed)

remains unclear. Researchers evaluating fibroids have reported an inverse association between parity and fibroids, suggestive of a protective effect. Pregnancies that occur while fibroids are small would be protective; whereas pregnancies occurring before fibroid development or after the tumors reach some critical size would not be protective. Herein, the case of a woman with a large uterine fibroid that was spontaneously regressed after a second successful vaginal delivery is reported. To our (...) Spontaneous complete regression of large uterine fibroid after the second vaginal delivery: Case report. Fibroids are common, hormone-dependent, benign uterine tumors. It is estimated that they occur in 20% to 40% of women during their reproductive years. The prevalence of fibroids among pregnant women is 10.7%. Most fibroids do not increase in size during pregnancy. Pregnancy has a variable and unpredictable effect on fibroid growth. The influence of pregnancy on uterine fibroid size still

2018 Medicine

23. Decrease in uterine perforations with ultrasound image-guided applicator insertion in intracavitary brachytherapy for cervical cancer: A systematic review and meta-analysis. (PubMed)

and the guided insertion group was calculated by using the random-effects model weighted by the inverse variance.A total of 690 articles were initially found, resulting in 12 studies that met the inclusion criteria. A total of 1757 insertions and 766 patients were included in the meta-analysis. The overall uterine perforation rate per insertion was 4.56% (95%CI: 2.35-8.67) and per patient was 7.39% (95%CI: 3.92-13.50). The pooled perforation rate per insertion without image guidance was 10.54% (95%CI: 6.12 (...) Decrease in uterine perforations with ultrasound image-guided applicator insertion in intracavitary brachytherapy for cervical cancer: A systematic review and meta-analysis. To estimate uterine perforations rates during intracavitary brachytherapy for cervical cancer with and without ultrasound (US) image guidance.A systematic search of databases (PubMed and EMBASE) was performed. The pooled summary uterine perforation rate (detected by postinsertion CT or MRI) for the un-guided insertion group

2018 Gynecologic Oncology

24. Combination of an intrauterine balloon and the "holding the cervix" technique for hemostasis of postpartum hemorrhage and for prophylaxis of acute recurrent uterine inversion. (PubMed)

Combination of an intrauterine balloon and the "holding the cervix" technique for hemostasis of postpartum hemorrhage and for prophylaxis of acute recurrent uterine inversion. 24127992 2014 07 28 2018 12 02 1600-0412 93 3 2014 Mar Acta obstetricia et gynecologica Scandinavica Acta Obstet Gynecol Scand Combination of an intrauterine balloon and the "holding the cervix" technique for hemostasis of postpartum hemorrhage and for prophylaxis of acute recurrent uterine inversion. 314-5 10.1111/aogs (...) .12282 Matsubara Shigeki S Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan. eng Letter Comment 2013 11 20 United States Acta Obstet Gynecol Scand 0370343 0001-6349 IM Acta Obstet Gynecol Scand. 2014 Mar;93(3):313-4 23941194 Acta Obstet Gynecol Scand. 2014 Mar;93(3):315-6 24299294 Blood Loss, Surgical prevention & control Female Humans Postpartum Hemorrhage therapy Pregnancy Pregnancy Outcome epidemiology Uterine Balloon Tamponade methods 2013 10 17 6 0 2013 10 17 6 0

2013 Acta Obstetricia et Gynecologica Scandinavica

25. Effect of vitamin E supplementation on uterine cervical neoplasm: A meta-analysis of case-control studies. (PubMed)

Effect of vitamin E supplementation on uterine cervical neoplasm: A meta-analysis of case-control studies. Several epidemiological studies have suggested that vitamin E could reduce the risk of uterine cervical neoplasm. However, controversial data were presented by different reports. Hence, we conducted a meta-analysis to assess the relationship between vitamin E and the risk of cervical neoplasia. We performed a comprehensive search of the PubMed, Embase and Cochrane databases through (...) controls. Our study suggested that higher category of vitamin E could reduce the cervical neoplasia risk (OR = 0.58, 95% CIs = 0.47-0.72, I2 = 83%). In subgroup-analysis, both vitamin E intake and blood levels of vitamin E had a significant inverse association with the risk of cervical neoplasm. Additionally, we found the same relationship between vitamin E and cervical neoplasia among different populations and types of cervical neoplasia. Meta-regression showed that none of the including covariates

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2017 PloS one

26. Admixture mapping of uterine fibroid size and number in African American women. (PubMed)

Admixture mapping of uterine fibroid size and number in African American women. To evaluate the relationship between genetic ancestry and uterine fibroid characteristics.Cross-sectional study.Not applicable.A total of 609 African American participants with image- or surgery-confirmed fibroids in a biorepository at Vanderbilt University electronic health record biorepository and the Coronary Artery Risk Development in Young Adults studies were included.None.Outcome measures include fibroid (...) number (single vs. multiple), volume of largest fibroid, and largest fibroid dimension of all fibroid measurements.Global ancestry meta-analyses revealed a significant inverse association between percentage of European ancestry and risk of multiple fibroids (odds ratio: 0.78; 95% confidence interval 0.66, 0.93; P=6.05 × 10-3). Local ancestry meta-analyses revealed five suggestive (P<4.80 × 10-3) admixture mapping peaks in 2q14.3-2q21.1, 3p14.2-3p14.1, 7q32.2-7q33, 10q21.1, 14q24.2-14q24.3, for number

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2017 Fertility and Sterility

27. Chlamydia Trachomatis Seroprevalence and Ultrasound Diagnosed Uterine Fibroids in a Large Population of Young African-American Women. (PubMed)

Chlamydia Trachomatis Seroprevalence and Ultrasound Diagnosed Uterine Fibroids in a Large Population of Young African-American Women. Reproductive tract infections have long been hypothesized to increase the risk of uterine fibroids. Few studies have been conducted, even for the common infection genital Chlamydia trachomatis (gCT), and only with self-reported gCT data. Our investigation used micro-immunofluorescence serology for gCT to characterize past exposure. We used cross-sectional (...) -adjusted odds ratio = 0.68, 95% confidence interval: 0.54, 0.87; multivariable-adjusted odds ratio = 0.80, 95% confidence interval: 0.62, 1.03). Inverse associations were similar across categories of fibroid size, number, and total volume. Participant groups likely to have had multiple or severe infections (multiple serovar groups, more sex partners, clinically diagnosed chlamydia) all showed statistically significantly reduced odds of fibroids. A protective association of gCT with fibroids

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2017 American Journal of Epidemiology

28. The Impact of Uterine Immaturity on Obstetrical Syndromes During Adolescence. (PubMed)

The Impact of Uterine Immaturity on Obstetrical Syndromes During Adolescence. Pregnant nulliparous adolescents are at increased risk, inversely proportional to their age, of major obstetric syndromes, including preeclampsia, fetal growth restriction, and preterm birth. Emerging evidence indicates that biological immaturity of the uterus accounts for the increased incidence of obstetrical disorders in very young mothers, possibly compounded by sociodemographic factors associated with teenage (...) pregnancy. The endometrium in most newborns is intrinsically resistant to progesterone signaling, and the rate of transition to a fully responsive tissue likely determines pregnancy outcome during adolescence. In addition to ontogenetic progesterone resistance, other factors appear important for the transition of the immature uterus to a functional organ, including estrogen-dependent growth and tissue-specific conditioning of uterine natural killer cells, which plays a critical role in vascular

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2017 American Journal of Obstetrics and Gynecology

29. Perinatal outcome and placental apoptosis in patients with late-onset pre-eclampsia and abnormal uterine artery Doppler at diagnosis. (PubMed)

Perinatal outcome and placental apoptosis in patients with late-onset pre-eclampsia and abnormal uterine artery Doppler at diagnosis. To determine the rate of placental apoptosis and adverse perinatal outcome in patients with late-onset pre-eclampsia (PE) and abnormal uterine artery (UtA) Doppler at diagnosis.This was a prospective cohort study of women with singleton pregnancy diagnosed with late PE, performed between August 2011 and January 2014 at the Maternal-Fetal Medicine Unit of Hospital (...) ratio (OR) = 7.5; 95% CI, 2.76-20.46; P < 0.001), late preterm delivery (OR = 13.7; 95% CI, 4.53-41.46; P < 0.001), small-for-gestational age at birth (OR = 12.3; 95% CI, 3.17-47.57; P < 0.001) and admission to the neonatal intensive care unit (OR = 12.8; 95% CI, 2.61-62.36; P = 0.002). Moreover, UtA Z-score demonstrated a significant inverse correlation with birth-weight Z-score (r = -0.34; P = 0.0013). Mean placental apoptotic index demonstrated an ascending linear trend according to UtA Doppler

2017 Ultrasound in Obstetrics and Gynecology

30. Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas (PubMed)

Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12). These mutations have been associated with conventional histology, smaller tumour size, and larger number of tumours within the uterus. Prior studies, with limited sample sizes, have failed to detect associations between other clinical features and MED12 mutations. Here, we prospectively collected 763 (...) uterine leiomyomas and the corresponding normal myometrial tissue from 244 hysterectomy patients, recorded tumour characteristics, collected clinical data from medical records, and screened the tissue samples for MED12 mutations to assess potential associations between clinical variables and mutation status. Out of 763 leiomyomas, 599 (79%) harboured a MED12 mutation. In the analysis of tumour characteristics, positive MED12-mutation status was significantly associated with smaller tumour size

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2017 Scientific reports

31. Defining age- and lactocrine-sensitive elements of the neonatal porcine uterine microRNA–mRNA interactome, (PubMed)

Defining age- and lactocrine-sensitive elements of the neonatal porcine uterine microRNA–mRNA interactome, Factors delivered to offspring in colostrum within 2 days of birth support neonatal porcine uterine development. The uterine mRNA transcriptome is affected by age and nursing during this period. Whether uterine microRNA (miRNA) expression is affected similarly is unknown. Objectives were to (1) determine effects of age and nursing on porcine uterine miRNA expression between birth (...) PND 0 comparisons, 31 differentially expressed (DE) miRNAs were identified for nursed, and 42 DE miRNAs were identified for replacer-fed gilts. Six DE miRNAs were identified for nursed versus replacer-fed gilts on PND 2. Target prediction for inversely correlated DE miRNA–mRNA pairings indicated 20 miRNAs targeting 251 mRNAs in nursed, versus 29 miRNAs targeting 585 mRNAs in replacer-fed gilts for PND 2 versus PND 0 comparisons, and 5 miRNAs targeting 81 mRNAs for nursed versus replacer-fed gilts

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2017 Biology of reproduction

32. Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer (PubMed)

Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer Apparent diffusion coefficient (ADC) values derived from diffusion-weighted magnetic resonance imaging (DW-MRI) are known to reflect the cellular environment of biological tissues. However, emerging evidence accentuates the influence of stromal elements on ADC values. The current study sought to elucidate whether a correlation exists between ADC and the fraction of collagen I-positive (...) tissue across different tumor models of uterine cervical cancer. Early and late generation tumors of four patient-derived xenograft (PDX) models of squamous cell carcinoma (BK-12, ED-15, HL-16, and LA-19) were included. DW-MRI was performed with diffusion encoding constants (b) of 200, 400, 700, and 1000 s/mm2 and diffusion gradient sensitization in three orthogonal directions. The fraction of collagen I-positive connective tissue was determined by immunohistochemistry. Mono-exponential decay curves

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2017 Oncotarget

33. DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment (PubMed)

DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment Abnormalities in the tumor microenvironment are associated with resistance to treatment, aggressive growth, and poor clinical outcome in patients with advanced cervical cancer. The potential of dynamic contrast-enhanced (DCE) MRI to assess the microvascular density (MVD), interstitial fluid pressure (IFP), and hypoxic fraction of patient-derived cervical cancer (...) xenografts was investigated in the present study.Four patient-derived xenograft (PDX) models of squamous cell carcinoma of the uterine cervix (BK-12, ED-15, HL-16, and LA-19) were subjected to Gd-DOTA-based DCE-MRI using a 7.05 T preclinical scanner. Parametric images of the volume transfer constant (K trans) and the fractional distribution volume (v e) of the contrast agent were produced by pharmacokinetic analyses utilizing the standard Tofts model. Whole tumor median values of the DCE-MRI parameters

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2017 Journal of translational medicine

34. Uterine Inversion

Uterine Inversion Uterine Inversion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Uterine Inversion Uterine Inversion Aka: Uterine (...) (from Bing) These images are a random sampling from a Bing search on the term "Uterine Inversion." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Uterine Inversion (C0162482) Definition (MSH) A complication of OBSTETRIC LABOR in which the corpus of the UTERUS is forced completely or partially through the UTERINE CERVIX. This can occur during the late stages of labor and is associated with IMMEDIATE POSTPARTUM

2015 FP Notebook

35. Puerperal uterine inversion in the Netherlands: a nationwide cohort study. (PubMed)

Puerperal uterine inversion in the Netherlands: a nationwide cohort study. Puerperal uterine inversion is a severe but rare obstetric complication of yet unknown origin. In this two-year study we determine the incidence of this complication and we describe associated risk factors to expose its etiology. All cases of uterine inversion were included from a nationwide cohort study which contained all 98 hospitals with a maternity unit in the Netherlands. We reviewed the medical records of 15 (...) patients, resulting an incidence of approximately 1 in 20 000 vaginal births. Fourteen cases (93.3%) were classified as low-risk pregnancies at booking. Nulliparous women were not overrepresented and the main associated factors were signs of prolonged labor followed by third stage manipulation. This study is the first population-based study for uterine inversion. With the reported associated factors and occurrence in women with a low-risk profile, we show that every birth attendant should be able

2012 Acta Obstetricia et Gynecologica Scandinavica

36. Ultrasound diagnosis of complete uterine inversion in a nulliparous woman. (PubMed)

Ultrasound diagnosis of complete uterine inversion in a nulliparous woman. Non-puerperal uterine inversion is an extremely rare event, and the diagnosis is made during vaginal examination or exploratory laparotomy. We report a case of complete uterine inversion which was diagnosed on abdominal ultrasound examination in a 50-year-old nulliparous virgin who was admitted to the hospital because of profuse vaginal bleeding, lower abdominal pain and anuria. The confirmatory diagnosis of complete (...) uterine inversion secondary to a fundal fibroid was made at exploratory laparotomy. Total abdominal hysterectomy was performed, and the pathological examination confirmed its benign nature. Ultrasound evaluation is useful in the diagnosis of non-puerperal uterine inversion.© 2012 The AuthorsActa Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.

2011 Acta Obstetricia et Gynecologica Scandinavica

37. Management of nonpuerperal uterine inversion using a combined laparoscopic and vaginal approach. (PubMed)

Management of nonpuerperal uterine inversion using a combined laparoscopic and vaginal approach. Although described as a postpartum complication, uterine inversion may also occur in nonpregnant women. We report a case of nonpuerperal uterine inversion, because of a large exteriorized submucous myoma in a 40-year-old woman, which was surgically managed by hysterectomy using a combined laparoscopic and vaginal approach.Copyright © 2011 Mosby, Inc. All rights reserved.

2011 American Journal of Obstetrics and Gynecology

38. Are Second Trimester Apparent Diffusion Coefficient Values of the Short Uterine Cervix Associated with Impending Preterm Delivery? (PubMed)

Are Second Trimester Apparent Diffusion Coefficient Values of the Short Uterine Cervix Associated with Impending Preterm Delivery? Purpose To prospectively determine whether the apparent diffusion coefficient (ADC) of the cervix is associated with preterm delivery in asymptomatic patients with a sonographic cervical length of 15 mm or less and positive fetal fibronectin test results between 23 and 28 weeks of gestation. Materials and Methods The institutional review board approved (...) ± 108.1] × 10(-6) mm(2)/sec and [657.3 ± 129.9] × 10(-6) mm(2)/sec vs [69.2 ± 70.2] × 10(-6) mm(2)/sec, respectively). Subglandular ADC inversely correlated with the interval between MR imaging and delivery (r = -0.75). Receiver operating characteristic curve analysis of subglandular ADC revealed 100% sensitivity (95% confidence interval: 63.1, 100) and 100% specificity (95% confidence interval: 84.6, 100) in association with impending delivery with a 1921 × 10(-6) mm(2)/sec threshold. Stromal ADC

2016 Radiology

39. Maternal Mortality Studies: Shock Associated with Uterine Inversion and Hemorrhage (PubMed)

Maternal Mortality Studies: Shock Associated with Uterine Inversion and Hemorrhage 20328559 2010 06 28 2010 06 28 0008-4409 94 23 1966 Jun 04 Canadian Medical Association journal Can Med Assoc J Maternal mortality studies: shock associated with uterine inversion and hemorrhage. 1240 Iffy L L eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 2010 3 24 6 0 1966 6 4 0 0 1966 6 4 0 1 ppublish 20328559 PMC1935498

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1966 Canadian Medical Association Journal

40. Maternal Mortality Studies: Shock Associated with Uterine Inversion and Hemorrhage (PubMed)

Maternal Mortality Studies: Shock Associated with Uterine Inversion and Hemorrhage 20328560 2010 06 28 2010 06 28 0008-4409 94 23 1966 Jun 04 Canadian Medical Association journal Can Med Assoc J Maternal mortality studies: shock associated with uterine inversion and hemorrhage. 1241 Green W G WG eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 2010 3 24 6 0 1966 6 4 0 0 1966 6 4 0 1 ppublish 20328560 PMC1935504

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1966 Canadian Medical Association Journal

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