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Uterine Inversion

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21. Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review. Full Text available with Trip Pro

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review. Extra-uterine mullerian adenosarcomas have varying biological behaviours depending on the presence of endometriosis or sarcomatous overgrowth. These behaviours manifest according to the tumours' histological characteristics and sites of origin. The best treatment and oncologic outcome have not been clarified because only a few cases of extra-uterine and extra-ovarian adenosarcoma have been (...) to the progressive poor condition, the patient died four months after diagnosis. Histological slides were reviewed by external expert pathologists and the final diagnosis was of extra-genital adenosarcoma with sarcomatous overgrowth. Furthermore, we also collected and analysed articles written in English regarding extra-uterine and extra-ovarian adenosarcomas published between January 1974 and October 2016. PubMed was used as a database for this search. Clinical and pathological characteristics, treatments

2018 BMC Cancer

22. Spontaneous complete regression of large uterine fibroid after the second vaginal delivery: Case report. Full Text available with Trip Pro

remains unclear. Researchers evaluating fibroids have reported an inverse association between parity and fibroids, suggestive of a protective effect. Pregnancies that occur while fibroids are small would be protective; whereas pregnancies occurring before fibroid development or after the tumors reach some critical size would not be protective. Herein, the case of a woman with a large uterine fibroid that was spontaneously regressed after a second successful vaginal delivery is reported. To our (...) Spontaneous complete regression of large uterine fibroid after the second vaginal delivery: Case report. Fibroids are common, hormone-dependent, benign uterine tumors. It is estimated that they occur in 20% to 40% of women during their reproductive years. The prevalence of fibroids among pregnant women is 10.7%. Most fibroids do not increase in size during pregnancy. Pregnancy has a variable and unpredictable effect on fibroid growth. The influence of pregnancy on uterine fibroid size still

2018 Medicine

23. Genomic profiling identifies GPC5 amplification in association with sarcomatous transformation in a subset of uterine carcinosarcomas Full Text available with Trip Pro

Genomic profiling identifies GPC5 amplification in association with sarcomatous transformation in a subset of uterine carcinosarcomas Uterine carcinosarcoma, also known as Malignant Mixed Müllerian Tumour, is a high-grade biphasic neoplasm composed of sarcomatous elements thought to originate via transdifferentiation from high-grade endometrial carcinoma. To identify molecular factors contributing to the histogenesis of this tumour, we analyzed DNA extracted from matched carcinoma and sarcoma (...) components from 12 cases of carcinosarcoma by a molecular inversion probe microarray to assess genomic copy number alterations (CNAs) and allelic imbalances. Widespread CNAs were identified in tumours with serous histology in the carcinoma component (9/12), while the remaining three cases with endometrioid carcinoma were near-diploid. Quantification of the extent of genomic aberrations revealed a significant increase in sarcoma relative to carcinoma in tumours with well-delineated histologic components

2018 The Journal of Pathology: Clinical Research

24. Uterine Foxl2 regulates the adherence of the Trophectoderm cells to the endometrial epithelium Full Text available with Trip Pro

of the Wnt/Fzd and apoptotic pathways, both of which are involved in uterine receptivity. Furthermore, FOXL2 expression was inversely correlated with G-protein signaling protein 2 (Rgs2) and cytokine expression.These results suggest that FOXL2 interferes with embryo attachment. Better understanding of the function of FOXL2 in the uterus would possibly suggest novel strategies for treatment of infertility attributed to repeated implantation failure. (...) Uterine Foxl2 regulates the adherence of the Trophectoderm cells to the endometrial epithelium Forkhead Transcription Factor L2 (FOXL2) is a member of the forkhead family with important roles in reproduction. Recent studies showed that FOXL2 is expressed in human and bovine endometrium and that its levels fluctuate during pregnancy. In this study, we aimed at evaluating the expression and function of FOXL2 in embryo implantation.Mouse uteri at different days of pregnancy were isolated

2018 Reproductive biology and endocrinology : RB&E

25. Combination of an intrauterine balloon and the "holding the cervix" technique for hemostasis of postpartum hemorrhage and for prophylaxis of acute recurrent uterine inversion. (Abstract)

Combination of an intrauterine balloon and the "holding the cervix" technique for hemostasis of postpartum hemorrhage and for prophylaxis of acute recurrent uterine inversion. 24127992 2014 07 28 2018 12 02 1600-0412 93 3 2014 Mar Acta obstetricia et gynecologica Scandinavica Acta Obstet Gynecol Scand Combination of an intrauterine balloon and the "holding the cervix" technique for hemostasis of postpartum hemorrhage and for prophylaxis of acute recurrent uterine inversion. 314-5 10.1111/aogs (...) .12282 Matsubara Shigeki S Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan. eng Letter Comment 2013 11 20 United States Acta Obstet Gynecol Scand 0370343 0001-6349 IM Acta Obstet Gynecol Scand. 2014 Mar;93(3):313-4 23941194 Acta Obstet Gynecol Scand. 2014 Mar;93(3):315-6 24299294 Blood Loss, Surgical prevention & control Female Humans Postpartum Hemorrhage therapy Pregnancy Pregnancy Outcome epidemiology Uterine Balloon Tamponade methods 2013 10 17 6 0 2013 10 17 6 0

2013 Acta Obstetricia et Gynecologica Scandinavica

26. Uterine Inversion

Uterine Inversion Uterine Inversion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Uterine Inversion Uterine Inversion Aka: Uterine (...) (from Bing) These images are a random sampling from a Bing search on the term "Uterine Inversion." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Uterine Inversion (C0162482) Definition (MSH) A complication of OBSTETRIC LABOR in which the corpus of the UTERUS is forced completely or partially through the UTERINE CERVIX. This can occur during the late stages of labor and is associated with IMMEDIATE POSTPARTUM

2015 FP Notebook

27. Puerperal uterine inversion in the Netherlands: a nationwide cohort study. Full Text available with Trip Pro

Puerperal uterine inversion in the Netherlands: a nationwide cohort study. Puerperal uterine inversion is a severe but rare obstetric complication of yet unknown origin. In this two-year study we determine the incidence of this complication and we describe associated risk factors to expose its etiology. All cases of uterine inversion were included from a nationwide cohort study which contained all 98 hospitals with a maternity unit in the Netherlands. We reviewed the medical records of 15 (...) patients, resulting an incidence of approximately 1 in 20 000 vaginal births. Fourteen cases (93.3%) were classified as low-risk pregnancies at booking. Nulliparous women were not overrepresented and the main associated factors were signs of prolonged labor followed by third stage manipulation. This study is the first population-based study for uterine inversion. With the reported associated factors and occurrence in women with a low-risk profile, we show that every birth attendant should be able

2012 Acta Obstetricia et Gynecologica Scandinavica

28. Puerperal uterine inversion: report of nine cases. Full Text available with Trip Pro

Puerperal uterine inversion: report of nine cases. Acute puerperal inversion of the uterus is considered to be rare. In one institution there were nine cases during an 11-year period, a rate of one for every 2176 vaginal deliveries. Analysis of these cases failed to identify any contributing factors occurring during the first or second stage of labour. Six cases were directly attributable to failure to administer an oxytocic preparation or, particularly, failure to await uterine contraction (...) before attempting to expel the placenta by fundal pressure or cord traction. Although active management of the third stage of labour may reduce the incidence of postpartum hemorrhage, incomplete application of its principles is extremely hazardous. Immediate uterine replacement was efficacious in seven cases, but the inadvisability of removing the placenta prior to replacement was demonstrated.

1978 Canadian Medical Association Journal

29. Shock associated with uterine inversion and hemorrhage. Full Text available with Trip Pro

Shock associated with uterine inversion and hemorrhage. 4952372 1990 04 25 2008 11 20 0008-4409 94 17 1966 Apr 23 Canadian Medical Association journal Can Med Assoc J Shock associated with uterine inversion and hemorrhage. 914-5 eng Case Reports Journal Article Canada Can Med Assoc J 0414110 0008-4409 AIM IM Adult Female Humans Obstetric Labor Complications etiology mortality Pregnancy Prognosis Shock etiology mortality Uterine Diseases complications mortality Uterine Hemorrhage etiology

1966 Canadian Medical Association Journal

30. Maternal Mortality Studies: Shock Associated with Uterine Inversion and Hemorrhage Full Text available with Trip Pro

Maternal Mortality Studies: Shock Associated with Uterine Inversion and Hemorrhage 20328559 2010 06 28 2010 06 28 0008-4409 94 23 1966 Jun 04 Canadian Medical Association journal Can Med Assoc J Maternal mortality studies: shock associated with uterine inversion and hemorrhage. 1240 Iffy L L eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 2010 3 24 6 0 1966 6 4 0 0 1966 6 4 0 1 ppublish 20328559 PMC1935498

1966 Canadian Medical Association Journal

31. Maternal Mortality Studies: Shock Associated with Uterine Inversion and Hemorrhage Full Text available with Trip Pro

Maternal Mortality Studies: Shock Associated with Uterine Inversion and Hemorrhage 20328560 2010 06 28 2010 06 28 0008-4409 94 23 1966 Jun 04 Canadian Medical Association journal Can Med Assoc J Maternal mortality studies: shock associated with uterine inversion and hemorrhage. 1241 Green W G WG eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 2010 3 24 6 0 1966 6 4 0 0 1966 6 4 0 1 ppublish 20328560 PMC1935504

1966 Canadian Medical Association Journal

32. Uterine Inversion Associated with Bicornuate Uterus Full Text available with Trip Pro

Uterine Inversion Associated with Bicornuate Uterus 5904110 1966 04 21 2018 11 13 0007-1447 1 5484 1966 Feb 12 British medical journal Br Med J Uterine inversion associated with bicornuate uterus. 401-2 Winer C E CE eng Journal Article England Br Med J 0372673 0007-1447 AIM IM Adult Female Humans Pregnancy Puerperal Disorders Uterine Diseases Uterus abnormalities 1966 2 12 1966 2 12 0 1 1966 2 12 0 0 ppublish 5904110 PMC1843561 Bol Soc Chil Obstet Ginecol. 1953 Nov;18(8):229-32 13189973 Am J

1966 British medical journal

33. Abdominal Hysterotomy for Chronic Uterine Inversion Full Text available with Trip Pro

Abdominal Hysterotomy for Chronic Uterine Inversion 19973204 2010 06 22 2010 06 22 0035-9157 1 Obstet Gynaecol Sect 1908 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Abdominal Hysterotomy for Chronic Uterine Inversion. 279-90 Haultain F W FW eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1908 1 1 0 0 1908 1 1 0 1 ppublish 19973204 PMC2046269

1908 Proceedings of the Royal Society of Medicine

34. DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment Full Text available with Trip Pro

DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment Abnormalities in the tumor microenvironment are associated with resistance to treatment, aggressive growth, and poor clinical outcome in patients with advanced cervical cancer. The potential of dynamic contrast-enhanced (DCE) MRI to assess the microvascular density (MVD), interstitial fluid pressure (IFP), and hypoxic fraction of patient-derived cervical cancer (...) xenografts was investigated in the present study.Four patient-derived xenograft (PDX) models of squamous cell carcinoma of the uterine cervix (BK-12, ED-15, HL-16, and LA-19) were subjected to Gd-DOTA-based DCE-MRI using a 7.05 T preclinical scanner. Parametric images of the volume transfer constant (K trans) and the fractional distribution volume (v e) of the contrast agent were produced by pharmacokinetic analyses utilizing the standard Tofts model. Whole tumor median values of the DCE-MRI parameters

2017 Journal of translational medicine

35. Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer Full Text available with Trip Pro

Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer Apparent diffusion coefficient (ADC) values derived from diffusion-weighted magnetic resonance imaging (DW-MRI) are known to reflect the cellular environment of biological tissues. However, emerging evidence accentuates the influence of stromal elements on ADC values. The current study sought to elucidate whether a correlation exists between ADC and the fraction of collagen I-positive (...) tissue across different tumor models of uterine cervical cancer. Early and late generation tumors of four patient-derived xenograft (PDX) models of squamous cell carcinoma (BK-12, ED-15, HL-16, and LA-19) were included. DW-MRI was performed with diffusion encoding constants (b) of 200, 400, 700, and 1000 s/mm2 and diffusion gradient sensitization in three orthogonal directions. The fraction of collagen I-positive connective tissue was determined by immunohistochemistry. Mono-exponential decay curves

2017 Oncotarget

36. Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas Full Text available with Trip Pro

Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12). These mutations have been associated with conventional histology, smaller tumour size, and larger number of tumours within the uterus. Prior studies, with limited sample sizes, have failed to detect associations between other clinical features and MED12 mutations. Here, we prospectively collected 763 (...) uterine leiomyomas and the corresponding normal myometrial tissue from 244 hysterectomy patients, recorded tumour characteristics, collected clinical data from medical records, and screened the tissue samples for MED12 mutations to assess potential associations between clinical variables and mutation status. Out of 763 leiomyomas, 599 (79%) harboured a MED12 mutation. In the analysis of tumour characteristics, positive MED12-mutation status was significantly associated with smaller tumour size

2017 Scientific reports

37. Defining age- and lactocrine-sensitive elements of the neonatal porcine uterine microRNA–mRNA interactome, Full Text available with Trip Pro

Defining age- and lactocrine-sensitive elements of the neonatal porcine uterine microRNA–mRNA interactome, Factors delivered to offspring in colostrum within 2 days of birth support neonatal porcine uterine development. The uterine mRNA transcriptome is affected by age and nursing during this period. Whether uterine microRNA (miRNA) expression is affected similarly is unknown. Objectives were to (1) determine effects of age and nursing on porcine uterine miRNA expression between birth (...) PND 0 comparisons, 31 differentially expressed (DE) miRNAs were identified for nursed, and 42 DE miRNAs were identified for replacer-fed gilts. Six DE miRNAs were identified for nursed versus replacer-fed gilts on PND 2. Target prediction for inversely correlated DE miRNA–mRNA pairings indicated 20 miRNAs targeting 251 mRNAs in nursed, versus 29 miRNAs targeting 585 mRNAs in replacer-fed gilts for PND 2 versus PND 0 comparisons, and 5 miRNAs targeting 81 mRNAs for nursed versus replacer-fed gilts

2017 Biology of reproduction

38. Perinatal outcome and placental apoptosis in patients with late-onset pre-eclampsia and abnormal uterine artery Doppler at diagnosis. Full Text available with Trip Pro

Perinatal outcome and placental apoptosis in patients with late-onset pre-eclampsia and abnormal uterine artery Doppler at diagnosis. To determine the rate of placental apoptosis and adverse perinatal outcome in patients with late-onset pre-eclampsia (PE) and abnormal uterine artery (UtA) Doppler at diagnosis.This was a prospective cohort study of women with singleton pregnancy diagnosed with late PE, performed between August 2011 and January 2014 at the Maternal-Fetal Medicine Unit of Hospital (...) ratio (OR) = 7.5; 95% CI, 2.76-20.46; P < 0.001), late preterm delivery (OR = 13.7; 95% CI, 4.53-41.46; P < 0.001), small-for-gestational age at birth (OR = 12.3; 95% CI, 3.17-47.57; P < 0.001) and admission to the neonatal intensive care unit (OR = 12.8; 95% CI, 2.61-62.36; P = 0.002). Moreover, UtA Z-score demonstrated a significant inverse correlation with birth-weight Z-score (r = -0.34; P = 0.0013). Mean placental apoptotic index demonstrated an ascending linear trend according to UtA Doppler

2017 Ultrasound in Obstetrics and Gynecology

39. Chlamydia Trachomatis Seroprevalence and Ultrasound Diagnosed Uterine Fibroids in a Large Population of Young African-American Women. Full Text available with Trip Pro

Chlamydia Trachomatis Seroprevalence and Ultrasound Diagnosed Uterine Fibroids in a Large Population of Young African-American Women. Reproductive tract infections have long been hypothesized to increase the risk of uterine fibroids. Few studies have been conducted, even for the common infection genital Chlamydia trachomatis (gCT), and only with self-reported gCT data. Our investigation used micro-immunofluorescence serology for gCT to characterize past exposure. We used cross-sectional (...) -adjusted odds ratio = 0.68, 95% confidence interval: 0.54, 0.87; multivariable-adjusted odds ratio = 0.80, 95% confidence interval: 0.62, 1.03). Inverse associations were similar across categories of fibroid size, number, and total volume. Participant groups likely to have had multiple or severe infections (multiple serovar groups, more sex partners, clinically diagnosed chlamydia) all showed statistically significantly reduced odds of fibroids. A protective association of gCT with fibroids

2017 American Journal of Epidemiology

40. The Impact of Uterine Immaturity on Obstetrical Syndromes During Adolescence. Full Text available with Trip Pro

The Impact of Uterine Immaturity on Obstetrical Syndromes During Adolescence. Pregnant nulliparous adolescents are at increased risk, inversely proportional to their age, of major obstetric syndromes, including preeclampsia, fetal growth restriction, and preterm birth. Emerging evidence indicates that biological immaturity of the uterus accounts for the increased incidence of obstetrical disorders in very young mothers, possibly compounded by sociodemographic factors associated with teenage (...) pregnancy. The endometrium in most newborns is intrinsically resistant to progesterone signaling, and the rate of transition to a fully responsive tissue likely determines pregnancy outcome during adolescence. In addition to ontogenetic progesterone resistance, other factors appear important for the transition of the immature uterus to a functional organ, including estrogen-dependent growth and tissue-specific conditioning of uterine natural killer cells, which plays a critical role in vascular

2017 American Journal of Obstetrics and Gynecology

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