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Uterine Inversion

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181. Varied Clinical Presentations, the Role of Magnetic Resonance Imaging in the Diagnosis, and Successful Management of Cervical Leiomyomas: A Case-Series and Review of Literature (PubMed)

Varied Clinical Presentations, the Role of Magnetic Resonance Imaging in the Diagnosis, and Successful Management of Cervical Leiomyomas: A Case-Series and Review of Literature Cervical leiomyomas or fibroids constitute a rare variety of benign pelvic tumors. The symptoms may vary from urinary retention, frequency, dyspareunia to rare clinical presentations such as prolapsed cervical fibroid polyp which may mimic procidentia or even uterine inversion. Preoperative clinical evaluation

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2018 Cureus

182. The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4 (PubMed)

The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4 The intra-uterine and external environmental factors not only affect the early development of fetuses, their interaction with genesis will also substantially program the physiological functions of offspring throughout life. Synthetic glucocorticoid (GC) is widely used for the management of women at risk of preterm birth or undergone (...) by prenatal DEX exposure both can be restored by BMP4 predisposing on neonatal cardiomyocytes 24 h prior to I/R. Inversely consistent with ΔΨm and ATP production, the release of reactive oxygen species was dramatically elevated in cardiomyocytes, which was significantly inhibited in the presence of BMP4 prior to I/R. These findings suggested that the excess GC exposure during pregnancy increases the susceptibility of male offspring's heart to "second strike", due to the decrease of BMP4 expression caused

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2018 Cell death & disease

183. Detection of Asherman’s syndrome after conservative management of placenta accreta: a case report (PubMed)

inversion or perforation, and no uterine cavity adhesion, were observed. Four months postoperatively, hysteroscopy was performed. Adhesion was detected at the fundus of her uterus where the placenta had adhered to the uterus. Asherman's syndrome was diagnosed.Asherman's syndrome might occur after conservative management of placenta accreta, which may be a direct cause of placenta accreta recurrence. When Asherman's syndrome is diagnosed, the site of the placenta and adhesion should be monitored during (...) Detection of Asherman’s syndrome after conservative management of placenta accreta: a case report We present a case involving conservative treatment of placenta accreta, with a subsequent diagnosis of Asherman's syndrome.A 41-year-old Japanese woman (G2P0A2) delivered a healthy male infant via cesarean section due to preeclampsia. The placenta did not spontaneously separate and was manually removed. Adhesion was tight and placenta accreta was diagnosed. During the procedure, no uterine

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2018 Journal of medical case reports

184. A Comparison of GATA3, TTF1, CD10, and Calretinin in Identifying Mesonephric and Mesonephric-like Carcinomas of the Gynecologic Tract. (PubMed)

remnants. GATA3 had the highest sensitivity and specificity (91% and 94%) compared with TTF1 (45% and 99%), CD10 (73% and 83%), and calretinin (36% and 89%). GATA3, however, also stained a substantial number of uterine carcinosarcomas (23/113, 20%). TTF1 was positive in 5/5 (100%) mesonephric-like carcinomas and only 1/8 (13%) mesonephric carcinomas. In 4/6 (67%) TTF1 positive cases, GATA3 exhibited an inverse staining pattern with TTF1. In summary, GATA3 was the best overall marker for mesonephric (...) to the traditional markers used for mesonephric carcinomas, CD10 and calretinin. We studied 694 cases: 8 mesonephric carcinomas (7 cervical [includes 3 mesonephric carcinosarcomas], 1 vaginal), 5 mesonephric-like carcinomas (4 uterine corpus, 1 ovarian), 585 endometrial adenocarcinomas, and 96 cervical adenocarcinomas. Mesonephric-like carcinomas were defined as tumors exhibiting the classic morphologic features of mesonephric carcinoma, but occurring outside of the cervix and without convincing mesonephric

2018 American Journal of Surgical Pathology

185. Impaired placental perfusion and major fetal cardiac defects. (PubMed)

Impaired placental perfusion and major fetal cardiac defects. To investigate the relationship between fetal congenital heart defects (CHD) and placental perfusion assessed by uterine artery pulsatility index (UtA-PI), in relation to development of pre-eclampsia (PE).This was a prospective screening study of singleton pregnancies at 19-24 weeks' gestation. Transvaginal ultrasound was used to measure UtA-PI and the values were converted into multiples of the normal median (MoM). Median MoM values (...) (95% CI, 1.42-8.09); P = 0.006). In the total population, median UtA-PI MoM was significantly higher in those that developed PE compared to those without PE (1.22 (interquartile range (IQR), 0.94-1.57) vs 1.00 (IQR, 0.84-1.19); P < 0.0001) and, in the PE group, the median UtA-PI MoM was inversely related to gestational age at delivery (r = -0.458; P < 0.0001). The same pattern of inverse relationship between UtA-PI MoM and gestational age at delivery with PE was observed in pregnancies

2018 Ultrasound in Obstetrics and Gynecology

186. Uteroplacental glucose uptake and fetal glucose consumption: A quantitative study in human pregnancies. (PubMed)

University Hospital, Norway.One hundred seventy-nine healthy women with elective cesarean section.Uterine and umbilical blood flow was determined using Doppler ultrasonography. Glucose and insulin were measured in the maternal radial artery and uterine vein and the umbilical artery and vein. In a subcohort (n = 33), GLUT1 expression was determined in isolated syncytiotrophoblast basal and microvillous plasma membranes.Uteroplacental glucose uptake and placental and fetal glucose consumption quantified (...) glucose consumption (ρ: 0.77; P < 0.001). Fetal and placental glucose consumptions were inversely correlated (ρ: -0.47; P < 0.001), but neither was correlated with placental GLUT1 expression.These findings suggest that fetal glucose consumption is balanced against the placental needs for glucose and that placental glucose consumption is a key modulator of maternal-fetal glucose transfer in women.

2018 Journal of Clinical Endocrinology and Metabolism

187. Use and Outcomes of Minimally Invasive Hysterectomy for Women with Non-Endometrioid Endometrial Cancers. (PubMed)

hysterectomy for women with uterine cancer and high-risk histologic subtypes.We used the National Cancer Database to identify women with stages I-III uterine cancer who underwent hysterectomy from 2010-2014. Women with serous carcinomas, clear cell carcinomas, and sarcomas were examined. Women who had laparoscopic or robotic-assisted hysterectomy were compared with those who underwent open abdominal hysterectomy. After a propensity score inverse probability of treatment weighted analysis, the effect (...) Use and Outcomes of Minimally Invasive Hysterectomy for Women with Non-Endometrioid Endometrial Cancers. Minimally invasive hysterectomy is now used routinely for women with uterine cancer. Most studies of minimally invasive surgery for endometrial cancer have focused on low-risk endometrioid tumors, with few reports of the safety of the procedure for women with higher risk histologic subtypes.The purpose of this study was to examine the use of and survival associated with minimally invasive

2018 American Journal of Obstetrics and Gynecology

188. Genetics of Skin Cancer (PDQ®): Health Professional Version

, sometimes following along nerves. A tendency for superficial necrosis has resulted in the name rodent ulcer .[ ] Some debate remains about the origin of SCC; however, these cancers are likely derived from epidermal stem cells associated with the hair follicle.[ ] A variety of tissues, such as lung and uterine cervix, can give rise to SCC, and this cancer has somewhat differing behavior depending on its source. Even in cancer derived from the skin, SCC from different anatomic locations can have

2016 PDQ - NCI's Comprehensive Cancer Database

189. Genetics of Breast and Ovarian Cancer (PDQ®): Health Professional Version

at an earlier age, with the median age at diagnosis of 48 years.[ ] Family history including inherited cancer genes Although the hyperestrogenic state is the most common predisposing factor for endometrial cancer, family history also plays a significant role in a woman’s risk for disease. Approximately 3% to 5% of uterine cancer cases are attributable to a hereditary cause,[ ] with the main hereditary endometrial cancer syndrome being Lynch syndrome, an autosomal dominant genetic condition with a population (...) lymphocytes, undifferentiated tumor histology, lower uterine segment origin, and synchronous tumors. Considerations in Risk Assessment and in Identifying a Family History of Breast and Ovarian Cancer Risk The accuracy and completeness of family histories must be taken into account when they are used to assess risk. A reported family history may be erroneous, or a person may be unaware of relatives affected with cancer. In addition, small family sizes and premature deaths may limit the information obtained

2016 PDQ - NCI's Comprehensive Cancer Database

190. Cigarette Smoking: Health Risks and How to Quit (PDQ®): Health Professional Version

of this summary is on clinical interventions by health professionals that decrease the use of tobacco. Effects of Smoking Cessation Based on solid evidence, cigarette smoking causes cancers of the lung, oral cavity and pharynx, larynx, esophagus, bladder, kidney, pancreas, stomach, uterine cervix, and acute myeloid leukemia.[ ] Smoking avoidance and smoking cessation result in decreased incidence and mortality from cancer. Description of the Evidence Study Design : Evidence obtained from a randomized (...) inversely with education, and was highest among adults who had earned a General Educational Development diploma (43.0%) and generally decreased with increasing years of education.[ ] ( ) From 2011 to 2014, significant declines occurred in the use of cigarettes among middle school (4.3% to 2.5%) and high school (15.8% to 9.2%) students.[ ] Cigarette smoking prevalence among male and female high school students increased substantially during the early 1990s in all ethnic groups, but in 2016, it declined

2016 PDQ - NCI's Comprehensive Cancer Database

192. Genetics of Kidney Cancer (Renal Cell Cancer) (PDQ®): Health Professional Version

. Hormonal and/or pain management medications may be given to provide release from uterine leiomyoma-related pain. The leiomyomas may also be removed surgically. Both and are typically managed with partial nephrectomy once they reach 3 cm. is being studied as a potential targeted therapy in individuals with HPRC-associated RCC. generally need no intervention. BHD patients are also at increased risk of , which is managed as it would be in the general population. Introduction [ Note: Many of the medical (...) sporadic clear cell RCC, presumably due to somatic variants in the VHL gene.[ ] Dietary intake of vegetables and fruits has been inversely associated with RCC. Greater intake of red meat and milk products have been associated with increased RCC risk, although not consistently.[ ] References American Cancer Society: Cancer Facts and Figures 2019. Atlanta, Ga: American Cancer Society, 2019. . Last accessed January 23, 2019. DeVita VT Jr, Lawrence TS, Rosenberg SA: Cancer: Principles and Practice

2016 PDQ - NCI's Comprehensive Cancer Database

193. Breast Cancer Prevention (PDQ®): Health Professional Version

of breast-feeding.[ ] The RR of breast cancer decreased by 4.3% (95%, CI, 2.9%–5.8%; P < .0001) for every 12 months of breast-feeding in addition to a decrease of 7.0% (95% CI, 5.0%–9.0%; P < .0001) for each birth. Exercise Active exercise may reduce breast cancer risk, particularly in young parous women.[ ] Numerous observational studies on the relationship between the level of physical activity and breast cancer risk have shown an inverse relationship.[ ] The average RR reduction is 30% to 40 (...) in the tamoxifen group. Adverse events of uterine cancer, venous thrombolic events, and cataracts were more common in tamoxifen-treated women, and there was no difference in ischemic heart disease events, strokes, or fractures.[ ] Treatment-associated symptoms of dyspareunia, musculoskeletal problems, and weight gain occurred less frequently in tamoxifen-treated women, whereas vasomotor flushing, bladder control symptoms, gynecologic symptoms, and leg cramps occurred less frequently in those receiving

2016 PDQ - NCI's Comprehensive Cancer Database

194. Postpartum Nursing Care Pathway

fr equently . Woman able to demonstrate palpation (if she • desir es) Variance – fundus Uterus – boggy , soft, deviated to one side (due to • r etained pr oducts, distended bladder , uterine atony , bleeding) Intervention – fundus Massage uterus (if boggy) – advise to empty bladder • May r equir e further interventions – e.g. intravenous, • oxytocin (or other uter otonic medications), in and out catheterization of bladder Nursing Assessment • Refer to appropriate PHCP prn • Variance – Infection (...) Infection S & S: T>38, • P , chills, anor exia, nausea, fatigue, lethar gy , pelvic pain, foul smelling and/or profuse lochia Intervention-Infection Monitor for increased uterine tenderness and • Monitor S & S of infection • Refer to Lochia • Refer to PHCP • norm and normal Variations Refer to POS • Rectus muscle intact • Client education/ Anticipatory Guidance Refer to POS • Variance – fundus and Infection Refer to POS • Intervention – fundus and Infection Refer to POS • Variance – diastasis recti

2011 British Columbia Perinatal Health Program

195. Hepatitis C virus infection and the risk of cancer among elderly US adults: A registry-based case-control study. (PubMed)

with HCV were Merkel cell carcinoma (aOR, 1.92; 95% CI, 1.30-2.85) and appendageal skin cancers (aOR, 2.02; 95% CI, 1.29-3.16). Inverse associations were observed with uterine cancer (aOR, 0.64; 95% CI, 0.51-0.80) and prostate cancer (aOR, 0.73; 95% CI, 0.66-0.82). Associations were maintained in sensitivity analyses conducted among individuals without documented alcohol abuse, cirrhosis, or hepatitis B or human immunodeficiency virus infections and after adjustment for socioeconomic status

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2017 Cancer

196. Retosiban prevents stretch-induced human myometrial contractility and delays labor in Cynomolgus monkeys. (PubMed)

Retosiban prevents stretch-induced human myometrial contractility and delays labor in Cynomolgus monkeys. Stretch of the myometrium promotes its contractility and is believed to contribute to the control of parturition at term and to the increased risk of preterm birth in multiple pregnancies.To determine the effects of the putative oxytocin receptor (OTR) inverse agonist retosiban on (1) the contractility of human myometrial explants and (2) labor in nonhuman primates.Human myometrial biopsies (...) contractility and phosphorylation of ERK1/2. Moreover, the inhibitory effect of retosiban on stretch-induced ERK1/2 phosphorylation was prevented by coincubation with a 100-fold excess of a peptide OTR antagonist, atosiban. Compared with vehicle-treated cynomolgus monkeys, treatment with oral retosiban (100 to 150 days of gestational age) reduced the risk of spontaneous delivery (hazard ratio = 0.07, 95% confidence interval 0.01 to 0.60, P = 0.015).The OTR acts as a uterine mechanosensor, whereby stretch

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2017 Journal of Clinical Endocrinology and Metabolism

197. Tocolysis after preterm premature rupture of membranes and neonatal outcome: a propensity-score analysis. (PubMed)

without severe morbidity, latency prolonged by ≥48 hours and histological chorioamnionitis. Uterine contractions at admission, individual and obstetric characteristics, and neonatal outcomes were compared by tocolytic treatment or not. Propensity scores and inverse probability of treatment weighting for each woman were used to minimize indication bias in estimating the association of tocolytic therapy with outcomes.The study population consisted of 803 women; 596 (73.4%) received tocolysis. Women (...) with and without tocolysis did not differ in neonatal survival without severe morbidity (86.7% vs 83.9%, P = .39), latency prolonged by ≥48 hours (75.1% vs 77.4%, P = .59), or histological chorioamnionitis (50.0% vs 47.6%, P = .73). After applying propensity scores and assigning inverse probability of treatment weighting, tocolysis was not associated with improved survival without severe morbidity as compared with no tocolysis (odds ratio, 1.01 [95% confidence interval, 0.94-1.09], latency prolonged by ≥48

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2017 American Journal of Obstetrics and Gynecology

198. A Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors

and clinical assessments (ie, neurologic status) will also be considered when determining overall response. Tumor assessments will be conducted by standard MRI with and without contrast using three MRI sequences (T1-weighted pre- and post-contrast, T2-weighted, fluid-attenuated inversion recovery [FLAIR]). Overall radiographic objective response will be assessed utilizing the sequence(s) best representative of tumor in the opinion of the neuroradiologist. Once treatment has been discontinued, subjects (...) , injectable, or implantable hormonal contraceptive; tubal ligation; intra-uterine device; vasectomized partner) and one additional effective barrier method (ie, male condom, diaphragm, cervical cap) 28 days prior to starting pomalidomide, throughout the entire duration of study treatment including dose interruptions and 28 days after discontinuation of pomalidomide. All male and female subjects must follow all requirements defined in the pomalidomide Pregnancy Prevention Program. Male subjects must

2017 Clinical Trials

199. Massively parallel sequencing and genome-wide copy number analysis revealed a clonal relationship in benign metastasizing leiomyoma (PubMed)

analyses based on X-chromosome inactivation assays. Here, we sought to address this issue by examining paired specimens of synchronous pulmonary and uterine leiomyomata from three patients using targeted massively parallel sequencing and molecular inversion probe array analysis for detecting somatic mutations and copy number aberrations. We detected identical non-hot-spot somatic mutations and similar patterns of copy number aberrations (CNAs) in paired pulmonary and uterine leiomyomata from two (...) Massively parallel sequencing and genome-wide copy number analysis revealed a clonal relationship in benign metastasizing leiomyoma Benign metastasizing leiomyoma (BML) is a rare disease entity typically presenting as multiple extrauterine leiomyomas associated with a uterine leiomyoma. It has been hypothesized that the extrauterine leiomyomata represent distant metastasis of the uterine leiomyoma. To date, the only molecular evidence supporting this hypothesis was derived from clonality

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2017 Oncotarget

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