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Uterine Inversion

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181. Cervical modifications after pessary placement in singleton pregnancies with maternal short cervical length: 2D and 3D ultrasound evaluation. (Abstract)

group (-2.56 mm). These inverse trends were statistically significant (P = .006).Cervical pessary reduces both uterocervical angles and corrects cervical angulation by pushing the cervix up toward the uterus. Maintaining the cervix aligned to the uterine axis leads to reduced cervical tissue stretch, so avoiding further cervical shortening. All these changes were present after pessary placement; however, the clinical implications of these findings remain unknown.© 2019 Nordic Federation of Societies

2019 Acta Obstetricia et Gynecologica Scandinavica

182. The pubertal development mode of Chinese girls with turner syndrome undergoing hormone replacement therapy. Full Text available with Trip Pro

), whereas the uterine volume of the control group was inversely greater than that of the TS group among those who reached stages B4 and 5 (P = 0.034). During HRT, the uterine volume grew significantly from all previous stages except for breast stage 5 (B3 vs.2: Z = - 2.031; P = 0.042; B4 vs. 3: Z = - 2.273; P = 0.023; B5 vs. 4: Z = - 1.368; P = 0.171). The paired data of 27 girls with TS showed that the uterine volume (17.93 ± 9.31 ml vs. 13.75 ± 6.67 ml) and width (2.54 ± 0.66 cm vs. 2.22 ± 0.36 cm (...) a retrospective, longitudinal study over the past two decades at The First Affiliated Hospital, Sun Yat-sen University.Seventy-one patients with TS and two groups of normal Chinese girls.The total investigation time was 3.00 (2.00, 4.66) years. The interval of each stage was significantly longer (P < 0.001) in the girls with TS than that in the normal Chinese girls, except for B2-3 (P = 0.011). The uterine volumes of the girls with TS in stages B2 and 3 were greater than those of the control group (P = 0.046

2019 BMC Endocrine Disorders

183. Placenta Accreta Spectrum (PAS) disorders: incidence, risk factors and outcomes of different management strategies in a tertiary referral hospital in Minia, Egypt: a prospective study. Full Text available with Trip Pro

(CS) with cervical inversion and ligation of both uterine arteries and group (C), (n = 16): the placenta was left in place.The incidence of PAS disorders during the study period was 9 / 1000 maternities (0.91%). The mean age of cases was 32.4 ± 4.2 years, 60% of them had a parity ≥3 and 82% of them had ≥2 previous CSs. Also, 1/3 of them had previous history of placenta previa. Estimated blood loss (EBL) and blood transfusion in group A were significantly higher than other groups. Group (C) had (...) higher mean hospital stay duration. Group A was associated with significantly higher complication rate.The incidence of PAS disorders was 0.91%. Maternal age > 32 years, previous C.S. (≥ 2), multiparity (≥ 3) and previous history of placenta previa were risk factors. The management of PAS disorders should be individualized. Women with PAS disorders who completed their family should be offered cesarean hysterectomy. Using the cervix as a tamponade combined with bilateral uterine artery ligation

2019 BMC Pregnancy and Childbirth

184. Does nifedipine improve outcomes of embryo transfer?: Interim analysis of a randomized, double blinded, placebo-controlled trial. Full Text available with Trip Pro

Does nifedipine improve outcomes of embryo transfer?: Interim analysis of a randomized, double blinded, placebo-controlled trial. Implantation failure is the main factor affecting the success rate of in vitro fertilization (IVF) procedures. Studies have reported that uterine contractions (UC) at the time of embryo transfer (ET) were inversely related to implantation and pregnancy rate, hence reducing the success of IVF treatments. Various pharmacological agents, with the exception of calcium

2019 Medicine Controlled trial quality: predicted high

185. Outcomes of operative vaginal delivery managed by residents under supervision and attending obstetricians: a prospective cross-sectional study. (Abstract)

with attending obstetricians and obstetric residents. Severe maternal morbidity was defined as third- or fourth-degree perineal laceration, perineal hematoma, cervical laceration, extended uterine incision for cesareans, postpartum hemorrhage > 1500 ml, surgical hemostatic procedures, uterine artery embolization, blood transfusion, infection, thromboembolic events, admission to the intensive care unit, or maternal death; severe neonatal morbidity was defined as a 5-minute Apgar score < 7, umbilical artery pH (...) was significantly and inversely associated with severe neonatal but not maternal morbidity. After propensity score matching, delivery managed by a resident was not significantly associated with severe maternal morbidity (adjusted OR: 0.74, 95% CI: 0.39-1.38) and was no longer associated with neonatal morbidity (adjusted OR: 0.51, 95% CI: 0.25-1.04).Management of attempted operative vaginal deliveries by residents under the supervision of attending obstetricians, compared with by the attending obstetricians

2019 American Journal of Obstetrics and Gynecology

186. Cigarette Smoking: Health Risks and How to Quit (PDQ®): Health Professional Version

of this summary is on clinical interventions by health professionals that decrease the use of tobacco. Effects of Smoking Cessation Based on solid evidence, cigarette smoking causes cancers of the lung, oral cavity and pharynx, larynx, esophagus, bladder, kidney, pancreas, stomach, uterine cervix, and acute myeloid leukemia.[ ] Smoking avoidance and smoking cessation result in decreased incidence and mortality from cancer. Description of the Evidence Study Design : Evidence obtained from a randomized (...) inversely with education, and was highest among adults who had earned a General Educational Development diploma (43.0%) and generally decreased with increasing years of education.[ ] ( ) From 2011 to 2014, significant declines occurred in the use of cigarettes among middle school (4.3% to 2.5%) and high school (15.8% to 9.2%) students.[ ] Cigarette smoking prevalence among male and female high school students increased substantially during the early 1990s in all ethnic groups, but in 2017, it declined

2017 PDQ - NCI's Comprehensive Cancer Database

188. Bexsero (Neisseria meningitidis)

such as pregnancy status, gravid uterine weights, number and distribution of corpora lutea, implantation sites, and live and dead foetuses as well as early and late resorptions. All foetuses were sexed, weighed, and examined macroscopically for any external anomalies to detect any embryofoetal toxicity/teratogenicity. Blood samples for antibody (ELISA) and Serum Bactericidal Activity (SBA) analyses were collected from does and foetuses. The major findings are presented in Table 1. Table 1: Summary

2012 European Medicines Agency - EPARs

190. Inlyta - axitinib

(Graphpad) using the sigmoidal doseresponse model revealed an EC50 for target inhibition of 0.49 (±3.1) nM or 0.19 ng/mL In the M24met human melanoma xenograft model it was found that a single oral dose of axitinib (50 mg/kg) suppressed murine VEGFR- 2 phosphorylation in tumour tissues for up to 7 hours compared to the vehicle-treated tumours. In the 30 mg/kg dose group, the level of VEGFR-2 phosphorylation in the tumours inversely correlated with axitinib plasma concentrations. The same study also

2012 European Medicines Agency - EPARs

191. A Comparison of GATA3, TTF1, CD10, and Calretinin in Identifying Mesonephric and Mesonephric-like Carcinomas of the Gynecologic Tract. (Abstract)

remnants. GATA3 had the highest sensitivity and specificity (91% and 94%) compared with TTF1 (45% and 99%), CD10 (73% and 83%), and calretinin (36% and 89%). GATA3, however, also stained a substantial number of uterine carcinosarcomas (23/113, 20%). TTF1 was positive in 5/5 (100%) mesonephric-like carcinomas and only 1/8 (13%) mesonephric carcinomas. In 4/6 (67%) TTF1 positive cases, GATA3 exhibited an inverse staining pattern with TTF1. In summary, GATA3 was the best overall marker for mesonephric (...) to the traditional markers used for mesonephric carcinomas, CD10 and calretinin. We studied 694 cases: 8 mesonephric carcinomas (7 cervical [includes 3 mesonephric carcinosarcomas], 1 vaginal), 5 mesonephric-like carcinomas (4 uterine corpus, 1 ovarian), 585 endometrial adenocarcinomas, and 96 cervical adenocarcinomas. Mesonephric-like carcinomas were defined as tumors exhibiting the classic morphologic features of mesonephric carcinoma, but occurring outside of the cervix and without convincing mesonephric

2018 American Journal of Surgical Pathology

192. The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4 Full Text available with Trip Pro

The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4 The intra-uterine and external environmental factors not only affect the early development of fetuses, their interaction with genesis will also substantially program the physiological functions of offspring throughout life. Synthetic glucocorticoid (GC) is widely used for the management of women at risk of preterm birth or undergone (...) by prenatal DEX exposure both can be restored by BMP4 predisposing on neonatal cardiomyocytes 24 h prior to I/R. Inversely consistent with ΔΨm and ATP production, the release of reactive oxygen species was dramatically elevated in cardiomyocytes, which was significantly inhibited in the presence of BMP4 prior to I/R. These findings suggested that the excess GC exposure during pregnancy increases the susceptibility of male offspring's heart to "second strike", due to the decrease of BMP4 expression caused

2018 Cell death & disease

193. Varied Clinical Presentations, the Role of Magnetic Resonance Imaging in the Diagnosis, and Successful Management of Cervical Leiomyomas: A Case-Series and Review of Literature Full Text available with Trip Pro

Varied Clinical Presentations, the Role of Magnetic Resonance Imaging in the Diagnosis, and Successful Management of Cervical Leiomyomas: A Case-Series and Review of Literature Cervical leiomyomas or fibroids constitute a rare variety of benign pelvic tumors. The symptoms may vary from urinary retention, frequency, dyspareunia to rare clinical presentations such as prolapsed cervical fibroid polyp which may mimic procidentia or even uterine inversion. Preoperative clinical evaluation

2018 Cureus

194. Association between fetal fraction on cell-free DNA testing and first trimester markers for pre-eclampsia. Full Text available with Trip Pro

and FGR between 11 + 0 and 13 + 6 weeks' gestation and who also had cfDNA as a primary or secondary screening test for chromosomal abnormalities at any gestational age at two fetal medicine clinics in Sydney and Melbourne, Australia, between March 2013 and May 2017. Logarithmically transformed fetal fraction results were adjusted for gestational age and maternal characteristics. Associations with mean arterial pressure (MAP), mean uterine artery pulsatility index (UtA-PI), pregnancy-associated plasma (...) , South Asian ethnicity and being parous without history of PE or FGR. Fetal fraction was associated inversely with MAP and UtA-PI and associated positively with PAPP-A and PlGF. The lower the fetal fraction, the higher were the risks for PE < 34 weeks, PE < 37 weeks and FGR < 37 weeks (P < 0.001 for all).There is a significant association between fetal fraction result and first-trimester markers for adverse pregnancy outcome. Low fetal fraction is associated with an increased risk for pregnancy

2018 Ultrasound in Obstetrics and Gynecology

195. In vitro differentiation of human oocyte-like cells from oogonial stem cells: single-cell isolation and molecular characterization. Full Text available with Trip Pro

menopausal and 13 non-menopausal women (who underwent hysterectomy for uterine fibroma, ovarian cyst, or other benign pathologies) and cultured for up to 3 weeks. Large and small cells were individually isolated and typed for early and late differentiation markers.Ovarian cortex fragments were processed by immuno-magnetic separation using a rabbit anti-human DDX4 antibody and the positive populations were measured by assessing both FRAGILIS and stage-specific embryonic antigen 4 (SSEA-4) expression (...) present at lower mean levels in menopausal (SSEA-4+: 46.7%; FRAGILIS+: 47.5%) than in non-menopausal (SSEA-4+: 64.9%; FRAGILIS+: 64.8) women (P < 0.05). A comparison of the women's age with the ratio of DDX4-positive cells/cm3 of ovarian cortex revealed an inverse correlation with OSC number (P < 0.05). Once cultured, cells from both groups differentiated to form large (up to 80 μm) mature oocyte-like cells with typical oocyte morphology. Despite the higher numbers of these cells in cultures from non

2018 Human Reproduction

196. Correlation between fetoplacental Dopplers and cardiac function in term fetuses. Full Text available with Trip Pro

), global left ventricular strain (P < 0.01, rho = 0.17) and global right ventricular strain (P < 0.001, rho = 0.22). The CPR was correlated inversely with the left ventricular myocardial performance index (P < 0.01, rho = -0.18) and the RVCO (P < 0.001, rho = -0.28). The LVCO and global left ventricular strain were correlated positively with umbilical venous flow (P = 0.04, rho = 0.18 and P < 0.001, rho = 0.25, respectively). There was minimal or no correlation between either the mean uterine artery

2018 Ultrasound in Obstetrics and Gynecology

197. Uteroplacental glucose uptake and fetal glucose consumption: A quantitative study in human pregnancies. (Abstract)

University Hospital, Norway.One hundred seventy-nine healthy women with elective cesarean section.Uterine and umbilical blood flow was determined using Doppler ultrasonography. Glucose and insulin were measured in the maternal radial artery and uterine vein and the umbilical artery and vein. In a subcohort (n = 33), GLUT1 expression was determined in isolated syncytiotrophoblast basal and microvillous plasma membranes.Uteroplacental glucose uptake and placental and fetal glucose consumption quantified (...) glucose consumption (ρ: 0.77; P < 0.001). Fetal and placental glucose consumptions were inversely correlated (ρ: -0.47; P < 0.001), but neither was correlated with placental GLUT1 expression.These findings suggest that fetal glucose consumption is balanced against the placental needs for glucose and that placental glucose consumption is a key modulator of maternal-fetal glucose transfer in women.

2018 Journal of Clinical Endocrinology and Metabolism

198. Impaired placental perfusion and major fetal cardiac defects. Full Text available with Trip Pro

Impaired placental perfusion and major fetal cardiac defects. To investigate the relationship between fetal congenital heart defects (CHD) and placental perfusion assessed by uterine artery pulsatility index (UtA-PI), in relation to development of pre-eclampsia (PE).This was a prospective screening study of singleton pregnancies at 19-24 weeks' gestation. Transvaginal ultrasound was used to measure UtA-PI and the values were converted into multiples of the normal median (MoM). Median MoM values (...) (95% CI, 1.42-8.09); P = 0.006). In the total population, median UtA-PI MoM was significantly higher in those that developed PE compared to those without PE (1.22 (interquartile range (IQR), 0.94-1.57) vs 1.00 (IQR, 0.84-1.19); P < 0.0001) and, in the PE group, the median UtA-PI MoM was inversely related to gestational age at delivery (r = -0.458; P < 0.0001). The same pattern of inverse relationship between UtA-PI MoM and gestational age at delivery with PE was observed in pregnancies

2018 Ultrasound in Obstetrics and Gynecology

199. Prevention of sPTB With Early Cervical Pessary Treatment in Women at High Risk for PTB

Posted : January 31, 2018 Last Update Posted : February 5, 2018 See Sponsor: Bürgerhospital Frankfurt Information provided by (Responsible Party): Ioannis Kyvernitakis, Bürgerhospital Frankfurt Study Details Study Description Go to Brief Summary: Prevention of preterm birth (PTB) is a key factor for a positive short-term and long-term outcome of the newborn children as mortality and morbidity are inversely related to gestational age at delivery. Consequently every week of prolonged pregnancy (...) of significant maternal adverse events [ Time Frame: enrollment till discharge from hospital, recorded for at least first 48 hrs after birth ] rate of : heavy bleeding, cervical tear due to pessary placement, uterine rupture infection/inflammation [ Time Frame: enrollment till discharge from hospital, recorded for at least first 48 hrs after birth ] rate of maternal infection and/or inflammation during pregnancy / birth physical or psychological intolerance to pessary [ Time Frame: time from placement

2018 Clinical Trials

200. Detection of Asherman’s syndrome after conservative management of placenta accreta: a case report Full Text available with Trip Pro

inversion or perforation, and no uterine cavity adhesion, were observed. Four months postoperatively, hysteroscopy was performed. Adhesion was detected at the fundus of her uterus where the placenta had adhered to the uterus. Asherman's syndrome was diagnosed.Asherman's syndrome might occur after conservative management of placenta accreta, which may be a direct cause of placenta accreta recurrence. When Asherman's syndrome is diagnosed, the site of the placenta and adhesion should be monitored during (...) Detection of Asherman’s syndrome after conservative management of placenta accreta: a case report We present a case involving conservative treatment of placenta accreta, with a subsequent diagnosis of Asherman's syndrome.A 41-year-old Japanese woman (G2P0A2) delivered a healthy male infant via cesarean section due to preeclampsia. The placenta did not spontaneously separate and was manually removed. Adhesion was tight and placenta accreta was diagnosed. During the procedure, no uterine

2018 Journal of medical case reports

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