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Uterine Fibroid

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161. Directed Ablation of Uterine Fibroids Using a Noninvasive Approach

Directed Ablation of Uterine Fibroids Using a Noninvasive Approach Directed Ablation of Uterine Fibroids Using a Noninvasive Approach - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Directed Ablation (...) of Uterine Fibroids Using a Noninvasive Approach (DIANA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03219385 Recruitment Status : Not yet recruiting First Posted : July 17, 2017 Last Update Posted : March 21, 2018 See

2017 Clinical Trials

162. Mode of Action Study of Vilaprisan and Ulipristal Acetate in Patients With Uterine Fibroids for Whom Surgery is Planned

Mode of Action Study of Vilaprisan and Ulipristal Acetate in Patients With Uterine Fibroids for Whom Surgery is Planned Mode of Action Study of Vilaprisan and Ulipristal Acetate in Patients With Uterine Fibroids for Whom Surgery is Planned - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Mode of Action Study of Vilaprisan and Ulipristal Acetate in Patients With Uterine Fibroids for Whom Surgery is Planned The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2017 Clinical Trials

163. Characterisation of Uterine Fibroid Tissue Stiffness

Characterisation of Uterine Fibroid Tissue Stiffness Characterisation of Uterine Fibroid Tissue Stiffness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Characterisation of Uterine Fibroid Tissue Stiffness (...) Party): Dr. Linda McLean, University of Ottawa Study Details Study Description Go to Brief Summary: Uterine fibroids (leiomyomas, myomas, fibroids) are benign tumors of the uterus that can cause heavy menstrual bleeding, pain, and/or infertility. Fibroids can be managed with medication, surgery, or interventional radiology. While conservative methods that avoid surgical risks and complications are becoming more common, there are limitations to medical therapies including side effects, short

2017 Clinical Trials

164. Repeated intermittent ulipristal acetate in the treatment of uterine fibroids: a cost-effectiveness analysis (PubMed)

Repeated intermittent ulipristal acetate in the treatment of uterine fibroids: a cost-effectiveness analysis There are limited treatment options available for women with moderate to severe symptoms of uterine fibroids (UFs) who wish to avoid surgery. For these women, treatment with standard pharmaceuticals such as contraceptives is often insufficient to relieve symptoms, and patients may require surgery despite their wish to avoid it. Clinical trials demonstrate that ulipristal acetate 5 mg

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2017 ClinicoEconomics and Outcomes Research: CEOR

165. Application of cone-beam computed tomography angiography in a uterine fibroid embolization procedure: A case report (PubMed)

Application of cone-beam computed tomography angiography in a uterine fibroid embolization procedure: A case report One of the main causes of failure in uterine fibroid embolization procedures is incomplete infarction of the fibroid due to alternate vascular supply to the fibroid which was not identified by the operator. Cone-beam computed tomography angiography was used in this case to avoid nontarget embolization via a uterine artery, as well as identify incomplete embolization of the fibroid (...) . This prompted a search for variant vascular supply to the fibroid, which was found to be originating from the right ovarian artery. Therefore, the use of cone-beam computed tomography angiography led to a successful outcome, which otherwise may not have been achieved.

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2017 Radiology Case Reports

166. Uterine Fibroids: Burden and Unmet Medical Need (PubMed)

Uterine Fibroids: Burden and Unmet Medical Need 29100234 2018 08 28 2018 11 13 1526-4564 35 6 2017 11 Seminars in reproductive medicine Semin. Reprod. Med. Uterine Fibroids: Burden and Unmet Medical Need. 473-480 10.1055/s-0037-1607264 Al-Hendy Ayman A Division of Translational Research, Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia. Myers Evan Robert ER Division of Clinical and Epidemiological Research, Department of Obstetrics and Gynecology, Duke University (...) economics genetics physiopathology therapy Leiomyomatosis economics genetics physiopathology therapy Practice Guidelines as Topic Quality of Life Uterine Neoplasms economics genetics physiopathology therapy Disclosure The authors report no conflicts of interest in this work. 2017 11 4 6 0 2017 11 4 6 0 2018 8 29 6 0 ppublish 29100234 10.1055/s-0037-1607264 PMC6193285 Oncotarget. 2011 Dec;2(12):966-9 22182697 JAMA Surg. 2015 Apr;150(4):368-70 25650751 Medicine (Baltimore). 2016 Nov;95(46):e5325 27861360

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2017 Seminars in Reproductive Medicine

167. Uterine fibroids – what’s new? (PubMed)

Uterine fibroids – what’s new? Uterine fibroids are the commonest benign tumours of women and affect all races with a cumulative lifetime risk of around 70%. Despite their high prevalence and the heavy economic burden of treatment, fibroids have received remarkably little attention compared to common female malignant tumours. This article reviews recent progress in understanding the biological nature of fibroids, their life cycle and their molecular genetic origins. Recent progress

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2017 F1000Research

168. Treating symptomatic uterine fibroids with myomectomy: current practice and views of UK consultants (PubMed)

Treating symptomatic uterine fibroids with myomectomy: current practice and views of UK consultants 29285023 2018 11 13 1613-2076 14 1 2017 Gynecological surgery Gynecol Surg Treating symptomatic uterine fibroids with myomectomy: current practice and views of UK consultants. 28 10.1186/s10397-017-1033-1 Mallick R R 0000-0001-7516-9132 Department of Gynaecology, Barts Health NHS Trust, Whipps Cross University Hospital, London, E11 1NR UK. grid.439471.c Odejinmi F F Department of Gynaecology

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2017 Gynecological surgery

169. Transcervical Radiofrequency Ablation of Uterine Fibroids Global Registry

Transcervical Radiofrequency Ablation of Uterine Fibroids Global Registry Transcervical Radiofrequency Ablation of Uterine Fibroids Global Registry - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Transcervical Radiofrequency Ablation of Uterine Fibroids Global Registry (SAGE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03118037 Recruitment Status : Recruiting First Posted : April 18, 2017 Last Update Posted : July 6

2017 Clinical Trials

170. Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids Compare to Ulipristal

Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids Compare to Ulipristal Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 5) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03240523 Recruitment Status : Active, not recruiting First Posted : August 7, 2017 Last Update Posted : March 7, 2019 Sponsor: Bayer Information provided

2017 Clinical Trials

171. LIBERTY 2: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids

LIBERTY 2: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids LIBERTY 2: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. LIBERTY 2: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03103087 Recruitment Status : Active

2017 Clinical Trials

172. A case of disseminated peritoneal leiomyomatosis after two laparoscopic procedures due to uterine fibroids (PubMed)

A case of disseminated peritoneal leiomyomatosis after two laparoscopic procedures due to uterine fibroids Disseminated peritoneal leiomyomatosis (DPL) is a rare disorder characterized by the presence of multifocal nodules and tumors composed of proliferating smooth muscle tissue, spread throughout the peritoneum. Estrogens and progesterone are considered to be the main factors initiating the formation of disseminated leiomyomatosis. Disseminated peritoneal leiomyomatosis is often asymptomatic (...) , and acyclic vaginal bleeding or pain in the lower abdomen is associated with leiomyomatous rebuilt uterus corpus. Disseminated peritoneal leiomyomatosis can have other ambiguous presentation. The difficulty in DPL diagnosis is that it is not always accompanied by scattered leiomyomas and can occur after menopause. Some cases of DPL are associated with surgical procedures on uterine fibroids, especially with the use of a morcellator. We present the case of a 39-year-old woman with DPL who underwent

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2017 Videosurgery and other Miniinvasive Techniques

173. Moderate-to-deep sedation technique, using propofol and ketamine, allowing synchronised breathing for magnetic resonance high-intensity focused ultrasound (MR-HIFU) treatment for uterine fibroids: a pilot study (PubMed)

Moderate-to-deep sedation technique, using propofol and ketamine, allowing synchronised breathing for magnetic resonance high-intensity focused ultrasound (MR-HIFU) treatment for uterine fibroids: a pilot study Magnetic resonance high-intensity focused ultrasound (MR-HIFU) treatment for uterine fibroids is rapidly gaining popularity as a treatment modality. This procedure is generally uncomfortable, painful, and requires minimal or absence of movement and an MR-HIFU synchronised breathing (...) patients were subjected to MR-HIFU treatment of uterine fibroids. Patients were deeply sedated using intravenous propofol and esketamine according to a standardised hospital protocol to allow synchronisation of the breathing pattern to the MR-HIFU. The quality of sedation for MR-HIFU and complications were recorded and analysed. The side effects of the sedation technique, the propofol and esketamine consumption rate, the duration of recovery, and patient satisfaction after 24 h were examined.A total

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2017 Journal of therapeutic ultrasound

174. Magnetic Resonance Imaging-Guided Focused Ultrasound Surgery for the Treatment of Symptomatic Uterine Fibroids (PubMed)

Magnetic Resonance Imaging-Guided Focused Ultrasound Surgery for the Treatment of Symptomatic Uterine Fibroids Uterine fibroids, the most common benign tumor in women of childbearing age, may cause symptoms including pelvic pain, menorrhagia, dysmenorrhea, pressure, urinary symptoms, and infertility. Various approaches are available to treat symptomatic uterine fibroids. Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) represents a recently introduced noninvasive safe and effective (...) technique that can be performed without general anesthesia, in an outpatient setting. We review the principles of MRgFUS, describing patient selection criteria for the treatments performed at our center and we present a series of five selected patients with symptomatic uterine fibroids treated with this not yet widely known technique, showing its efficacy in symptom improvement and fibroid volume reduction.

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2017 Case Reports in Radiology

175. Patient-reported prevalence and symptomatic burden of uterine fibroids among women in the United States: findings from a cross-sectional survey analysis (PubMed)

Patient-reported prevalence and symptomatic burden of uterine fibroids among women in the United States: findings from a cross-sectional survey analysis To estimate the prevalence of women diagnosed with uterine fibroids and the associated symptom burden in the US.Responses of women aged 18-54 years, who completed an online survey, were analyzed. Data were weighted based on age, education, race, geographic region, income, and propensity score to derive national estimates of the prevalence (...) of women diagnosed with uterine fibroids and associated symptom burden. Weighted means and percentages were reported. Prevalence across age and ethnic groups was examined. Symptom burden among women with and without uterine fibroids was compared using weighted logistic regressions.Of 59,411 respondents who met study inclusion criteria, 7.7% reported receiving a diagnosis of uterine fibroids. Of these, 5,670 women (1,402 in the uterine fibroid group and 4,268 in the control group) were excluded from

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2017 International journal of women's health

176. Clinical limitations of the International Federation of Gynecology and Obstetrics (FIGO) classification of uterine fibroids (PubMed)

Clinical limitations of the International Federation of Gynecology and Obstetrics (FIGO) classification of uterine fibroids To determine the reproducibility of classifying uterine fibroids using the 2011 International Federation of Gynecology and Obstetrics (FIGO) staging system.The present retrospective cohort study included patients presenting for the treatment of symptomatic uterine fibroids at the Gynecology Fibroid Clinic at Mayo Clinic, Rochester, USA, between April 1, 2013 and April 1 (...) , 2014. Magnetic resonance imaging of fibroid uteri was performed and the images were independently reviewed by two academic gynecologists and two radiologists specializing in fibroid care. Fibroid classifications assigned by each physician were compared and the significance of the variations was graded by whether they would affect surgical planning.There were 42 fibroids from 23 patients; only 6 (14%) fibroids had unanimous classification agreement. The majority (36 [86%]) had at least two unique

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2017 International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

177. Curative effect of laparoscopic hysterectomy for uterine fibroids and its impact on ovarian blood supply (PubMed)

Curative effect of laparoscopic hysterectomy for uterine fibroids and its impact on ovarian blood supply This study evaluates the curative effects laparo-scopic hysterectomies performed to treat uterine fibroids and determined the impact of the procedures on ovarian blood supply. A total of 124 patients with uterine fibroids admitted and treated in our hospital from December 2014 to December 2015 participated in the study. Two groups of 62 patients each were formed according to different (...) always significantly higher than those of patients in the control group, at every different time point examined (1, 4, 8 and 12 months after surgery) (P<0.01). At the end of the 24 months of the follow-up period, the recurrence rate of fibroids for patients in the observation group was 4.8%. In our hands, the laparoscopic hysterectomy procedure to treat uterine fibroids showed the usual advantages over the abdominal open hysterectomy, like small trauma, short surgical procedure and rapid

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2017 Experimental and therapeutic medicine

178. Volumetric magnetic resonance-guided high-intensity focused ultrasound ablation of uterine fibroids through abdominal scars: the impact of a scar patch on therapeutic efficacy and adverse effects (PubMed)

Volumetric magnetic resonance-guided high-intensity focused ultrasound ablation of uterine fibroids through abdominal scars: the impact of a scar patch on therapeutic efficacy and adverse effects To retrospectively compare the treatment success, therapeutic efficacy, and adverse effects of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) treatment for uterine fibroid patients with and without abdominal scars.Seventy-six women who underwent treatment were divided into group (...) ., sciatic nerve symptoms), and are typically manifested inter-procedurally and resolved shortly thereafter.The findings in this study suggest that the scar patch could be used safely and efficiently in MRgHIFU treatment for the patients with uterine fibroids and abdominal scars in the ultrasound beam path.

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2017 Journal of therapeutic ultrasound

179. Defective expression of ATG4D abrogates autophagy and promotes growth in human uterine fibroids (PubMed)

Defective expression of ATG4D abrogates autophagy and promotes growth in human uterine fibroids Uterine fibroids (UF) are the most common pelvic tumors in women of reproductive-age and they usually cause heavy menstrual bleeding, pain and infertility. Autophagy is a collection of processes that enables the cells to digest and recycle their cytoplasmic contents, such as toxic protein aggregates, defunct or disused organelles and invading microorganisms. Dysregulation in autophagy process were

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2017 Cell Death Discovery

180. Uterine fibroid shrinkage after short-term use of selective progesterone receptor modulator or gonadotropin-releasing hormone agonist (PubMed)

Uterine fibroid shrinkage after short-term use of selective progesterone receptor modulator or gonadotropin-releasing hormone agonist The aim of this study was to evaluate the effect of short-term use of selective progesterone receptor modulator (SPRM) or gonadotropin-releasing hormone (GnRH) agonist on uterine fibroid shrinkage among Korean women.This retrospective study involved 101 women with symptomatic uterine fibroids who received ulipristal acetate (SPRM, n=51) and leuprolide acetate (...) (GnRH agonist, n=50) for 3 months between November 2013 and February 2015. The fibroid volume was measured both before and after treatment using ultrasonography, computed tomography, and magnetic resonance imaging. The outcomes were compared between the SPRM and GnRH agonist groups.The median rate of fibroid volume reduction after SPRM treatment was 12.4% (IQR -14.5% to 40.5%) which was significantly lower than the reduction rate observed after GnRH agonist treatment (median 34.9%, IQR 14.7% to 48.6

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2017 Obstetrics & gynecology science

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