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Uterine Fibroid

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161. Application of cone-beam computed tomography angiography in a uterine fibroid embolization procedure: A case report Full Text available with Trip Pro

Application of cone-beam computed tomography angiography in a uterine fibroid embolization procedure: A case report One of the main causes of failure in uterine fibroid embolization procedures is incomplete infarction of the fibroid due to alternate vascular supply to the fibroid which was not identified by the operator. Cone-beam computed tomography angiography was used in this case to avoid nontarget embolization via a uterine artery, as well as identify incomplete embolization of the fibroid (...) . This prompted a search for variant vascular supply to the fibroid, which was found to be originating from the right ovarian artery. Therefore, the use of cone-beam computed tomography angiography led to a successful outcome, which otherwise may not have been achieved.

2017 Radiology Case Reports

162. Uterine Fibroids: Burden and Unmet Medical Need Full Text available with Trip Pro

Uterine Fibroids: Burden and Unmet Medical Need 29100234 2018 08 28 2018 11 13 1526-4564 35 6 2017 11 Seminars in reproductive medicine Semin. Reprod. Med. Uterine Fibroids: Burden and Unmet Medical Need. 473-480 10.1055/s-0037-1607264 Al-Hendy Ayman A Division of Translational Research, Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia. Myers Evan Robert ER Division of Clinical and Epidemiological Research, Department of Obstetrics and Gynecology, Duke University (...) economics genetics physiopathology therapy Leiomyomatosis economics genetics physiopathology therapy Practice Guidelines as Topic Quality of Life Uterine Neoplasms economics genetics physiopathology therapy Disclosure The authors report no conflicts of interest in this work. 2017 11 4 6 0 2017 11 4 6 0 2018 8 29 6 0 ppublish 29100234 10.1055/s-0037-1607264 PMC6193285 Oncotarget. 2011 Dec;2(12):966-9 22182697 JAMA Surg. 2015 Apr;150(4):368-70 25650751 Medicine (Baltimore). 2016 Nov;95(46):e5325 27861360

2017 Seminars in Reproductive Medicine

163. Incarceration of a pedunculated uterine fibroid in an umbilical hernia Full Text available with Trip Pro

Incarceration of a pedunculated uterine fibroid in an umbilical hernia Uterine fibroids are common benign tumors that may cause an umbilical hernia in patients with increased intra-abdominal pressure due to pregnancy, obesity, ascites, and intra-abdominal tumors. However, the simultaneous occurrence of uterine fibroids and umbilical hernias, or fibroids and an associated umbilical hernia, during pregnancy has rarely been reported. Here, we present the case of a fibroid presenting

2017 Obstetrics & gynecology science

164. Self-reported Bacterial Vaginosis and Risk of Ultrasound Diagnosed Incident Uterine Fibroid Cases in a Prospective Cohort Study of Young African-American Women Full Text available with Trip Pro

Self-reported Bacterial Vaginosis and Risk of Ultrasound Diagnosed Incident Uterine Fibroid Cases in a Prospective Cohort Study of Young African-American Women 29066031 2018 11 13 1873-2585 27 11 2017 Nov Annals of epidemiology Ann Epidemiol Self-reported bacterial vaginosis and risk of ultrasound-diagnosed incident uterine fibroid cases in a prospective cohort study of young African American women. 749-751.e1 S1047-2797(17)30089-3 10.1016/j.annepidem.2017.10.003 Moore Kristen R KR Epidemiology

2017 Annals of Epidemiology

165. Role of Transforming Growth Factor β in Uterine Fibroid Biology Full Text available with Trip Pro

Role of Transforming Growth Factor β in Uterine Fibroid Biology Uterine fibroids (UFs) are benign tumors of the female genital tract made of the smooth muscle of the uterus. UF growth depends mostly on the influence of the steroid hormones and selected growth factors. Transforming growth factor β (TGF-βs) is a polypeptide that consists of three isoforms: TGF-β1, TGF-β2, and TGF-β3. At present, TGF-β is considered to be one of the key factors in the pathophysiology of UFs. It plays a major role (...) their search in PubMed of the National Library of Medicine with the use of the following selected keywords: "uterine fibroid", "leiomyoma", and "transforming growth factor β". After reviewing the titles and abstracts, more than 115 full articles were evaluated. We focused on the TGF-β-related molecular aspects and their influence on the most common symptoms that are associated with UFs. Also, we described how the available data might implicate the current medical management of UFs.

2017 International journal of molecular sciences

166. Clinical limitations of the International Federation of Gynecology and Obstetrics (FIGO) classification of uterine fibroids Full Text available with Trip Pro

Clinical limitations of the International Federation of Gynecology and Obstetrics (FIGO) classification of uterine fibroids To determine the reproducibility of classifying uterine fibroids using the 2011 International Federation of Gynecology and Obstetrics (FIGO) staging system.The present retrospective cohort study included patients presenting for the treatment of symptomatic uterine fibroids at the Gynecology Fibroid Clinic at Mayo Clinic, Rochester, USA, between April 1, 2013 and April 1 (...) , 2014. Magnetic resonance imaging of fibroid uteri was performed and the images were independently reviewed by two academic gynecologists and two radiologists specializing in fibroid care. Fibroid classifications assigned by each physician were compared and the significance of the variations was graded by whether they would affect surgical planning.There were 42 fibroids from 23 patients; only 6 (14%) fibroids had unanimous classification agreement. The majority (36 [86%]) had at least two unique

2017 International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

167. Defective expression of ATG4D abrogates autophagy and promotes growth in human uterine fibroids Full Text available with Trip Pro

Defective expression of ATG4D abrogates autophagy and promotes growth in human uterine fibroids Uterine fibroids (UF) are the most common pelvic tumors in women of reproductive-age and they usually cause heavy menstrual bleeding, pain and infertility. Autophagy is a collection of processes that enables the cells to digest and recycle their cytoplasmic contents, such as toxic protein aggregates, defunct or disused organelles and invading microorganisms. Dysregulation in autophagy process were

2017 Cell Death Discovery

168. Curative effect of laparoscopic hysterectomy for uterine fibroids and its impact on ovarian blood supply Full Text available with Trip Pro

Curative effect of laparoscopic hysterectomy for uterine fibroids and its impact on ovarian blood supply This study evaluates the curative effects laparo-scopic hysterectomies performed to treat uterine fibroids and determined the impact of the procedures on ovarian blood supply. A total of 124 patients with uterine fibroids admitted and treated in our hospital from December 2014 to December 2015 participated in the study. Two groups of 62 patients each were formed according to different (...) always significantly higher than those of patients in the control group, at every different time point examined (1, 4, 8 and 12 months after surgery) (P<0.01). At the end of the 24 months of the follow-up period, the recurrence rate of fibroids for patients in the observation group was 4.8%. In our hands, the laparoscopic hysterectomy procedure to treat uterine fibroids showed the usual advantages over the abdominal open hysterectomy, like small trauma, short surgical procedure and rapid

2017 Experimental and therapeutic medicine

169. A multi-stage genome-wide association study of uterine fibroids in African Americans Full Text available with Trip Pro

A multi-stage genome-wide association study of uterine fibroids in African Americans Uterine fibroids are benign tumors of the uterus affecting up to 77% of women by menopause. They are the leading indication for hysterectomy, and account for $34 billion annually in the United States. Race/ethnicity and age are the strongest known risk factors. African American (AA) women have higher prevalence, earlier onset, and larger and more numerous fibroids than European American women. We conducted (...) a multi-stage genome-wide association study (GWAS) of fibroid risk among AA women followed by in silico genetically predicted gene expression profiling of top hits. In Stage 1, cases and controls were confirmed by pelvic imaging, genotyped and imputed to 1000 Genomes. Stage 2 used self-reported fibroid and GWAS data from 23andMe, Inc. and the Black Women's Health Study. Associations with fibroid risk were modeled using logistic regression adjusted for principal components, followed by meta-analysis

2017 Human Genetics

170. Burden of uterine fibroids in Italy: epidemiology, treatment outcomes, and consumption of health care resources in more than 5,000 women Full Text available with Trip Pro

Burden of uterine fibroids in Italy: epidemiology, treatment outcomes, and consumption of health care resources in more than 5,000 women Epidemiological studies on uterine fibroids (UFs) are mostly based on surveys or analyses of small samples of patients. In 50% of women, the quality of life is worsened by disease-related symptoms; furthermore, treatments imply a remarkable health care cost. The aim of this observational study was to analyze a large sample of Italian patients with UFs

2017 ClinicoEconomics and Outcomes Research: CEOR

171. Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids Full Text available with Trip Pro

Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids Uterine fibroids (UFs, AKA leiomyoma) are the most important benign neoplastic threat to women's health, with costs up to hundreds of billions of health care dollars worldwide. Uterine fibroids caused morbidities exert a tremendous health toll, impacting the quality of life of women of all ethnicities, especially women of color. Clinical presentations include heavy vaginal bleeding

2017 Biology of reproduction

172. Volumetric magnetic resonance-guided high-intensity focused ultrasound ablation of uterine fibroids through abdominal scars: the impact of a scar patch on therapeutic efficacy and adverse effects Full Text available with Trip Pro

Volumetric magnetic resonance-guided high-intensity focused ultrasound ablation of uterine fibroids through abdominal scars: the impact of a scar patch on therapeutic efficacy and adverse effects To retrospectively compare the treatment success, therapeutic efficacy, and adverse effects of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) treatment for uterine fibroid patients with and without abdominal scars.Seventy-six women who underwent treatment were divided into group (...) ., sciatic nerve symptoms), and are typically manifested inter-procedurally and resolved shortly thereafter.The findings in this study suggest that the scar patch could be used safely and efficiently in MRgHIFU treatment for the patients with uterine fibroids and abdominal scars in the ultrasound beam path.

2017 Journal of therapeutic ultrasound

173. Updated approaches for management of uterine fibroids Full Text available with Trip Pro

Updated approaches for management of uterine fibroids Uterine anatomy and uterine fibroids (UFs) characteristics have been classically considered as almost a unique issue in gynecology and reproductive medicine. Nowadays, the management of UF pathology is undergoing an important evolution, with the patient's quality of life being the most important aspect to consider. Accordingly, surgical techniques and aggressive treatments are reserved for only those cases with heavy symptomatology, while

2017 International journal of women's health

174. Metastatic uterine cancer looking as cervical fibroid in recurrent breast cancer woman: a case report Full Text available with Trip Pro

Metastatic uterine cancer looking as cervical fibroid in recurrent breast cancer woman: a case report Metastasis to the female genital tract from extragenital primary cancer is uncommon. In this case, a 46-year-old woman was diagnosed with invasive lobular carcinoma of the left breast in 2011. She had left breast conserving surgery, chemotherapy, radiation, and hormonal therapy (gosereline and tamoxifen). However, she developed menorrhagia after interruption of hormonal therapy and incidentally (...) , the ultrasonogram of her pelvis showed a solid, large mass in the cervix. It looked like leiomyoma. Because of massive vaginal bleeding requiring multiple blood transfusions, she underwent total hysterectomy with bilateral salpingo-oophorectomy. Unexpectedly, however, histopathological examination revealed metastatic carcinoma, consistent with breast origin.The metastatic tumor involved the uterine corpus with spreading to the endocervix, left ovary, and multiple lymphovascular invasion was present. We

2017 Obstetrics & gynecology science

175. Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases Full Text available with Trip Pro

Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases The role of the extracellular matrix (ECM) in uterine fibroids (UF) has recently been appreciated. Overhydroxylation of lysine residues and the subsequent formation of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) cross-links underlie the ECM stiffness and profoundly affect tumor progression. The aim of the current study

2017 BioMed research international

176. A network pharmacology approach to investigate the pharmacological effects of Guizhi Fuling Wan on uterine fibroids Full Text available with Trip Pro

A network pharmacology approach to investigate the pharmacological effects of Guizhi Fuling Wan on uterine fibroids To investigate the pharmacological mechanism of Guizhi Fuling Wan (GFW) in the treatment of uterine fibroids, a network pharmacology approach was used. Information on GFW compounds was collected from traditional Chinese medicine (TCM) databases, and input into PharmMapper to identify the compound targets. Genes associated with uterine fibroids genes were then obtained from (...) -compound target-uterine fibroids target network of GWF; and a compound target-uterine fibroids target-other human proteins protein-protein interaction network, which were subjected to GO and pathway enrichment analyses. According to this approach, a number of novel signaling pathways and biological processes underlying the effects of GFW on uterine fibroids were identified, including the negative regulation of smooth muscle cell proliferation, apoptosis, and the Ras, wingless-type, epidermal growth

2017 Experimental and therapeutic medicine

177. Fears and Concerns of Patients with Uterine Fibroids – a Survey of 807 Women Full Text available with Trip Pro

Fears and Concerns of Patients with Uterine Fibroids – a Survey of 807 Women What specific fears and concerns do patients with uterine fibroids have? How are these influenced by sociodemographic factors, duration of condition and level of knowledge among these women?Between January 2016 and January 2017 807 patients were consecutively surveyed at a university hospital speciality fibroid clinic using a two page locally developed and validated questionnaire focusing on fibroid-associated fears (...) since diagnosis also affected fears with different concerns between patients with shorter duration of diagnosis (< 12 months) vs. longer duration (> 12 months). Overall only slight differences could be attributed to immigrant background. Higher level of education correlated with less anxiety. Proper information about fibroids relieved fears of malignant change in particular. Doctors and the internet were the most important sources of patient information.Due to the benign nature of uterine fibroids

2017 Geburtshilfe Und Frauenheilkunde

178. Contrast-enhanced ultrasound is better than magnetic resonance imaging in evaluating the short-term results of microwave ablation treatment of uterine fibroids Full Text available with Trip Pro

Contrast-enhanced ultrasound is better than magnetic resonance imaging in evaluating the short-term results of microwave ablation treatment of uterine fibroids Contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI) were compared in evaluating the short-term effects of microwave ablation (MWA) on uterine fibroids. A total of 60 patients with uterine fibroids treated by MWA were enrolled in the experimental group during their two-year follow-up period according to the inclusion (...) criteria. Conventional two-dimensional US, MRI and CEUS were performed to determine the volume reduction and the fibroid residue by displaying the size, echo and signal intensity of fibroids prior to and after MWA treatment. As the control group, 60 consecutive patients were recruited on their follow-up visit at least two years after MWA treatment of uterine fibroids. Significant differences were observed in the wash-in rate (WiR) of the fibroid tissue, start time difference, rise time ratio (RTR

2017 Experimental and therapeutic medicine

179. Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans Full Text available with Trip Pro

Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans The article "A multi-stage genome-wide association study of uterine fibroids in African Americans", written by Jacklyn N. Hellwege, was originally published Online First without open access. After publication in volume 136, issue 10, page 1363-1373 the author decided to opt for Open Choice and to make the article an open access publication. Therefore, the copyright of the article has been changed

2017 Human Genetics

180. Review of magnetic resonance-guided focused ultrasound in the treatment of uterine fibroids Full Text available with Trip Pro

Review of magnetic resonance-guided focused ultrasound in the treatment of uterine fibroids Uterine leiomyoma is the most frequently occurring solid pelvic tumor in women during the reproductive period. Magnetic resonance-guided high-intensity focused ultrasound is a promising technique for decreasing menorrhagia and dysmenorrhea in symptomatic women. The aim of this study is to review the role of Magnetic resonance-guided high-intensity focused ultrasound in the treatment of uterine fibroids (...) in symptomatic patients. We performed a review of the MEDLINE and Cochrane databases up to April 2016. The analysis and data collection were performed using the following keywords: Leiomyoma, High-Intensity Focused Ultrasound Ablation, Ultrasonography, Magnetic Resonance Imaging, Menorrhagia. Two reviewers independently performed a quality assessment; when there was a disagreement, a third reviewer was consulted. Nineteen studies of Magnetic resonance-guided high-intensity focused ultrasound-treated fibroid

2017 Clinics

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