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Uterine Fibroid

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141. Economic impact of ulipristal acetate on surgical procedures for uterine fibroids in France. (PubMed)

Economic impact of ulipristal acetate on surgical procedures for uterine fibroids in France. To assess the budget impact of using ulipristal acetate (UPA) 5 mg to treat women with uterine fibroids (UF) causing moderate to severe symptoms.We modelled trends in the number of surgical procedures for symptomatic UF, with and without the use of UPA for preoperative or intermittent treatment and assessed the budget impact of UPA use from the French national healthcare insurance system perspective.A (...) French national hospital database (PMSI) that records admissions and relative procedures to public and private hospitals.Women eligible for surgical procedures for uterine fibroids.Economic impact of UPA treatment.This study based on observational retrospective data shows that the current use of UPA in its preoperative indication was associated with 5645 fewer surgeries from 2013 to 2015. Extrapolation suggests 17 885 fewer surgeries from 2016 to 2019. Overall, preoperative use of UPA results

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2017 BMJ open

142. Efficacy and safety of ultrasound-guided high intensity focused ultrasound ablation of symptomatic uterine fibroids in Black women: a preliminary study. (PubMed)

Efficacy and safety of ultrasound-guided high intensity focused ultrasound ablation of symptomatic uterine fibroids in Black women: a preliminary study. To evaluate the therapeutic effect and safety of ultrasound-guided high-intensity focused ultrasound (USgHIFU) treatment on symptomatic uterine fibroids in Black women.A feasibility study.Gynaecological department in a teaching hospital in South Africa.Premenopausal women with uterus fibroids.Twenty-six patients with 53 fibroids who underwent (...) USgHIFU treatment were enrolled. The USgHIFU treatment information was recorded, including treatment time, sonication time and total energy. Adverse events were also observed and recorded during and after treatment.Safety and efficacy of USgHIFU for the treatment of uterine fibroids in Black women.The median volume of fibroids was 52.7 (interquartile range, 18.6-177.4) cm3 . According to USgHIFU treatment plan, total energy of 298.6 ± 169.3 kJ (range, 76.0-889.2) within treatment time of 90.3 ± 43.3

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2017 BJOG

143. High-intensity focused ultrasound and laparoscopic myomectomy in the treatment of uterine fibroids: a comparative study. (PubMed)

High-intensity focused ultrasound and laparoscopic myomectomy in the treatment of uterine fibroids: a comparative study. To compare the clinical efficacies of high-intensity focused ultrasound (HIFU) and laparoscopic myomectomy (LM) in the treatment of uterine fibroids and their effects on patients' quality of life.A non-randomised control study.Gynaecological department in a university teaching hospital.Patients with uterine fibroids.From November 2014 to November 2015, 166 patients (...) with uterine fibroids were enrolled and underwent HIFU (n = 99) and LM (n = 67) surgeries, respectively. Clinical efficacy, postoperative complications and quality of life after treatment were evaluated using the SF-36 Scale to compare the differences in each variable at the 1-year follow up.Differences in efficacy, safety and quality of life between the patients treated with HIFU and LM.The 12-month follow-up results showed that the HIFU group had a total effective rate of 99%; only one patient underwent

2017 BJOG

144. The effect of exercise on high-intensity focused ultrasound treatment efficacy in uterine fibroids and adenomyosis: a retrospective study. (PubMed)

The effect of exercise on high-intensity focused ultrasound treatment efficacy in uterine fibroids and adenomyosis: a retrospective study. We conducted a retrospective study to evaluate whether exercise after high-intensity focused ultrasound (HIFU) treatment can improve the absorption of uterine fibroids and the relief of dysmenorrhea caused by adenomyosis.A retrospective study.Gynaecological department of a single centre in China.Patients with uterine fibroids and adenomyosis.From January (...) 2011 to August 2015,83 MRI-confirmed uterine fibroid patients and 102 adenomyosis patients who received HIFU treatment at Chongqing Haifu Hospital and attended the 1-year and 6-month follow up, respectively, were included in our retrospective study. Among the fibroid patients, 51 were assigned to the 'no exercise group' and 32 to the 'exercise group'. Among the adenomyosis patients, 45 were assigned to the 'no exercise group' and to the 57 'exercise group'.Symptom improvement, uterine fibroid

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2017 BJOG

145. Pregnancy outcomes in patients with uterine fibroids treated with ultrasound-guided high-intensity focused ultrasound. (PubMed)

Pregnancy outcomes in patients with uterine fibroids treated with ultrasound-guided high-intensity focused ultrasound. To investigate the effect of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids on pregnancy.A retrospective observational study.Department of Gynaecology in a single centre in China.Patients with uterine fibroids who wish to become pregnant.Patients with uterine fibroids who wished become pregnant and have children, were treated using HIFU from April 2011 (...) -term normal deliveries, one patient planned to use contraception after complete curettage of the uterine cavity; and one patient had her labour induced (after 13-weeks pregnancy). The fetuses of all the patients developed well during both the pregnancy and child-bearing without uterine rapture or perinatal and postpartum complications.HIFU treatment can effectively treat patients with uterine fibroids who wish to have children; it could significantly reduce the preparation period for pregnancy

2017 BJOG

146. Changes in anti-müllerian hormone levels as a biomarker for ovarian reserve after ultrasound-guided high-intensity focused ultrasound treatment of adenomyosis and uterine fibroid. (PubMed)

Changes in anti-müllerian hormone levels as a biomarker for ovarian reserve after ultrasound-guided high-intensity focused ultrasound treatment of adenomyosis and uterine fibroid. To assess the changes in antimüllerian hormone (AMH) levels after ablation for symptomatic uterine fibroids and adenomyosis using ultrasound-guided high-intensity focused ultrasound (USgHIFU).A prospective study.Gynaecological department in multiple hospitals in South Korea.Patients with uterus fibroids (...) and adenomyosis.Seventy-nine women with symptomatic uterine fibroids and adenomyosis who met the inclusion criteria were enrolled in our study between January 2014 and December 2014. All patients underwent USgHIFU ablations. Each patient was examined before and after treatment, and at 6 and 12 months after treatment by T2-weighted MRI imaging (T2WI) and T1-weighted MRI imaging (T1WI) with gadolinium injection. Symptom severity scores (SSS), Uterine Fibroid Symptom Quality of Life (UFS-QOL) questionnaire subscales

2017 BJOG

147. Spontaneous Pregnancy with a Live Birth after Conventional and Partial Uterine Fibroid Embolization. (PubMed)

Spontaneous Pregnancy with a Live Birth after Conventional and Partial Uterine Fibroid Embolization. Purpose To determine pregnancy rates after conventional and partial uterine fibroid embolization (UFE). Materials and Methods The study received institutional review board approval and all patients gave written informed consent. A retrospective analysis of data collected prospectively was performed between June 2004 and June 2014 in a cohort of 359 women (mean age, 35.9 years ± 4.8) with uterine (...) fibroids and/or adenomyosis who were unable to conceive. The median follow-up period was 69 months (range, 6-126 months). Under local anesthesia, both uterine arteries were embolized. In 160 patients, partial embolization was intentionally performed to preserve fertility, which may be decreased after conventional UFE. In partial UFE, only the small arterial vessels to the fibroids were embolized, leaving the large vessels of the fibroids patent. The Kaplan-Meier method and Cox regression were used

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2017 Radiology

148. Chlamydia Trachomatis Seroprevalence and Ultrasound Diagnosed Uterine Fibroids in a Large Population of Young African-American Women. (PubMed)

Chlamydia Trachomatis Seroprevalence and Ultrasound Diagnosed Uterine Fibroids in a Large Population of Young African-American Women. Reproductive tract infections have long been hypothesized to increase the risk of uterine fibroids. Few studies have been conducted, even for the common infection genital Chlamydia trachomatis (gCT), and only with self-reported gCT data. Our investigation used micro-immunofluorescence serology for gCT to characterize past exposure. We used cross-sectional (...) enrollment data from a prospective fibroid study carried out in the Detroit, Michigan, area; ultrasound examinations systematically screened for fibroids. Participants were African-American women aged 23-34 years (recruited in 2010-2012). Age- and multivariable-adjusted logistic regression models were used to estimate odds ratios. A total of 1,587 women (94% of participants) had unequivocal gCT serology results; 22% had fibroids. Those who were seropositive for gCT were less likely to have fibroids (age

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2017 American Journal of Epidemiology

149. Combining situ-morcellation with continuous-fill-mattress suture in laparoscopic myomectomy: A surgical approach of choice for patients with large uterine fibroids. (PubMed)

Combining situ-morcellation with continuous-fill-mattress suture in laparoscopic myomectomy: A surgical approach of choice for patients with large uterine fibroids. To investigate the efficacy and advantage of combining situ-morcellation with continuous-fill-mattress suture compared with conventional morcellation and suture in laparoscopic myomectomy.One hundred sixteen patients who underwent laparoscopic myomectomy from March 2014 to October 2016.Patients were divided into combining situ

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2017 Medicine

150. Uterine fibroids: from observational epidemiology to clinical management. (PubMed)

Uterine fibroids: from observational epidemiology to clinical management. 28498567 2018 12 11 2018 12 11 1471-0528 124 10 2017 09 BJOG : an international journal of obstetrics and gynaecology BJOG Uterine fibroids: from observational epidemiology to clinical management. 1513 10.1111/1471-0528.14730 Vercellini P P Fondazione Ca' Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. Frattaruolo M P MP (...) Fondazione Ca' Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. eng Journal Article Comment 2017 06 22 England BJOG 100935741 1470-0328 AIM IM BJOG. 2017 Sep;124(10):1501-1512 28296146 Humans Leiomyoma epidemiology Uterine Neoplasms epidemiology 2017 5 13 6 0 2018 12 12 6 0 2017 5 13 6 0 ppublish 28498567 10.1111/1471-0528.14730

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2017 BJOG

151. Uterine Fibroid Torsion during Pregnancy: A Case of Laparotomic Myomectomy at 18 Weeks' Gestation with Systematic Review of the Literature. (PubMed)

Uterine Fibroid Torsion during Pregnancy: A Case of Laparotomic Myomectomy at 18 Weeks' Gestation with Systematic Review of the Literature. Uterine myomas are the most common benign growths affecting female reproductive system, occurring in 20-40% of women, whereas the incidence rate in pregnancy is estimated from 0.1 to 3.9%. The lower incidence in pregnancy is due to the association with infertility and low pregnancy rates and implantation rates after in vitro fertilization treatment. Uterine (...) myomas, usually, are asymptomatic during pregnancy. However, occasionally, pedunculated fibroids torsion or other superimposed complications may cause acute abdominal pain. There are many controversies in performing myomectomy during cesarean section because of the risk of hemorrhage. Nevertheless, the majority of indication arises before labor and delivery due to acute symptoms leading to a discussion regarding the need for intervention during pregnancy. Therefore, we present a case of successful

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2017 Case reports in obstetrics and gynecology

152. Role of robotic surgery in treating fibroids and benign uterine mass. (PubMed)

Role of robotic surgery in treating fibroids and benign uterine mass. Fibroid uterus can be managed medically, surgically, or through non-extirpative procedures, depending on the clinical situation. Myomectomy may be beneficial, especially to those desiring to preserve the uterus and/or fertility, with outcomes comparable to those of hysterectomy, with a laparoscopic approach being favored when feasible. For definitive therapy, hysterectomy can be pursued where the surgical approach should (...) be individualized. Comparison of robotic-assisted laparoscopic approach shows that the robotic approach may be favored for cases with higher complexity and multiple fibroids in myomectomy; however, no clear advantage is seen with hysterectomy at this time, necessitating further research in the area of robotics for hysterectomy in benign uterine mass treatment to justify the cost.Copyright © 2017. Published by Elsevier Ltd.

2017 Best practice & research. Clinical obstetrics & gynaecology

153. Prospective Cohort Study of Uterine Fibroids and Miscarriage Risk. (PubMed)

Prospective Cohort Study of Uterine Fibroids and Miscarriage Risk. We sought to determine the relationship of fibroids to pregnancy loss in a prospective cohort in which fibroid status was uniformly documented in early pregnancy. Participants had an intake interview, transvaginal ultrasonography, computer-assisted telephone interview, and follow-up assessment of outcomes. We recruited diverse participants for the Right From the Start study from 8 metropolitan areas in 3 states in the United (...) States during 2000-2012. Participants were at least 18 years of age, trying to become pregnant or at less than 12 weeks' gestation, not using fertility treatments, fluent in English or Spanish, and available for telephone interviews. Miscarriage was defined as loss before 20 weeks' gestation. Fibroid presence, number, type, and volume were assessed using standardized ultrasonography methods. We used proportional hazards models to estimate associations. Among 5,512 participants, 10.4% had at least 1

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2017 American Journal of Epidemiology

154. Evaluation of HIFU Ablation for Uterine Fibroids: an IDEAL Prospective Exploration Study. (PubMed)

Evaluation of HIFU Ablation for Uterine Fibroids: an IDEAL Prospective Exploration Study. To evaluate the clinical outcomes of high-intensity focused ultrasound (HIFU) and surgery in treating uterine fibroids, and prepare for a definitive randomised trial.Prospective multicentre patient choice cohort study (IDEAL Exploratory study) of HIFU, myomectomy or hysterectomy for treating symptomatic uterine fibroids.20 Chinese hospitals.2411 Chinese women with symptomatic fibroids.Prospective non (...) (interquartile range, 0-5 days), 10 days (interquartile range, 8-12.5 days) and 8 days (interquartile range, 7-10 days).HIFU caused substantially less morbidity than surgery, with similar longer-term QoL. Despite group baseline differences and lack of blinding, these findings support the need for a randomised controlled trial (RCT) of HIFU treatment for fibroids. The IDEAL Exploratory design facilitated RCT protocol development.HIFU had much better short-term outcomes than surgery for fibroids in 2411

2017 BJOG

155. Evaluating the role of race and medication in protection of uterine fibroids by type 2 diabetes exposure. (PubMed)

Evaluating the role of race and medication in protection of uterine fibroids by type 2 diabetes exposure. Uterine fibroids (UF) affect 77% of women by menopause, and account for $9.4 billion in annual healthcare costs. Type-2-diabetes (T2D) has inconsistently associated with protection from UFs in prior studies. To further evaluate the relationship between T2D and UFs we tested for association between T2D and UF risk in a large clinical population as well as the potential differences due to T2D

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2017 BMC Women's Health

156. Epidemiology of uterine fibroids: a systematic review. (PubMed)

Epidemiology of uterine fibroids: a systematic review. Uterine fibroids (UFs) are the most common neoplasm affecting women that can cause significant morbidity and may adversely impact fertility.To examine UF epidemiology and to evaluate the relative strengths of putative risk factors.MEDLINE and Embase were searched for studies published in English between January 1995 and April 2015.Publications reporting relevant data from registries and other observational studies with over 1000 patients (...) observational data are needed to improve our understanding of UF epidemiology, and thus its aetiology and optimal management.Uterine fibroids occur in about 70% of women. Black race and 11 other factors affect uterine fibroid risk.© 2017 IPAS. BJOG An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists.

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2017 BJOG : an international journal of obstetrics and gynaecology

157. Recent Advances in Uterine Fibroid Etiology. (PubMed)

Recent Advances in Uterine Fibroid Etiology. Uterine fibroids, also known as uterine leiomyoma (UL), are monoclonal tumors of the smooth muscle tissue layer (myometrium) of the uterus. Although ULs are considered benign, uterine fibroids are the source of major quality-of-life issues for approximately 25% of all women, who suffer from clinically significant symptoms of UL. Despite the prevalence of UL, there is no treatment option for UL which is long term, cost-effective, and leaves fertility (...) intact. The lack of understanding about the etiology of UL contributes to the scarcity of medical therapies available. Studies have identified an important role for sex steroid hormones in the pathogenesis of UL, and have driven the use of hormonal treatment for fibroids, with mixed results. Dysregulation of cell signaling pathways, miRNA expression, and cytogenetic abnormalities have also been implicated in UL etiology. Recent discoveries on the etiology of UL and the development of relevant

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2017 Seminars in Reproductive Medicine

158. Long-Term Safety and Efficacy of Elagolix in Combination With Estradiol/ Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women

Long-Term Safety and Efficacy of Elagolix in Combination With Estradiol/ Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women Long-Term Safety and Efficacy of Elagolix in Combination With Estradiol/ Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer (...) to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Long-Term Safety and Efficacy of Elagolix in Combination With Estradiol/ Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women The safety and scientific validity of this study is the responsibility

2017 Clinical Trials

159. A Study on the Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With Safety and Efficacy

A Study on the Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With Safety and Efficacy A Study on the Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With Safety and Efficacy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. A Study on the Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With Safety and Efficacy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2017 Clinical Trials

160. Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids

Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Assess (...) Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 6) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03194646 Recruitment Status : Active, not recruiting First Posted : June 21, 2017 Last Update Posted : March 5, 2019 Sponsor: Bayer Information provided by (Responsible

2017 Clinical Trials

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