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Uterine Fibroid

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121. Hyperkalemia and acute kidney failure associated with preoperative uterine artery embolization for a large uterine fibroid: a case report (PubMed)

Hyperkalemia and acute kidney failure associated with preoperative uterine artery embolization for a large uterine fibroid: a case report Preoperative uterine artery embolization has been shown to help reduce blood loss, with few complications. Most reports indicated that uterine artery embolization is safe for uterine fibrosis; the occurrence of hyperkalemia and acute kidney failure as complications of preoperative uterine artery embolization has not been reported previously. Here we report (...) the occurrence of hyperkalemia and acute kidney failure after preoperative uterine artery embolization for a large uterine fibroid. To the best of our knowledge, this is the first report on the occurrence of hyperkalemia and acute kidney failure after preoperative uterine artery embolization.A 48-year-old Japanese woman presented to our hospital complaining of compression in her abdomen and an abdominal mass. Magnetic resonance imaging showed a large uterine fibroid measuring 37.5×27×13.5 cm. Therefore, we

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2016 Journal of medical case reports

122. Management of Uterine Fibroids: A Focus on Uterine-sparing Interventional Techniques. (PubMed)

Management of Uterine Fibroids: A Focus on Uterine-sparing Interventional Techniques. Uterine fibroids occur in approximately 50% of women over the age of 40 years, and an estimated 50% of those are symptomatic. Menorrhagia is the most common symptom and the primary indication for treatment, although bulk symptoms often occur and can be treated. Pharmacotherapy is typically inadequate unless it can be expected to successfully bridge to menopause or allow for a less-invasive intervention (...) . However, hormonal therapies have risks. Hysterectomy is still the most commonly performed procedure for symptomatic fibroids and has the lowest rate of reintervention (compared with myomectomy or uterine artery embolization [UAE]), but rates of more serious complications are higher and patient satisfaction and ability to return to normal activities may also be less favorable. Myomectomy is not necessarily less morbid than hysterectomy and may have a greater failure rate than UAE. Techniques

2016 Radiology

123. Uterine artery embolization versus hysterectomy in the treatment of symptomatic uterine fibroids: 10-years' outcomes from the randomized EMMY trial. (PubMed)

Uterine artery embolization versus hysterectomy in the treatment of symptomatic uterine fibroids: 10-years' outcomes from the randomized EMMY trial. Since 1995 uterine artery embolization has been described as an alternative for hysterectomy in patients with symptomatic fibroids. Many studies including several randomized controlled trials established uterine artery embolization as a valuable treatment. These randomized controlled trials reported outcomes in terms of health-related quality (...) of life, clinical outcomes, efficacy, and cost-effectiveness after 1, 2, and 5 years of follow-up.The purpose of this study was to compare clinical outcome and health-related quality of life 10 years after uterine artery embolization or hysterectomy in the treatment of heavy menstrual bleeding caused by uterine fibroids in a randomized controlled trial.In all, 28 Dutch hospitals recruited patients with symptomatic uterine fibroids who were eligible for hysterectomy. Patients were 1:1 randomly assigned

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2016 American Journal of Obstetrics and Gynecology Controlled trial quality: predicted high

124. Uterine artery embolization versus surgery in the treatment of symptomatic fibroids: a systematic review and metaanalysis

Uterine artery embolization versus surgery in the treatment of symptomatic fibroids: a systematic review and metaanalysis Uterine artery embolization versus surgery in the treatment of symptomatic fibroids: a systematic review and metaanalysis Uterine artery embolization versus surgery in the treatment of symptomatic fibroids: a systematic review and metaanalysis van der Kooij SM, Bipat S, Hehenkamp WJ, Ankum WM, Reekers JA CRD summary The authors concluded that uterine artery embolization had (...) short-term advantages over surgery. Benefits were similar at mid- and long-term follow-up except for a high re-intervention rate after uterine artery embolization. Parts of the review were well-conducted, but some caution is needed when interpreting the magnitude of effect in relation to the authors' conclusion. Authors' objectives To compare uterine artery embolization with surgery for the treatment of symptomatic fibroids. Searching Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE

2011 DARE.

125. Satisfaction of Patients With Trans-Arterial Radial Access: Quality of Life in Uterine Fibroid Embolization Trial

Satisfaction of Patients With Trans-Arterial Radial Access: Quality of Life in Uterine Fibroid Embolization Trial Satisfaction of Patients With Trans-Arterial Radial Access: Quality of Life in Uterine Fibroid Embolization Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Satisfaction of Patients With Trans-Arterial Radial Access: Quality of Life in Uterine Fibroid Embolization Trial (SPARQLE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03021720 Recruitment Status : Unknown Verified January 2017

2017 Clinical Trials

126. LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids

LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03049735 Recruitment Status : Active

2017 Clinical Trials

127. Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids

Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids (PRIMROSE 2) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2017 Clinical Trials

128. Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids

Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids (PRIMROSE 1) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2017 Clinical Trials

129. Epidemiology and Risk Factors of Uterine Fibroids. (PubMed)

Epidemiology and Risk Factors of Uterine Fibroids. Risk factors, both modifiable and non-modifiable, are associated with the development of fibroids. These include age, race, endogenous and exogenous hormonal factors, obesity, uterine infection, and lifestyle (diet, caffeine and alcohol consumption, physical activity, stress, and smoking). Some of the epidemiological data were conflicting; consequently, further studies are needed to better understand the factors that influence fibroid

2017 Best practice & research. Clinical obstetrics & gynaecology

130. Fertility after uterine artery embolization of fibroids: a systematic review. (PubMed)

Fertility after uterine artery embolization of fibroids: a systematic review. The impact of uterine artery embolization (UAE) for the purpose of diminishing the effect of uterine fibroids on fertility is unclear. We have investigated the reported rates of pregnancy and miscarriage after treatment of uterine fibroids with UAE.We searched for relevant information in PubMed and Embase for randomized controlled trials (RCT), controlled clinical trials, comparative before-after trials, cohort (...) studies, case-control studies and case series where UAE treatment of premenopausal women was performed for uterine fibroids with and where a control intervention was included. The PRISMA guideline was used to do a systematic review using the main outcomes pregnancy rate and miscarriage rate. Risk of bias was assessed by the Cochrane risk of bias tool or by ROBINS-I. The quality of evidence was assessed by the GRADE approach.We included 17 studies (989 patients): 1 RCT, 2 cohort studies, and 14 case

2017 Archives of gynecology and obstetrics

131. Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids

Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment of Heavy (...) Menstrual Bleeding in Women With Uterine Fibroids The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03317795 Recruitment Status : Recruiting First Posted : October 23, 2017 Last Update Posted : January 14, 2019 See Sponsor

2017 Clinical Trials

132. Impact of uterine fibroid symptoms on health-related quality of life of US women: evidence from a cross-sectional survey. (PubMed)

Impact of uterine fibroid symptoms on health-related quality of life of US women: evidence from a cross-sectional survey. Uterine fibroids (UF) are associated with significant health-related quality of life (HRQL) impact. This study examined the impact of UF symptoms on HRQL.An online cross-sectional survey of 18 to 49 year old US women was conducted and collected demographics, UF prevalence, symptoms, and HRQL using the UFS-QOL. Descriptive statistics were used to examine the impact of symptom

2017 Current medical research and opinion

133. Proteomic profiling of human uterine fibroids reveals upregulation of the extracellular matrix protein periostin. (PubMed)

Proteomic profiling of human uterine fibroids reveals upregulation of the extracellular matrix protein periostin. The central characteristic of uterine fibroids is excessive deposition of extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little is known about patterns of ECM protein expression in fibroids and whether these are influenced by the most common genetic anomalies, which relate to MED12. We performed extensive genetic (...) and proteomic analyses of clinically annotated fibroids and adjacent normal myometrium to identify the composition and expression patterns of ECM proteins in MED12 mutation-positive and mutation-negative uterine fibroids. Genetic sequencing of tissue samples revealed MED12 alterations in 39 of 65 fibroids (60%) from 14 patients. Using isobaric tagged-based quantitative mass spectrometry on three selected patients (n = 9 fibroids), we observed a common set of upregulated (>1.5-fold) and downregulated (<0.66

2017 Endocrinology

134. The past, present, and future of selective progesterone receptor modulators in the management of uterine fibroids. (PubMed)

The past, present, and future of selective progesterone receptor modulators in the management of uterine fibroids. Uterine fibroids are common in women of reproductive age and can have a significant impact on quality of life and fertility. Although a number of international obstetrics/gynecology societies have issued evidence-based clinical practice guidelines for the management of symptomatic uterine fibroids, many of these guidelines do not yet reflect the most recent clinical evidence (...) in uterine fibroids and other gynecologic conditions.Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

2017 American Journal of Obstetrics and Gynecology

135. High-intensity focused ultrasound (HIFU) treatment for uterine fibroids: a meta-analysis. (PubMed)

High-intensity focused ultrasound (HIFU) treatment for uterine fibroids: a meta-analysis. High-intensity focused ultrasound (HIFU) is a non-invasive uterine-preserving treatment alternative to hysterectomy for women with fibroids.We performed this meta-analysis to evaluate the efficacy of HIFU in the treatment of women with symptomatic fibroids comparing it to other approaches including medical treatment with mifepristone (Mife), traditional surgery with myomectomy or hysterectomy (MYC/HRM (...) , transfusion, genital tract, gastrointestinal tract, and anesthesia-related complications, while no superiority was identified for skin burn, urinary tract, and nervous system complications.These results suggest that HIFU treatment of uterine leiomyomas leads to clinical improvement with few significant clinical complications and adverse events.

2017 Archives of gynecology and obstetrics

136. Uterine fibroids with positive 18F-FDG PET/CT image and significantly increased CA19-9: A case report. (PubMed)

Uterine fibroids with positive 18F-FDG PET/CT image and significantly increased CA19-9: A case report. Uterine fibroids are the most common pelvic solid tumors and common to 25% of women. F-fluorodexyglucose (F-FDG) is an energy metabolism tracer. Although FDG is generally concentrated in malignant lesions with high glucose metabolism, it can also accumulate in normal tissues, benign lesions, and inflammatory sites. The exact mechanism of FDG uptake by uterine fibroids is not clear. Here, we (...) report a case of uterine fibroids with positive F-FDG positron emission tomography/computed tomography (PET/CT) imaging and significantly increased CA19-9.The patient was a 43-year-old woman and admitted to our hospital because of "1-year-extended menstrual periods." At admission, she had normal CA125, AFP, and CEA level and CA19-9>1000.00 U/mL. Gynecological transvaginal ultrasound found enlarged uterus with an anterior hypoechoic area of 3.9 × 4.2 cm. CT and contrast-enhanced CT showed

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2017 Medicine

137. The current place of medical therapy in uterine fibroid management. (PubMed)

The current place of medical therapy in uterine fibroid management. Uterine fibroids (also known as leiomyomas or myomas) are the most common form of benign uterine tumors. Current management strategies mainly involve surgical interventions, but the choice of treatment is guided by patient's age and desire to preserve fertility or avoid "radical" surgery. Surgical and non-surgical approaches include hysterectomy myomectomy by hysteroscopy, myomectomy by laparotomy or laparoscopy, uterine artery (...) embolization, and magnetic resonance-guided focused ultrasound surgery. The need for alternatives to surgical intervention is very real, especially for women seeking to preserve their fertility. There is growing evidence of the crucial role of progesterone pathways in the pathophysiology of uterine fibroids, and the efficacy of long-term intermittent use of selective progesterone receptor modulators such as ulipristal acetate was recently demonstrated by randomized controlled studies.Copyright © 2017

2017 Best practice & research. Clinical obstetrics & gynaecology

138. Admixture mapping of uterine fibroid size and number in African American women. (PubMed)

Admixture mapping of uterine fibroid size and number in African American women. To evaluate the relationship between genetic ancestry and uterine fibroid characteristics.Cross-sectional study.Not applicable.A total of 609 African American participants with image- or surgery-confirmed fibroids in a biorepository at Vanderbilt University electronic health record biorepository and the Coronary Artery Risk Development in Young Adults studies were included.None.Outcome measures include fibroid (...) number (single vs. multiple), volume of largest fibroid, and largest fibroid dimension of all fibroid measurements.Global ancestry meta-analyses revealed a significant inverse association between percentage of European ancestry and risk of multiple fibroids (odds ratio: 0.78; 95% confidence interval 0.66, 0.93; P=6.05 × 10-3). Local ancestry meta-analyses revealed five suggestive (P<4.80 × 10-3) admixture mapping peaks in 2q14.3-2q21.1, 3p14.2-3p14.1, 7q32.2-7q33, 10q21.1, 14q24.2-14q24.3, for number

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2017 Fertility and Sterility

139. The Effect of Uterine Fibroids on Infertility: A Systematic Review. (PubMed)

The Effect of Uterine Fibroids on Infertility: A Systematic Review. 29100240 2018 08 28 2018 12 02 1526-4564 35 6 2017 11 Seminars in reproductive medicine Semin. Reprod. Med. The Effect of Uterine Fibroids on Infertility: A Systematic Review. 523-532 10.1055/s-0037-1607295 Whynott Rachel M RM Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida. Vaught Kamaria C Cayton KCC Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, Maryland (...) effects trends Humans Infertility etiology prevention & control therapy Leiomyoma physiopathology surgery therapy Leiomyomatosis physiopathology surgery therapy Practice Guidelines as Topic Reproductive Techniques, Assisted Uterine Myomectomy adverse effects Uterine Neoplasms physiopathology surgery therapy Disclosure The authors report no conflicts of interest in this work. 2017 11 4 6 0 2017 11 4 6 0 2018 8 29 6 0 ppublish 29100240 10.1055/s-0037-1607295

2017 Seminars in Reproductive Medicine

140. Focus on Uterine Fibroids: Evolving Options to Optimize Care. (PubMed)

Focus on Uterine Fibroids: Evolving Options to Optimize Care. 28866121 2018 01 26 2018 01 26 1097-6868 217 5 2017 11 American journal of obstetrics and gynecology Am. J. Obstet. Gynecol. Focus on uterine fibroids: evolving options to optimize care. 626 S0002-9378(17)30966-3 10.1016/j.ajog.2017.08.019 Singh Sukhbir Sony SS Associate Professor and Vice-Chair of Gynecology, Department of Obstetrics and Gynecology, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada. Marsh Erica E EE (...) Associate Professor and Chief, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan Health System University of Michigan, Ann Arbor, Michigan. eng Journal Article Research Support, Non-U.S. Gov't 2017 09 01 United States Am J Obstet Gynecol 0370476 0002-9378 AIM IM Female Humans Leiomyoma diagnosis therapy Uterine Neoplasms diagnosis therapy 2017 9 4 6 0 2018 1 27 6 0 2017 9 4 6 0 ppublish 28866121 S0002-9378(17)30966-3 10.1016/j.ajog

2017 American Journal of Obstetrics and Gynecology

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