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Uterine Fibroid

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21. Uterine fibroids: Correlations of anemia and pain to fibroid location and uterine weight. (PubMed)

Uterine fibroids: Correlations of anemia and pain to fibroid location and uterine weight. To estimate the prevalence of anemia, pelvic pain and heavy vaginal bleeding among symptomatic women with and without submucosal fibroids who presented for uterine fibroid embolization (UFE), and to determine if uterine weight was related to patient reports of heavy bleeding and pelvic pain.A case series study was performed that reviewed the ambulatory medical records of 357 symptomatic women with uterine (...) fibroids seeking UFE from 2001 to 2009. Women with at least one submucosal fibroid were included as cases. Uterine weight was calculated by using ultrasound measurements.Women, regardless of fibroid location, were equally likely to report heavy bleeding or be diagnosed with anemia. However, among women with complaints of pelvic pain or heavy bleeding, uterine weight was found to be higher in women with at least one submucosal fibroid as compared to women with fibroids in locations other than

2017 Journal of Reproductive Medicine

22. Evidence of biomechanical and collagen heterogeneity in uterine fibroids. (PubMed)

Evidence of biomechanical and collagen heterogeneity in uterine fibroids. Uterine fibroids (leiomyomas) are common benign tumors of the myometrium but their molecular pathobiology remains elusive. These stiff and often large tumors contain abundant extracellular matrix (ECM), including large amounts of collagen, and can lead to significant morbidities. After observing structural multiformities of uterine fibroids, we aimed to explore this heterogeneity by focusing on collagen and tissue (...) through the investigation of the complexity of the chemical and biochemical signaling in fibroid development, the correlation of collagen content and mechanical properties in uterine fibroids, and the mechanical forces involved in fibroid development as affected by the various components of the ECM.

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2019 PLoS ONE

23. Phthalates exposure and uterine fibroid burden among women undergoing surgical treatment for fibroids: a preliminary study. (PubMed)

Phthalates exposure and uterine fibroid burden among women undergoing surgical treatment for fibroids: a preliminary study. To examine the association between phthalate exposure and two measures of uterine fibroid burden: diameter of largest fibroid and uterine volume.Pilot, cross-sectional study.Academic medical center.Fifty-seven premenopausal women undergoing either hysterectomy or myomectomy for fibroids.None.The diameter of the largest fibroid and uterine dimensions were abstracted from (...) for individual DEHP metabolites (MEHHP, MEOHP, MECPP), ∑DEHP, and ∑AA Phthalates. For example, a doubling in ∑DEHP and ∑AA Phthalates was associated with 33.2% (95% confidence interval 6.6-66.5) and 26.8% (95% confidence interval 2.2-57.4) increase in uterine volume, respectively. There were few associations between phthalate biomarkers and fibroid size.Exposure to some phthalate biomarkers was positively associated with uterine volume, which further supports the hypothesis that phthalate exposures may

2018 Fertility and Sterility

24. Uterine Necrosis after Uterine Artery Embolization for Symptomatic Fibroids (PubMed)

Uterine Necrosis after Uterine Artery Embolization for Symptomatic Fibroids Uterine artery embolization (UAE) is a minimally invasive intervention that is used in the treatment of fibroids. UAE can lead to complications including postembolization syndrome, postprocedure pain, infection, endometrial atrophy leading to secondary amenorrhea, and uterine necrosis. Uterine necrosis after UAE is very rare and hence poses a clinical dilemma for any clinician in its identification and management. We (...) document a case of uterine necrosis after UAE and conduct a literature review on its causation, clinical features, and management principles.A patient presented one month after UAE with abdominal pain and abdominal vaginal discharge. Her work-up revealed features of possible uterine necrosis with sepsis and she was scheduled for a laparotomy and a subtotal hysterectomy was performed. She was subsequently managed with broad spectrum antibiotic and recovered well.Uterine necrosis after UAE is a rare

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2018 Case reports in obstetrics and gynecology

25. Application of a ‘Baseball’ Suture Technique in Uterine Myomectomy Following Laparoscopic Enucleation of Uterine Leiomyoma (Fibroid) (PubMed)

Application of a ‘Baseball’ Suture Technique in Uterine Myomectomy Following Laparoscopic Enucleation of Uterine Leiomyoma (Fibroid) BACKGROUND The aim of this study was to evaluate the safety and efficacy of a 'baseball' suture technique for uterine myomectomy incision closure in laparoscopic surgical enucleation of uterine leiomyoma (fibroid). MATERIAL AND METHODS The study included 20 patients who underwent laparoscopic myomectomy with a 'baseball' suture technique, compared with 20 (...) in pregnancy outcomes between the two groups. CONCLUSIONS The 'baseball' suture technique for closure of the uterine incision is a safe and effective method for use in laparoscopic myomectomy. However, the long-term recovery outcomes require further study.

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2018 Medical science monitor : international medical journal of experimental and clinical research

26. Uterine anteversion after uterine fibroid embolization (PubMed)

Uterine anteversion after uterine fibroid embolization Uterine fibroid embolization has been proven effective in treating symptomatic uterine fibroids for appropriately selected patients as an alternative option to surgical approaches. The most common adult uterine position is anteverted followed by a retroverted uterus which can be found in roughly 15%-20% of normal adult females. The positioning of the uterus can change from anteversion to retroversion due to the filling of bladder or during (...) pregnancy; however, changing from retroverted to anteverted position without prior pregnancy or endometriosis is rather uncommon. Here, we describe a case of uterine orientation change from retroversion to anteversion presenting 6 months after uterine fibroid embolization.

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2018 Radiology Case Reports

27. Utility of Laparoscopic Uterine Myomectomy as a Treatment for Infertility with No Obvious Cause Except for Uterine Fibroids (PubMed)

Utility of Laparoscopic Uterine Myomectomy as a Treatment for Infertility with No Obvious Cause Except for Uterine Fibroids Uterine fibroids are capable of causing infertility, but there are no definite criteria for which laparoscopic uterine myomectomy (LM) is known to be beneficial. To investigate the usefulness of LM, we examined pregnancy rates in patients with infertility with no obvious cause except for the presence of uterine fibroids.We retrospectively reviewed the clinical records (...) ) in the non-LM group. There were no pregnancies in patients with >10 fibroids. The postoperative pregnancy rate in the LM group was comparable to previously reported pregnancy rates.Our criteria for performing LM in patients with no obvious cause for infertility except for uterine fibroids seem appropriate, especially when the fibroids are large and the number of fibroids is between 4 and 9. However, our results suggest that the effectiveness of LM is low in patients with 10 or more uterine fibroids.

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2018 Gynecology and Minimally Invasive Therapy

28. Reintervention Rates After Myomectomy, Endometrial Ablation, and Uterine Artery Embolization for Patients with Uterine Fibroids (PubMed)

Reintervention Rates After Myomectomy, Endometrial Ablation, and Uterine Artery Embolization for Patients with Uterine Fibroids Women with uterine fibroids (UF) may undergo less invasive procedures than hysterectomy, including myomectomy, endometrial ablation (EA), and uterine artery embolization (UAE); however, long-term need for reintervention is not well characterized. We estimated reintervention rates for 5 years and identified predictors of reintervention.A longitudinal retrospective

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2018 Journal of Women's Health

29. Effects of TGF-β on uterine fibroids of women of childbearing age and uterine artery embolization. (PubMed)

Effects of TGF-β on uterine fibroids of women of childbearing age and uterine artery embolization. To evaluate the effects of transforming growth factor-β (TGF-β) on uterine fibroids of women of childbearing age and uterine artery embolization (UAE) using Embosphere microspheres.A total of 128 eligible women were randomly divided into an experimental group and a control group (n = 64) who received UAE using Embosphere microspheres and panhysterectomy, respectively. Another 128 healthy women (...) receiving physical examination in the same period were also enrolled. Serum TGF-β levels were detected by enzyme-linked immunosorbent assay (ELISA). Serum TGF-β level, size of uterine fibroid and prognosis were followed up.The serum TGF-β level of patients was significantly higher than that of healthy subjects. After treatment, the red blood cell counts and hemoglobin levels of the two patient groups significantly increased compared with those before (p < .05). After UAE, the diameter of uterine

2018 Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy Controlled trial quality: uncertain

30. Magnetic Resonance-Guided High-Intensity Focused Ultrasound for Treatment of Women with Symptomatic Uterine Fibroids

Magnetic Resonance-Guided High-Intensity Focused Ultrasound for Treatment of Women with Symptomatic Uterine Fibroids Magnetic Resonance –Guided High-Intensity Focused Ultrasound (MRgHIFU) for Treatment of Symptomatic Uterine Fibroids: OHTAC Recommendation ONTARIO HEALTH TECHNOLOGY ADVISORY COMMITTEE MARCH 2015 Magnetic Resonance –Guided High-Intensity Focused Ultrasound (MRgHIFU) for Treatment of Symptomatic Uterine Fibroids: OHTAC Recommendation. March 2015; pp. 1 –13 Magnetic Resonance (...) –Guided High-Intensity Focused Ultrasound (MRgHIFU) for Treatment of Symptomatic Uterine Fibroids: OHTAC Recommendation. March 2015; pp. 1 –13 2 Suggested Citation This report should be cited as follows: Ontario Health Technology Advisory Committee (OHTAC). Magnetic resonance –guided high-intensity focused ultrasound (MRgHIFU) for treatment of symptomatic uterine fibroids: OHTAC recommendation [Internet]. Toronto: Queen's Printer for Ontario; 2015 March. 13 p. Available from: http://www.hqontario.ca

2015 Health Quality Ontario

31. The Management of Uterine Fibroids in Women With Otherwise Unexplained Infertility

The Management of Uterine Fibroids in Women With Otherwise Unexplained Infertility The Management of Uterine Fibroids in Women With Otherwise Unexplained Infertility - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 37, Issue 3, Pages 277–285 The Management of Uterine Fibroids in Women With Otherwise Unexplained Infertility PRINCIPAL AUTHORS, x Belina Carranza-Mamane , MD Sherbrooke QC x Jon Havelock , MD Vancouver BC x (...) and outcomes with management of fibroids in women with infertility. Evidence Published literature was retrieved through searches of PubMed, MEDLINE, the Cochrane Library in November 2013 using appropriate controlled vocabulary (e.g., leiomyoma, infertility, uterine artery embolization, fertilization in vitro) and key words (e.g., fibroid, myomectomy). Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies published in English

2015 Society of Obstetricians and Gynaecologists of Canada

32. Interventions for the Management of Symptomatic Uterine Fibroids

Interventions for the Management of Symptomatic Uterine Fibroids Interventions for the Management of Symptomatic Uterine Fibroids | CADTH.ca Find the information you need Interventions for the Management of Symptomatic Uterine Fibroids Interventions for the Management of Symptomatic Uterine Fibroids Published on: July 16, 2015 Project Number: RE0030 Product Line: Result type: Report The Canadian Agency for Drugs and Technologies in Health (CADTH) is undertaking a project on less invasive (...) treatment options for women who suffer from symptomatic uterine fibroids. Uterine fibroids are the most common benign pelvic tumours in women and can have a major impact on women’s health due to abnormal bleeding, pelvic or abdominal pain, and infertility. Surgical removal of the uterus (hysterectomy) is the conventional treatment for symptomatic uterine fibroids. While this can solve some of the problems, hysterectomy is also associated with a high risk of post-operative complications such as pain

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

33. The Management of Uterine Fibroids in Women With Otherwise Unexplained Infertility

The Management of Uterine Fibroids in Women With Otherwise Unexplained Infertility MARCH JOGC MARS 2015 l 277 No. 321, March 2015 SOGC CLINICAL PRACTICE GUIDELINE The Management of Uterine Fibroids in Women With Otherwise Unexplained Infertility This document reflects emerging clinical and scientific advances on the date issued and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed. Local institutions can (...) Tannys Vause, MD, Ottawa ON Benjamin Wong, MD, Calgary AB SPECIAL CONTRIBUTOR Margaret Burnett, MD, Winnipeg MB Disclosure statements have been received from all contributors . Keywords: Female infertility, unexplained infertility, fibroid, leiomyoma, myomectomy, uterine artery embolization, in vitro fertilization, ovarian reserve, ulipristal acetate, magnetic resonance-guided focused ultrasound surgery . J Obstet Gynaecol Can 2015;37(3):277–285 Abstract Objective: To provide recommendations

2015 Society of Obstetricians and Gynaecologists of Canada

34. Effect of radiofrequency ablation on the treatment of uterine fibroid and a postprocedural inpatient hospitalization: a systematic review and meta analysis

Effect of radiofrequency ablation on the treatment of uterine fibroid and a postprocedural inpatient hospitalization: a systematic review and meta analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

35. Uterine artery embolization versus surgery for symptomatic uterine fibroids: a randomized controlled trial and a meta-analysis of the literature

Uterine artery embolization versus surgery for symptomatic uterine fibroids: a randomized controlled trial and a meta-analysis of the literature Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

36. Uterine Fibroid Embolization (UFE) for Symptomatic Fibroids: Comparison of Gel-Bead to Commonly Used Embolic Agents.

Uterine Fibroid Embolization (UFE) for Symptomatic Fibroids: Comparison of Gel-Bead to Commonly Used Embolic Agents. Uterine Fibroid Embolization (UFE) for Symptomatic Fibroids: Comparison of Gel-Bead to Commonly Used Embolic Agents. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Uterine Fibroid Embolization (UFE) for Symptomatic Fibroids: Comparison of Gel-Bead to Commonly Used Embolic Agents. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03072446 Recruitment Status : Completed First Posted : March

2017 Clinical Trials

37. Fibroid vascularisation as a predictor for uterine fibroid growth. (PubMed)

Fibroid vascularisation as a predictor for uterine fibroid growth. 28485851 2019 02 15 2019 02 15 1471-0528 125 5 2018 04 BJOG : an international journal of obstetrics and gynaecology BJOG Fibroid vascularisation as a predictor for uterine fibroid growth. 585 10.1111/1471-0528.14727 Dueholm M M Aarhus University Hospital, Aarhus, Denmark. eng Journal Article Comment 2017 07 17 England BJOG 100935741 1470-0328 AIM IM BJOG. 2018 Apr;125(5):577-584 28211610 Humans Leiomyoma Prospective Studies (...) Ultrasonography Ultrasonography, Doppler Uterine Neoplasms 2017 5 10 6 0 2019 2 16 6 0 2017 5 10 6 0 ppublish 28485851 10.1111/1471-0528.14727

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2017 BJOG

38. Fibroid vascularisation assessed with three dimensional Power Doppler ultrasound is a predictor for uterine fibroid growth: a prospective cohort study. (PubMed)

Fibroid vascularisation assessed with three dimensional Power Doppler ultrasound is a predictor for uterine fibroid growth: a prospective cohort study. To analyse fibroid vascularisation measured with three-dimensional (3D) power Doppler in relation to absolute fibroid volume change during 12 months of follow up and in relation to fibroid growth rate per year.A prospective cohort study was performed between March 2012 and March 2014.Outpatient clinic of the VU medical centre, Amsterdam.All (...) rate per year (P = 0.04).In women with uterine fibroids without therapy, baseline vascularisation (VI) measured with 3D power Doppler is correlated with absolute fibroid volume change at 12 months and with fibroid growth rate per year.Fibroid vascularisation correlates with absolute fibroid volume change and fibroid growth rate per year.© 2017 Royal College of Obstetricians and Gynaecologists.

2017 BJOG

39. Diagnostic ambiguity of aseptic necrobiosis of a uterine fibroid in a term pregnancy: a case report. (PubMed)

Diagnostic ambiguity of aseptic necrobiosis of a uterine fibroid in a term pregnancy: a case report. Uterine fibroids are the most common uterine tumours in females of reproductive age. During pregnancy, uterine fibroids may be complicated by aseptic necrobiosis. We herein report an ambiguous clinical presentation of uterine fibroids in pregnancy and discuss the diagnostic challenges encountered in our resource-constraint setting.A term pregnant Cameroonian woman was admitted to our maternity (...) unit with clinical findings suggestive of a strangulated umbilical hernia. She underwent an emergency caesarean section which fortuitously revealed aseptic necrobiosis of a uterine fibroid, managed within the same surgical intervention by myomectomy. Her post-operative course was uneventful.The authors highlight the need for a high index of suspicion by healthcare providers, as well as the need for a multidisciplinary approach for a favourable maternal and foetal outcome.

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2019 BMC Pregnancy and Childbirth

40. Ultrasound-guided high-intensity focused ultrasound in the treatment of uterine fibroids. (PubMed)

Ultrasound-guided high-intensity focused ultrasound in the treatment of uterine fibroids. The aim of the present study was to investigate factors affecting ablation effect and safety of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for uterine fibroids (UFs).A retrospective analysis of 346 patients with symptomatic UFs who were treated with USgHIFU was performed. All UFs was grouped based on magnetic resonance imaging (MRI) characteristics before HIFU; all adverse events (...) , hypointense (T2WI), and mild enhancement (T1WI contrast enhancement) UFs had the highest ablation rate. The EEF of the anterior, intramural, hypointense (T2WI), mild enhancement (T1WI contrast enhancement), and >5 cm UFs had minimum value, with a statistically significant difference (P < .01). According to multiple linear regression model, the distance from the UFs ventral side to the skin, enhancement type on T1WI, size of UFs, signal intensity on T2WI, location of UFs, type and volume of fibroids all

2019 Medicine

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