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Uterine Fibroid

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2621. Fibroids (Uterine Leiomyoma)

Fibroids (Uterine Leiomyoma) Fibroids | Doctor | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Fibroids Authored by , Reviewed by | Last edited 20 Jan 2015 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the article more (...) useful, or one of our other . In this article In This Article Fibroids In this article Synonyms: uterine leiomyomas; myomas Fibroids are extremely common benign monoclonal tumours of the smooth muscle cells of the uterine myometrium, containing a large amount of extracellular matrix with disordered collagen. They start as multiple, single-cell seedlings distributed throughout the uterine wall. These then increase in size very slowly over many years, stimulated by oestrogens and progestogens

2008 Mentor

2622. The EMMY trial of uterine artery embolization for the treatment of symptomatic uterine fibroid tumors: randomized, yes, but a flawed trial nonetheless. (Abstract)

The EMMY trial of uterine artery embolization for the treatment of symptomatic uterine fibroid tumors: randomized, yes, but a flawed trial nonetheless. 16567666 2006 09 12 2007 11 15 1051-0443 17 3 2006 Mar Journal of vascular and interventional radiology : JVIR J Vasc Interv Radiol The EMMY trial of uterine artery embolization for the treatment of symptomatic uterine fibroid tumors: randomized, yes, but a flawed trial nonetheless. 413-5 Spies James B JB Department of Radiology, Georgetown (...) Failure Uterine Neoplasms therapy Uterus blood supply 2006 3 29 9 0 2006 9 13 9 0 2006 3 29 9 0 ppublish 16567666 17/3/413 10.1097/01.rvi.0000203420.62462.0f

2006 Journal of vascular and interventional radiology : JVIR Controlled trial quality: uncertain

2623. Emmy Trial: Uterine Artery Embolization (UAE) Versus Hysterectomy for Uterine Fibroids

Emmy Trial: Uterine Artery Embolization (UAE) Versus Hysterectomy for Uterine Fibroids Emmy Trial: Uterine Artery Embolization (UAE) Versus Hysterectomy for Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Emmy Trial: Uterine Artery Embolization (UAE) Versus Hysterectomy for Uterine Fibroids The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00100191 Recruitment Status : Completed First Posted : December 24, 2004 Last Update Posted : June 24, 2005 Sponsor: ZonMw: The Netherlands

2004 Clinical Trials

2624. Pain Management During Uterine Artery Embolization for Symptomatic Uterine Fibroids (Full text)

Pain Management During Uterine Artery Embolization for Symptomatic Uterine Fibroids 17533543 2007 11 30 2018 11 13 0174-1551 30 4 2007 Jul-Aug Cardiovascular and interventional radiology Cardiovasc Intervent Radiol Pain management during uterine artery embolization for symptomatic uterine fibroids. 809-11 Lampmann L E LE Lohle P N PN Smeets A A Boekkooi P F PF Vervest H H van Oirschot C M CM Bremer R C RC eng Comment Letter 2007 05 29 United States Cardiovasc Intervent Radiol 8003538 0174-1551 (...) & dosage Dexamethasone administration & dosage Diclofenac administration & dosage Droperidol administration & dosage Drug Administration Schedule Drug Therapy, Combination Embolization, Therapeutic methods Female Humans Infusions, Intravenous Leiomyoma blood supply therapy Pain drug therapy Pain Measurement Pirinitramide administration & dosage Suppositories Uterine Neoplasms blood supply therapy Uterus blood supply 2007 03 29 2007 04 13 2007 03 29 2007 5 30 9 0 2007 12 6 9 0 2007 5 30 9 0 ppublish

2007 Cardiovascular and interventional radiology PubMed abstract

2625. Uterine artery embolisation to treat symptomatic uterine fibroids (Full text)

Uterine artery embolisation to treat symptomatic uterine fibroids 17916857 2007 10 15 2018 11 13 1756-1833 335 7622 2007 Oct 06 BMJ (Clinical research ed.) BMJ Uterine artery embolisation to treat symptomatic uterine fibroids. 720-2 Watkinson A A Royal Devon and Exeter Hospital and Peninsula Medical School, Exeter EX2 5DW. Anthony.Watkinson@rdeft.nhs.uk Nicholson A A eng Case Reports Journal Article Review England BMJ 8900488 0959-8138 AIM IM Adult Embolization, Therapeutic adverse effects (...) methods Female Humans Leiomyoma therapy Treatment Outcome Uterine Neoplasms therapy Uterus blood supply 11 2007 10 6 9 0 2007 10 16 9 0 2007 10 6 9 0 ppublish 17916857 335/7622/720 10.1136/bmj.39251.440069.AD PMC2001040 BJOG. 2003 Dec;110(12):1139 14664893 Presse Med. 1995 Dec 2;24(37):1754 8545421 Am J Obstet Gynecol. 2005 Nov;193(5):1618-29 16260201 Obstet Gynecol. 2005 Dec;106(6):1309-18 16319257 N Engl J Med. 2007 Jan 25;356(4):360-70 17251532 Cochrane Database Syst Rev. 2006;(1):CD005073 16437515

2007 BMJ : British Medical Journal PubMed abstract

2626. Markers of muscle ischemia, necrosis, and inflammation following uterine artery embolization in the treatment of symptomatic uterine fibroids. (Abstract)

Markers of muscle ischemia, necrosis, and inflammation following uterine artery embolization in the treatment of symptomatic uterine fibroids. The objective of the study was to quantify markers of myometrial ischemia, necrosis, and inflammation in women undergoing uterine artery embolization (UAE).Women with symptomatic fibroids were randomized to treatment with UAE (n = 14) or abdominal myomectomy (n = 11). Peripheral venous blood samples were taken before and after the procedure, at 24 hours (...) in the myometrium following UAE, whereas the delayed rise in CRP is likely to reflect necrosis in fibroids.

2007 American journal of obstetrics and gynecology Controlled trial quality: uncertain

2627. Uterine artery embolization in the treatment of symptomatic uterine fibroid tumors (EMMY trial): periprocedural results and complications. (Abstract)

Uterine artery embolization in the treatment of symptomatic uterine fibroid tumors (EMMY trial): periprocedural results and complications. Uterine artery embolization (UAE) is an emerging treatment for symptomatic uterine fibroid tumors. This study was performed to evaluate the periprocedural results of the UAE procedure and identify risk factors for technical failure, fever after UAE, pain, and other complications.As part of a multicenter, randomized trial to compare UAE versus hysterectomy (...) in patients with symptomatic uterine fibroid tumors, 81 patients underwent UAE. Univariate and multivariate analyses were used to identify predictors for technical failure, postprocedural fever, complications as defined by the Society of Interventional Radiology (SIR), and pain scores.The technical failure rate according to SIR guidelines was 5.3% (95% CI, 2.3%-10.1%). The procedural failure rate was 17.3% (95% CI, 9.8%-27.3%). Bilateral failure occurred in four of 81 patients and unilateral failure

2006 Journal of vascular and interventional radiology : JVIR Controlled trial quality: uncertain

2628. Pain and return to daily activities after uterine artery embolization and hysterectomy in the treatment of symptomatic uterine fibroids: results from the randomized EMMY trial. (Abstract)

Pain and return to daily activities after uterine artery embolization and hysterectomy in the treatment of symptomatic uterine fibroids: results from the randomized EMMY trial. To evaluate the safety and efficacy of uterine artery embolization (UAE) and hysterectomy for symptomatic uterine fibroids by means of a randomized controlled trial. The present paper analyses short-term outcomes, i.e., pain and return to daily activities.Patients were randomized (1:1) to UAE or hysterectomy. Pain

2006 Cardiovascular and interventional radiology Controlled trial quality: uncertain

2629. Uterine artery embolization versus hysterectomy in the treatment of symptomatic uterine fibroids (EMMY trial): peri- and postprocedural results from a randomized controlled trial. (Abstract)

Uterine artery embolization versus hysterectomy in the treatment of symptomatic uterine fibroids (EMMY trial): peri- and postprocedural results from a randomized controlled trial. This was a randomized controlled trial to evaluate the safety of uterine artery embolization (UAE) compared with hysterectomy.Twenty-eight Dutch hospitals recruited 177 patients with symptomatic uterine fibroids and menorrhagia who were eligible for hysterectomy. Patients were randomized to UAE (n = 88

2005 American journal of obstetrics and gynecology Controlled trial quality: predicted high

2630. Sexuality and body image after uterine artery embolization and hysterectomy in the treatment of uterine fibroids: a randomized comparison. (Full text)

Sexuality and body image after uterine artery embolization and hysterectomy in the treatment of uterine fibroids: a randomized comparison. In this paper the effect of uterine artery embolization (UAE) on sexual functioning and body image is investigated in a randomized comparison to hysterectomy for symptomatic uterine fibroids. The EMbolization versus hysterectoMY (EMMY) trial is a randomized controlled study, conducted at 28 Dutch hospitals. Patients were allocated hysterectomy (n = 89

2007 Cardiovascular and interventional radiology Controlled trial quality: uncertain PubMed abstract

2631. Uterine artery embolization versus hysterectomy in the treatment of symptomatic uterine fibroids: 2 years' outcome from the randomized EMMY trial. (Abstract)

Uterine artery embolization versus hysterectomy in the treatment of symptomatic uterine fibroids: 2 years' outcome from the randomized EMMY trial. The purpose of this study was to compare the 2 years' efficiency of uterine artery embolization (UAE) with hysterectomy in the treatment of menorrhagia caused by uterine fibroids in a randomized controlled trial.Twenty-eight Dutch hospitals recruited patients with uterine fibroids and menorrhagia, who were eligible for hysterectomy. Patients were (...) randomized to UAE or hysterectomy. The primary endpoint was if UAE could avoid a subsequent hysterectomy in at least 75% of cases. Secondary endpoints were changes in pain, bulk-related complaints, and uterine and dominant fibroid volume reduction.One hundred seventy-seven patients were randomized to UAE (n = 88) or hysterectomy (n = 89). Two years after treatment 23.5% of UAE patients had undergone a hysterectomy. There were no significant differences in improvement compared to baseline in pain and bulk

2007 American journal of obstetrics and gynecology Controlled trial quality: uncertain

2632. Economic evaluation of uterine artery embolization versus hysterectomy in the treatment of symptomatic uterine fibroids: results from the randomized EMMY trial. (Abstract)

Economic evaluation of uterine artery embolization versus hysterectomy in the treatment of symptomatic uterine fibroids: results from the randomized EMMY trial. To investigate whether uterine artery embolization (UAE) is a cost-effective alternative to hysterectomy for patients with symptomatic uterine fibroids, the authors performed an economic evaluation alongside the multicenter randomized EMMY (EMbolization versus hysterectoMY) trial.Between February 2002 and February 2004, 177 patients (...) cumulative cost of UAE is lower than that of hysterectomy. From a societal economic perspective, UAE is the superior treatment strategy in women with symptomatic uterine fibroids.

2008 Journal of vascular and interventional radiology : JVIR Controlled trial quality: predicted high

2633. Symptomatic uterine fibroids: treatment with uterine artery embolization or hysterectomy--results from the randomized clinical Embolisation versus Hysterectomy (EMMY) Trial. (Abstract)

Symptomatic uterine fibroids: treatment with uterine artery embolization or hysterectomy--results from the randomized clinical Embolisation versus Hysterectomy (EMMY) Trial. To prospectively evaluate health-related quality of life (HRQOL) outcomes for uterine artery embolization (UAE) and hysterectomy up to 24 months after the intervention in terms of mental and physical health, urinary and defecatory function, and overall patient satisfaction.Ethics committee approval and informed consent were (...) obtained for the Embolisation versus Hysterectomy Trial. Women (n = 177) with uterine fibroids and heavy menstrual bleeding who were scheduled to undergo hysterectomy were randomly assigned to undergo UAE (n = 88) or hysterectomy (n = 89). HRQOL was measured six times during a 24-month follow-up period with the following validated questionnaires: Medical Outcome Study Short Form 36 (SF-36) mental component summary (MCS) and physical component summary (PCS), Health Utilities Index Mark 3, EuroQol 5D

2008 Radiology Controlled trial quality: uncertain

2634. MR reproducibility in the assessment of uterine fibroids for patients scheduled for uterine artery embolization. (Abstract)

MR reproducibility in the assessment of uterine fibroids for patients scheduled for uterine artery embolization. Magnetic resonance imaging (MRI) is increasingly applied in the evaluation of uterine fibroids. However, little is known about the reproducibility of MRI in the assessment of uterine fibroids. This study evaluates the inter- and intraobserver variation in the assessment of the uterine fibroids and concomitant adenomyosis in women scheduled for uterine artery embolization (UAE). Forty (...) patients (mean age: 44.5 years) with symptomatic uterine fibroids who were scheduled for UAE underwent T(1)- and T(2)-weighted MRI. To study inter- and intraobserver agreement 40 MR images were evaluated independently by two observers and reevaluated by both observers 4 months later. Inter- and intraobserver agreement was calculated using Cohen's kappa statistic and intraclass correlation coefficient for categorical and continuous variables, respectively. Inter-observer agreement for uterine volumes

2008 Cardiovascular and interventional radiology

2635. A UK multicentre retrospective cohort study comparing hysterectomy and uterine artery embolisation for the treatment of symptomatic uterine fibroids (HOPEFUL study): main results on medium-term safety and efficacy. (Abstract)

A UK multicentre retrospective cohort study comparing hysterectomy and uterine artery embolisation for the treatment of symptomatic uterine fibroids (HOPEFUL study): main results on medium-term safety and efficacy. Comparison of medium-term safety and efficacy of hysterectomy and uterine artery embolisation (UAE) for symptomatic uterine fibroids.Multicentre retrospective cohort.18 UK NHS hospital trusts.Four hundred and fifty nine women who had hysterectomy within a national audit during 12 (...) months from October 1994 (VALUE study) (average follow up of 8.6 years) and 649 women receiving UAE from 1996 to 2002 (average follow up of 4.6 years).Clinical data from existing hospital records and patient completed postal questionnaires.Complication rates, side effects of embolisation, satisfaction with treatment, relief from symptoms and requirement for further fibroid treatment.Fewer complications were experienced by women receiving UAE (19 versus 26% hysterectomy, P = 0.001), the adjusted odds

2007 BJOG

2636. Temporary uterine artery occlusion for treatment of menorrhagia and uterine fibroids using an incisionless Doppler-guided transvaginal clamp: case report. (Full text)

Temporary uterine artery occlusion for treatment of menorrhagia and uterine fibroids using an incisionless Doppler-guided transvaginal clamp: case report. We report the successful treatment of a 43-year-old woman with menorrhagia and multiple uterine fibroids by temporary uterine artery occlusion. Using a Doppler-guided transvaginal clamp, her uterine arteries were non-invasively identified and occluded by mechanical compression against the cervix for 6 h. Following removal of the clamp, blood (...) flow in the uterine arteries returned immediately. Menorrhagia symptoms were tracked with the Ruta Menorrhagia Severity Scale. Uterine and fibroid volumes were measured by analysis of magnetic resonance images. The patient's self-reported menorrhagia symptoms were significantly reduced at 6 months (70% reduction in Ruta score) and both uterine volume and fibroid volume had decreased by more than 44% at 6 months. This case report illustrates the potential applicability of a simple-to-use, non

2006 Human Reproduction PubMed abstract

2637. Laparoscopic occlusion of uterine vessels for the treatment of symptomatic fibroids: Initial experience and comparison to uterine artery embolization. (Abstract)

Laparoscopic occlusion of uterine vessels for the treatment of symptomatic fibroids: Initial experience and comparison to uterine artery embolization. Our purpose was to evaluate the effects of laparoscopic occlusion of uterine vessels in treating symptomatic fibroids and compare with embolization of the uterine arteries.We studied 46 premenopausal women, aged 43 (34-51) years with symptomatic uterine fibroids, undergoing radiologic embolization (n=24) and laparoscopy closure of the uterine (...) to the obturator nerve in three patients.Laparoscopic occlusion of uterine vessels is a promising new method for treating fibroid-related symptoms, with less postoperative pain than embolization and comparable effects on symptoms.

2004 American Journal of Obstetrics and Gynecology

2638. Sexual functioning and psychological well-being after uterine artery embolization in women with symptomatic uterine fibroids. (Abstract)

Sexual functioning and psychological well-being after uterine artery embolization in women with symptomatic uterine fibroids. To assess the effects of uterine artery embolization (UAE) on psychological and sexual well-being 3 months after treatment.Prospective study.Large teaching hospital in Tilburg, the Netherlands.141 Premenopausal women with symptomatic uterine fibroids.UAE for symptomatic fibroids.Changes in scores on a questionnaire concerning sexual well-being (ranging from 0 to 32 (...) of lubrication, orgasm, or pain decreased 7%, 36%, and 14%, respectively. The total SCL-90 score showed a statistically significant decrease from 133 to 116, 3 months after UAE, indicating a decrease in emotional and somatic concerns.Sexual and psychological well-being improved significantly 3 months after UAE in women with symptomatic uterine fibroids. Sixty-eight percent had an increase in the total score for sexual functioning. Problems with sexual functioning were statistically significantly decreased.

2008 Fertility and Sterility

2639. The role of uterine artery embolization in the management of uterine fibroids. (Abstract)

The role of uterine artery embolization in the management of uterine fibroids. Uterine artery embolization is increasingly being offered as an alternative to hysterectomy and myomectomy for the treatment of symptomatic uterine fibroids. This review is intended to evaluate the role of this technique in the management of uterine fibroids using information provided from recently published literature.A growing body of literature supports the efficacy of uterine artery embolization in relieving (...) fibroid-related menorrhagia, pelvic pain and pressure symptoms and in substantially reducing the fibroid size in most patients. Recent publications also show significant improvements in health-related quality of life and high long-term satisfaction rates. The procedure is associated with shorter hospitalization and recovery times and lower morbidity rates compared with conventional surgical treatments. However, serious complications, such as uterine infarction or infection leading to emergency

2005 Current Opinion in Obstetrics and Gynecology

2640. Safety and Effectiveness Study of RF Ablation of Uterine Fibroids to Reduce Menstrual Bleeding: the Fibroid Ablation Study

Safety and Effectiveness Study of RF Ablation of Uterine Fibroids to Reduce Menstrual Bleeding: the Fibroid Ablation Study Safety and Effectiveness Study of RF Ablation of Uterine Fibroids to Reduce Menstrual Bleeding: the Fibroid Ablation Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety and Effectiveness Study of RF Ablation of Uterine Fibroids to Reduce Menstrual Bleeding: the Fibroid Ablation Study (FAST) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00768742 Recruitment Status

2008 Clinical Trials

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