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Uterine Fibroid

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181. Updated approaches for management of uterine fibroids (PubMed)

Updated approaches for management of uterine fibroids Uterine anatomy and uterine fibroids (UFs) characteristics have been classically considered as almost a unique issue in gynecology and reproductive medicine. Nowadays, the management of UF pathology is undergoing an important evolution, with the patient's quality of life being the most important aspect to consider. Accordingly, surgical techniques and aggressive treatments are reserved for only those cases with heavy symptomatology, while

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2017 International journal of women's health

182. A multi-stage genome-wide association study of uterine fibroids in African Americans (PubMed)

A multi-stage genome-wide association study of uterine fibroids in African Americans Uterine fibroids are benign tumors of the uterus affecting up to 77% of women by menopause. They are the leading indication for hysterectomy, and account for $34 billion annually in the United States. Race/ethnicity and age are the strongest known risk factors. African American (AA) women have higher prevalence, earlier onset, and larger and more numerous fibroids than European American women. We conducted (...) a multi-stage genome-wide association study (GWAS) of fibroid risk among AA women followed by in silico genetically predicted gene expression profiling of top hits. In Stage 1, cases and controls were confirmed by pelvic imaging, genotyped and imputed to 1000 Genomes. Stage 2 used self-reported fibroid and GWAS data from 23andMe, Inc. and the Black Women's Health Study. Associations with fibroid risk were modeled using logistic regression adjusted for principal components, followed by meta-analysis

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2017 Human Genetics

183. Burden of uterine fibroids in Italy: epidemiology, treatment outcomes, and consumption of health care resources in more than 5,000 women (PubMed)

Burden of uterine fibroids in Italy: epidemiology, treatment outcomes, and consumption of health care resources in more than 5,000 women Epidemiological studies on uterine fibroids (UFs) are mostly based on surveys or analyses of small samples of patients. In 50% of women, the quality of life is worsened by disease-related symptoms; furthermore, treatments imply a remarkable health care cost. The aim of this observational study was to analyze a large sample of Italian patients with UFs

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2017 ClinicoEconomics and Outcomes Research: CEOR

184. A network pharmacology approach to investigate the pharmacological effects of Guizhi Fuling Wan on uterine fibroids (PubMed)

A network pharmacology approach to investigate the pharmacological effects of Guizhi Fuling Wan on uterine fibroids To investigate the pharmacological mechanism of Guizhi Fuling Wan (GFW) in the treatment of uterine fibroids, a network pharmacology approach was used. Information on GFW compounds was collected from traditional Chinese medicine (TCM) databases, and input into PharmMapper to identify the compound targets. Genes associated with uterine fibroids genes were then obtained from (...) -compound target-uterine fibroids target network of GWF; and a compound target-uterine fibroids target-other human proteins protein-protein interaction network, which were subjected to GO and pathway enrichment analyses. According to this approach, a number of novel signaling pathways and biological processes underlying the effects of GFW on uterine fibroids were identified, including the negative regulation of smooth muscle cell proliferation, apoptosis, and the Ras, wingless-type, epidermal growth

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2017 Experimental and therapeutic medicine

185. Contrast-enhanced ultrasound is better than magnetic resonance imaging in evaluating the short-term results of microwave ablation treatment of uterine fibroids (PubMed)

Contrast-enhanced ultrasound is better than magnetic resonance imaging in evaluating the short-term results of microwave ablation treatment of uterine fibroids Contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI) were compared in evaluating the short-term effects of microwave ablation (MWA) on uterine fibroids. A total of 60 patients with uterine fibroids treated by MWA were enrolled in the experimental group during their two-year follow-up period according to the inclusion (...) criteria. Conventional two-dimensional US, MRI and CEUS were performed to determine the volume reduction and the fibroid residue by displaying the size, echo and signal intensity of fibroids prior to and after MWA treatment. As the control group, 60 consecutive patients were recruited on their follow-up visit at least two years after MWA treatment of uterine fibroids. Significant differences were observed in the wash-in rate (WiR) of the fibroid tissue, start time difference, rise time ratio (RTR

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2017 Experimental and therapeutic medicine

186. Fears and Concerns of Patients with Uterine Fibroids – a Survey of 807 Women (PubMed)

Fears and Concerns of Patients with Uterine Fibroids – a Survey of 807 Women What specific fears and concerns do patients with uterine fibroids have? How are these influenced by sociodemographic factors, duration of condition and level of knowledge among these women?Between January 2016 and January 2017 807 patients were consecutively surveyed at a university hospital speciality fibroid clinic using a two page locally developed and validated questionnaire focusing on fibroid-associated fears (...) since diagnosis also affected fears with different concerns between patients with shorter duration of diagnosis (< 12 months) vs. longer duration (> 12 months). Overall only slight differences could be attributed to immigrant background. Higher level of education correlated with less anxiety. Proper information about fibroids relieved fears of malignant change in particular. Doctors and the internet were the most important sources of patient information.Due to the benign nature of uterine fibroids

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2017 Geburtshilfe Und Frauenheilkunde

187. Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans (PubMed)

Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans The article "A multi-stage genome-wide association study of uterine fibroids in African Americans", written by Jacklyn N. Hellwege, was originally published Online First without open access. After publication in volume 136, issue 10, page 1363-1373 the author decided to opt for Open Choice and to make the article an open access publication. Therefore, the copyright of the article has been changed

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2017 Human Genetics

188. Review of magnetic resonance-guided focused ultrasound in the treatment of uterine fibroids (PubMed)

Review of magnetic resonance-guided focused ultrasound in the treatment of uterine fibroids Uterine leiomyoma is the most frequently occurring solid pelvic tumor in women during the reproductive period. Magnetic resonance-guided high-intensity focused ultrasound is a promising technique for decreasing menorrhagia and dysmenorrhea in symptomatic women. The aim of this study is to review the role of Magnetic resonance-guided high-intensity focused ultrasound in the treatment of uterine fibroids (...) in symptomatic patients. We performed a review of the MEDLINE and Cochrane databases up to April 2016. The analysis and data collection were performed using the following keywords: Leiomyoma, High-Intensity Focused Ultrasound Ablation, Ultrasonography, Magnetic Resonance Imaging, Menorrhagia. Two reviewers independently performed a quality assessment; when there was a disagreement, a third reviewer was consulted. Nineteen studies of Magnetic resonance-guided high-intensity focused ultrasound-treated fibroid

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2017 Clinics

189. Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids (PubMed)

Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids Uterine fibroids (UFs, AKA leiomyoma) are the most important benign neoplastic threat to women's health, with costs up to hundreds of billions of health care dollars worldwide. Uterine fibroids caused morbidities exert a tremendous health toll, impacting the quality of life of women of all ethnicities, especially women of color. Clinical presentations include heavy vaginal bleeding

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2017 Biology of reproduction

190. Burden of uterine fibroids in Italy: epidemiology, treatment outcomes, and consumption of health care resources in more than 5,000 women [Corrigendum] (PubMed)

Burden of uterine fibroids in Italy: epidemiology, treatment outcomes, and consumption of health care resources in more than 5,000 women [Corrigendum] [This corrects the article on p. 525 in vol. 9, PMID: 28919793.].

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2017 ClinicoEconomics and Outcomes Research: CEOR

191. Self-reported Bacterial Vaginosis and Risk of Ultrasound Diagnosed Incident Uterine Fibroid Cases in a Prospective Cohort Study of Young African-American Women (PubMed)

Self-reported Bacterial Vaginosis and Risk of Ultrasound Diagnosed Incident Uterine Fibroid Cases in a Prospective Cohort Study of Young African-American Women 29066031 2018 11 13 1873-2585 27 11 2017 Nov Annals of epidemiology Ann Epidemiol Self-reported bacterial vaginosis and risk of ultrasound-diagnosed incident uterine fibroid cases in a prospective cohort study of young African American women. 749-751.e1 S1047-2797(17)30089-3 10.1016/j.annepidem.2017.10.003 Moore Kristen R KR Epidemiology

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2017 Annals of Epidemiology

192. Ineffectiveness of magnetic resonance imaging enhancement to predict fibroid volume reduction after uterine artery embolization (PubMed)

Ineffectiveness of magnetic resonance imaging enhancement to predict fibroid volume reduction after uterine artery embolization Fibroid nonenhancement is considered a relative contraindication to uterine artery embolization (UAE) for symptomatic fibroids. This retrospective study assessed the impact of UAE on nonenhancing fibroids to determine imaging predictors of fibroid shrinkage. All women who underwent UAE for symptomatic fibroids between May 2009 and July 2014 and had follow-up magnetic (...) resonance imaging 6 months after UAE were included. There were 59 fibroids (5 nonenhancing, 54 enhancing) among 18 women aged 40 to 53 (mean 46) years. All fibroids were assessed for size, position, and enhancement on subtraction and apparent diffusion constant (ADC) images. Enhancing fibroids had an average decrease in diameter of 19% ± 3%, not significantly different than nonenhancing fibroids, which decreased 23% ± 6% (P = 0.49). Multiple linear regression with percent change in fibroid diameter

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2017 Proceedings (Baylor University. Medical Center)

193. One year symptom severity and health-related quality of life changes among Black African patients undergoing uterine fibroid embolisation (PubMed)

One year symptom severity and health-related quality of life changes among Black African patients undergoing uterine fibroid embolisation The main aim in the treatment of symptomatic fibroids by various modalities including uterine fibroid embolisation (UFE) is to alleviate symptoms and ultimately improve the quality of life. The efficacy of this modality of treatment in Black African women with significant fibroid burden and large uterine volumes is not clear. The main objective of the study (...) was to examine potential changes in symptom severity among Black African patients 1 year following UFE for symptomatic uterine fibroids in a resource-constrained setting, rated using a validated questionnaire (UFS-QOL). Secondary outcomes examined were changes in quality of life and potential associations with age, parity, uterine volume and fibroid number prior to UFE. Additional interventions after UFE were also recorded.A prospective before and after study of Black African patients undergoing UFE

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2017 BMC research notes

194. Treating symptomatic uterine fibroids with myomectomy: current practice and views of UK consultants (PubMed)

Treating symptomatic uterine fibroids with myomectomy: current practice and views of UK consultants The demand for uterus-sparing treatments is increasing as more women postpone childbirth to their 30-40s, when fibroids are more symptomatic. With an increasing choice of treatment options and changing care-provider profiles, now is an opportune time to survey current practices and opinions. Using a 25-stem questionnaire, a web-based survey was used to capture the practices and opinions of UK (...) consultant gynecologists on the treatment of symptomatic fibroids, including the types of procedure most frequently used, methods used to reduce blood loss, and awareness and acceptability of treatment options, and to assess the impact of gender and experience of the treating gynecologist.The response rate was 22%. Laparascopic myomectomy is used least frequently, with 80% of the respondents using GnRHa preoperatively to minimize blood loss and correct anemia, while vasopressin is most frequently used

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2017 Gynecological surgery

195. Pregnancy outcomes in nulliparous women after ultrasound ablation of uterine fibroids: A single-central retrospective study (PubMed)

Pregnancy outcomes in nulliparous women after ultrasound ablation of uterine fibroids: A single-central retrospective study To explore the impact of high-intensity focused ultrasound (HIFU) ablation of uterine fibroids in nulliparous women on subsequent pregnancy and delivery. A retrospective analysis was conducted of nulliparous women who received HIFU treatment at Chongqing Medical University, Chongqing,China, from January 1, 2010, to January 1, 2015. A total of 189 cases were enrolled (...) ), and a pair of them were identical twins. The incidence of complications during pregnancy and delivery were 10.8% (10/93) and 7.5% (7/93),respectively,except one woman failed on-going pregnancy and one woman suffered hysterectomy due to the complications,others all successful pregnant and delivered. Multiple-factor regression analysis found that age and infertility history were the important factors that may affect pregnancy after HIFU (P < 0.01). Nulliparous women who undergo HIFU treatment for uterine

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2017 Scientific reports

196. Blood cadmium and volume of uterine fibroids in premenopausal women (PubMed)

Blood cadmium and volume of uterine fibroids in premenopausal women A number of studies have found associations between heavy metals and uterine fibroids, but the results are inconsistent. Here, we conducted this research to demonstrate the relationships between blood heavy metal concentrations and uterine fibroid volume as well as the rate of uterine fibroid presence.In a cross-sectional study, we collected data from 308 premenopausal women aged 30-49 years in Seoul; uterine fibroids (...) are ascertained by past history of myomectomy and pelvic ultrasonography. In the analytic phase, we first analyzed the presence of the fibroids and the concentrations of heavy metals via logistic regression. In subgroup analysis, we used simple and multiple linear regression analyses to examine the associations between heavy metals and uterine fibroid volume.There was no connection between the heavy metal concentrations and the presence of uterine fibroids, but the odds of women having fibroids were higher

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2017 Annals of occupational and environmental medicine

197. Consensus Meetings Regarding Uterine Artery Embolization and Focused Ultrasound in Fibroid Treatment: an Analysis (PubMed)

Consensus Meetings Regarding Uterine Artery Embolization and Focused Ultrasound in Fibroid Treatment: an Analysis 28769130 2018 11 13 0016-5751 77 6 2017 Jun Geburtshilfe und Frauenheilkunde Geburtshilfe Frauenheilkd Consensus Meetings Regarding Uterine Artery Embolization and Focused Ultrasound in Fibroid Treatment: an Analysis. 693-695 10.1055/s-0043-109281 Kröncke Thomas T Radiologie, Klinikum Augsburg, Germany. David Matthias M Gynäkologie, Charité, Berlin, Germany. Matzko Matthias Fritz MF

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2017 Geburtshilfe Und Frauenheilkunde

198. Uterine Artery Embolization (UAE) for Fibroid Treatment: Results of the 6th Radiological Gynecological Expert Meeting (PubMed)

Uterine Artery Embolization (UAE) for Fibroid Treatment: Results of the 6th Radiological Gynecological Expert Meeting 28769129 2018 07 05 0016-5751 77 6 2017 Jun Geburtshilfe und Frauenheilkunde Geburtshilfe Frauenheilkd Uterine Artery Embolization (UAE) for Fibroid Treatment: Results of the 6th Radiological Gynecological Expert Meeting. 689-692 10.1055/s-0043-106259 Kröncke Thomas T Radiologie, Klinikum Augsburg, Germany. David Matthias M Gynäkologie, Charité, Berlin, Germany. eng Journal

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2017 Geburtshilfe Und Frauenheilkunde

199. African genetic ancestry interacts with body mass index to modify risk for uterine fibroids (PubMed)

African genetic ancestry interacts with body mass index to modify risk for uterine fibroids Race, specifically African ancestry, and obesity are important risk factors for uterine fibroids, and likely interact to provide the right conditions for fibroid growth. However, existing studies largely focus on the main-effects rather than their interaction. Here, we firstly provide evidence for interaction between categories of body mass index (BMI) and reported-race in relation to uterine fibroids (...) . We then investigate whether the association between inferred local European ancestry and fibroid risk is modified by BMI in African American (AA) women in the Vanderbilt University Medical Center bio-repository (BioVU) (539 cases and 794 controls) and the Coronary Artery Risk Development in Young Adults study (CARDIA, 264 cases and 173 controls). We used multiple logistic regression to evaluate interactions between local European ancestry and BMI in relation to fibroid risk, then performed fixed

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2017 PLoS genetics

200. Role of Transforming Growth Factor β in Uterine Fibroid Biology (PubMed)

Role of Transforming Growth Factor β in Uterine Fibroid Biology Uterine fibroids (UFs) are benign tumors of the female genital tract made of the smooth muscle of the uterus. UF growth depends mostly on the influence of the steroid hormones and selected growth factors. Transforming growth factor β (TGF-βs) is a polypeptide that consists of three isoforms: TGF-β1, TGF-β2, and TGF-β3. At present, TGF-β is considered to be one of the key factors in the pathophysiology of UFs. It plays a major role (...) their search in PubMed of the National Library of Medicine with the use of the following selected keywords: "uterine fibroid", "leiomyoma", and "transforming growth factor β". After reviewing the titles and abstracts, more than 115 full articles were evaluated. We focused on the TGF-β-related molecular aspects and their influence on the most common symptoms that are associated with UFs. Also, we described how the available data might implicate the current medical management of UFs.

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2017 International journal of molecular sciences

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