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Uterine Bleeding in Pregnancy

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1. Abnormal Uterine Bleeding in Pre-Menopausal Women

to immaturity of the hypothalamic-pituitary-ovarian axis (II-2). Recommendations 1 Adoption of standardized international terminology for abnormal uterine bleeding should be considered (III-C). 2 A complete blood count is recommended for women with heavy or prolonged bleeding (II-2A). 3 If there is any possibility of pregnancy, a sensitive urine or serum pregnancy test should be performed (III-C). 4 Testing for coagulation disorders should be considered only in women who have a history of heavy menstrual (...) Abnormal Uterine Bleeding in Pre-Menopausal Women No. 292-Abnormal Uterine Bleeding in Pre-Menopausal Women - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 40, Issue 5, Pages e391–e415 No. 292-Abnormal Uterine Bleeding in Pre-Menopausal Women x Sukhbir Singh , MD Ottawa, ON x Carolyn Best , MD Toronto, ON x Sheila Dunn , MD Toronto, ON x Nicholas Leyland , MD Toronto, ON x Wendy Lynn Wolfman , MD Toronto, ON No 292

2018 Society of Obstetricians and Gynaecologists of Canada

2. Dysfunctional uterine bleeding

-menopausal women that is not due to pregnancy or any recognisable uterine or systemic diseases. The underlying pathophysiology is believed to be due to ovarian hormonal dysfunction. However, the exact mechanisms remain unknown. DUB usually presents as heavy, prolonged, or frequent bleeding of uterine origin. Speroff L, Fritz M, eds. Dysfunctional uterine bleeding. In: Clinical gynecologic endocrinology and infertility. 7th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2004:547-571. History and exam (...) uterine bleeding use of hormone therapy menstrual irregularity anaemia premenstrual molimina hirsutism, acne, acanthosis nigricans age (years after puberty and before menopause) polycystic ovary syndrome (PCOS) other anovulatory disorders endocrine disorders obesity Diagnostic investigations pregnancy test FBC coagulation profile serum progesterone level serum prolactin level serum TSH level serum FSH and LH levels serum androgen levels serum 17-alpha-hydroxyprogesterone level ultrasound ultrasound

2017 BMJ Best Practice

3. Tiny Tips: Approach to Abnormal Uterine Bleeding

Tiny Tips: Approach to Abnormal Uterine Bleeding Tiny Tips: Approach to Abnormal Uterine Bleeding - CanadiEM Tiny Tips: Approach to Abnormal Uterine Bleeding In , by Zoe Polsky July 14, 2017 Whether the patient is an expecting mother, a post-menopausal woman, or a young adolescent, abnormal uterine bleeding is distressing for the patient, and often overwhelming for learners. Consider the ‘ CAUSES OF bLOOD ’ to better tailor your investigations and management. C ancer A bruption U rogenital (...) uterine bleeding. This approach will be helpful to junior learners who want to ensure that they consider various causes of uterine bleeding. Advanced learners should have expanded differentials that are based on categorical clusters such the patient’s reproductive status (e.g. premenarchal, fertile, pregnant, postmenopausal) and/or categories of disease (e.g. reproductive tract disease, iatrogenic causes, systemic causes). Always remember that fertile females presenting to the emergency department

2017 CandiEM

4. The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. (PubMed)

The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. Human pregnancy requires robust hemostasis to prevent hemorrhage during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification of spiral arteries and post-partum processes. However, decidual hemorrhage (abruption) can occur throughout pregnancy from poorly transformed spiral arteries, causing fetal death or spontaneous preterm (...) birth (PTB), or it can promote the aberrant placentation observed in intrauterine growth restriction (IUGR) and pre-eclampsia; all leading causes of perinatal or maternal morbidity and mortality. In non-fertile cycles, the decidua undergoes controlled menstrual bleeding. Abnormal uterine bleeding (AUB) accompanying progestin-only, long-acting, reversible contraception (pLARC) accounts for most discontinuations of these safe and highly effective agents, thereby contributing to unwanted pregnancies

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2016 Human Reproduction Update

5. A severed IP ligament as a cause for trans-vaginal uterine bleeding post termination of pregnancy: a case report (PubMed)

A severed IP ligament as a cause for trans-vaginal uterine bleeding post termination of pregnancy: a case report Uterine perforation is an uncommon yet serious complication of surgical management of first and second trimester termination of pregnancies. The rate of uterine perforation is under reported, as patients are usually asymptomatic. Although uncommon, uterine perforation can cause life-threatening complications for some patients. This case report discusses a second trimester surgical (...) termination resulting in uterine perforation and haemorrhage secondary to an avulsion of the infundibulopelvic ligament and prolapse of the left fallopian tube and ovary into the uterine cavity. A literature search was undertaken to compare this case report to those previously published. To the best of our knowledge, this is the first case report in Australia that discusses a unique case of a severed infundibulo-pelvic ligament as a cause for trans-vaginal uterine bleeding post second trimester

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2017 The Pan African medical journal

6. Risk factors for massive postpartum bleeding in pregnancies in which incomplete placenta previa are located on the posterior uterine wall (PubMed)

Risk factors for massive postpartum bleeding in pregnancies in which incomplete placenta previa are located on the posterior uterine wall To identify factors associated with massive postpartum bleeding in pregnancies complicated by incomplete placenta previa located on the posterior uterine wall.A retrospective case-control study was performed. We identified 210 healthy singleton pregnancies with incomplete placenta previa located on the posterior uterine wall, who underwent elective (...) or emergency cesarean section after 24 weeks of gestation between January 2006 and April 2016. The cases with intraoperative blood loss (≥2,000 mL) or transfusion of packed red blood cells (≥4) or uterine artery embolization or hysterectomy were defined as massive bleeding.Twenty-three women experienced postpartum profuse bleeding (11.0%). After multivariable analysis, 4 variables were associated with massive postpartum hemorrhage (PPH): experience of 2 or more prior uterine curettage (adjusted odds ratio

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2017 Obstetrics & gynecology science

7. Uterine Bleeding in Pregnancy

Uterine Bleeding in Pregnancy Uterine Bleeding in Pregnancy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Uterine Bleeding (...) in Pregnancy Uterine Bleeding in Pregnancy Aka: Uterine Bleeding in Pregnancy , Pregnancy Related Uterine Bleeding From Related Chapters II. Causes e Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Uterine Bleeding in Pregnancy." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Hemorrhage About FPnotebook.com is a rapid access, point-of-care

2018 FP Notebook

8. Uterine Artery Pseudoaneurysm: A Life-Threatening Cause of Vaginal Bleeding in the Emergency Department. (PubMed)

 days post dilation and evacuation for an elective termination of a pregnancy at 20 weeks, presented to the ED with profuse vaginal bleeding. She was hypotensive and tachycardic at presentation, requiring resuscitation with 0.9% normal saline and transfusions of packed red blood cells. Transvaginal ultrasound completed in the ED demonstrated a pulsatile mass in the cervix with internal "ying-yang" flow on Doppler images, suggestive of a uterine artery pseudoaneurysm within the cervix. The patient (...) Uterine Artery Pseudoaneurysm: A Life-Threatening Cause of Vaginal Bleeding in the Emergency Department. Vaginal bleeding is a common presenting complaint in the emergency department (ED); life-threatening hemorrhage is rare. Uterine artery pseudoaneurysm (UAP) is an uncommon but potentially life-threatening cause of vaginal bleeding that is most likely to present primarily to EDs, given its delayed postpartum or postoperative presentation.A 25-year-old female gravida two, para one, who was 19

2019 Journal of Emergency Medicine

9. Sonohysterography for assessment of abnormal uterine bleeding

Sonohysterography for assessment of abnormal uterine bleeding Sonohysterography for assessment of abnormal uterine bleeding Sonohysterography for assessment of abnormal uterine bleeding HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Sonohysterography for assessment of abnormal uterine bleeding. Lansdale: HAYES, Inc.. Directory (...) Publication. 2015 Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Female; Genital Diseases, Female; Humans; Hysteroscopy; Pregnancy; Uterine Hemorrhage Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com

2015 Health Technology Assessment (HTA) Database.

10. Clinical analysis of uterine artery embolization combined with double balloon catheter plus curettage for patients with placenta previa who underwent pregnancy termination and suffered antenatal massive hemorrhage in the 2nd trimester: Three case reports. (PubMed)

Clinical analysis of uterine artery embolization combined with double balloon catheter plus curettage for patients with placenta previa who underwent pregnancy termination and suffered antenatal massive hemorrhage in the 2nd trimester: Three case reports. It is very difficult to treat patients with placenta previa who underwent pregnancy termination and suffered antenatal massive hemorrhage in the 2nd trimester.In this study, case 1 was with fetal malformation of 18-trisomy syndrome (...) at gestation of 19 weeks + 2 days, case 2 was with fetal malformation of 18-trisomy syndrome at gestation of 22 weeks + 1 day, and case 3 was for intrauterine fetal death at gestation of 27 weeks. All the 3 cases were completely placenta previa.For the 3 patients, completely placenta previa was confirmed by ultrasound examination after hospitalization and underwent pregnancy termination for fetal death or fetal malformation in the 2nd trimester.The 3 patients with placenta previa underwent pregnancy

2019 Medicine

11. Outcomes of monopolar versus bipolar endometrial ablation on uterine bleeding and psychophysical wellbeing. (PubMed)

Outcomes of monopolar versus bipolar endometrial ablation on uterine bleeding and psychophysical wellbeing. To compare outcomes of endometrial ablation with monopolar versus bipolar resection on uterine bleeding and psychophysical wellbeing.In a prospective randomized study, 100 perimenopausal patients, without desire of pregnancy and with no response to pharmacological treatment, underwent endometrial ablation from 2012 to 2014. They were randomly divided in two groups: 50 patients treated

2018 Minerva ginecologica

12. A Study to Assess the Safety and Efficacy of Vilaprisan in Japanese Subjects With Uterine Fibroids and Heavy Menstrual Bleeding

A Study to Assess the Safety and Efficacy of Vilaprisan in Japanese Subjects With Uterine Fibroids and Heavy Menstrual Bleeding A Study to Assess the Safety and Efficacy of Vilaprisan in Japanese Subjects With Uterine Fibroids and Heavy Menstrual Bleeding - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Assess the Safety and Efficacy of Vilaprisan in Japanese Subjects With Uterine Fibroids and Heavy Menstrual Bleeding (ASTEROID 8) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03476928 Recruitment

2018 Clinical Trials

13. Abnormal Uterine Bleeding and Progestin-only Contraceptives

Abnormal Uterine Bleeding and Progestin-only Contraceptives Abnormal Uterine Bleeding and Progestin-only Contraceptives - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Abnormal Uterine Bleeding (...) on uterine bleeding which occurs in a significant number of users. Information revealed from many clinical trials shows that abnormal uterine bleeding with progestin-only contraception ranging from 10 to 25 % at first year of use. Condition or disease Intervention/treatment Phase Contraception Drug: Depot medroxy-progesterone acetate Drug: Etonogestrel Drug: Levonorgestrel Acetate Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated

2018 Clinical Trials

14. Economic evaluation of the levonorgestrel-releasing intrauterine system for the treatment of dysfunctional uterine bleeding in Spain

Economic evaluation of the levonorgestrel-releasing intrauterine system for the treatment of dysfunctional uterine bleeding in Spain Economic evaluation of the levonorgestrel-releasing intrauterine system for the treatment of dysfunctional uterine bleeding in Spain Economic evaluation of the levonorgestrel-releasing intrauterine system for the treatment of dysfunctional uterine bleeding in Spain Lete I, Cristobal I, Febrer L, Crespo C, Arbat A, Hernandez FJ, Brosa M Record Status (...) bleeding. The authors concluded that the LNG-IUS was more effective and less expensive than either the combined oral contraceptive or progestogens from the perspective of the Spanish health system. The methods were appropriate and well-reported, which should ensure the validity of the authors’ conclusions. Type of economic evaluation Cost-effectiveness analysis, cost-utility analysis Study objective This study assessed the cost-effectiveness of the levonorgestrel-releasing intra-uterine system (LNG-IUS

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2011 NHS Economic Evaluation Database.

15. Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids

hematin method. Key Exclusion Criteria: The subject is pregnant or breast-feeding or is planning a pregnancy within the duration of the treatment period of the study. History of uterus surgery that would interfere with the study. The subject's condition is so severe that she will require surgery within 6 months regardless of the treatment provided. Undiagnosed abnormal uterine bleeding. Significant risk of osteoporosis or history of, or known osteoporosis or other metabolic bone disease. Contacts (...) Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2017 Clinical Trials

16. Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids

hematin method. Key Exclusion Criteria: The subject is pregnant or breast-feeding or is planning a pregnancy within the duration of the treatment period of the study. History of uterus surgery that would interfere with the study. The subject's condition is so severe that she will require surgery within 6 months regardless of the treatment provided. Undiagnosed abnormal uterine bleeding. Significant risk of osteoporosis or history of, or known osteoporosis or other metabolic bone disease. Contacts (...) Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2017 Clinical Trials

17. Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids

Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment of Heavy (...) Menstrual Bleeding in Women With Uterine Fibroids The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03317795 Recruitment Status : Recruiting First Posted : October 23, 2017 Last Update Posted : January 14, 2019 See Sponsor

2017 Clinical Trials

18. Long-Term Safety and Efficacy of Elagolix in Combination With Estradiol/ Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women

has a diagnosis of uterine fibroids documented by a Pelvic Ultrasound [Transabdominal ultrasound (TAU) and transvaginal ultrasound (TVU)]. Participant has Heavy Menstrual Bleeding (HMB) associated with uterine fibroids as evidenced by Menstrual Blood Loss (MBL) > 80 mL during each of two screening menses as measured by the alkaline hematin method. Participant has negative urine and/or serum pregnancy test in Washout (if applicable) and/or Screening and just prior to first dose. Participant has (...) Long-Term Safety and Efficacy of Elagolix in Combination With Estradiol/ Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women Long-Term Safety and Efficacy of Elagolix in Combination With Estradiol/ Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2017 Clinical Trials

19. Role of Office Hysteroscope in Premenopausal Uterine Bleeding

Role of Office Hysteroscope in Premenopausal Uterine Bleeding Role of Office Hysteroscope in Premenopausal Uterine Bleeding - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Role of Office Hysteroscope (...) in Premenopausal Uterine Bleeding The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03205111 Recruitment Status : Not yet recruiting First Posted : July 2, 2017 Last Update Posted : July 2, 2017 See Sponsor: Assiut University

2017 Clinical Trials

20. Prevalence of Cesarean Section Niche in Women With Unexplained Abnormal Uterine Bleeding

Prevalence of Cesarean Section Niche in Women With Unexplained Abnormal Uterine Bleeding Prevalence of Cesarean Section Niche in Women With Unexplained Abnormal Uterine Bleeding - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Prevalence of Cesarean Section Niche in Women With Unexplained Abnormal Uterine Bleeding (Niche) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03130387 Recruitment Status : Completed First Posted : April 26, 2017 Last Update Posted : April 26, 2017 Sponsor: Ain Shams University

2017 Clinical Trials

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