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Urine Vanillylmandelic Acid

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21. Catecholamines profiles at diagnosis: Increased diagnostic sensitivity and correlation with biological and clinical features in neuroblastoma patients. (PubMed)

Catecholamines profiles at diagnosis: Increased diagnostic sensitivity and correlation with biological and clinical features in neuroblastoma patients. Neuroblastoma (NBL) accounts for 10% of the paediatric malignancies and is responsible for 15% of the paediatric cancer-related deaths. Vanillylmandelic acid (VMA) and homovanillic acid (HVA) are most commonly analysed in urine of NBL patients. However, their diagnostic sensitivity is suboptimal (82%). Therefore, we performed in-depth analysis

2017 European Journal of Cancer

22. Corticomedullary mixed tumour resembling a small adrenal gland-involvement of cancer stem cells: case report. (PubMed)

for 3 years. His 24-h urine vanillylmandelic acid (VMA) levels were slightly elevated. An abnormal circadian cortisol rhythm was noted, and his cortisol levels were not suppressed by dexamethasone. Abdominal computed tomography (CT) revealed a right adrenal gland lesion (diameter, 30 × 38 mm), while an enhanced CT showed enhancement and hypervascularization. The tumour was positive for adrenocorticotropic hormone, chromogranin A (CGA), and steroidogenic factor-1 (SF-1) on the tumour surface

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2017 BMC Endocrine Disorders

23. Changes in cardiovascular function based on adrenalin and norepinephrine metabolism in ovariectomized rats. (PubMed)

in plasma and vanillylmandelic acid in urine. Echocardiography, Doppler blood flow detection technologyand hamnatodynamometer were applied to assess cardiovascular function. After ovariectomy, levels of estrogen reduced, adrenalin and metanephrine increased, and norepinephrine and normetanephrine in the plasma and vanillylmandelic acid in urine decreased. Symptoms indicative of cardiac diastolic dysfunction, including decreased diastolic left ventricular cavity capacity, increased wall thickness

2017 Experimental Gerontology

24. Synchronous bilateral pheochromocytomas and paraganglioma with novel germline mutation in MAX: a case report (PubMed)

and paraganglioma with novel MYC associated factor X (MAX) gene mutation.A 24-year-old female had hyperhidrosis and hypertension. Her urine test showed high normetanephrine and vanillylmandelic acid. Enhanced computed tomography revealed three enhanced masses in right adrenal gland, left adrenal gland, and left renal hilus. She was diagnosed with PPGL. Because 123I-metaiodobenzylguanidine scintigraphy indicated the accumulations in the left adrenal gland mass and the left renal hilus mass and not in the right

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2017 Surgical Case Reports

25. Marker-Negative Pheochromocytoma Associated with Inferior Vena Cava Thrombosis (PubMed)

of confluence with hepatic veins. Her routine laboratory investigations including 24-hour urine fractionated metanephrines, vanillylmandelic acid, and cortisol were normal. Right adrenalectomy with IVC thrombectomy was done. Perioperative period was uneventful. Histopathology of the mass turned out to be pheochromocytoma with thrombus revealing fibroadipose tissue with fibrin. Pheochromocytoma may present with IVC thrombus as well as normal serum and urinary markers. Thus, clinical suspicion is imperative

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2017 Case reports in urology

26. Polychlorinated biphenyls and depression: cross-sectional and longitudinal investigation of a dopamine-related Neurochemical path in the German HELPcB surveillance program (PubMed)

of depressive symptoms. As a surrogate for DA, we measured its metabolites homovanillic acid (HVA) and vanillylmandelic acid (VMA) in urine. Mediation analyses were performed to test whether the association between PCB exposure and severity of depressive symptoms is mediated by urinary concentration of DA metabolites HVA and VMA. The mediation was tested with the SPSS macro MEDIATE.We found a significant mediation over time for lower-chlorinated, higher-chlorinated and dioxin-like PCBs. The positive

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2017 Environmental Health

27. Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study (PubMed)

. Blood and urine samples were collected pre-exposure, and 1-hour and 21-hour post-exposure to determine neural biomarker levels. Mixed-model regressions assessed associations between exposures and changes in biomarker levels.Results were expressed as percent change from daily pre-exposure biomarker levels. Exposure to coarse CAP was significantly associated with increased urinary levels of the stress-related biomarkers vanillylmandelic acid (VMA) and cortisol when compared with exposure to filtered

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2017 Environment international Controlled trial quality: uncertain

28. Clinical Trial on Ganoderma Spore Lipids Combined With Chemo in Patients With G.I. Cancers

). ] Estradiol (female), progesterone (female), testosterone (male) in blood. [ Time Frame: Cycle 2, cycle 4, cycle 6(each cycle is 21 days). ] Vanillylmandelic acid (VMA) in urine. [ Time Frame: Cycle 2, cycle 4, cycle 6(each cycle is 21 days). ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study

2016 Clinical Trials

29. Giant Pheochromocytoma with Leukemoid Reaction: a Case Report. (PubMed)

Giant Pheochromocytoma with Leukemoid Reaction: a Case Report. We present a rare case of silent giant pheochromocytoma with leukemoid reaction that has not been reported before. The patient was a 61-year-old woman who complained of progressive weight loss for 3 months. Preoperatively the urine vanillylmandelic acid was 105.54 mg/24 hours. White blood cell count was 56.9 × 109/L. Abdominal ultrasound and computed tomography revealed a mass measuring 18 × 11 cm in the left adrenal area

2016 Urology

30. Pheochromocytoma after Cesarean Section (PubMed)

hypertension at first. In laboratory data, epinephrine, norepinephrine, metanephrine, normetanephrine, and vanillylmandelic acid were increased in 24 h urine collection. An adrenal mass was detected in abdominal computed tomography. Regarding clinical and paraclinical findings, pheochromocytoma was diagnosed. The patient received medical treatment, but it was not effective; hence, she underwent adrenalectomy.

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2016 International journal of preventive medicine

31. Neuroblastoma

Periorbital or Raccoon Eyes (from retrobulbar tumor infiltration) Blue Skin s (infants with Stage 4S tumors) VII. Evaluation Evaluation (advanced imaging, labs) is typically deferred to tertiary center work-up Urine s (e.g. vanillylmandelic acid) VIII. References Arndt in Burg (2006) Current Pediatric Therapy, Saunders Elsevier, Philadelphia, p. 1185-7 Shohet and Nuchtern in Park (2016) UpToDate, accessed on IOS 2/19/2016 Images: Related links to external sites (from Bing) These images are a random

2018 FP Notebook

32. Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. (PubMed)

2000 and 2010.Of 808 consecutive localized NT, 162 (20 %) were classified as GN and 55 (7 %) as GNBI. GN/GNBI patients presented more often with stage 1 disease (68 % vs. 37 %, p < 0.001), less frequently with adrenal tumors (31 % vs. 43 %, p = 0.001) and positive mIBG-uptake (34 % vs. 90 %, p < 0.001), and had less often elevated urine catecholamine metabolites (homovanillic acid 39 % vs. 62 %, p < 0.001, vanillylmandelic acid 27 % vs. 64 %, p < 0.001). Median age at diagnosis increased with grade

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2016 BMC Cancer

33. Changes of adrenomedullin and natriuretic peptides in patients with adrenal medullary hyperplasia prior to and following pharmacological therapy and adrenalectomy (PubMed)

and contralateral adrenal vein. Plasma ADM concentration was correlated with serum epinephrine and norepinephrine and urine vanillylmandelic acid, in addition to systolic and diastolic blood pressure, left ventricular ejection fraction, left ventricular mass index and ANP and BNP values in the AMH group. Following antihypertensive treatment, ADM, ANP and BNP were significantly decreased in EH patients, but remained unchanged in AMH subjects. However, these concentrations significantly decreased following

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2016 Experimental and therapeutic medicine

34. Risk factors for hypertensive attack during pheochromocytoma resection (PubMed)

, preoperative hormonal status (including epinephrine, norepinephrine, vanillylmandelic acid, and metanephrine levels in a 24-hour urine sample), tumor size, and postoperative systolic blood pressure were significantly associated with the development of hypertensive attack. In the multivariate analysis, preoperative epinephrine level and tumor size were independent factors that predicted hypertensive attack. The highest odds ratio for tumor size (2.169) was obtained at a cutoff value of 4.25 cm

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2016 Investigative and clinical urology

35. Neuroblastoma

Periorbital or Raccoon Eyes (from retrobulbar tumor infiltration) Blue Skin s (infants with Stage 4S tumors) VII. Evaluation Evaluation (advanced imaging, labs) is typically deferred to tertiary center work-up Urine s (e.g. vanillylmandelic acid) VIII. References Arndt in Burg (2006) Current Pediatric Therapy, Saunders Elsevier, Philadelphia, p. 1185-7 Shohet and Nuchtern in Park (2016) UpToDate, accessed on IOS 2/19/2016 Images: Related links to external sites (from Bing) These images are a random

2017 FP Notebook

36. Neuroblastoma Treatment (PDQ®): Patient Version

of the abdomen called a . The picture can be printed to be looked at later. studies : A procedure in which a urine sample is checked to measure the amount of certain substances, vanillylmandelic acid (VMA) and homovanillic acid (HVA), that are made when catecholamines break down and are released into the urine. A higher than normal amount of VMA or HVA can be a sign of neuroblastoma. : An of the and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making (...) . The exam checks a person’s mental status, coordination, and ability to walk normally, and how well the muscles, senses, and reflexes work. This may also be called a neuro exam or a neurologic exam. Urine catecholamine studies : A procedure in which a urine sample is checked to measure the amount of certain substances, vanillylmandelic acid (VMA) and homovanillic acid (HVA), that are made when catecholamines break down and are released into the urine. A higher than normal amount of VMA or HVA can

2015 PDQ - NCI's Comprehensive Cancer Database

37. Insulin Glargine Versus Regular Insulin Based Regimens in Glycemic Control After Acute Stroke

. Blood biomarkers [ Time Frame: 72 hours after recruitment ] Blood biomarkers include soluble form of receptor for glycation end-product (sRAGE), high mobility group box 1(HMGB1), heat shock protein 70 (HSP 70), C-reactive protein (CRP), D-dimer, fibrinogen Urine biomarkers [ Time Frame: 72 hours after recruitment ] Urine biomarkers include catecholamines such as normetanephrine and vanillylmandelic acid (VMA) Eligibility Criteria Go to Information from the National Library of Medicine Choosing (...) will be measured every 4-hours to adjust the next insulin dose. Glucometric parameters will also be analyzed by continuous blood glucose monitoring system. 10 ml blood and same amount of urine from 24 hours urine collection will be collected every day for further measurement of a variety of blood inflammatory markers and urine catecholamine levels. Study outcomes: The primary endpoint is the percentage of time in the range of 80-180 mg/dL during the sugar monitoring period. The secondary endpoints include: (1

2015 Clinical Trials

38. New insights into Brunner syndrome and potential for targeted therapy. (PubMed)

family had a missense variant in MAOA (p.R45W). Affected males had borderline-mild ID, attention deficit disorder and limited friendships. One had a history of explosive aggression in childhood and episodic symptoms of flushing, headaches and diarrhoea. Their carrier mother had normal intelligence but similar episodic symptoms. Characteristic biochemical abnormalities included high serum serotonin and urinary metanephrines and low urinary 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (...) (VMA). Symptomatic individuals in the second family had particularly high serotonin levels, and treatment with a serotonin reuptake inhibitor and dietary modification resulted in reversal of biochemical abnormalities, reduction of 'serotonergic' symptoms and behavioural improvement. Brunner syndrome should be considered as a cause of mild ID with paroxysmal behavioural symptoms. It can be screened for with serum/urine metanephrine and serotonin measurement. Cautious treatment with a serotonin

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2015 Clinical Genetics

39. Eye on Children: Acute Work-up for Pediatric Horner's Syndrome. Case Presentation and Review of the Literature. (PubMed)

be considered congenital or acquired and may be from benign or malignant causes. When an isolated, acquired Horner syndrome is suspected in a pediatric patient, physical examination of the neck and abdomen for masses, as well as spot urine catecholamines, vanillylmandelic acid and homovanillic acid, and varying degrees of imaging are recommended as part of the initial evaluation. These evaluations may be performed in the ED or may require hospitalization, depending on the suspected anatomical localization

2014 Journal of Emergency Medicine

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