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Urine Vanillylmandelic Acid

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21. Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study Full Text available with Trip Pro

. Blood and urine samples were collected pre-exposure, and 1-hour and 21-hour post-exposure to determine neural biomarker levels. Mixed-model regressions assessed associations between exposures and changes in biomarker levels.Results were expressed as percent change from daily pre-exposure biomarker levels. Exposure to coarse CAP was significantly associated with increased urinary levels of the stress-related biomarkers vanillylmandelic acid (VMA) and cortisol when compared with exposure to filtered

2017 Environment international Controlled trial quality: uncertain

22. Polychlorinated biphenyls and depression: cross-sectional and longitudinal investigation of a dopamine-related Neurochemical path in the German HELPcB surveillance program Full Text available with Trip Pro

of depressive symptoms. As a surrogate for DA, we measured its metabolites homovanillic acid (HVA) and vanillylmandelic acid (VMA) in urine. Mediation analyses were performed to test whether the association between PCB exposure and severity of depressive symptoms is mediated by urinary concentration of DA metabolites HVA and VMA. The mediation was tested with the SPSS macro MEDIATE.We found a significant mediation over time for lower-chlorinated, higher-chlorinated and dioxin-like PCBs. The positive

2017 Environmental Health

23. Marker-Negative Pheochromocytoma Associated with Inferior Vena Cava Thrombosis Full Text available with Trip Pro

of confluence with hepatic veins. Her routine laboratory investigations including 24-hour urine fractionated metanephrines, vanillylmandelic acid, and cortisol were normal. Right adrenalectomy with IVC thrombectomy was done. Perioperative period was uneventful. Histopathology of the mass turned out to be pheochromocytoma with thrombus revealing fibroadipose tissue with fibrin. Pheochromocytoma may present with IVC thrombus as well as normal serum and urinary markers. Thus, clinical suspicion is imperative

2017 Case reports in urology

24. Phase 2 Study of ONC201 in Neuroendocrine Tumors

and/or presence of a detectable serum or urine biomarker (3-methoxytyramine, normetanephrine, metanephrines, homovanillic acid (HVA), vanillylmandelic acid (VMA), and dopamine, Varieties will include neuroblastoma, Ewing sarcoma, neuroectodermal tumor, clear call sarcoma, myoepithelial tumor, primitive neuroectodermal tumor (PNET), desmoplastic small round cell tumor, round cell sarcoma, and unresectable, metastatic or locally advanced , well-differentiated neuroendocrine tumors who have relapsed

2017 Clinical Trials

25. Urine Catecholamine Levels as Diagnostic Markers for Neuroblastoma in a Defined Population: Implications for Ophthalmic Practice Full Text available with Trip Pro

elevated urinary catecholamine metabolites at the initial presentation. Urinary vanillylmandelic acid (VMA) levels were greater than twice the upper limit of normal in eight (57%) of 14 cases, whereas homovanillic acid (HVA) levels were greater than two times the upper limit of normal in 10 (71%) of the 14 cases. Three (75%) of the four cases without significantly elevated urinary VMA or HVA levels were diagnosed with stage IV disease, whereas one (25%) had stage II neuroblastoma.urinary catecholamine (...) Urine Catecholamine Levels as Diagnostic Markers for Neuroblastoma in a Defined Population: Implications for Ophthalmic Practice although elevated urinary catecholamine levels have been reported in 90-95% of patients with neuroblastoma, more recent studies of pediatric Horner syndrome caused by an underling neuroblastoma have reported normal values at presentation. The purpose of this population-based study is to report the percentage of cases of neuroblastoma with elevated urinary

2010 Eye

26. Neuroblastoma

Periorbital or Raccoon Eyes (from retrobulbar tumor infiltration) Blue Skin s (infants with Stage 4S tumors) VII. Evaluation Evaluation (advanced imaging, labs) is typically deferred to tertiary center work-up Urine s (e.g. vanillylmandelic acid) VIII. References Arndt in Burg (2006) Current Pediatric Therapy, Saunders Elsevier, Philadelphia, p. 1185-7 Shohet and Nuchtern in Park (2016) UpToDate, accessed on IOS 2/19/2016 Images: Related links to external sites (from Bing) These images are a random

2018 FP Notebook

27. Neuroblastoma Treatment (PDQ®): Health Professional Version

syndrome and germline CDKN1C mutations. Individuals with Costello syndrome and HRAS mutations. Individuals with neuroblastoma and a strong family history of neuroblastoma or clearly bilateral/multifocal neuroblastoma. Surveillance consists of the following:[ ] Abdominal ultrasonography. Quantitative, normalized assessment of urinary catecholamines, such as urine vanillylmandelic acid (VMA) and homovanillic acid (HVA), by gas chromatography and mass spectroscopy (can be a random urine collection (...) normalized for urine creatinine). Chest x-ray. Surveillance begins at birth or at diagnosis of neuroblastoma predisposition and continues every 3 months until age 6 years and then continues every 6 months until age 10 years. Patients with Costello syndrome may have elevated urinary catecholamines in the absence of a catecholamine-secreting tumor, so only very high levels or significantly rising levels should prompt further investigation beyond the ultrasonography and chest x-ray.[ ] Patients with Li

2016 PDQ - NCI's Comprehensive Cancer Database

29. Neuroblastoma Treatment (PDQ®): Patient Version

(ultrasound) are bounced off the abdomen and make echoes. The echoes form a picture of the abdomen called a . The picture can be printed to be looked at later. studies : A test in which a urine sample is checked to measure the amount of certain substances, vanillylmandelic acid (VMA) and homovanillic acid (HVA), that are made when catecholamines break down and are released into the urine. A higher than normal amount of VMA or HVA can be a sign of neuroblastoma. : An of the and bones inside the chest. An x (...) . A history of the patient’s health habits and past illnesses and treatments will also be taken. : A series of questions and tests to check the brain, , and nerve function. The exam checks a person’s mental status, coordination, ability to walk normally, and how well the muscles, senses, and reflexes work. This may also be called a neuro exam or a neurologic exam. Urine catecholamine studies : A test in which a urine sample is checked to measure the amount of certain substances, vanillylmandelic acid (VMA

2015 PDQ - NCI's Comprehensive Cancer Database

30. Neuroblastoma

Periorbital or Raccoon Eyes (from retrobulbar tumor infiltration) Blue Skin s (infants with Stage 4S tumors) VII. Evaluation Evaluation (advanced imaging, labs) is typically deferred to tertiary center work-up Urine s (e.g. vanillylmandelic acid) VIII. References Arndt in Burg (2006) Current Pediatric Therapy, Saunders Elsevier, Philadelphia, p. 1185-7 Shohet and Nuchtern in Park (2016) UpToDate, accessed on IOS 2/19/2016 Images: Related links to external sites (from Bing) These images are a random

2017 FP Notebook

31. Giant Pheochromocytoma with Leukemoid Reaction: a Case Report. (Abstract)

Giant Pheochromocytoma with Leukemoid Reaction: a Case Report. We present a rare case of silent giant pheochromocytoma with leukemoid reaction that has not been reported before. The patient was a 61-year-old woman who complained of progressive weight loss for 3 months. Preoperatively the urine vanillylmandelic acid was 105.54 mg/24 hours. White blood cell count was 56.9 × 109/L. Abdominal ultrasound and computed tomography revealed a mass measuring 18 × 11 cm in the left adrenal area

2016 Urology

32. Risk factors for hypertensive attack during pheochromocytoma resection Full Text available with Trip Pro

, preoperative hormonal status (including epinephrine, norepinephrine, vanillylmandelic acid, and metanephrine levels in a 24-hour urine sample), tumor size, and postoperative systolic blood pressure were significantly associated with the development of hypertensive attack. In the multivariate analysis, preoperative epinephrine level and tumor size were independent factors that predicted hypertensive attack. The highest odds ratio for tumor size (2.169) was obtained at a cutoff value of 4.25 cm

2016 Investigative and clinical urology

33. Changes of adrenomedullin and natriuretic peptides in patients with adrenal medullary hyperplasia prior to and following pharmacological therapy and adrenalectomy Full Text available with Trip Pro

and contralateral adrenal vein. Plasma ADM concentration was correlated with serum epinephrine and norepinephrine and urine vanillylmandelic acid, in addition to systolic and diastolic blood pressure, left ventricular ejection fraction, left ventricular mass index and ANP and BNP values in the AMH group. Following antihypertensive treatment, ADM, ANP and BNP were significantly decreased in EH patients, but remained unchanged in AMH subjects. However, these concentrations significantly decreased following

2016 Experimental and therapeutic medicine

34. Pheochromocytoma after Cesarean Section Full Text available with Trip Pro

hypertension at first. In laboratory data, epinephrine, norepinephrine, metanephrine, normetanephrine, and vanillylmandelic acid were increased in 24 h urine collection. An adrenal mass was detected in abdominal computed tomography. Regarding clinical and paraclinical findings, pheochromocytoma was diagnosed. The patient received medical treatment, but it was not effective; hence, she underwent adrenalectomy.

2016 International journal of preventive medicine

35. Clinical Trial on Ganoderma Spore Lipids Combined With Chemo in Patients With G.I. Cancers

). ] Estradiol (female), progesterone (female), testosterone (male) in blood. [ Time Frame: Cycle 2, cycle 4, cycle 6(each cycle is 21 days). ] Vanillylmandelic acid (VMA) in urine. [ Time Frame: Cycle 2, cycle 4, cycle 6(each cycle is 21 days). ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study

2016 Clinical Trials

36. Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. Full Text available with Trip Pro

2000 and 2010.Of 808 consecutive localized NT, 162 (20 %) were classified as GN and 55 (7 %) as GNBI. GN/GNBI patients presented more often with stage 1 disease (68 % vs. 37 %, p < 0.001), less frequently with adrenal tumors (31 % vs. 43 %, p = 0.001) and positive mIBG-uptake (34 % vs. 90 %, p < 0.001), and had less often elevated urine catecholamine metabolites (homovanillic acid 39 % vs. 62 %, p < 0.001, vanillylmandelic acid 27 % vs. 64 %, p < 0.001). Median age at diagnosis increased with grade

2016 BMC Cancer

37. Insulin Glargine Versus Regular Insulin Based Regimens in Glycemic Control After Acute Stroke

. Blood biomarkers [ Time Frame: 72 hours after recruitment ] Blood biomarkers include soluble form of receptor for glycation end-product (sRAGE), high mobility group box 1(HMGB1), heat shock protein 70 (HSP 70), C-reactive protein (CRP), D-dimer, fibrinogen Urine biomarkers [ Time Frame: 72 hours after recruitment ] Urine biomarkers include catecholamines such as normetanephrine and vanillylmandelic acid (VMA) Eligibility Criteria Go to Information from the National Library of Medicine Choosing (...) will be measured every 4-hours to adjust the next insulin dose. Glucometric parameters will also be analyzed by continuous blood glucose monitoring system. 10 ml blood and same amount of urine from 24 hours urine collection will be collected every day for further measurement of a variety of blood inflammatory markers and urine catecholamine levels. Study outcomes: The primary endpoint is the percentage of time in the range of 80-180 mg/dL during the sugar monitoring period. The secondary endpoints include: (1

2015 Clinical Trials

38. New insights into Brunner syndrome and potential for targeted therapy. Full Text available with Trip Pro

family had a missense variant in MAOA (p.R45W). Affected males had borderline-mild ID, attention deficit disorder and limited friendships. One had a history of explosive aggression in childhood and episodic symptoms of flushing, headaches and diarrhoea. Their carrier mother had normal intelligence but similar episodic symptoms. Characteristic biochemical abnormalities included high serum serotonin and urinary metanephrines and low urinary 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (...) (VMA). Symptomatic individuals in the second family had particularly high serotonin levels, and treatment with a serotonin reuptake inhibitor and dietary modification resulted in reversal of biochemical abnormalities, reduction of 'serotonergic' symptoms and behavioural improvement. Brunner syndrome should be considered as a cause of mild ID with paroxysmal behavioural symptoms. It can be screened for with serum/urine metanephrine and serotonin measurement. Cautious treatment with a serotonin

2015 Clinical Genetics

39. Neuroblastoma, Childhood

with neuroblastoma and a strong family history of neuroblastoma or clearly bilateral/multifocal neuroblastoma. Surveillance consists of the following:[ ] Abdominal ultrasonography. Quantitative, normalized assessment of urinary catecholamines, such as urine vanillylmandelic acid (VMA) and homovanillic acid (HVA), by gas chromatography and mass spectroscopy (can be a random urine collection normalized for urine creatinine). Chest x-ray. Surveillance begins at birth or at diagnosis of neuroblastoma predisposition (...) .) Urine catecholamine metabolites: Urinary excretion of the catecholamine metabolites VMA and HVA per milligram of excreted creatinine is measured before therapy. Collection of urine for 24 hours is not needed. If they remain elevated, these markers can be used to suggest the persistence of disease. In contrast to urine, serum catecholamines are not routinely used in the diagnosis of neuroblastoma except in unusual circumstances. Biopsy: Tumor tissue is often needed to obtain all the biological data

2012 PDQ - NCI's Comprehensive Cancer Database

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