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Urine Uric Acid

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141. Bioassay of aldosterone antagonists in normal human subjects: a relationship between the level of plasma uric acid before treatment and apparent drug responses. (PubMed)

sodium excretion and the sodium : potassium (Na/K) ratio, and decreased potassium excretion, when compared with placebo. The response to the two active drugs did not differ significantly. 3 The urine Na/K ratio, and log10 Na/K, in response to spironolactone correlated negatively with the level of plasma uric acid measured 12 h before treatment. Similar trends were present after SC-23992 and placebo treatments. 4 It is suggested that the correlations between plasma uric acid and apparent drug response (...) Bioassay of aldosterone antagonists in normal human subjects: a relationship between the level of plasma uric acid before treatment and apparent drug responses. The activity of single doses of SC-23992, a new aldosterone antagonist, and spironolactone in reversing the effects of fludrocortisone on urinary electrolyte composition in normal subjects was compared with that of placebo in a double-blind crossover study. 2 SC-23992 (50 mg) and spironolactone (125 mg) each significantly increased

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1975 British journal of clinical pharmacology Controlled trial quality: uncertain

142. Effect of atromid and its components on uric acid excretion and on gout. (PubMed)

Humans Male Uric Acid Uricosuric Agents therapeutic use Urine 1965 11 1 1965 11 1 0 1 1965 11 1 0 0 ppublish 5855251 PMC1010409 J Atheroscler Res. 1963 Sep-Dec;3:475-81 14100888 J Atheroscler Res. 1963 Sep-Dec;3:554-60 14100898 J Clin Invest. 1959 Aug;38(8):1298-315 13673086 J Lab Clin Med. 1959 Dec;54:903-13 14416793 Proc Soc Exp Biol Med. 1950 May;74(1):148-51 15430417 J Atheroscler Res. 1963 Sep-Dec;3:593-616 14104298 Lancet. 1962 Jun 23;1(7243):1321-3 14481816 Ann Rheum Dis. 1957 Dec;16(4):425-37 (...) Effect of atromid and its components on uric acid excretion and on gout. 5855251 1966 03 27 2018 11 13 0003-4967 24 6 1965 Nov Annals of the rheumatic diseases Ann. Rheum. Dis. Effect of atromid and its components on uric acid excretion and on gout. 572-5 Trevaks G G Lovell R R RR eng Journal Article England Ann Rheum Dis 0372355 0003-4967 0 Butyrates 0 Uricosuric Agents 268B43MJ25 Uric Acid C24W7J5D5R Androsterone IM Adult Androsterone therapeutic use Butyrates therapeutic use Female Gout

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1965 Annals of the Rheumatic Diseases

143. Factors inhibiting the excretion of uric acid. (PubMed)

Factors inhibiting the excretion of uric acid. 5937678 1966 08 29 2018 11 13 0035-9157 59 4 1966 Apr Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Factors inhibiting the excretion of uric acid. 310-3 Scott J T JT eng Journal Article England Proc R Soc Med 7505890 0035-9157 268B43MJ25 Uric Acid IM Blood Gout etiology Humans Uric Acid metabolism Urine 1966 4 1 1966 4 1 0 1 1966 4 1 0 0 ppublish 5937678 PMC1900627 J Chronic Dis. 1961 Nov;14:495-506 14483759 Metabolism. 1965 Feb

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1966 Proceedings of the Royal Society of Medicine

144. Urinary hydrogen ion excretion in patients with uric acid calculi. (PubMed)

Urinary hydrogen ion excretion in patients with uric acid calculi. 5937679 1966 08 29 2018 11 13 0035-9157 59 4 1966 Apr Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Urinary hydrogen ion excretion in patients with uric acid calculi. 313-5 Wrong O O eng Journal Article England Proc R Soc Med 7505890 0035-9157 7664-41-7 Ammonia IM Ammonia metabolism Humans Hydrogen-Ion Concentration Urinary Calculi etiology Urine 1966 4 1 1966 4 1 0 1 1966 4 1 0 0 ppublish 5937679 PMC1900628 Q

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1966 Proceedings of the Royal Society of Medicine

145. Effects of Allopurinol on Gouty and Non-Gouty Uric Acid Nephropathy (PubMed)

Sulfinpyrazone IM Allopurinol therapeutic use Blood Urea Nitrogen Enzyme Therapy Female Gout complications Humans Kidney Calculi drug therapy Kidney Diseases drug therapy Male Salicylates therapeutic use Sulfinpyrazone therapeutic use Uric Acid blood urine Xanthine Oxidase 1966 11 1 1966 11 1 0 1 1966 11 1 0 0 ppublish 5958697 PMC2453415 10.1136/ard.25.Suppl_6.673 (...) Effects of Allopurinol on Gouty and Non-Gouty Uric Acid Nephropathy 5958697 1967 04 13 2018 11 30 0003-4967 25 6 Suppl 1966 Nov Annals of the rheumatic diseases Ann. Rheum. Dis. Effects of allopurinol on gouty and non-gouty uric acid nephropathy. 673-80 10.1136/ard.25.Suppl_6.673 Ogryzlo M A MA Urowitz M B MB Weber H M HM Houpt J B JB eng Journal Article England Ann Rheum Dis 0372355 0003-4967 0 Salicylates 268B43MJ25 Uric Acid 63CZ7GJN5I Allopurinol EC 1.17.3.2 Xanthine Oxidase V6OFU47K3W

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1966 Annals of the Rheumatic Diseases

146. Allopurinol in the Prophylaxis of Uric Acid Stones (PubMed)

complications Humans Hydrogen-Ion Concentration Kidney Calculi drug therapy Male Uric Acid urine Xanthine Oxidase 1966 11 1 1966 11 1 0 1 1966 11 1 0 0 ppublish 5958700 PMC2453421 10.1136/ard.25.Suppl_6.691 (...) Allopurinol in the Prophylaxis of Uric Acid Stones 5958700 1967 04 13 2018 11 30 0003-4967 25 6 Suppl 1966 Nov Annals of the rheumatic diseases Ann. Rheum. Dis. Allopurinol in the prophylaxis of uric acid stones. 691-3 10.1136/ard.25.Suppl_6.691 de Vries A A Frank M M Liberman U A UA Sperling O O eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid 63CZ7GJN5I Allopurinol EC 1.17.3.2 Xanthine Oxidase IM Allopurinol therapeutic use Enzyme Therapy Female Gout

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1966 Annals of the Rheumatic Diseases

147. The Treatment of Gout and Disorders of Uric Acid Metabolism with Allopurinol (PubMed)

concentration and uric acid excretion to normal levels, while not significantly affecting the clearance of urate or other aspects of renal function. Oxypurine excretion increased concomitantly with the fall in urine uric acid. The agent is particularly valuable in the management of problems of gout with azotemia, acute uric acid nephropathy and uric acid urolithiasis. The minor side effects, clinical indications and theoretical complications are discussed. (...) The Treatment of Gout and Disorders of Uric Acid Metabolism with Allopurinol Allopurinol (4-hydroxypyrazolo (3,4-d)-pyrimidine) is a potent xanthine oxidase inhibitor which inhibits the oxidation of naturally occurring oxypurines, thus decreasing uric acid formation. The clinical and metabolic effects of this agent were studied in 80 subjects with primary and secondary gout and other disorders of uric acid metabolism. Allopurinol has been universally successful in lowering the serum uric acid

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1966 Canadian Medical Association Journal

148. Inborn enzymatic defect as the probable cause of the formation of renal stones consisting of uric acid (PubMed)

Inborn enzymatic defect as the probable cause of the formation of renal stones consisting of uric acid In four persons of one family the existence of an enzymatic defect, presumably consisting of a deficiency of glutaminase in the cells of the renal tubules, is postulated, and is implied by a reduced elimination of ammonia in the urine, by a relatively low urinary pH, and by its increased titratable acidity. The most characteristic clinical symptom is irritation of the distal part (...) of the urinary tract, connected with numerous crystals of uric acid appearing in the urinary sediment. The elimination of uric acid is normal, or even reduced, and the level of uric acid in the blood serum is also within normal limits. After the administration of glutaminic acid elimination of ammonia is further decreased and the quantity of uric acid crystals is increased. Loading with glutaminic acid may also cause an attack of renal pain in the individual suffering from this defect but the administration

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1965 Journal of Clinical Pathology

149. Metabolic studies on the formation of calcium oxalate stones, with special emphasis on vitamin B6 and uric acid metabolism. (PubMed)

Med 7505398 0028-7091 0 Oxalates 268B43MJ25 Uric Acid SY7Q814VUP Calcium IM Calcium urine Female Humans Male Oxalates urine Uric Acid metabolism Urinary Calculi etiology Vitamin B 6 Deficiency complications 1968 1 1 1968 1 1 0 1 1968 1 1 0 0 ppublish 5239150 PMC1749976 Proc Soc Exp Biol Med. 1951 Jul;77(3):399-401 14864603 Am J Clin Nutr. 1960 Nov-Dec;8:812-6 13704750 Clin Sci (Lond). 1957 Aug;16(3):405-11 13473154 J Lab Clin Med. 1959 Dec;54:903-13 14416793 Clin Chem. 1963 Jun;9:334-9 13934121 J (...) Metabolic studies on the formation of calcium oxalate stones, with special emphasis on vitamin B6 and uric acid metabolism. 5239150 1968 06 07 2018 11 13 0028-7091 44 1 1968 Jan Bulletin of the New York Academy of Medicine Bull N Y Acad Med Metabolic studies on the formation of calcium oxalate stones, with special emphasis on vitamin B6 and uric acid metabolism. 28-44 Mayer G G GG Chase T T Farvar B B Waidh M A MA Longo F F Karp F F Zinsser H H HH eng Journal Article United States Bull N Y Acad

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1968 Bulletin of the New York Academy of Medicine

150. A specific enzyme defect in gout associated with overproduction of uric acid. (PubMed)

Hypoxanthines 268B43MJ25 Uric Acid 5Z93L87A1R Guanine EC 2.4.1.- Glucosyltransferases IM Adult Diphosphates Erythrocytes enzymology Glucosyltransferases metabolism Gout metabolism Guanine Hot Temperature Humans Hypoxanthines In Vitro Techniques Leukocytes enzymology Male Middle Aged Molecular Biology Mutation Purine-Pyrimidine Metabolism, Inborn Errors Uric Acid biosynthesis blood urine 1967 6 1 1967 6 1 0 1 1967 6 1 0 0 ppublish 4291947 PMC224540 Science. 1967 Mar 31;155(3770):1682-4 6020292 Proc Soc Exp (...) A specific enzyme defect in gout associated with overproduction of uric acid. 4291947 1967 10 13 2018 11 13 0027-8424 57 6 1967 Jun Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. A specific enzyme defect in gout associated with overproduction of uric acid. 1735-9 Kelley W N WN Rosenbloom F M FM Henderson J F JF Seegmiller J E JE eng Journal Article United States Proc Natl Acad Sci U S A 7505876 0027-8424 0 Diphosphates 0

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1967 Proceedings of the National Academy of Sciences of the United States of America

151. C14 studies of uric acid turnover. (PubMed)

C14 studies of uric acid turnover. 5677169 1968 11 06 2013 11 21 0003-4967 27 5 1968 Sep Annals of the rheumatic diseases Ann. Rheum. Dis. C14 studies of uric acid turnover. 476-7 Scott J T JT Arnot R R Glass H I HI Holloway V P VP eng Journal Article England Ann Rheum Dis 0372355 0003-4967 0 Carbon Isotopes 268B43MJ25 Uric Acid 63CZ7GJN5I Allopurinol IM Acute Kidney Injury Allopurinol therapeutic use Carbon Isotopes Gout drug therapy Humans Mathematics Uric Acid urine 1968 9 1 1968 9 1 0 1

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1968 Annals of the Rheumatic Diseases

152. Studies of uric acid pool size and turnover rate. (PubMed)

Hypertension complications Male Mathematics Metabolic Clearance Rate Middle Aged Uric Acid blood metabolism urine 1969 7 1 1969 7 1 0 1 1969 7 1 0 0 ppublish 5794063 PMC1010504 Lancet. 1966 Jan 1;1(7427):15-8 4159153 Strahlentherapie Sonderb. 1968;67:223-33 5719123 J Clin Invest. 1951 Aug;30(8):879-88 14861310 J Biol Chem. 1952 May;196(1):179-84 12980954 Biochem J. 1954 Nov;58(3):426-37 13208633 J Clin Invest. 1961 Jul;40:1304-14 13749616 Biophys J. 1962 May;2:275-87 13867975 J Biol Chem. 1949 Nov;181(1 (...) Studies of uric acid pool size and turnover rate. 5794063 1969 08 30 2018 11 13 0003-4967 28 4 1969 Jul Annals of the rheumatic diseases Ann. Rheum. Dis. Studies of uric acid pool size and turnover rate. 366-73 Scott J T JT Holloway V P VP Glass H I HI Arnot R N RN eng Journal Article England Ann Rheum Dis 0372355 0003-4967 0 Carbon Isotopes 268B43MJ25 Uric Acid 63CZ7GJN5I Allopurinol IM Adolescent Adult Aged Allopurinol therapeutic use Carbon Isotopes Female Gout drug therapy metabolism Humans

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1969 Annals of the Rheumatic Diseases

153. Uric acid metabolism in starvation. (PubMed)

Uric acid metabolism in starvation. 5476683 1970 12 22 2018 11 13 0003-4967 29 5 1970 Sep Annals of the rheumatic diseases Ann. Rheum. Dis. Uric acid metabolism in starvation. 553-5 Lloyd-Mostyn R H RH Lord P S PS Glover R R West C C Gilliland I C IC eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid 63CZ7GJN5I Allopurinol IM Allopurinol adverse effects therapeutic use Female Gout Humans Male Obesity therapy Starvation metabolism Uric Acid blood metabolism urine

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1970 Annals of the Rheumatic Diseases

154. Uric acid excretion in the relatives of patients with gout. (PubMed)

Uric acid excretion in the relatives of patients with gout. 4916770 1970 10 17 2018 11 13 0003-4967 29 4 1970 Jul Annals of the rheumatic diseases Ann. Rheum. Dis. Uric acid excretion in the relatives of patients with gout. 397-400 Scott J T JT Pollard A C AC eng Journal Article Review England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid AYI8EX34EU Creatinine IM Creatinine urine Female Gout blood genetics urine Humans Male Sex Factors Uric Acid blood urine 11 1970 7 1 1970 7 1 0 1 1970

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1970 Annals of the Rheumatic Diseases

155. The metabolic basis of uric acid stone formation. (PubMed)

The metabolic basis of uric acid stone formation. 5124821 1972 02 11 2013 11 21 0264-6021 122 1 1971 Mar The Biochemical journal Biochem. J. The metabolic basis of uric acid stone formation. 9P Wrong O M OM eng Journal Article England Biochem J 2984726R 0264-6021 0 Bicarbonates 0 Citrates 268B43MJ25 Uric Acid IM Adult Bicarbonates therapeutic use Chemical Precipitation Citrates therapeutic use Humans Hydrogen-Ion Concentration Uric Acid urine Urinary Calculi metabolism prevention & control 1971

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1971 Biochemical Journal

156. Uric acid clearance in patients with gout and normal subjects. (PubMed)

Rate Middle Aged Uric Acid blood metabolism urine 1971 5 1 1971 5 1 0 1 1971 5 1 0 0 ppublish 5090245 PMC1005769 Ann Rheum Dis. 1970 Jul;29(4):397-400 4916770 Am J Med. 1969 Oct;47(4):575-92 4898522 J Lab Clin Med. 1959 Dec;54:903-13 14416793 Aust J Exp Biol Med Sci. 1958 Aug;36(4):383-94 13607346 J Clin Invest. 1961 Jul;40:1304-14 13749616 J Clin Invest. 1959 Nov;38:1890-8 14427889 J Pediatr. 1968 Oct;73(4):583-92 5678000 J Clin Invest. 1962 Nov;41(11):1955-63 16695885 Proc R Soc Med. 1969 Aug;62 (...) Uric acid clearance in patients with gout and normal subjects. 5090245 1971 08 13 2018 11 13 0003-4967 30 3 1971 May Annals of the rheumatic diseases Ann. Rheum. Dis. Uric acid clearance in patients with gout and normal subjects. 285-9 Snaith M L ML Scott J T JT eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid AYI8EX34EU Creatinine IM Adult Aged Body Height Body Weight Creatinine metabolism Female Gout metabolism Humans Kidney metabolism Male Metabolic Clearance

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1971 Annals of the Rheumatic Diseases

157. Effect of ACTH and Sodium Salicylate on the Urinary Uric Acid: Creatinine Ratio, and Circulating Eosinophils in Man (PubMed)

Creatinine O414PZ4LPZ Salicylic Acid WIQ1H85SYP Sodium Salicylate OM Adrenocorticotropic Hormone pharmacology Arthritis Arthritis, Rheumatoid metabolism Creatinine Eosinophils drug effects Gout metabolism Humans Male Osteoarthritis metabolism Salicylic Acid pharmacology Sodium Salicylate Uric Acid urine 5425:46618:8:46:161:201:333:412:486 ACTH/effects ARTHRITIS, RHEUMATOID/metabolism in EOSINOPHILS/effect of drugs on GOUT/metabolism in OSTEOARTHRITIS/metabolism in SALICYLIC ACID/effects URIC ACID (...) Effect of ACTH and Sodium Salicylate on the Urinary Uric Acid: Creatinine Ratio, and Circulating Eosinophils in Man 13125229 2003 05 01 2018 12 01 0003-4967 12 4 1953 Dec Annals of the rheumatic diseases Ann. Rheum. Dis. Effect of ACTH and sodium salicylate on the urinary uric acid: creatinine ratio, and circulating eosinophils in man. 296-300 MARSON F G FG eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid 9002-60-2 Adrenocorticotropic Hormone AYI8EX34EU

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1953 Annals of the Rheumatic Diseases

158. CHEMICAL STUDIES ON INTESTINAL INFANTILISM : I. ENDOGENOUS METABOLISM: KREATININ, KREATIN, URIC ACID. (PubMed)

CHEMICAL STUDIES ON INTESTINAL INFANTILISM : I. ENDOGENOUS METABOLISM: KREATININ, KREATIN, URIC ACID. In my three cases of intestinal infantilism, the kreatinin excretion was more irregular than normally, and the kreatinin coefficient was low. Kreatin was found in the urine on a kreatin-free diet. The sum of kreatinin and kreatin was also irregular. The endogenous uric acid was irregular from day to day. The kreatin excretion is apparently lower on a high fat diet than on a high carbohydrate

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1912 The Journal of experimental medicine

159. Pattern of Uric-acid Excretion During a Leukaemic Remission (PubMed)

Pattern of Uric-acid Excretion During a Leukaemic Remission 13816601 1998 11 01 2018 12 01 0007-1447 1 5178 1960 Apr 02 British medical journal Br Med J Pattern of uric-acid excretion during a leukaemic remission. 1027-9 DICKINSON C J CJ eng Journal Article England Br Med J 0372673 0007-1447 268B43MJ25 Uric Acid OM Biological Transport Body Fluids Humans Leukemia urine Uric Acid urine LEUKEMIA/urine URIC ACID/urine 1960 4 2 1960 4 2 0 1 1960 4 2 0 0 ppublish 13816601 PMC1967518 Scand J Clin Lab

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1960 British medical journal

160. Plasma uric acid and spironolactone response in healthy subjects. (PubMed)

Sodium AYI8EX34EU Creatinine RWP5GA015D Potassium IM Biological Availability Canrenone analysis Creatinine metabolism Humans Potassium urine Sodium urine Spironolactone administration & dosage metabolism pharmacology Tablets Uric Acid blood 1977 4 1 1977 4 1 0 1 1977 4 1 0 0 ppublish 861142 PMC1429001 J Pharmacol Exp Ther. 1962 Mar;135:312-6 13899372 Br J Clin Pharmacol. 1975 Jun;2(3):271-6 1234508 Br J Clin Pharmacol. 1975 Aug;2(4):361-2 1233997 Clin Pharmacol Ther. 1975 Oct;18(4):391-400 1100306 (...) Plasma uric acid and spironolactone response in healthy subjects. 861142 1977 07 29 2018 11 13 0306-5251 4 2 1977 Apr British journal of clinical pharmacology Br J Clin Pharmacol Plasma uric acid and spironolactone response in healthy subjects. 247-9 Ramsay L E LE Shelton J R JR Harrison I R IR eng Clinical Trial Journal Article Randomized Controlled Trial England Br J Clin Pharmacol 7503323 0306-5251 0 Tablets 268B43MJ25 Uric Acid 27O7W4T232 Spironolactone 78O20X9J0U Canrenone 9NEZ333N27

1977 British journal of clinical pharmacology Controlled trial quality: uncertain

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