How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,797 results for

Urine Uric Acid

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. Uric Acid Stones (Diagnosis)

precipitation in metastable urine concentrates (see ). Uric acid stones. The terms gouty nephropathy, urate nephropathy, and uric acid nephropathy are used to describe renal insufficiency due to uric acid precipitation within the renal tubules. Uric acid urolithiasis or uric acid kidney stones refer to development of a stone or calculus composed of significant amounts of urate in the renal pelvis, ureter, or bladder. Next: Pathophysiology Uric acid is a weak acid, with an ionization constant of acid (pK (...) in urine exceeds its solubility at the urine pH, uric acid changes from a compound dissolved in solution to an insoluble precipitate. Urate stones are formed by 1 of 3 general mechanisms: overproduction, increased tubular secretion, or decreased tubular reabsorption. Uric acid results as a relatively insoluble end-product of purine metabolism. The concentration of uric acid in plasma depends on dietary ingestion, de novo purine synthesis, and uric acid elimination by the kidneys and intestine. Normal

2014 eMedicine Pediatrics

122. Uric Acid Stones (Treatment)

Stones Treatment & Management Updated: Jun 11, 2018 Author: Sahar Fathallah-Shaykh, MD; Chief Editor: Craig B Langman, MD Share Email Print Feedback Close Sections Sections Uric Acid Stones Treatment Medical Care The primary treatments are to alkalinize (citrate or bicarbonate) and dilute (large water intake) the urine. Sodium urate is 15 times more soluble than uric acid. At a urine pH level of 6.8, 10 times as much sodium urate as uric acid is present. At a urine pH level of 7.8, 100 times as much (...) if necessary. A urine Gram stain may guide in the selection of antibiotic coverage. Consultation with a pediatric urologist should be obtained because surgery may be necessary to provide drainage. A child with acute pain and large stones (>0.3 cm) is likely to require lithotripsy or surgical stone removal. Analgesics and adequate hydration should be provided. For smaller stones or incidental stones, allowing time for the stone to pass is appropriate. The primary treatment for uric acid stones includes

2014 eMedicine Pediatrics

123. THE ROLE OF LACTIC ACID IN THE REDUCED EXCRETION OF URIC ACID IN TOXEMIA OF PREGNANCY Full Text available with Trip Pro

-Eclampsia urine Pregnancy Uric Acid blood LACTATES/pharmacology PREGNANCY TOXEMIAS/urine URIC ACID/blood 1960 10 1 1960 10 1 0 1 1960 10 1 0 0 ppublish 13711188 10.1172/JCI104172 PMC441887 Proc Soc Exp Biol Med. 1957 Dec;96(3):809-13 13505867 J Clin Invest. 1940 May;19(3):525-35 16694770 J Obstet Gynaecol Br Emp. 1953 Jun;60(3):335-44 13061996 Lancet. 1955 Feb 12;268(6859):323-5 13234369 Bull N Y Acad Med. 1958 May;34(5):287-96 13523299 Am J Obstet Gynecol. 1957 Mar;73(3):492-506 13402821 J Clin Invest (...) THE ROLE OF LACTIC ACID IN THE REDUCED EXCRETION OF URIC ACID IN TOXEMIA OF PREGNANCY 13711188 1998 11 01 2018 11 30 0021-9738 39 1960 Oct The Journal of clinical investigation J. Clin. Invest. The role of lactic acid in the reduced excretion of uric acid in toxemia of pregnancy. 1526-32 HANDLER J S JS eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Lactates 268B43MJ25 Uric Acid 33X04XA5AT Lactic Acid OM Body Fluids Female Humans Lactates pharmacology Lactic Acid Pre

1960 Journal of Clinical Investigation

124. A comparison of the metabolic profiles of diabetic and non-diabetic uric acid stone formers Full Text available with Trip Pro

. Information included patients' clinical histories, 24 hour urine collections, blood chemistry and stone analysis.Complete data were obtained from 68 patients with uric acid stones. Twenty-two patients had diabetes. There were no statistically significant differences in mean age, body mass index, or history of gout. Among diabetics, pure uric acid stones were identified in 14 patients (63%) and mixed uric acid in 8 (36%). Pure uric acid stones were more common in the diabetic cohort (63% vs. 46%, p = 0.16 (...) ). Urine pH, serum and urine uric acid levels and 24-hour urine volumes were similar in both groups. The diabetic group had an increased average oxalate excretion (424 μmol/d vs. 324 μmol/d, p = 0.003).The exact etiological basis for the higher oxalate excretion in diabetic uric acid stone formers is unclear. Whether this is a metabolic feature of diabetes, due to dietary indiscretion or the iatrogenic consequence of dietary advice requires further investigation.

2013 Canadian Urological Association Journal

125. Montmorency Cherry Juice and Uric Acid Metabolism

Montmorency Cherry Juice and Uric Acid Metabolism Montmorency Cherry Juice and Uric Acid Metabolism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Montmorency Cherry Juice and Uric Acid Metabolism (...) to Brief Summary: Cherries have been show to possess the ability to reduce uric acid concentrations and inflammation. Tart Montmorency cherries possess a higher concentration of the plant compounds than other cherries and hence makes the expectation possible that Montmorency cherries will lower uric acid and inflammation. Condition or disease Intervention/treatment Phase Inflammation Dietary Supplement: Montmorency cherry concentrate Not Applicable Detailed Description: Plasma and urinary uric acid

2013 Clinical Trials

126. Who makes uric acid stones and why--observations from a renal stones clinic. Full Text available with Trip Pro

Who makes uric acid stones and why--observations from a renal stones clinic. Excessively acidic urine is the dominant factor in uric acid stone formation. Recent evidence implicating insulin resistance has revived interest in its causation. We reviewed data on uric acid stone formers attending a general stones clinic to find out whether this supports and adds to current concepts.A retrospective database study of 1504 stone formers investigated at the Southampton renal stones clinic from 1990 (...) and uric acid stone formers with diabetes, gout or ileostomies. The median urine pH of men with idiopathic calcium stones was 6.20, idiopathic uric acid stones 5.47, diabetes 5.68, gout 6.05, diabetes and gout 5.20 and ileostomy 5.10. Plasma urate was higher with gout and idiopathic uric acid stones. Urate excretion was increased in gout. Oxalate excretion was lower with idiopathic uric acid stones (new finding). Urine volume decreased and oxalate concentration increased with ileostomy.Uric acid stones

2013 Journal of Clinical Pathology

127. Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients With Hyperuricemia (PUSH-PATH) Study. (Abstract)

Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients With Hyperuricemia (PUSH-PATH) Study. Chronic drug interactions that exist between symptomatic congestive heart failure (CHF) therapy and pharmacologic agents used for hyperuricemia and gout are a challenging problem in clinical practice. Recent observational studies showed that prednisone can induce a potent diuresis and lower serum uric acid concentration (SUA) in CHF. We therefore designed a randomized study to compare (...) the effect of prednisone with allopurinol on SUA in symptomatic CHF patients with hyperuricemia.Thirty-four symptomatic CHF participants with hyperuricemia (≥ 565 μmol/L) were randomized to receive prednisone (1 mg/kg/d, orally) or allopurinol (100 mg, thrice daily, orally) for 4 weeks. The primary outcome measure was change from baseline in SUA. The secondary outcome measures were change from baseline in serum creatinine levels, estimated glomerular filtration rate, daily urine output, body weight, N

2013 The Canadian journal of cardiology Controlled trial quality: uncertain

128. Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Full Text available with Trip Pro

population from 642 American twins and siblings of European and Hispanic ancestry. Transcriptional activity of promoter variants was estimated in luciferase reporter plasmids transfected into HEK-293 cells and mIMCD3 cells. In the primary Chinese population, we found that carriers of the GCC haplotype had higher plasma uric acid, and three promoter variants were associated with plasma uric acid. UMOD promoter variants displayed reciprocal effects on urine uric acid excretion and plasma uric acid (...) Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Uromodulin (UMOD) genetic variants cause familial juvenile hyperuricemic nephropathy, characterized by hyperuricemia with decreased renal excretion of UMOD and uric acid, suggesting a role for UMOD in the regulation of plasma uric acid. To determine this, we screened common variants across the UMOD locus in one community-based Chinese population of 1000 individuals and the other

2013 Kidney International

129. Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. (Abstract)

Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. Serum uric acid (SUA) is a novel risk factor for acute kidney injury (AKI), which adversely affects renal blood flow autoregulation, glomerular filtration rate (GFR), and promotes inflammation and angiogenesis. This pilot study investigated the effect of lowering SUA therapy on AKI, by using traditional and non-traditional markers.In this prospective, double-blind, placebo-controlled (...) , randomized pilot trial, 26 hyperuricemic patients undergoing cardiac surgery were randomized to receive rasburicase or placebo in the preoperative period.Subjects receiving rasburicase showed no difference in serum creatinine compared with the control group receiving placebo. Despite no difference in primary endpoint, the rasburicase group had less evidence of renal structural injury as reflected by urine neutrophil-associated lipocalin (uNGAL) concentrations, especially in subjects with higher SUA

2013 International urology and nephrology Controlled trial quality: uncertain

130. Uric Acid

) These images are a random sampling from a Bing search on the term "Uric Acid." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Uric Acid (C0041980) Definition (NCI_NCI-GLOSS) A waste product left over from normal chemical processes in the body and found in the urine and blood. Abnormal buildup of uric acid in the body may cause a condition called gout. Increased levels of uric acid in the blood and urine can be a side (...) Uric Acid Uric Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Uric Acid Uric Acid Aka: Uric Acid II. Physiology Uric Acid

2015 FP Notebook

131. Uric Acid Nephrolithiasis

Acid Nephrolithiasis Aka: Uric Acid Nephrolithiasis , Urate Stones , Hyperuricosuria , Uric Acid Calculi From Related Chapters II. Epidemiology Represents 10% of s III. Evaluation See IV. Types Pure Uric Acid Calculi Mixed calcium and Uric Acid Calculi V. Causes Primary cause Acidic urine (pH <5.5) Other causes (confers 2 fold risk of calculi) Excessive dietary purine intake (meats) End Ileostomy Results in impaired ammonia and citrate excretion Results in lower pH and increased urinary ammonia (...) Increased crystallization VI. Labs AM spot urine for and Crystaluria stones form in acidic urine VII. Imaging Non-contrast XRay Pure Uric Acid Calculi are radiolucent May be visualized if mixed calcium and VIII. Management: Prevention of Uric Acid stone recurrence ral Restrict dietary intake of and protein Maintain : over 2.5 liters per day Alkalinize urine (especially if is low, acidic) Maintain >5.5 (6.5 - 7.0 preferred) Citrate 10-20 mEq orally three times daily with meals 500 mg, two tablets daily

2015 FP Notebook

132. Urinary calcium and uric acid excretion in children with vesicoureteral reflux. (Abstract)

healthy children without any history of reflux or urinary tract infection (30 boys, 80 girls; age range 2 months to 12 years). Fasting urine was analyzed for the calcium/creatinine (Ca/Cr) and uric acid/creatinine (UA/Cr) ratios. Hypercalciuria was more frequently diagnosed in the VUR patients than in the control group (21.3 vs. 3.6%; P = 0.0001). Significant differences between the two groups were also found for the mean Ca/Cr and UA/Cr ratios (P = 0.0001 and P = 0.0001, respectively). No differences (...) Urinary calcium and uric acid excretion in children with vesicoureteral reflux. Urolithiasis is relatively common in children, and identifiable predisposing factors for stone formation, including metabolic and structural derangements, can be established in most cases. Vesicoureteral reflux (VUR) is a common cause of kidney stone formation. The pathophysiological mechanism of urolithiasis in reflux is related to urinary tract infection and urinary stasis, both of which promote urinary crystal

2012 Pediatric Nephrology

133. THE EFFECT OF SALICYLATES AND ADRENOCORTICOTROPIC HORMONE UPON THE MISCIBLE POOL OF URIC ACID IN GOUT Full Text available with Trip Pro

-2 Adrenocorticotropic Hormone OM Adrenocorticotropic Hormone Body Fluids Gout Humans Salicylates Uric Acid Urine 5019:27523:3:99:213:257 ACTH GOUT SALICYL COMPOUNDS URINE 1950 8 1 1950 8 1 0 1 1950 8 1 0 0 ppublish 15436881 10.1172/JCI102343 PMC436151 J Biol Chem. 1949 Nov;181(1):183-93 15390405 Science. 1949 Mar 18;109(2829):280-1 17775053 (...) THE EFFECT OF SALICYLATES AND ADRENOCORTICOTROPIC HORMONE UPON THE MISCIBLE POOL OF URIC ACID IN GOUT 15436881 2004 09 30 2018 12 01 0021-9738 29 8 1950 Aug The Journal of clinical investigation J. Clin. Invest. The effect of salicylates and adrenocorticotropic hormone upon the miscible pool of uric acid in gout. 1104-11 BENEDICT J D JD FORSHAM P H PH ROCHE M M SOLOWAY S S STETTEN D D Jr eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Salicylates 268B43MJ25 Uric Acid 9002-60

1950 Journal of Clinical Investigation

134. Effect of ACTH and Sodium Salicylate on the Urinary Uric Acid: Creatinine Ratio, and Circulating Eosinophils in Man Full Text available with Trip Pro

Creatinine O414PZ4LPZ Salicylic Acid WIQ1H85SYP Sodium Salicylate OM Adrenocorticotropic Hormone pharmacology Arthritis Arthritis, Rheumatoid metabolism Creatinine Eosinophils drug effects Gout metabolism Humans Male Osteoarthritis metabolism Salicylic Acid pharmacology Sodium Salicylate Uric Acid urine 5425:46618:8:46:161:201:333:412:486 ACTH/effects ARTHRITIS, RHEUMATOID/metabolism in EOSINOPHILS/effect of drugs on GOUT/metabolism in OSTEOARTHRITIS/metabolism in SALICYLIC ACID/effects URIC ACID (...) Effect of ACTH and Sodium Salicylate on the Urinary Uric Acid: Creatinine Ratio, and Circulating Eosinophils in Man 13125229 2003 05 01 2018 12 01 0003-4967 12 4 1953 Dec Annals of the rheumatic diseases Ann. Rheum. Dis. Effect of ACTH and sodium salicylate on the urinary uric acid: creatinine ratio, and circulating eosinophils in man. 296-300 MARSON F G FG eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid 9002-60-2 Adrenocorticotropic Hormone AYI8EX34EU

1953 Annals of the Rheumatic Diseases

135. ON THE MECHANISM OF OVERPRODUCTION OF URIC ACID IN PATIENTS WITH PRIMARY GOUT Full Text available with Trip Pro

ON THE MECHANISM OF OVERPRODUCTION OF URIC ACID IN PATIENTS WITH PRIMARY GOUT 13539198 2000 07 01 2018 12 01 0021-9738 37 4 1958 Apr The Journal of clinical investigation J. Clin. Invest. On the mechanism of overproduction of uric acid in patients with primary gout. 579-90 WYNGAARDEN J B JB BLAIR A E AE HILLEY L L eng Journal Article United States J Clin Invest 7802877 0021-9738 268B43MJ25 Uric Acid OM Gout urine Humans Hyperuricemia Uric Acid metabolism 5834:31738:254:621 GOUT/urine in URIC (...) ACID/metabolism 1958 4 1 1958 4 1 0 1 1958 4 1 0 0 ppublish 13539198 10.1172/JCI103641 PMC293124 J Biol Chem. 1954 Jul;209(1):23-39 13192056 Metabolism. 1957 May;6(3):244-68 13430358 Arch Biochem Biophys. 1955 May;56(1):184-95 14377564 Biochem J. 1952 Jan;50(3):404-7 14915965 J Biol Chem. 1957 Jan;224(1):423-34 13398418 Am J Med. 1953 Dec;15(6):845-6 13104455 J Biol Chem. 1953 May;202(1):241-52 13061451 Metabolism. 1952 Jan;1(1):3-12 14890550 Am J Med. 1957 Oct;23(4):600-22 13469831 J Biol Chem

1958 Journal of Clinical Investigation

136. Plasma uric acid and spironolactone response in healthy subjects. (Abstract)

Sodium AYI8EX34EU Creatinine RWP5GA015D Potassium IM Biological Availability Canrenone analysis Creatinine metabolism Humans Potassium urine Sodium urine Spironolactone administration & dosage metabolism pharmacology Tablets Uric Acid blood 1977 4 1 1977 4 1 0 1 1977 4 1 0 0 ppublish 861142 PMC1429001 J Pharmacol Exp Ther. 1962 Mar;135:312-6 13899372 Br J Clin Pharmacol. 1975 Jun;2(3):271-6 1234508 Br J Clin Pharmacol. 1975 Aug;2(4):361-2 1233997 Clin Pharmacol Ther. 1975 Oct;18(4):391-400 1100306 (...) Plasma uric acid and spironolactone response in healthy subjects. 861142 1977 07 29 2018 11 13 0306-5251 4 2 1977 Apr British journal of clinical pharmacology Br J Clin Pharmacol Plasma uric acid and spironolactone response in healthy subjects. 247-9 Ramsay L E LE Shelton J R JR Harrison I R IR eng Clinical Trial Journal Article Randomized Controlled Trial England Br J Clin Pharmacol 7503323 0306-5251 0 Tablets 268B43MJ25 Uric Acid 27O7W4T232 Spironolactone 78O20X9J0U Canrenone 9NEZ333N27

1977 British journal of clinical pharmacology Controlled trial quality: uncertain

137. Fractional excretion of uric acid in infancy and childhood: Index of tubular maturation Full Text available with Trip Pro

Child Child, Preschool Creatinine urine Female Glomerular Filtration Rate Humans Hydrogen-Ion Concentration Infant Infant, Newborn Kidney Tubules growth & development Male Regression Analysis Uric Acid blood urine Urine 1974 11 1 1974 11 1 0 1 1974 11 1 0 0 ppublish 4441122 PMC1649243 Arch Dis Child. 1971 Jun;46(247):356-62 5104539 N Engl J Med. 1963 Mar 28;268:712-6 contd 13987629 N Engl J Med. 1971 May 27;284(21):1193-6 4929385 Nephron. 1964;1:144-57 14246792 Pediatrics. 1968 Sep;42(3):395-404 (...) Fractional excretion of uric acid in infancy and childhood: Index of tubular maturation 4441122 1975 02 27 2018 11 13 1468-2044 49 11 1974 Nov Archives of disease in childhood Arch. Dis. Child. Fractional excretion of uric acid in infancy and childhood. Index of tubular maturation. 878-82 Passwell J H JH Modan M M Brish M M Orda S S Boichis H H eng Journal Article England Arch Dis Child 0372434 0003-9888 268B43MJ25 Uric Acid AYI8EX34EU Creatinine IM Age Factors Birth Weight Body Surface Area

1974 Archives of Disease in Childhood

138. The metabolic basis of uric acid stone formation. Full Text available with Trip Pro

The metabolic basis of uric acid stone formation. 5124821 1972 02 11 2013 11 21 0264-6021 122 1 1971 Mar The Biochemical journal Biochem. J. The metabolic basis of uric acid stone formation. 9P Wrong O M OM eng Journal Article England Biochem J 2984726R 0264-6021 0 Bicarbonates 0 Citrates 268B43MJ25 Uric Acid IM Adult Bicarbonates therapeutic use Chemical Precipitation Citrates therapeutic use Humans Hydrogen-Ion Concentration Uric Acid urine Urinary Calculi metabolism prevention & control 1971

1971 Biochemical Journal

139. Uric acid excretion in the relatives of patients with gout. Full Text available with Trip Pro

Uric acid excretion in the relatives of patients with gout. 4916770 1970 10 17 2018 11 13 0003-4967 29 4 1970 Jul Annals of the rheumatic diseases Ann. Rheum. Dis. Uric acid excretion in the relatives of patients with gout. 397-400 Scott J T JT Pollard A C AC eng Journal Article Review England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid AYI8EX34EU Creatinine IM Creatinine urine Female Gout blood genetics urine Humans Male Sex Factors Uric Acid blood urine 11 1970 7 1 1970 7 1 0 1 1970

1970 Annals of the Rheumatic Diseases

140. Uric acid excretion and surgery. Full Text available with Trip Pro

Uric acid excretion and surgery. 5032447 1972 08 09 2018 11 13 0003-4967 31 3 1972 May Annals of the rheumatic diseases Ann. Rheum. Dis. Uric acid excretion and surgery. 162-5 Snaith M L ML Scott J T JT eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid AYI8EX34EU Creatinine IM Adult Aged Creatinine urine Female Gout etiology Humans Kidney metabolism Male Metabolic Clearance Rate Middle Aged Postoperative Complications Time Factors Uric Acid blood metabolism urine

1972 Annals of the Rheumatic Diseases

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>