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Urine Uric Acid

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121. Uric Acid Stones (Diagnosis)

precipitation in metastable urine concentrates (see ). Uric acid stones. The terms gouty nephropathy, urate nephropathy, and uric acid nephropathy are used to describe renal insufficiency due to uric acid precipitation within the renal tubules. Uric acid urolithiasis or uric acid kidney stones refer to development of a stone or calculus composed of significant amounts of urate in the renal pelvis, ureter, or bladder. Next: Pathophysiology Uric acid is a weak acid, with an ionization constant of acid (pK (...) in urine exceeds its solubility at the urine pH, uric acid changes from a compound dissolved in solution to an insoluble precipitate. Urate stones are formed by 1 of 3 general mechanisms: overproduction, increased tubular secretion, or decreased tubular reabsorption. Uric acid results as a relatively insoluble end-product of purine metabolism. The concentration of uric acid in plasma depends on dietary ingestion, de novo purine synthesis, and uric acid elimination by the kidneys and intestine. Normal

2014 eMedicine Pediatrics

122. Uric Acid Stones (Follow-up)

processing > Uric Acid Stones Follow-up Updated: Jun 11, 2018 Author: Sahar Fathallah-Shaykh, MD; Chief Editor: Craig B Langman, MD Share Email Print Feedback Close Sections Sections Uric Acid Stones Follow-up Further Outpatient Care The child should continue a low-purine diet if prescribed. Continue Bicitra (2-6 mEq/kg/d) for urinary alkalinization. Parents can be provided urine dipsticks to monitor urine pH level and specific gravity to assess the adequacy of treatment. Urine pH levels should (...) be maintained above 7. Urine specific gravity should be maintained below 1.01. Fluid intake should be sufficient to maintain urine output of 30 mL/kg/24h or more. Allopurinol is continued to lower uric acid production if prescribed. Children with urinary tract uric acid stones and/or urinary tract anatomic abnormalities or a previous urinary tract infection may require urinary tract infection uroprophylaxis. Next: Further Inpatient Care See the list below: Inpatient care is indicated for management of renal

2014 eMedicine Pediatrics

123. Uric Acid Nephropathy (Diagnosis)

at the glomerulus. An active anion-exchange process in the early proximal convoluted tubule reabsorbs most of it. Most urinary uric acid appears to be derived from tubular secretion, possibly from the S2 segment of the proximal tubule. Overall, 98-100% of filtered urate is reabsorbed; 6-10% is secreted, ultimately appearing in the final urine. Several factors influence the renal handling of urate. Many medications can affect the renal transport of uric acid through effects of proximal tubular absorption (...) calculi in the United States, also result from uric acid precipitation in the collecting system. Uric acid stones are related to uric acid exceeding its solubility in the urine; thus, patients with hyperuricosuria have an increased risk of uric acid nephrolithiasis. Urine oversaturation with uric acid and subsequent crystal formation is determined largely by urinary pH. Individuals who form uric acid stones tend to excrete less ammonium, which contributes directly to low urinary pH. In addition

2014 eMedicine.com

124. THE ROLE OF LACTIC ACID IN THE REDUCED EXCRETION OF URIC ACID IN TOXEMIA OF PREGNANCY Full Text available with Trip Pro

-Eclampsia urine Pregnancy Uric Acid blood LACTATES/pharmacology PREGNANCY TOXEMIAS/urine URIC ACID/blood 1960 10 1 1960 10 1 0 1 1960 10 1 0 0 ppublish 13711188 10.1172/JCI104172 PMC441887 Proc Soc Exp Biol Med. 1957 Dec;96(3):809-13 13505867 J Clin Invest. 1940 May;19(3):525-35 16694770 J Obstet Gynaecol Br Emp. 1953 Jun;60(3):335-44 13061996 Lancet. 1955 Feb 12;268(6859):323-5 13234369 Bull N Y Acad Med. 1958 May;34(5):287-96 13523299 Am J Obstet Gynecol. 1957 Mar;73(3):492-506 13402821 J Clin Invest (...) THE ROLE OF LACTIC ACID IN THE REDUCED EXCRETION OF URIC ACID IN TOXEMIA OF PREGNANCY 13711188 1998 11 01 2018 11 30 0021-9738 39 1960 Oct The Journal of clinical investigation J. Clin. Invest. The role of lactic acid in the reduced excretion of uric acid in toxemia of pregnancy. 1526-32 HANDLER J S JS eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Lactates 268B43MJ25 Uric Acid 33X04XA5AT Lactic Acid OM Body Fluids Female Humans Lactates pharmacology Lactic Acid Pre

1960 Journal of Clinical Investigation

125. Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. (Abstract)

Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. Serum uric acid (SUA) is a novel risk factor for acute kidney injury (AKI), which adversely affects renal blood flow autoregulation, glomerular filtration rate (GFR), and promotes inflammation and angiogenesis. This pilot study investigated the effect of lowering SUA therapy on AKI, by using traditional and non-traditional markers.In this prospective, double-blind, placebo-controlled (...) , randomized pilot trial, 26 hyperuricemic patients undergoing cardiac surgery were randomized to receive rasburicase or placebo in the preoperative period.Subjects receiving rasburicase showed no difference in serum creatinine compared with the control group receiving placebo. Despite no difference in primary endpoint, the rasburicase group had less evidence of renal structural injury as reflected by urine neutrophil-associated lipocalin (uNGAL) concentrations, especially in subjects with higher SUA

2013 International urology and nephrology

126. Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients With Hyperuricemia (PUSH-PATH) Study. (Abstract)

Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients With Hyperuricemia (PUSH-PATH) Study. Chronic drug interactions that exist between symptomatic congestive heart failure (CHF) therapy and pharmacologic agents used for hyperuricemia and gout are a challenging problem in clinical practice. Recent observational studies showed that prednisone can induce a potent diuresis and lower serum uric acid concentration (SUA) in CHF. We therefore designed a randomized study to compare (...) the effect of prednisone with allopurinol on SUA in symptomatic CHF patients with hyperuricemia.Thirty-four symptomatic CHF participants with hyperuricemia (≥ 565 μmol/L) were randomized to receive prednisone (1 mg/kg/d, orally) or allopurinol (100 mg, thrice daily, orally) for 4 weeks. The primary outcome measure was change from baseline in SUA. The secondary outcome measures were change from baseline in serum creatinine levels, estimated glomerular filtration rate, daily urine output, body weight, N

2013 The Canadian journal of cardiology Controlled trial quality: uncertain

127. Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Full Text available with Trip Pro

population from 642 American twins and siblings of European and Hispanic ancestry. Transcriptional activity of promoter variants was estimated in luciferase reporter plasmids transfected into HEK-293 cells and mIMCD3 cells. In the primary Chinese population, we found that carriers of the GCC haplotype had higher plasma uric acid, and three promoter variants were associated with plasma uric acid. UMOD promoter variants displayed reciprocal effects on urine uric acid excretion and plasma uric acid (...) Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Uromodulin (UMOD) genetic variants cause familial juvenile hyperuricemic nephropathy, characterized by hyperuricemia with decreased renal excretion of UMOD and uric acid, suggesting a role for UMOD in the regulation of plasma uric acid. To determine this, we screened common variants across the UMOD locus in one community-based Chinese population of 1000 individuals and the other

2013 Kidney International

128. Who makes uric acid stones and why--observations from a renal stones clinic. Full Text available with Trip Pro

Who makes uric acid stones and why--observations from a renal stones clinic. Excessively acidic urine is the dominant factor in uric acid stone formation. Recent evidence implicating insulin resistance has revived interest in its causation. We reviewed data on uric acid stone formers attending a general stones clinic to find out whether this supports and adds to current concepts.A retrospective database study of 1504 stone formers investigated at the Southampton renal stones clinic from 1990 (...) and uric acid stone formers with diabetes, gout or ileostomies. The median urine pH of men with idiopathic calcium stones was 6.20, idiopathic uric acid stones 5.47, diabetes 5.68, gout 6.05, diabetes and gout 5.20 and ileostomy 5.10. Plasma urate was higher with gout and idiopathic uric acid stones. Urate excretion was increased in gout. Oxalate excretion was lower with idiopathic uric acid stones (new finding). Urine volume decreased and oxalate concentration increased with ileostomy.Uric acid stones

2013 Journal of Clinical Pathology

129. Montmorency Cherry Juice and Uric Acid Metabolism

Montmorency Cherry Juice and Uric Acid Metabolism Montmorency Cherry Juice and Uric Acid Metabolism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Montmorency Cherry Juice and Uric Acid Metabolism (...) to Brief Summary: Cherries have been show to possess the ability to reduce uric acid concentrations and inflammation. Tart Montmorency cherries possess a higher concentration of the plant compounds than other cherries and hence makes the expectation possible that Montmorency cherries will lower uric acid and inflammation. Condition or disease Intervention/treatment Phase Inflammation Dietary Supplement: Montmorency cherry concentrate Not Applicable Detailed Description: Plasma and urinary uric acid

2013 Clinical Trials

130. A comparison of the metabolic profiles of diabetic and non-diabetic uric acid stone formers Full Text available with Trip Pro

. Information included patients' clinical histories, 24 hour urine collections, blood chemistry and stone analysis.Complete data were obtained from 68 patients with uric acid stones. Twenty-two patients had diabetes. There were no statistically significant differences in mean age, body mass index, or history of gout. Among diabetics, pure uric acid stones were identified in 14 patients (63%) and mixed uric acid in 8 (36%). Pure uric acid stones were more common in the diabetic cohort (63% vs. 46%, p = 0.16 (...) ). Urine pH, serum and urine uric acid levels and 24-hour urine volumes were similar in both groups. The diabetic group had an increased average oxalate excretion (424 μmol/d vs. 324 μmol/d, p = 0.003).The exact etiological basis for the higher oxalate excretion in diabetic uric acid stone formers is unclear. Whether this is a metabolic feature of diabetes, due to dietary indiscretion or the iatrogenic consequence of dietary advice requires further investigation.

2013 Canadian Urological Association Journal

131. Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. (Abstract)

Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. Serum uric acid (SUA) is a novel risk factor for acute kidney injury (AKI), which adversely affects renal blood flow autoregulation, glomerular filtration rate (GFR), and promotes inflammation and angiogenesis. This pilot study investigated the effect of lowering SUA therapy on AKI, by using traditional and non-traditional markers.In this prospective, double-blind, placebo-controlled (...) , randomized pilot trial, 26 hyperuricemic patients undergoing cardiac surgery were randomized to receive rasburicase or placebo in the preoperative period.Subjects receiving rasburicase showed no difference in serum creatinine compared with the control group receiving placebo. Despite no difference in primary endpoint, the rasburicase group had less evidence of renal structural injury as reflected by urine neutrophil-associated lipocalin (uNGAL) concentrations, especially in subjects with higher SUA

2013 International urology and nephrology

132. Uric Acid Nephrolithiasis

Acid Nephrolithiasis Aka: Uric Acid Nephrolithiasis , Urate Stones , Hyperuricosuria , Uric Acid Calculi From Related Chapters II. Epidemiology Represents 10% of s III. Evaluation See IV. Types Pure Uric Acid Calculi Mixed calcium and Uric Acid Calculi V. Causes Primary cause Acidic urine (pH <5.5) Other causes (confers 2 fold risk of calculi) Excessive dietary purine intake (meats) End Ileostomy Results in impaired ammonia and citrate excretion Results in lower pH and increased urinary ammonia (...) Increased crystallization VI. Labs AM spot urine for and Crystaluria stones form in acidic urine VII. Imaging Non-contrast XRay Pure Uric Acid Calculi are radiolucent May be visualized if mixed calcium and VIII. Management: Prevention of Uric Acid stone recurrence ral Restrict dietary intake of and protein Maintain : over 2.5 liters per day Alkalinize urine (especially if is low, acidic) Maintain >5.5 (6.5 - 7.0 preferred) Citrate 10-20 mEq orally three times daily with meals 500 mg, two tablets daily

2015 FP Notebook

133. Uric Acid

) These images are a random sampling from a Bing search on the term "Uric Acid." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Uric Acid (C0041980) Definition (NCI_NCI-GLOSS) A waste product left over from normal chemical processes in the body and found in the urine and blood. Abnormal buildup of uric acid in the body may cause a condition called gout. Increased levels of uric acid in the blood and urine can be a side (...) Uric Acid Uric Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Uric Acid Uric Acid Aka: Uric Acid II. Physiology Uric Acid

2015 FP Notebook

134. Urinary calcium and uric acid excretion in children with vesicoureteral reflux. (Abstract)

healthy children without any history of reflux or urinary tract infection (30 boys, 80 girls; age range 2 months to 12 years). Fasting urine was analyzed for the calcium/creatinine (Ca/Cr) and uric acid/creatinine (UA/Cr) ratios. Hypercalciuria was more frequently diagnosed in the VUR patients than in the control group (21.3 vs. 3.6%; P = 0.0001). Significant differences between the two groups were also found for the mean Ca/Cr and UA/Cr ratios (P = 0.0001 and P = 0.0001, respectively). No differences (...) Urinary calcium and uric acid excretion in children with vesicoureteral reflux. Urolithiasis is relatively common in children, and identifiable predisposing factors for stone formation, including metabolic and structural derangements, can be established in most cases. Vesicoureteral reflux (VUR) is a common cause of kidney stone formation. The pathophysiological mechanism of urolithiasis in reflux is related to urinary tract infection and urinary stasis, both of which promote urinary crystal

2012 Pediatric Nephrology

135. Overproduction of Uric Acid in Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency: CONTRIBUTION BY IMPAIRED PURINE SALVAGE Full Text available with Trip Pro

phosphoribosyltransferase-deficient subjects and Lesch-Nyhan patients show increases of 18.6+/-10.8 and 17.3+/-11.8 mmol/g creatinine, respectively. Of the observed rise in purine exretion in control subjects, 40% occurs from inosine excretion and 32% occurs from oxypurine excretion. The rise in total purine excretion with Lesch-Nyhan syndrome is almost entirely accounted for by an elevated uric acid excretion. Increases in urine radioactivity after fructose infusion are distributed in those purines that are excreted (...) Overproduction of Uric Acid in Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency: CONTRIBUTION BY IMPAIRED PURINE SALVAGE The contribution of reduced purine salvage to the hyperuricemia associated with hypoxanthine-guanine phosphoribosyltransferase deficiency was measured by the intravenous administration of tracer doses of [8-(14)C]adenine to nine patients with normal enzyme activity, three patients with a partial deficiency of hypoxanthine-guanine phosphoribosyltransferase, and six

1979 Journal of Clinical Investigation

136. THE EFFECT OF SALICYLATES AND ADRENOCORTICOTROPIC HORMONE UPON THE MISCIBLE POOL OF URIC ACID IN GOUT Full Text available with Trip Pro

-2 Adrenocorticotropic Hormone OM Adrenocorticotropic Hormone Body Fluids Gout Humans Salicylates Uric Acid Urine 5019:27523:3:99:213:257 ACTH GOUT SALICYL COMPOUNDS URINE 1950 8 1 1950 8 1 0 1 1950 8 1 0 0 ppublish 15436881 10.1172/JCI102343 PMC436151 J Biol Chem. 1949 Nov;181(1):183-93 15390405 Science. 1949 Mar 18;109(2829):280-1 17775053 (...) THE EFFECT OF SALICYLATES AND ADRENOCORTICOTROPIC HORMONE UPON THE MISCIBLE POOL OF URIC ACID IN GOUT 15436881 2004 09 30 2018 12 01 0021-9738 29 8 1950 Aug The Journal of clinical investigation J. Clin. Invest. The effect of salicylates and adrenocorticotropic hormone upon the miscible pool of uric acid in gout. 1104-11 BENEDICT J D JD FORSHAM P H PH ROCHE M M SOLOWAY S S STETTEN D D Jr eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Salicylates 268B43MJ25 Uric Acid 9002-60

1950 Journal of Clinical Investigation

137. CHANGES IN SERUM AND URINARY URIC ACID WITH THE DEVELOPMENT OF SYMPTOMATIC GOUT Full Text available with Trip Pro

CHANGES IN SERUM AND URINARY URIC ACID WITH THE DEVELOPMENT OF SYMPTOMATIC GOUT 14083171 1996 12 01 2018 12 01 0021-9738 42 1963 Nov The Journal of clinical investigation J. Clin. Invest. CHANGES IN SERUM AND URINARY URIC ACID WITH THE DEVELOPMENT OF SYMPTOMATIC GOUT. 1835-9 AYVAZIAN J H JH AYVAZIAN I F IF eng Journal Article United States J Clin Invest 7802877 0021-9738 268B43MJ25 Uric Acid OM Blood Chemical Analysis Body Fluids Gout Humans Uric Acid Urine BLOOD CHEMICAL ANALYSIS GOUT URIC (...) ACID URINE 1963 11 1 1963 11 1 0 1 1963 11 1 0 0 ppublish 14083171 10.1172/JCI104867 PMC289465 N Engl J Med. 1963 Apr 11;268:821-7 concl 13987630 Postgrad Med. 1954 Mar;15(3):255-64 13133834 J Biol Chem. 1954 Oct;210(2):923-32 13211630 N Engl J Med. 1960 Nov 17;263:999-1002 13685390 Minn Med. 1959 Aug;42(8):1044-52 13674316 N Engl J Med. 1959 Apr 30;260(18):893-900 13657306 J Clin Invest. 1961 Nov;40:1961-6 13863518 Perspect Biol Med. 1959;2(2):185-96 13623382 J Clin Invest. 1959 Nov;38:1890-8

1963 Journal of Clinical Investigation

138. Localization and Pyrazinamide Inhibition of Distal Transtubular Movement of Uric Acid-2-C14 with a Modified Stop-Flow Technique Full Text available with Trip Pro

Isotopes 268B43MJ25 Uric Acid 2KNI5N06TI Pyrazinamide 9005-80-5 Inulin AYI8EX34EU Creatinine MU72812GK0 Creatine Y79XT83BJ9 p-Aminohippuric Acid OM Biological Transport Carbon Isotopes Creatine Creatinine Dogs Fluids and Secretions Inulin Kidney Tubules Physiology Pyrazinamide Renal Artery Research Uric Acid Urine p-Aminohippuric Acid AMINOHIPPURIC ACID BIOLOGICAL TRANSPORT CARBON ISOTOPES CREATINE AND CREATININE DOGS EXCRETION EXPERIMENTAL LAB STUDY INULIN KIDNEY TUBULES PHYSIOLOGY PYRAZINAMIDE RENAL (...) ARTERY URIC ACID URINE 1965 5 1 1965 5 1 0 1 1965 5 1 0 0 ppublish 14276129 10.1172/JCI105184 PMC292548 Am J Physiol. 1960 Jul;199:9-12 14414436 J Clin Invest. 1959 Oct;38:1778-81 13830462 Am J Physiol. 1959 Sep;197:601-3 14408687 J Clin Invest. 1963 Aug;42:1330-9 14060403 J Exp Med. 1950 Aug;92(2):121-8 15428581 Am J Med. 1962 Sep;33:408-20 13874135 Am J Med. 1957 Oct;23(4):587-95 13469829 Am J Physiol. 1960 Dec;199:1199-204 13787542 Proc Soc Exp Biol Med. 1955 Nov;90(2):542-7 13273509 Acta

1965 Journal of Clinical Investigation

139. ON THE MECHANISM OF OVERPRODUCTION OF URIC ACID IN PATIENTS WITH PRIMARY GOUT Full Text available with Trip Pro

ON THE MECHANISM OF OVERPRODUCTION OF URIC ACID IN PATIENTS WITH PRIMARY GOUT 13539198 2000 07 01 2018 12 01 0021-9738 37 4 1958 Apr The Journal of clinical investigation J. Clin. Invest. On the mechanism of overproduction of uric acid in patients with primary gout. 579-90 WYNGAARDEN J B JB BLAIR A E AE HILLEY L L eng Journal Article United States J Clin Invest 7802877 0021-9738 268B43MJ25 Uric Acid OM Gout urine Humans Hyperuricemia Uric Acid metabolism 5834:31738:254:621 GOUT/urine in URIC (...) ACID/metabolism 1958 4 1 1958 4 1 0 1 1958 4 1 0 0 ppublish 13539198 10.1172/JCI103641 PMC293124 J Biol Chem. 1954 Jul;209(1):23-39 13192056 Metabolism. 1957 May;6(3):244-68 13430358 Arch Biochem Biophys. 1955 May;56(1):184-95 14377564 Biochem J. 1952 Jan;50(3):404-7 14915965 J Biol Chem. 1957 Jan;224(1):423-34 13398418 Am J Med. 1953 Dec;15(6):845-6 13104455 J Biol Chem. 1953 May;202(1):241-52 13061451 Metabolism. 1952 Jan;1(1):3-12 14890550 Am J Med. 1957 Oct;23(4):600-22 13469831 J Biol Chem

1958 Journal of Clinical Investigation

140. Effect of atromid and its components on uric acid excretion and on gout. Full Text available with Trip Pro

Humans Male Uric Acid Uricosuric Agents therapeutic use Urine 1965 11 1 1965 11 1 0 1 1965 11 1 0 0 ppublish 5855251 PMC1010409 J Atheroscler Res. 1963 Sep-Dec;3:475-81 14100888 J Atheroscler Res. 1963 Sep-Dec;3:554-60 14100898 J Clin Invest. 1959 Aug;38(8):1298-315 13673086 J Lab Clin Med. 1959 Dec;54:903-13 14416793 Proc Soc Exp Biol Med. 1950 May;74(1):148-51 15430417 J Atheroscler Res. 1963 Sep-Dec;3:593-616 14104298 Lancet. 1962 Jun 23;1(7243):1321-3 14481816 Ann Rheum Dis. 1957 Dec;16(4):425-37 (...) Effect of atromid and its components on uric acid excretion and on gout. 5855251 1966 03 27 2018 11 13 0003-4967 24 6 1965 Nov Annals of the rheumatic diseases Ann. Rheum. Dis. Effect of atromid and its components on uric acid excretion and on gout. 572-5 Trevaks G G Lovell R R RR eng Journal Article England Ann Rheum Dis 0372355 0003-4967 0 Butyrates 0 Uricosuric Agents 268B43MJ25 Uric Acid C24W7J5D5R Androsterone IM Adult Androsterone therapeutic use Butyrates therapeutic use Female Gout

1965 Annals of the Rheumatic Diseases

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