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Urine Uric Acid

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61. The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers. Full Text available with Trip Pro

The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers. Many biological functions follow circadian rhythms driven by internal and external cues that synchronize and coordinate organ physiology to diurnal changes in the environment and behavior. Urinary acid-base parameters follow diurnal patterns and it is thought these changes are due to periodic surges in gastric acid secretion. Abnormal urine pH is a risk factor for specific types (...) of nephrolithiasis and uric acid stones result from excessively low urine pH. Here we placed 9 healthy volunteers and 10 uric acid stone formers on fixed metabolic diets to study the diurnal pattern of urinary acidification. All showed clear diurnal trends in urinary acidification, but none of the patterns were affected by inhibitors of the gastric proton pump. Uric acid stone formers had similar patterns of change throughout the day but their urine pH was always lower compared to healthy volunteers. Uric acid

2012 Kidney international Controlled trial quality: uncertain

62. The occurrence of substituted uric acids in human urine Full Text available with Trip Pro

The occurrence of substituted uric acids in human urine 14944545 2004 02 15 2018 12 01 0264-6021 51 1 1952 Apr The Biochemical journal Biochem. J. The occurrence of substituted uric acids in human urine. 133-8 JOHNSON E A EA eng Journal Article England Biochem J 2984726R 0264-6021 268B43MJ25 Uric Acid OM Humans Uric Acid 5222:30881:483 URIC ACID 1952 4 1 1952 4 1 0 1 1952 4 1 0 0 ppublish 14944545 PMC1197800 Science. 1949 Apr 15;109(2833):377-8 17749594 Biochem J. 1930;24(3):619-25 16744401

1952 Biochemical Journal

63. Effect of weight reduction on levels of uric acid in plasma and urine. Full Text available with Trip Pro

Effect of weight reduction on levels of uric acid in plasma and urine. 4715551 1973 09 06 2018 11 13 0003-4967 32 3 1973 May Annals of the rheumatic diseases Ann. Rheum. Dis. Effect of weight reduction on levels of uric acid in plasma and urine. 280-1 Nicholls A A Yablonsky H H Scott J T JT eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid AYI8EX34EU Creatinine IM Body Weight Creatinine metabolism Female Humans Male Uric Acid blood urine 1973 5 1 1973 5 1 0 1 1973

1973 Annals of the Rheumatic Diseases

64. Effect of stilboestrol on levels of uric acid in plasma and urine. Full Text available with Trip Pro

Effect of stilboestrol on levels of uric acid in plasma and urine. 4726074 1973 10 26 2018 11 13 0003-4967 32 4 1973 Jul Annals of the rheumatic diseases Ann. Rheum. Dis. Effect of stilboestrol on levels of uric acid in plasma and urine. 386-7 Nicholls A A Snaith M L ML Yablonsky H H Scott J T JT eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid 731DCA35BT Diethylstilbestrol IM Adult Diethylstilbestrol pharmacology Female Humans Male Sex Factors Transsexualism (...) blood urine Uric Acid blood urine 1973 7 1 1973 7 1 0 1 1973 7 1 0 0 ppublish 4726074 PMC1006122 Lancet. 1966 Oct 8;2(7467):777-8 4162328 Am J Med. 1965 Aug;39:242-51 14320691 Ann Rheum Dis. 1970 Jul;29(4):397-400 4916770

1973 Annals of the Rheumatic Diseases

65. On the state in which the uric acid exists in the urine Full Text available with Trip Pro

On the state in which the uric acid exists in the urine 20895789 2011 03 29 2011 03 29 0959-5287 27 1844 Medico-chirurgical transactions Med Chir Trans On the state in which the uric acid exists in the urine. 102-18 Jones H B HB eng Journal Article England Med Chir Trans 0156105 0959-5287 2010 10 5 6 0 1844 1 1 0 0 1844 1 1 0 1 ppublish 20895789 PMC2116937

1844 Medico-chirurgical transactions

66. On the Estimation of Uric Acid in Human Urine Full Text available with Trip Pro

On the Estimation of Uric Acid in Human Urine 16991994 2007 02 05 2008 11 20 0022-3751 12 5-6 1891 Dec The Journal of physiology J. Physiol. (Lond.) On the Estimation of Uric Acid in Human Urine. 485-9 Groves E W EW eng Journal Article England J Physiol 0266262 0022-3751 1891 12 1 0 0 1891 12 1 0 1 1891 12 1 0 0 ppublish 16991994 PMC1514325

1891 The Journal of physiology

67. Does Uric Acid taken by mouth increase the Excretion of that substance in the Urine? Full Text available with Trip Pro

Does Uric Acid taken by mouth increase the Excretion of that substance in the Urine? 16992091 2007 02 05 2008 11 20 0022-3751 15 3 1893 Sep The Journal of physiology J. Physiol. (Lond.) Does Uric Acid taken by mouth increase the Excretion of that substance in the Urine? 167-248.25 Haig A A eng Journal Article England J Physiol 0266262 0022-3751 1893 9 1 0 0 1893 9 1 0 1 1893 9 1 0 0 ppublish 16992091 PMC1514430

1893 The Journal of physiology

68. Notes on the Urine of the Tortoise with special reference to Uric Acid and Urea Full Text available with Trip Pro

Notes on the Urine of the Tortoise with special reference to Uric Acid and Urea 16991448 2007 02 05 2008 11 20 0022-3751 7 5-6 1886 Nov The Journal of physiology J. Physiol. (Lond.) Notes on the Urine of the Tortoise with special reference to Uric Acid and Urea. 453-7 Mills T W TW eng Journal Article England J Physiol 0266262 0022-3751 1886 11 1 0 0 1886 11 1 0 1 1886 11 1 0 0 ppublish 16991448 PMC1485072

1886 The Journal of physiology

69. On the Estimation of Uric Acid in the Urine: A Reply to Criticisms upon the Silver Method Full Text available with Trip Pro

On the Estimation of Uric Acid in the Urine: A Reply to Criticisms upon the Silver Method 20753358 2011 03 29 2011 03 29 0007-1447 2 1592 1891 Jul 04 British medical journal Br Med J On the Estimation of Uric Acid in the Urine: A Reply to Criticisms upon the Silver Method. 10 Haycraft J B JB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1891 7 4 0 0 1891 7 4 0 1 ppublish 20753358 PMC2272884

1891 British medical journal

70. Note on the Value of Piperazin as a Solvent of Uric Acid Stones in Urine Full Text available with Trip Pro

Note on the Value of Piperazin as a Solvent of Uric Acid Stones in Urine 20755222 2011 03 29 2011 03 29 0007-1447 2 1773 1894 Dec 22 British medical journal Br Med J Note on the Value of Piperazin as a Solvent of Uric Acid Stones in Urine. 1426 Fawcett J J eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1894 12 22 0 0 1894 12 22 0 1 ppublish 20755222 PMC2405512

1894 British medical journal

71. A NEW VOLUMETRIC METHOD of ESTIMATING URIC ACID in URINE Full Text available with Trip Pro

A NEW VOLUMETRIC METHOD of ESTIMATING URIC ACID in URINE 20757613 2011 03 29 2011 03 29 0007-1447 1 1936 1898 Feb 05 British medical journal Br Med J A NEW VOLUMETRIC METHOD of ESTIMATING URIC ACID in URINE. 364 Tunnicliffe F W FW Rosenheim O O eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1898 2 5 0 0 1898 2 5 0 1 ppublish 20757613 PMC2410629

1898 British medical journal

72. A CLINICAL METHOD FOR THE QUANTITATIVE ESTIMATION OF URIC ACID IN URINE Full Text available with Trip Pro

A CLINICAL METHOD FOR THE QUANTITATIVE ESTIMATION OF URIC ACID IN URINE 20762197 2011 03 29 2011 03 29 0007-1447 2 2323 1905 Jul 08 British medical journal Br Med J A CLINICAL METHOD FOR THE QUANTITATIVE ESTIMATION OF URIC ACID IN URINE. 69-72 Surveyor N F NF eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1905 7 8 0 0 1905 7 8 0 1 ppublish 20762197 PMC2321094

1905 British medical journal

73. Potential mechanisms for low uric acid in Parkinson disease Full Text available with Trip Pro

for definite or probable PD (n = 20) and controls (n = 20) aged 55-80 years were recruited. Twenty-four hour urine samples were collected from all participants, and both uric acid and allantoin were measured and corrected for body mass index (BMI). Urinary metabolites were compared using a twoway ANOVA with diagnosis and sex as the explanatory variables. There were no significant differences between PD and controls for total UA (p = 0.60), UA corrected for BMI (p = 0.37), or in the interaction of diagnosis (...) Potential mechanisms for low uric acid in Parkinson disease Several epidemiologic studies have described an association between low serum uric acid (UA) and Parkinson disease (PD). Uric acid is a known antioxidant, and one proposed mechanism of neurodegeneration in PD is oxidative damage of dopamine neurons. However, other complex metabolic pathways may contribute. The purpose of this study is to elucidate potential mechanisms of low serum UA in PD. Subjects who met diagnostic criteria

2016 Journal of neural transmission (Vienna, Austria : 1996)

74. Simultaneous Detection of Dopamine and Uric Acid Using a Poly(l-lysine)/Graphene Oxide Modified Electrode Full Text available with Trip Pro

Simultaneous Detection of Dopamine and Uric Acid Using a Poly(l-lysine)/Graphene Oxide Modified Electrode A novel, simple and selective electrochemical method was investigated for the simultaneous detection of dopamine (DA) and uric acid (UA) on a poly(l-lysine)/graphene oxide (GO) modified glassy carbon electrode (PLL/GO/GCE) by differential pulse voltammetry (DPV). The electrochemically prepared PLL/GO sensory platform toward the oxidation of UA and DA exhibited several advantages, including (...) of UA and DA, using DPV in the linear concentration ranges of 0.5 to 20.0 and 0.5 to 35 μM, respectively. In addition, the PLL/GO/GCE demonstrated good reproducibility, long-term stability, excellent selectivity and negligible interference of ascorbic acid (AA). The proposed modified electrode was successfully implemented in the simultaneous detection of DA and UA in human blood serum, urine and dopamine hydrochloride injection with satisfactory results.

2016 Nanomaterials

75. The Association of Vitamin D Status and Vitamin D Replacement Therapy with Glycemic Control, Serum Uric Acid Levels, and Microalbuminuria in Patients with Type 2 Diabetes and Chronic Kidney Disease Full Text available with Trip Pro

The Association of Vitamin D Status and Vitamin D Replacement Therapy with Glycemic Control, Serum Uric Acid Levels, and Microalbuminuria in Patients with Type 2 Diabetes and Chronic Kidney Disease To evaluate the relationship of vitamin D status and vitamin D replacement therapy with glycemic control, serum uric acid (SUA) levels, and microalbuminuria (MAU) in patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD). Subjectsand Methods: A total of 1,463 patients with T2DM and CKD (...) (aged 14-88 years), 927 females and 536 males, were included in this study. The serum data of 25-hydroxyvitamin D, i.e., 25(OH)D, level, SUA, hemoglobin (Hb)A1c, creatinine, estimated glomerular filtration rate, and urine albumin-to-creatinine ratio (UACR) were obtained from the medical records. The Mann-Whitney U test, the χ2 test, the Mantel-Haenszel test, and linear regression models were used for data analysis.Vitamin D deficiency and insufficiency were evident in 770 (52.0%) and 357 (24.0

2016 Medical Principles and Practice

76. Heat stress, hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of Mesoamerican nephropathy in Nicaragua. Full Text available with Trip Pro

gravity (≥1.030). Sugarcane cutters also more often had proteinuria and blood and leucocytes in the urine. Workers with eGFR <80 mL/min/1.73 m2 reported a higher intake of water and lower intake of sugary beverages. Serum uric acid levels related strongly and inversely to eGFR levels (adj β -10.4 mL/min/1.73 m2, 95% CI -12.2 to -8.5, p<0.001). No associations were observed for other metabolic risk factors, pesticides, non-steroidal anti-inflammatory drugs or alcohol. Among cane cutters, consumption (...) Heat stress, hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of Mesoamerican nephropathy in Nicaragua. To study Mesoamerican nephropathy (MeN) and its risk factors in three hot occupations.Cross-sectional.Chinandega and León municipalities, a MeN hotspot on the Nicaraguan Pacific coast, January-February 2013.194 male workers aged 17-39 years: 86 sugarcane cutters, 56 construction workers, 52 small-scale farmers.(1) Differences between the three

2016 BMJ open

77. Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. Full Text available with Trip Pro

Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. In cystic fibrosis (CF) there is an urgent need for earlier diagnosis of pulmonary infections and inflammation using blood- and urine-based biomarkers.Using mass spectrometry, oxidation products of glutathione and uric acid were measured in matched samples of bronchoalveolar lavage (BAL), serum and urine from 36 infants and children with CF, and related to markers of neutrophilic inflammation and infection (...) in BAL.Oxidation products of glutathione (glutathione sulfonamide, GSA) and uric acid (allantoin), were elevated in BAL of children with pulmonary infections with Pseudomonas aeruginosa (PsA) compared to those without (p<0.05) and correlated with other markers of neutrophilic inflammation. Serum GSA was significantly elevated in children with PsA infections (p<0.01). Urinary GSA correlated with pulmonary GSA (r=0.42, p<0.05) and markers of neutrophilic inflammation.This proof-of-concept study demonstrates

2016 Journal of Cystic Fibrosis

78. Association of plasma and urine viscosity with cardiometabolic risk factors and oxidative status. A pilot study in subjects with abdominal obesity. Full Text available with Trip Pro

with markers of oxidative status, and plasma viscosity with blood glucose. Categorical Principal Component Analysis plots showed that urine viscosity measurements at different shear rates clustered in three groups (low, intermediate and high shear rates) were selectively associated with uric acid, polyphenols and antioxidant capacity respectively. Plasma viscosity did not seem to be a relevant clinical marker in subjects with abdominal obesity. Therefore, urine viscosity could potentially serve (...) Association of plasma and urine viscosity with cardiometabolic risk factors and oxidative status. A pilot study in subjects with abdominal obesity. There is increasing interest in the search for accurate, repeatable and widely applicable clinical biomarkers for the early detection of cardiometabolic alterations and oxidative status. Viscosity is a promising tool in that sense, although most studies have used simple viscosimeters, providing limited information, and have not considered oxidative

2018 PLoS ONE

79. Low urine pH affects the development of metabolic syndrome, associative with the increase of dyslipidemia and dysglycemia: Nationwide cross-sectional study (KNHANES 2013-2015) and a single-center retrospective cohort study. Full Text available with Trip Pro

Low urine pH affects the development of metabolic syndrome, associative with the increase of dyslipidemia and dysglycemia: Nationwide cross-sectional study (KNHANES 2013-2015) and a single-center retrospective cohort study. Low urine pH (UpH) and high serum uric acid are considered evidence of metabolic disorders. The effect of low UpH on the development of metabolic syndrome (MetS) is less clear than that of high serum uric acid. We investigated the association between low UpH (...) was measured using an automatic urine analyzer in the range of 5.0-9.0 at first visit.In the cross-sectional study, low UpH (= 5.0) was associated with the prevalence of MetS (odds ratio [OR] = 1.480, 95% confidence interval [CI] 1.334-1.643, p<0.001), particularly central obesity, dyslipidemia, and dysglycemia (OR ranges 1.282-1.422, p<0.001, all). In the retrospective cohort study, compared with the highest UpH subgroup, the lowest UpH subgroup (= 5.0) was associated with higher risk of MetS development

2018 PLoS ONE

80. Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH Full Text available with Trip Pro

that variants in common genes involved in ammonia metabolism may substantively contribute to basal urine pH regulation. These variations might influence the likelihood of developing disease conditions associated with altered urine pH, such as uric acid or calcium phosphate kidney stones. (...) Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH Urine pH is critical for net acid and solute excretion, but the genetic factors that contribute to its regulation are incompletely understood.We tested the association of single nucleotide polymorphisms (SNPs) from 16 genes related to ammonia (NH3) metabolism (15 biological candidates selected a priori, 1 selected from a previous genome-wide association study analysis) to that of 24-hour urine pH in 2493 individuals

2017 Kidney international reports

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