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Urine Uric Acid

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61. Association between sodium intake and change in uric Acid, urine albumin excretion, and the risk of developing hypertension. (PubMed)

Association between sodium intake and change in uric Acid, urine albumin excretion, and the risk of developing hypertension. A high-sodium diet has little short-term effect on blood pressure in nonhypertensive individuals but, for unclear reasons, is associated with hypertension if consumed long term. We hypothesized that a chronically high sodium intake would be associated with increases in biomarkers of endothelial dysfunction, specifically serum uric acid (SUA) and urine albumin excretion (...) hazard ratios were 0.99 (confidence interval, 0.93-1.06) among participants whose UAE was <10 mg/d and 1.18 (confidence interval, 1.07-1.29) among those whose UAE was >15 mg/d.Over time, higher sodium intake is associated with increases in SUA and UAE. Among individuals with higher SUA and urine UAE, a higher sodium intake is an independent risk factor for developing hypertension.

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2012 Circulation

62. Urine Uric Acid

Urine Uric Acid Urine Uric Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Uric Acid Urine Uric Acid Aka: Urine Uric Acid (...) II. Indication evaluation III. Technique 24 hour collection Measure after acute gout episode resolves Patient must be on purine free diet for accuracy IV. Interpretation Normal excretion: 250-750mg per 24 hours Over-production excretion >750mg per 24 hours Under-excretion excretion <750mg per 24 hours Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Urine Uric Acid." Click on the image (or right click) to open the source

2015 FP Notebook

63. The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers. (PubMed)

The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers. Many biological functions follow circadian rhythms driven by internal and external cues that synchronize and coordinate organ physiology to diurnal changes in the environment and behavior. Urinary acid-base parameters follow diurnal patterns and it is thought these changes are due to periodic surges in gastric acid secretion. Abnormal urine pH is a risk factor for specific types (...) of nephrolithiasis and uric acid stones result from excessively low urine pH. Here we placed 9 healthy volunteers and 10 uric acid stone formers on fixed metabolic diets to study the diurnal pattern of urinary acidification. All showed clear diurnal trends in urinary acidification, but none of the patterns were affected by inhibitors of the gastric proton pump. Uric acid stone formers had similar patterns of change throughout the day but their urine pH was always lower compared to healthy volunteers. Uric acid

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2012 Kidney international

64. Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH (PubMed)

that variants in common genes involved in ammonia metabolism may substantively contribute to basal urine pH regulation. These variations might influence the likelihood of developing disease conditions associated with altered urine pH, such as uric acid or calcium phosphate kidney stones. (...) Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH Urine pH is critical for net acid and solute excretion, but the genetic factors that contribute to its regulation are incompletely understood.We tested the association of single nucleotide polymorphisms (SNPs) from 16 genes related to ammonia (NH3) metabolism (15 biological candidates selected a priori, 1 selected from a previous genome-wide association study analysis) to that of 24-hour urine pH in 2493 individuals

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2017 Kidney international reports

65. Urine metabolic profiles in paediatric asthma. (PubMed)

to explore the different types of metabolite profile in paediatric asthma. Additionally, we employed a comprehensive strategy to elucidate the relationship between significant metabolites and asthma-related genes.We identified 51 differential metabolites mainly related to dysfunctional amino acid, carbohydrate and purine metabolism. A combination of eight candidate metabolites, including uric acid, stearic acid, threitol, acetylgalactosamine, heptadecanoic acid, aspartic acid, xanthosine and hypoxanthine (...) Urine metabolic profiles in paediatric asthma. Asthma is a global problem and complex disease suited for metabolomic profiling. This study explored the candidate biomarkers specific to paediatric asthma and provided insights into asthmatic pathophysiology.Children (aged 6-11 years) meeting the criteria for healthy control (n = 29), uncontrolled asthma (n = 37) or controlled asthma (n = 43) were enrolled. Gas chromatography-mass spectrometry was performed on urine samples of the patients

2019 Respirology

66. Association of plasma and urine viscosity with cardiometabolic risk factors and oxidative status. A pilot study in subjects with abdominal obesity. (PubMed)

with markers of oxidative status, and plasma viscosity with blood glucose. Categorical Principal Component Analysis plots showed that urine viscosity measurements at different shear rates clustered in three groups (low, intermediate and high shear rates) were selectively associated with uric acid, polyphenols and antioxidant capacity respectively. Plasma viscosity did not seem to be a relevant clinical marker in subjects with abdominal obesity. Therefore, urine viscosity could potentially serve (...) Association of plasma and urine viscosity with cardiometabolic risk factors and oxidative status. A pilot study in subjects with abdominal obesity. There is increasing interest in the search for accurate, repeatable and widely applicable clinical biomarkers for the early detection of cardiometabolic alterations and oxidative status. Viscosity is a promising tool in that sense, although most studies have used simple viscosimeters, providing limited information, and have not considered oxidative

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2018 PLoS ONE

67. Mechanisms for Falling Urine pH With Age in Stone Formers. (PubMed)

Mechanisms for Falling Urine pH With Age in Stone Formers. One of the main functions of the kidney is to excrete an acid load derived from both dietary and endogenous sources, thus maintaining body fluid pH. Urine pH is of particular interest in stone formers, as it determines the presence of either calcium phosphate or uric acid in stones. Others have noted in epidemiologic studies a rise in incidence of low pH-dependent uric acid stones with age, coinciding with a decrease in the incidence (...) determinants of urine pH such as urinary buffers, estimates of glomerular filtration, and dietary acid load, but these accounted for a small fraction of the pH fall. GI Anion absorption was the strongest predictor of urine pH in all age groups as we have previously reported in middle-aged normal men and women. However, we found that despite a decreasing urine pH, GI Anion absorption increases monotonically with age. In fact, after adjustment for GI Anion absorption urine pH declines more markedly

2019 American Journal of Physiology. Renal physiology

68. The occurrence of substituted uric acids in human urine (PubMed)

The occurrence of substituted uric acids in human urine 14944545 2004 02 15 2018 12 01 0264-6021 51 1 1952 Apr The Biochemical journal Biochem. J. The occurrence of substituted uric acids in human urine. 133-8 JOHNSON E A EA eng Journal Article England Biochem J 2984726R 0264-6021 268B43MJ25 Uric Acid OM Humans Uric Acid 5222:30881:483 URIC ACID 1952 4 1 1952 4 1 0 1 1952 4 1 0 0 ppublish 14944545 PMC1197800 Science. 1949 Apr 15;109(2833):377-8 17749594 Biochem J. 1930;24(3):619-25 16744401

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1952 Biochemical Journal

69. On the state in which the uric acid exists in the urine (PubMed)

On the state in which the uric acid exists in the urine 20895789 2011 03 29 2011 03 29 0959-5287 27 1844 Medico-chirurgical transactions Med Chir Trans On the state in which the uric acid exists in the urine. 102-18 Jones H B HB eng Journal Article England Med Chir Trans 0156105 0959-5287 2010 10 5 6 0 1844 1 1 0 0 1844 1 1 0 1 ppublish 20895789 PMC2116937

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1844 Medico-chirurgical transactions

70. Effect of weight reduction on levels of uric acid in plasma and urine. (PubMed)

Effect of weight reduction on levels of uric acid in plasma and urine. 4715551 1973 09 06 2018 11 13 0003-4967 32 3 1973 May Annals of the rheumatic diseases Ann. Rheum. Dis. Effect of weight reduction on levels of uric acid in plasma and urine. 280-1 Nicholls A A Yablonsky H H Scott J T JT eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid AYI8EX34EU Creatinine IM Body Weight Creatinine metabolism Female Humans Male Uric Acid blood urine 1973 5 1 1973 5 1 0 1 1973

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1973 Annals of the Rheumatic Diseases

71. Effect of stilboestrol on levels of uric acid in plasma and urine. (PubMed)

Effect of stilboestrol on levels of uric acid in plasma and urine. 4726074 1973 10 26 2018 11 13 0003-4967 32 4 1973 Jul Annals of the rheumatic diseases Ann. Rheum. Dis. Effect of stilboestrol on levels of uric acid in plasma and urine. 386-7 Nicholls A A Snaith M L ML Yablonsky H H Scott J T JT eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid 731DCA35BT Diethylstilbestrol IM Adult Diethylstilbestrol pharmacology Female Humans Male Sex Factors Transsexualism (...) blood urine Uric Acid blood urine 1973 7 1 1973 7 1 0 1 1973 7 1 0 0 ppublish 4726074 PMC1006122 Lancet. 1966 Oct 8;2(7467):777-8 4162328 Am J Med. 1965 Aug;39:242-51 14320691 Ann Rheum Dis. 1970 Jul;29(4):397-400 4916770

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1973 Annals of the Rheumatic Diseases

72. On the Estimation of Uric Acid in Human Urine (PubMed)

On the Estimation of Uric Acid in Human Urine 16991994 2007 02 05 2008 11 20 0022-3751 12 5-6 1891 Dec The Journal of physiology J. Physiol. (Lond.) On the Estimation of Uric Acid in Human Urine. 485-9 Groves E W EW eng Journal Article England J Physiol 0266262 0022-3751 1891 12 1 0 0 1891 12 1 0 1 1891 12 1 0 0 ppublish 16991994 PMC1514325

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1891 The Journal of physiology

73. Does Uric Acid taken by mouth increase the Excretion of that substance in the Urine? (PubMed)

Does Uric Acid taken by mouth increase the Excretion of that substance in the Urine? 16992091 2007 02 05 2008 11 20 0022-3751 15 3 1893 Sep The Journal of physiology J. Physiol. (Lond.) Does Uric Acid taken by mouth increase the Excretion of that substance in the Urine? 167-248.25 Haig A A eng Journal Article England J Physiol 0266262 0022-3751 1893 9 1 0 0 1893 9 1 0 1 1893 9 1 0 0 ppublish 16992091 PMC1514430

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1893 The Journal of physiology

74. Note on the Value of Piperazin as a Solvent of Uric Acid Stones in Urine (PubMed)

Note on the Value of Piperazin as a Solvent of Uric Acid Stones in Urine 20755222 2011 03 29 2011 03 29 0007-1447 2 1773 1894 Dec 22 British medical journal Br Med J Note on the Value of Piperazin as a Solvent of Uric Acid Stones in Urine. 1426 Fawcett J J eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1894 12 22 0 0 1894 12 22 0 1 ppublish 20755222 PMC2405512

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1894 British medical journal

75. Notes on the Urine of the Tortoise with special reference to Uric Acid and Urea (PubMed)

Notes on the Urine of the Tortoise with special reference to Uric Acid and Urea 16991448 2007 02 05 2008 11 20 0022-3751 7 5-6 1886 Nov The Journal of physiology J. Physiol. (Lond.) Notes on the Urine of the Tortoise with special reference to Uric Acid and Urea. 453-7 Mills T W TW eng Journal Article England J Physiol 0266262 0022-3751 1886 11 1 0 0 1886 11 1 0 1 1886 11 1 0 0 ppublish 16991448 PMC1485072

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1886 The Journal of physiology

76. On the Estimation of Uric Acid in the Urine: A Reply to Criticisms upon the Silver Method (PubMed)

On the Estimation of Uric Acid in the Urine: A Reply to Criticisms upon the Silver Method 20753358 2011 03 29 2011 03 29 0007-1447 2 1592 1891 Jul 04 British medical journal Br Med J On the Estimation of Uric Acid in the Urine: A Reply to Criticisms upon the Silver Method. 10 Haycraft J B JB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1891 7 4 0 0 1891 7 4 0 1 ppublish 20753358 PMC2272884

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1891 British medical journal

77. A NEW VOLUMETRIC METHOD of ESTIMATING URIC ACID in URINE (PubMed)

A NEW VOLUMETRIC METHOD of ESTIMATING URIC ACID in URINE 20757613 2011 03 29 2011 03 29 0007-1447 1 1936 1898 Feb 05 British medical journal Br Med J A NEW VOLUMETRIC METHOD of ESTIMATING URIC ACID in URINE. 364 Tunnicliffe F W FW Rosenheim O O eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1898 2 5 0 0 1898 2 5 0 1 ppublish 20757613 PMC2410629

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1898 British medical journal

78. A CLINICAL METHOD FOR THE QUANTITATIVE ESTIMATION OF URIC ACID IN URINE (PubMed)

A CLINICAL METHOD FOR THE QUANTITATIVE ESTIMATION OF URIC ACID IN URINE 20762197 2011 03 29 2011 03 29 0007-1447 2 2323 1905 Jul 08 British medical journal Br Med J A CLINICAL METHOD FOR THE QUANTITATIVE ESTIMATION OF URIC ACID IN URINE. 69-72 Surveyor N F NF eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1905 7 8 0 0 1905 7 8 0 1 ppublish 20762197 PMC2321094

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1905 British medical journal

79. Toxicity of Perirenal Fat in Overweight or Obese Subjects: A Pathophysiological Link Between Uric Acid Stones and Renal Ammonium Formation

Identifier: NCT02561858 Recruitment Status : Completed First Posted : September 28, 2015 Last Update Posted : March 12, 2018 Sponsor: Centre Hospitalier Universitaire de Nice Information provided by (Responsible Party): Centre Hospitalier Universitaire de Nice Study Details Study Description Go to Brief Summary: Patients who are overweight or obese, diabetic or not, share with those who are suffering from uric stones the same way to remove abnormal acidity of the body in urine, ie a kidney ammoniogenesis (...) default. This results in an overly acidic urine pH which is directly pathogenic in people predisposed to develop uric stones because the precipitation of urate soluble uric acid is accelerated in acid medium. Excess visceral fat, particularly perirenal, this defect may promote formation of renal ammonium. Indeed, the perirenal fat is adjacent to the renal cortex and shares with it a common arterial supply via the plexus Turner. Adipokines and fatty acids of the perirenal fat are predisposed to gain

2015 Clinical Trials

80. Assessment of urinary inhibitor or promoter activity in uric acid nephrolithiasis. (PubMed)

Assessment of urinary inhibitor or promoter activity in uric acid nephrolithiasis. We assessed decreased inhibitor activity or increased promoter activity in the urine of idiopathic uric acid stone formers compared to nonstone formers independent of urinary pH.A total of 30 idiopathic uric acid stone formers, and 9 obese and 12 lean nonstone formers collected 24-hour urine while on a metabolic diet. Three urine aliquots per subject were used to assess spontaneous nucleation (de novo crystal (...) formation), crystal growth using a 0.1 mg/ml anhydrous uric acid seed and steady-state uric acid solubility (the maximum amount of uric acid dissolvable in urine) using a 5 mg/ml uric acid seed. All experiments were performed for 6 hours at a constant pH of 5.0. Uric acid concentration was measured in filtered aliquots at 0, 3 and 6 hours.At baseline 24-hour urinary pH was significantly lower and uric acid saturation was significantly higher in idiopathic uric acid stone formers. No significant

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2015 Journal of Urology

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