How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,779 results for

Urine Uric Acid

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

41. Uric acid upregulates the adiponectin-adiponectin receptor 1 pathway in renal proximal tubule epithelial cells (PubMed)

study investigated the expression of APN and AdipoR1 in cultured PTECs that were exposed to SUA through immunofluorescence and western blot analysis. In addition, Sprague‑Dawley rats with oxonic acid‑induced hyperuricemia (HUA) with or without febuxostat treatment were employed as an animal model to measure 24 h urine protein, serum creatinine, urea nitrogen, uric acid and homeostasis model assessment of insulin resistance. Renal pathology was evaluated using hematoxylin and eosin (...) Uric acid upregulates the adiponectin-adiponectin receptor 1 pathway in renal proximal tubule epithelial cells Adiponectin (APN) is a protein hormone that is primarily derived from adipocytes. It can also be secreted by renal cells. Hypoadiponectinemia has been documented in patients with hyperuricemia, however, whether soluble uric acid (SUA) regulates the expression of APN and APN receptor 1 (AdipoR1) in renal proximal tubule epithelial cells (PTECs) remains to be elucidated. The present

Full Text available with Trip Pro

2017 Molecular medicine reports

42. Intensive Uric Acid Lowering With RDEA3170 and Febuxostat in Patients With Albuminuria

Intensive Uric Acid Lowering With RDEA3170 and Febuxostat in Patients With Albuminuria Intensive Uric Acid Lowering With RDEA3170 and Febuxostat in Patients With Albuminuria - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Intensive Uric Acid Lowering With RDEA3170 and Febuxostat in Patients With Albuminuria The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03118739 Recruitment Status : Completed First Posted : April 18, 2017 Last Update Posted : March 13, 2019 Sponsor: AstraZeneca Information provided

2017 Clinical Trials

43. Excretion rates of 1,5-anhydro-D-glucitol, uric acid and microalbuminuria as glycemic control indexes in patients with type 2 diabetes (PubMed)

Excretion rates of 1,5-anhydro-D-glucitol, uric acid and microalbuminuria as glycemic control indexes in patients with type 2 diabetes 1,5-anhydroglucitol (1,5-AG), uric acid and urinary proteins are excreted into the urine with increasing glucosuria. In the present retrospective study we analyzed whether these factors could be used as indicators for type 2 diabetes mellitus (T2DM) glucose control in 6,766 (T2DM) patients. There were 3,988 cases (58.9%) with HbA1c ≤ 6.5%, 853 cases (12.61 (...) %) with HbA1c levels ranging from 6.5% to 7% and 1,925 cases (28.5%) with HbA1c > 7%. HbA1c percentages were correlated with age, MA and 1,5-AG serum concentrations (P < 0.001). The serum uric acid concentration (P < 0.001) was significantly lower in elevated MA (P < 0.001) and 24-hour urinary protein (P = 0.024) patients. Hb1Ac percentages (P < 0.001) were significantly enhanced in patients with 1,5-AG serum concentrations ≤10 mg/L compared to >10 mg/L. With a derived receiver operating characteristic (ROC

Full Text available with Trip Pro

2017 Scientific reports

44. Urinary Uric Acid/Creatinine Ratio - A Marker For Perinatal Asphyxia (PubMed)

Urinary Uric Acid/Creatinine Ratio - A Marker For Perinatal Asphyxia Perinatal hypoxia is one of the leading causes of perinatal mortality in developing countries. Both apgar score and arterial blood pH predict the neonatal mortality in asphyxia. Apgar score alone does not predict neurologic outcome and as it is influenced by various factors. This study was conducted to evaluate the utility and sensitivity of urinary uric acid to creatinine ratio (UA/Cr ratio) in asphyxia diagnosis, compared (...) to invasive Arterial Blood Gas (ABG) analysis.To assess the urinary uric acid/creatinine ratio as an additional marker for perinatal asphyxia compared with ABG analysis in apgar score monitoring.The present case control study was conducted at a teaching hospital in Central Gujarat. Data of 40 healthy newborns and 40 asphyxiated newborns were collected. In absence of regional estimates, a sample of size 39 was required to attain a power of 80% at 5% alpha (type I error) considering a moderate effect size

Full Text available with Trip Pro

2017 Journal of clinical and diagnostic research : JCDR

45. Uric acid, an important screening tool to detect inborn errors of metabolism: a case series (PubMed)

Uric acid, an important screening tool to detect inborn errors of metabolism: a case series Uric acid is the metabolic end product of purine metabolism in humans. Altered serum and urine uric acid level (both above and below the reference ranges) is an indispensable marker in detecting rare inborn errors of metabolism. We describe different case scenarios of 4 Sri Lankan patients related to abnormal uric acid levels in blood and urine. CASE 1: A one-and-half-year-old boy was investigated (...) for haematuria and a calculus in the bladder. Xanthine crystals were seen in microscopic examination of urine sediment. Low uric acid concentrations in serum and low urinary fractional excretion of uric acid associated with high urinary excretion of xanthine and hypoxanthine were compatible with xanthine oxidase deficiency. CASE 2: An 8-month-old boy presented with intractable seizures, feeding difficulties, screaming episodes, microcephaly, facial dysmorphism and severe neuro developmental delay. Low uric

Full Text available with Trip Pro

2017 BMC research notes

46. Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice (PubMed)

Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice Tea (Camellia sinensis (L.) Kuntze [Theaceae]) is used to induce urination and inducing nervous excitation. Green and black teas have multifarious physiological functions. The different effects of green and black tea aqueous extracts (GTEs and BTEs) on hyperuricemia are not definitely reported.The different effects of GTEs and BTEs on lowering serum uric acid (UA) in hyperuricemic mice were

Full Text available with Trip Pro

2017 Pharmaceutical biology

47. Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy adult male subjects (PubMed)

and multiple ascending dose study. Panels of eight male subjects received a single oral dose of verinurad or placebo in either a fasted or fed state; panels of 10-12 male subjects received ascending doses of once-daily verinurad or placebo in a fasted state for 10 days. Serial blood and urine samples were assayed for verinurad and uric acid. Safety was assessed by adverse event (AE) reports, laboratory tests, vital signs, and electrocardiograms (ECGs).A total of 81 adult males completed the study (...) Pharmacokinetics, pharmacodynamics, and tolerability of verinurad, a selective uric acid reabsorption inhibitor, in healthy adult male subjects Verinurad (RDEA3170) is a selective uric acid reabsorption inhibitor in clinical development for the treatment of gout and asymptomatic hyperuricemia. The aim of this study was to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of verinurad in healthy adult males.This was a Phase I, randomized, double-blind, placebo-controlled, single

Full Text available with Trip Pro

2017 Drug design, development and therapy

48. Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN)

ash content, and 3000 cc distilled water) for 5 days to exclude dietary confounders (3 days as outpatient and the final 2 days as inpatient). On days 4 and 5, two fasting blood samples will be collected for the measurement of CMP, insulin, FFa and two 24-h urine samples will be collected under mineral oil to be analyzed for total volume, pH, Cr, na, K, Ca, Mg, Cl, P, uric acid, nH4+, titratable acidity (Ta), sulfate, HCo3- and citrate. The morning of day 6, patients will undergo dual 123i-BMiPP (...) Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN) Renal Uptake of Fatty Acids (FFA) in Patients With Idiopathic Uric Acid Nephrolithiasis (IUAN) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2016 Clinical Trials

49. Simultaneous Detection of Dopamine and Uric Acid Using a Poly(l-lysine)/Graphene Oxide Modified Electrode (PubMed)

Simultaneous Detection of Dopamine and Uric Acid Using a Poly(l-lysine)/Graphene Oxide Modified Electrode A novel, simple and selective electrochemical method was investigated for the simultaneous detection of dopamine (DA) and uric acid (UA) on a poly(l-lysine)/graphene oxide (GO) modified glassy carbon electrode (PLL/GO/GCE) by differential pulse voltammetry (DPV). The electrochemically prepared PLL/GO sensory platform toward the oxidation of UA and DA exhibited several advantages, including (...) of UA and DA, using DPV in the linear concentration ranges of 0.5 to 20.0 and 0.5 to 35 μM, respectively. In addition, the PLL/GO/GCE demonstrated good reproducibility, long-term stability, excellent selectivity and negligible interference of ascorbic acid (AA). The proposed modified electrode was successfully implemented in the simultaneous detection of DA and UA in human blood serum, urine and dopamine hydrochloride injection with satisfactory results.

Full Text available with Trip Pro

2016 Nanomaterials

50. Heat stress, hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of Mesoamerican nephropathy in Nicaragua. (PubMed)

gravity (≥1.030). Sugarcane cutters also more often had proteinuria and blood and leucocytes in the urine. Workers with eGFR <80 mL/min/1.73 m2 reported a higher intake of water and lower intake of sugary beverages. Serum uric acid levels related strongly and inversely to eGFR levels (adj β -10.4 mL/min/1.73 m2, 95% CI -12.2 to -8.5, p<0.001). No associations were observed for other metabolic risk factors, pesticides, non-steroidal anti-inflammatory drugs or alcohol. Among cane cutters, consumption (...) Heat stress, hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of Mesoamerican nephropathy in Nicaragua. To study Mesoamerican nephropathy (MeN) and its risk factors in three hot occupations.Cross-sectional.Chinandega and León municipalities, a MeN hotspot on the Nicaraguan Pacific coast, January-February 2013.194 male workers aged 17-39 years: 86 sugarcane cutters, 56 construction workers, 52 small-scale farmers.(1) Differences between the three

Full Text available with Trip Pro

2016 BMJ open

51. Potential mechanisms for low uric acid in Parkinson disease (PubMed)

for definite or probable PD (n = 20) and controls (n = 20) aged 55-80 years were recruited. Twenty-four hour urine samples were collected from all participants, and both uric acid and allantoin were measured and corrected for body mass index (BMI). Urinary metabolites were compared using a twoway ANOVA with diagnosis and sex as the explanatory variables. There were no significant differences between PD and controls for total UA (p = 0.60), UA corrected for BMI (p = 0.37), or in the interaction of diagnosis (...) Potential mechanisms for low uric acid in Parkinson disease Several epidemiologic studies have described an association between low serum uric acid (UA) and Parkinson disease (PD). Uric acid is a known antioxidant, and one proposed mechanism of neurodegeneration in PD is oxidative damage of dopamine neurons. However, other complex metabolic pathways may contribute. The purpose of this study is to elucidate potential mechanisms of low serum UA in PD. Subjects who met diagnostic criteria

Full Text available with Trip Pro

2016 Journal of neural transmission (Vienna, Austria : 1996)

52. Uric Acid

) These images are a random sampling from a Bing search on the term "Uric Acid." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Uric Acid (C0041980) Definition (NCI_NCI-GLOSS) A waste product left over from normal chemical processes in the body and found in the urine and blood. Abnormal buildup of uric acid in the body may cause a condition called gout. Increased levels of uric acid in the blood and urine can be a side (...) Uric Acid Uric Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Uric Acid Uric Acid Aka: Uric Acid II. Physiology Uric Acid

2018 FP Notebook

53. Uric Acid Nephrolithiasis

Acid Nephrolithiasis Aka: Uric Acid Nephrolithiasis , Urate Stones , Hyperuricosuria , Uric Acid Calculi From Related Chapters II. Epidemiology Represents 10% of s III. Evaluation See IV. Types Pure Uric Acid Calculi Mixed calcium and Uric Acid Calculi V. Causes Primary cause Acidic urine (pH <5.5) Other causes (confers 2 fold risk of calculi) Excessive dietary purine intake (meats) End Ileostomy Results in impaired ammonia and citrate excretion Results in lower pH and increased urinary ammonia (...) Increased crystallization VI. Labs AM spot urine for and Crystaluria stones form in acidic urine VII. Imaging Non-contrast XRay Pure Uric Acid Calculi are radiolucent May be visualized if mixed calcium and VIII. Management: Prevention of Uric Acid stone recurrence ral Restrict dietary intake of and protein Maintain : over 2.5 liters per day Alkalinize urine (especially if is low, acidic) Maintain >5.5 (6.5 - 7.0 preferred) Citrate 10-20 mEq orally three times daily with meals 500 mg, two tablets daily

2018 FP Notebook

54. The Association of Vitamin D Status and Vitamin D Replacement Therapy with Glycemic Control, Serum Uric Acid Levels, and Microalbuminuria in Patients with Type 2 Diabetes and Chronic Kidney Disease (PubMed)

The Association of Vitamin D Status and Vitamin D Replacement Therapy with Glycemic Control, Serum Uric Acid Levels, and Microalbuminuria in Patients with Type 2 Diabetes and Chronic Kidney Disease To evaluate the relationship of vitamin D status and vitamin D replacement therapy with glycemic control, serum uric acid (SUA) levels, and microalbuminuria (MAU) in patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD). Subjectsand Methods: A total of 1,463 patients with T2DM and CKD (...) (aged 14-88 years), 927 females and 536 males, were included in this study. The serum data of 25-hydroxyvitamin D, i.e., 25(OH)D, level, SUA, hemoglobin (Hb)A1c, creatinine, estimated glomerular filtration rate, and urine albumin-to-creatinine ratio (UACR) were obtained from the medical records. The Mann-Whitney U test, the χ2 test, the Mantel-Haenszel test, and linear regression models were used for data analysis.Vitamin D deficiency and insufficiency were evident in 770 (52.0%) and 357 (24.0

Full Text available with Trip Pro

2016 Medical Principles and Practice

55. Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. (PubMed)

Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. In cystic fibrosis (CF) there is an urgent need for earlier diagnosis of pulmonary infections and inflammation using blood- and urine-based biomarkers.Using mass spectrometry, oxidation products of glutathione and uric acid were measured in matched samples of bronchoalveolar lavage (BAL), serum and urine from 36 infants and children with CF, and related to markers of neutrophilic inflammation and infection (...) in BAL.Oxidation products of glutathione (glutathione sulfonamide, GSA) and uric acid (allantoin), were elevated in BAL of children with pulmonary infections with Pseudomonas aeruginosa (PsA) compared to those without (p<0.05) and correlated with other markers of neutrophilic inflammation. Serum GSA was significantly elevated in children with PsA infections (p<0.01). Urinary GSA correlated with pulmonary GSA (r=0.42, p<0.05) and markers of neutrophilic inflammation.This proof-of-concept study demonstrates

2016 Journal of Cystic Fibrosis

56. Comparison of the Metabolic Profile of Mixed Calcium Oxalate/Uric Acid Stone Formers to That of Pure Calcium Oxalate and Pure Uric Acid Stone Formers. (PubMed)

Comparison of the Metabolic Profile of Mixed Calcium Oxalate/Uric Acid Stone Formers to That of Pure Calcium Oxalate and Pure Uric Acid Stone Formers. To compare the metabolic profile of patients who form mixed calcium oxalate (CaOx)/uric acid (UA) stones to those of pure CaOx and pure UA stone formers.We performed a retrospective review of 232 patients, with both stone composition analysis and 24-hour urine collection, seen between March 2002 and April 2012. Analysis of 24-hour urine (...) constituents across the 3 stone groups (pure UA, pure CaOx, and mixed CaOx/UA) was performed using univariate analysis of variance and multivariate linear regression models adjusting for clinical and demographic factors and 24-hour urine collection elements.A total of 27 patients (11.6%) had mixed CaOx/UA, 122 (52.6%) had pure CaOx, and 83 (35.8%) had pure UA calculi. Univariate analysis demonstrated significant differences between mixed CaOx/UA patients and pure CaOx patients for urine pH (mixed, 5.63

2014 Urology

57. The Relation of the Degree of Acidity of the Urine and the Percentage of Uric Acid therein contained to the Precipitation of the latter in the form of Uric Acid Gravel (PubMed)

The Relation of the Degree of Acidity of the Urine and the Percentage of Uric Acid therein contained to the Precipitation of the latter in the form of Uric Acid Gravel 16992461 2007 02 05 2008 11 20 0022-3751 23 4 1898 Nov 25 The Journal of physiology J. Physiol. (Lond.) The Relation of the Degree of Acidity of the Urine and the Percentage of Uric Acid therein contained to the Precipitation of the latter in the form of Uric Acid Gravel. 315-24 Jerome W J WJ eng Journal Article England J Physiol

Full Text available with Trip Pro

1898 The Journal of physiology

58. On the History of Uric Acid in the Urine, with reference to the Formation of Uric Acid Concretions and Deposits (PubMed)

On the History of Uric Acid in the Urine, with reference to the Formation of Uric Acid Concretions and Deposits 20896767 2011 03 29 2011 03 29 0959-5287 73 1890 Medico-chirurgical transactions Med Chir Trans On the History of Uric Acid in the Urine, with reference to the Formation of Uric Acid Concretions and Deposits. 245-71 Roberts W W eng Journal Article England Med Chir Trans 0156105 0959-5287 2010 10 5 6 0 1890 1 1 0 0 1890 1 1 0 1 ppublish 20896767 PMC2036258

Full Text available with Trip Pro

1890 Medico-chirurgical transactions

59. Using Hounsfield Unit Measurement and Urine Parameters to Predict Uric Acid Stones. (PubMed)

Using Hounsfield Unit Measurement and Urine Parameters to Predict Uric Acid Stones. To determine the in vivo ability to predict uric acid stone composition by Hounsfield units (HU) with the addition of urine parameters.We reviewed all consecutive stones sent for analysis during a 4-year period from our institution for patients with an in-house computed tomography (CT) scan within the prior 6 months and urinalysis within the prior week. CT scans were independently reviewed by a radiologist (...) blinded to stone composition.Of the 507 patients with stones sent for analysis, 235 met the criteria for inclusion. Analysis showed 212 stones were predominantly calcium-based, and 22 were predominantly uric acid in composition. There was a significant difference between calcium stones and uric acid stones in mean HU (890 ± 20 vs 484 ± 44; P <.01) and urine pH (6.4 ± 0.8 vs 5.1 ± 0.2; P <.01). Receiver operating characteristic curve evaluation gave optimal predictive values of HU ≤494 (rounded to 500

2013 Urology

60. Influence of genetic variants on renal uric acid handling in response to frusemide: an acute intervention study (PubMed)

a study visit with oral intake of 40 mg frusemide. Blood and urine samples were obtained at baseline and 30, 60, 120 and 180 min after frusemide intake. The primary end point was change in fractional excretion of uric acid (FEUA).Following intake of frusemide, FEUA initially increased (mean (SD) change from baseline +1.9% (3.0%) at 60 min, p<0.001) and then decreased (mean (SD) change from baseline -1.5% (2.1%) at 180 min, p<0.001). A very small increase in serum urate was observed over the study (...) Influence of genetic variants on renal uric acid handling in response to frusemide: an acute intervention study Genetic variation in the renal urate transporters SLC2A9 (GLUT9) and SLC22A11 (OAT4) has been reported to interact with diuretics to increase the risk of developing gout. The aim of this study was to determine whether variation in SLC2A9 or SLC22A11 influences acute renal handling of uric acid in response to frusemide.Following an overnight fast, healthy participants (n=100) attended

Full Text available with Trip Pro

2017 RMD open

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>