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Urine Uric Acid

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381. Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress. Full Text available with Trip Pro

of fructose (supplied in a 2-L volume of 10% fructose in water) daily for 2 weeks. Participants were evaluated at the Unit of Nephrology of the Mateo Orfila Hospital in Menorca. Changes in serum levels of magnesium, calcium, uric acid, phosphorus, vitamin D, and intact PTH levels were evaluated. Urine magnesium, calcium, uric acid, phosphorus, citrate, oxalate, sodium, potassium, as well as urinary pH, were measured.Ingestion of fructose was associated with an increased serum level of uric acid (p < 0.001 (...) ), a decrease in serum ionized calcium (p = 0.003) with a mild increase in PTH (p < 0.05) and a drop in urinary pH (p = 0.02), an increase in urine oxalate (p = 0.016) and decrease in urinary magnesium (p = 0.003).Fructose appears to increase urinary stone formation in part via effects on urate metabolism and urinary pH, and also via effects on oxalate. Fructose may be a contributing factor for the development of kidney stones in subjects with metabolic syndrome and those suffering from heat

2018 BMC Nephrology Controlled trial quality: uncertain

382. Amelioration of diabetic nephropathy in db/db mice treated with tibetan medicine formula Siwei Jianghuang Decoction Powder extract Full Text available with Trip Pro

the effects of SWJH on DN in db/db mice and possible underlying mechanisms. The ten weeks old db/db mice treated with SWJH by intra-gastric administration once a day for 8 weeks. After 8 weeks, body weight, water and food intake of mice were recorded. The level of fasting blood glucose (FBG) was measured. Serum creatinine (Scr), blood urea nitrogen (BUN), urine microalbumin (UMAlb), serum uric acid (UA) and urinary albumin excretion (UAE) were detected. An enzyme-linked immunosorbent assay was performed

2018 Scientific reports

383. Impact of Dietary Intervention on Tumor Immunity: the DigesT Trial

, cholesterol, amino acids) FMD-induced changes in urine metabolites [ Time Frame: 3 years ] FMD-induced changes in urine metabolites (ketone bodies) FMD-induced changes in serum growth factors. [ Time Frame: 3 years ] FMD-induced changes in serum growth factors. Qualitative changes in tumor-infiltrating immune cells [ Time Frame: 3 years ] Qualitative changes in the type of tumor-infiltrating immune cell populations before and after the diet in breast cancer patients undergoing curative surgery (Cohort (...) blood uric acid < 10 mg/dl ALT and AST ≤ 2.5 x ULN total bilirubin < ULN except for patients with Gilbert syndrome who may only be included in the total bilirubin is < 3.0 x ULN or direct bilirubin < 1.5 x ULN Albumin > 3 g/dL Fasting glucose ≤ 200 mg/dl. Total Cholesterol ≤ 300 mg/dl. Triglycerides ≤ 300 mg/dl. Female patients of childbearing potential must agree to sexual abstinence or to use two highly effective method of contraception throughout the study and for at least 30 days after the end

2018 Clinical Trials

384. Investigating the Effect of Deep Sea Krill Oil Supplementation in Osteoarthritis of the Knee

. Clinically significant changes in biochemistry from baseline [ Time Frame: from Baseline to 6 months ] The following parameters will be measured at baseline, 3 months and 6 months: Sodium, Potassium, Chloride, Bicarbonate, Glucose, Urea, Creatinine, Calcium, C reactive protein (CRP), Uric acid, Phosphate, Albumin, Globulins, Protein, Total bilirubin, Gamma-glutamyl transpeptidase (GGT), Alkaline Phosphatase (ALP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Lactate Dehyrogenase (LD (...) sustainably from the Southern Ocean and is extracted from the Antarctic Krill, the most abundant marine biomass. Krill oil is a source of omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for the maintenance of good health. Omega-3, EPA and DHA are also found in phospholipid form which are much easier absorbed than triglyceride form of omega-3 which is found in fish oil. Omega-3 supports cardiovascular health, brain health and eye health. Preliminary research suggests krill

2018 Clinical Trials

385. Daprodustat Bioequivalence and Food Effect Study

, Alkaline phosphate, total protein, total and direct bilirubin, albumin, uric acid, triglyceride, total cholesterol, LDL-cholesterol, HDL-cholesterol, lactate dehydrogenase, GGT, CPK, amylase, chloride, and phosphorus. Number of subjects with abnormal urinalysis: Part 1 [ Time Frame: Up to Day 16 ] Laboratory assessment for urine analysis will include specific gravity, hydrogen-ion exponent (pH), glucose, blood, ketones, bilirubin, urobilinogen by dipstick, microscopic examination Number of subjects (...) , uric acid, triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, lactate dehydrogenase, gamma glutamyl transpeptidase (GGT), Creatine phosphokinase (CPK), amylase, chloride, and phosphorus. Number of subjects with abnormal clinical chemistry parameters: Part 2 [ Time Frame: Up to Day 16 ] Laboratory assessment for clinical chemistry parameters will include BUN, potassium, calcium, sodium, creatinine, fasting glucose, AST, ALT

2018 Clinical Trials

386. A Single Dose Study of SHR0410 in Healthy Male Participants

, Specific gravity, Protein, Blood, Leukocytes, Glucose, Ketones, Bilirubin, Nitrites Incidence of Adverse events in terms of changes in Biochemistry (fasting) [ Time Frame: Up to Day 8 ] Including Serum creatinine, Urea, Alanine aminotransferase, Aspartate aminotransferase, Gamma glutamyl transferase, Total bilirubin, Total protein, Albumin, Alkaline phosphatase, Serum uric acid, Glucose, Triglycerides, Total cholesterol, High-density lipoprotein cholesterol, Low-density lipoprotein cholesterol (...) Concentration (Cmax) [ Time Frame: Up to 24 hours post dose ] Peak Plasma SHR0410 Concentration Half-time (T1/2) [ Time Frame: Up to 24 hours post dose ] Half-time of SHR0410 Urine output rate [ Time Frame: Up to 48 hours post dose ] Changes in urine output rate from baseline Serum prolactin release rate [ Time Frame: Up to 48 hours post dose ] Changes in serum prolactin release rate from baseline Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study

2018 Clinical Trials

387. Fructose Supplementation in Carriers for Hereditary Fructose Intolerance

according to a crossover design Urine uric acid concentration [ Time Frame: Time Frame: 24 hour urine collection before ingestion of a test meal and after 7 days of 2 conditions (enriched fructose diet vs poor fructose diet) according to a crossover design ] Change in urine uric acid profile after low fructose diet and an enriched fructose diet according to a crossover design Body weight [ Time Frame: Time Frame: at baseline before study intervention and at the end of each conditions (enriched fructose (...) , controlled, crossover trial. Condition or disease Intervention/treatment Phase Hereditary Fructose Intolerance Other: Experimental diet Fru rich diet Other: Experimental low Fru diet Not Applicable Detailed Description: A high fructose intake also increases blood lactate and uric acid concentrations. It has been proposed that uric acid may contribute to insulin resistance by impairing endothelium-dependent vasodilation, promoting pro-inflammatory effects and dyslipidemia by activating de novo lipogenesis

2018 Clinical Trials

388. The Diet Gout Trial

compliance, and urine electrolytes will be assessed throughout the study as well. The primary comparison will be serum uric acid concentrations measured after the 4-week dietitian-directed diet versus uric acid concentrations measured after the 4-week self-directed diet (DD vs. SD). Comparisons will be made within person using generalized estimating equations (GEE) with and without adjustment for baseline uric acid concentration. Investigators will use GEE models for secondary outcomes as well. Study (...) Foundation Information provided by (Responsible Party): Johns Hopkins University Study Details Study Description Go to Brief Summary: Unhealthy diet has long been associated with high uric acid levels and gout. The DASH diet may lower uric acid levels. This study will examine the effects of the DASH diet on uric acid in adults with a history of gout. Condition or disease Intervention/treatment Phase Gout Hyperuricemia Other: Subsidy for food purchases and dietitian education Not Applicable Detailed

2018 Clinical Trials

389. The Efficacy and Safety of UGN-102 as a Primary Chemoablation Agent in Patients With LG NMIBC at Intermediate Risk of Recurrence

, including red blood cell indices and white blood cell differential Platelet count Creatinine Blood urea nitrogen Uric acid Sodium Potassium Phosphorus Calcium Bicarbonate Chloride SGOT/AST SGPT/ALT GGT Alkaline phosphatase Total bilirubin Direct bilirubin Albumin Total protein Clinically meaningful changes in full physical examination [ Time Frame: Screening visit and Twelve (12) months after the first instillation of UGN-102 ] Changes in Full Physical Examination findings which will be defined (...) ) and, if there are remaining lesions, by histopathology of the remaining lesions. CR is defined as having no detectable disease (NDD) and will be assessed visually during cystoscopy and also upon urine cytology. In the event that the investigator is not sure, and there is suspect tissue, a small biopsy will be taken from the suspect tissue to confirm CR in addition to cystoscopy and urine cytology. Patients who achieve a CR will receive monthly maintenance treatments with UGN-102 and will be assessed at 6, 9, and 12

2018 Clinical Trials

390. A Ph 1 Study of Epanova® in Healthy Chineses

). ] Measurement of red blood cell count, white blood cell count, haemoglobin and platelets Safety as determined by abnormality in clinical chemistry [ Time Frame: Blood samples will be collected at Visit1(any day between Day-28 to Day-2), Visit2 (Day -2) and Visit23(Day20). ] Measurement of kidney function (e.g.urea ,creatinine, Uric acid), liver function(ALP, ALT, AST, albumin, total bilirubin, direct bilirubin), lipid profile(total cholesterol, triglycerides), potassium and hs-CRP Safety as determined (...) of Epanova 4 g will be administered once daily for 14 consecutive days. Other Name: Omega-3 carboxylic acids Outcome Measures Go to Primary Outcome Measures : 1. Plasma concentrations versus time profile of EPA and DHA [ Time Frame: Blood sample will be collected on Day-1, Day1(-1h, -5min Pre-dose and 1h, 2h, 3h, 4h, 5h, 6h, 7.5h, 9h, 12h, 16h Post-dose),Day2,3,4,7,11,14,16,and Day17 (-5min Pre-dose, 1h, 2h, 3h, 4h, 5h, 6h, 7.5h, 9h, 12h, 16h Post-dose), Day18,19 and Day20 ] To evaluate the PK of single

2018 Clinical Trials

391. Study of Multiple Doses of PRS-060 Administered by Oral Inhalation in Subjects With Mild Asthma

levels as part of standard serum chemistry panel [ Time Frame: Screening, Day −1, post-dose (second dose) of 12 hours on Day 1, pre-dose (first dose) on Days 4 & 7, post-dose (last dose) of 12 hours on Day 10, Day 17 (±1 day), Day 40 (±3 days) ] To assess changes in total lipase levels as measured in U/L Change in total uric acid levels as part of standard serum chemistry panel [ Time Frame: Screening, Day −1, post-dose (second dose) of 12 hours on Day 1, pre-dose (first dose) on Days 4 & 7, post (...) -dose (last dose) of 12 hours on Day 10, Day 17 (±1 day), Day 40 (±3 days) ] To assess changes in total uric acid levels as measured in mmol/L Change in total creatine kinase (CK) levels as part of standard serum chemistry panel [ Time Frame: Screening, Day −1, post-dose (second dose) of 12 hours on Day 1, pre-dose (first dose) on Days 4 & 7, post-dose (last dose) of 12 hours on Day 10, Day 17 (±1 day), Day 40 (±3 days) ] To assess changes in total CK levels as measured in U/L Change in total

2018 Clinical Trials

392. To Evaluate Safety, Tolerability, and Clinical Activity of the Antibody-drug Conjugate, GSK2857916 Administered in Combination With Lenalidomide Plus Dexamethasone (Arm A), or in Combination With Bortezomib Plus Dexamethasone (Arm B) in Subjects With Rela

, sodium, magnesium, potassium, chloride, Total CO2, phosphorous, calcium, AST, ALT, GGT, alkaline phosphatase, CK, total and direct bilirubin, uric acid, albumin, total protein, and LDH. Number of subjects with abnormal urinalysis parameters, Part 2 [ Time Frame: Up to 4.5 years ] Urine samples will be collected to measure specific gravity, pH, glucose, protein, blood and ketones by dipstick method at specified time points. Number of subjects with vital signs of PCI, Part 2 [ Time Frame: up to 4.5 (...) of subjects with abnormal clinical chemistry parameters, Part 1 [ Time Frame: up to 4.5 years ] Blood samples will be collected to measure blood urea nitrogen (BUN), creatinine, fasting glucose, sodium, magnesium, potassium, chloride, Total carbon dioxide (CO2), phosphorous, calcium, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), alkaline phosphatase, creatinine kinase (CK), total and direct bilirubin, uric acid, albumin, total protein, lactate

2018 Clinical Trials

393. Lipid-lowering Therapies in Vietnamese Chronic Kidney Disease Population

Measures : To measure the serum level of TC, LDL-C, HDL-C, TG, Creatinine, uric acid, and allantoin in Vietnamese CKD population and in healthy persons at the base time. [ Time Frame: At the base time ] The serum level of TC, LDL-C, HDL-C, TG, Creatinine, uric acid, and allantoin will be measured in mg/dL. To measure the serum level of Taurine, Tryp, and Kyn in Vietnamese CKD population and in healthy persons at the base time. [ Time Frame: At the base time ] The serum level of Taurine, Tryp, and Kyn (...) level of TC, LDL-C, HDL-C, TG, Creatinine, uric acid, and allantoin in Vietnamese CKD population at 4th, 8th, 12th month. [ Time Frame: at 4th, 8th and 12th month ] The serum level of TC, LDL-C, HDL-C, TG, Creatinine, uric acid, and allantoin will be measured in mg/dL. The change of results during treatment will be described and will be compared in 3 different groups To measure the serum level of Taurine, Tryp, and Kyn in Vietnamese CKD population at 4th, 8th, 12th month. [ Time Frame: at 4th, 8th

2018 Clinical Trials

394. The Effect of Tart Cherry Juice on Risk of Gout Attacks

: Measured at 0, 6 and 12 months ] Difference in fractional excretion of uric acid in tart cherry juice group versus placebo group from baseline to 12 months. Measured from 24 hour urine sample. Change in inflammatory markers (in milligrams per litre (mg/l)) [ Time Frame: Measured at 0, 6 and 12 months ] Difference in inflammatory markers (c reactive protein (CRP), inter leukin-6 (IL-6) and tumour necrosis factor- alpha (TNF-alpha)) in tart cherry juice group versus placebo group from baseline to 12 (...) Intervention/treatment Phase Gout Flare Gout Attack Dietary Supplement: Tart cherry juice Other: Fruit-flavoured placebo drink Not Applicable Detailed Description: Gout is a painful and often debilitating condition affecting around 3% of adults in the UK. It is a type of inflammatory arthritis caused by high levels of uric acid which is deposited as crystals in joints, resulting in painful gout flares. Cherries and cherry products have received attention for their possible role in gout management owing

2018 Clinical Trials

395. First Time in Human (FTIH) Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Single and Repeat Doses of GSK3439171A in Healthy Subjects and to Assess Food Effect

of subjects with abnormal Clinical Chemistry values including: Blood Urea Nitrogen, Creatinine, Glucose, Sodium, Potassium, Chloride, Calcium, total carbon dioxide, Alkaline phosphatase, Gamma-glutamyl Transferase (GGT), Alanine Transferase (ALT), Aspartate Aminotransferase (AST), Total and direct bilirubin, Uric Acid, Albumin, Total Protein, Creatine Phosphokinase for Part A will be reported. Part B: Number of subjects with abnormal Clinical Chemistry Values [ Time Frame: Up to 5 weeks ] Number (...) of subjects with abnormal Clinical Chemistry values including: Blood Urea Nitrogen, Creatinine, Glucose, Sodium, Potassium, Chloride, Calcium, total carbon dioxide, Alkaline phosphatase, GGT, ALT, AST, Total and direct bilirubin, Uric Acid, Albumin, Total Protein, Creatine Phosphokinase for Part B will be reported. Part C: Number of subjects with abnormal Clinical Chemistry Values [ Time Frame: Up to 4 weeks ] Number of subjects with abnormal Clinical Chemistry values including: Blood Urea Nitrogen

2018 Clinical Trials

396. Drug-Drug Interaction Study to Evaluate the Effect of PF-06865571 on Metformin Pharmacokinetics

of study medication ] The following parameters were analyzed for laboratory examination: hematology (hemoglobin, hematocrit, red blood cell count, platelet count, white blood cell count, total neutrophils, eosinophils, monocytes, basophils, lymphocytes); blood chemistry (blood urea nitrogen, creatinine, glucose, calcium, sodium, potassium, chloride, total bicarbonate, aspartate aminotransferase, alanine aminotransferase, total bilirubin, alkaline phosphatase, uric acid albumin, total protein (...) ); urinalysis (decimal logarithm of reciprocal of hydrogen ion activity [pH], glucose, protein, blood, ketones, microscopy [if urine tested positive for blood or protein]). Number of Participants With Clinically Significant Change From Baseline in Vital Signs [ Time Frame: 0 and 48 hours (h) post-dose ] the following parameters were analyzed for examination of vital signs: systolic and diastolic blood pressure and pulse rate. Number of Participants With Change From Baseline in Electrocardiogram (ECG

2018 Clinical Trials

397. A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD8233 in Healthy Male Subjects With Increased Elevated LDL-C Levels.

clinical chemistry -Uric acid [ Time Frame: From screening to 4 month follow-up. ] To assess serum level of Uric acid as a variable of safety and tolerability of AZD8233 following SC administration of single ascending doses. Secondary Outcome Measures : Plasma PK analysis: Time delay between drug administration and the first observed concentration in plasma (tlag) [ Time Frame: At treatment Days 1 to 3 (Pre-dose and 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 12, 16, 24, 36, 48 hours post-dose); Day 4 (72 (...) diction. Prolong the length of the stay at the Clinical Unit. Adjust the timing and number of assessments and/or blood/urine samples for subsequent cohorts. Adjust the length of the Follow-up Period. Each subject will be involved in the study for up to 20 weeks. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 56 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Participant) Masking

2018 Clinical Trials

398. Glasdegib Renal Impairment Study

/dL), Uric acid/Chemistry Lab Panel [ Time Frame: 34 days ] Uric acid (mg/dL) Magnesium/Chemistry Lab Panel [ Time Frame: 34 days ] Magnesium (mg/dL) QTc/ECGs [ Time Frame: 34 days ] QTc interval (msec) QRS/ECGs [ Time Frame: 34 days ] QRS interval (msec) Glucose/Urinalysis Lab Panel [ Time Frame: 34 days ] Glucose (qual) (no unit) Protein/Urinalysis Lab Panel [ Time Frame: 34 days ] Protein (qual) (no unit) Blood/Urinalysis Lab Panel [ Time Frame: 34 days ] Blood (qual) (no units) Ketones (...) /Urinalysis Lab Panel [ Time Frame: 34 days ] Ketones (no units) Nitrites/Urinalysis Lab Panel [ Time Frame: 34 days ] Nitrites (no units) Leukocyte /Urinalysis Lab Panel [ Time Frame: 34 days ] Leukocyte esterase (no units) Urobilinogen/Urinalysis Lab Panel [ Time Frame: 34 days ] Urobilinogen (no unit) Urine bilirubin/Urinalysis Lab Panel [ Time Frame: 34 days ] Urine bilirubin (no unit) Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study

2018 Clinical Trials

399. Phase I Study of GSK2982772 in Japanese Healthy Male Participants

Frame: Up to Day 39 ] The following hematology parameters will be analyzed: platelet count, red blood cell (RBC) count, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), percent reticulocytes, neutrophils, lymphocytes, monocytes, eosinophils and basophils. Number of subjects with abnormal clinical chemistry parameters [ Time Frame: Up to Day 39 ] The following clinical chemistry parameters will be analyzed: blood urea nitrogen (BUN), creatinine, uric acid (...) , glucose, calcium, phosphorous, sodium, potassium, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), alkaline phosphatase, creatinine phosphokinase, total and direct bilirubin, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, amylase, triglyceride, chloride, lactate dehydrogenase (LDH), total cholesterol, C-reactive protein, total protein and albumin. Number of subjects with abnormal urine parameters [ Time Frame

2018 Clinical Trials

400. Modification of Diet in Renal Transplantation (MDRT)

concentration of bicarbonate (safety outcome) Serum uric acid [ Time Frame: 6 weeks and 3 months ] Serum uric acid concentration (safety outcome) Micronutrient status of Selenium (safety outcome) [ Time Frame: 6 weeks and 3 months ] Plasma Selenium concentration n-3 Polyunsaturated Fatty Acid (PUFA) status [ Time Frame: 6 weeks and 3 months ] n-3 PUFA content of erythrocyte lipid fraction Urinary C-X-C motif chemokine 10 (CXCL10) [ Time Frame: 6 weeks and 3 months ] Urinary levels of C-X-C motif chemokine (...) group will receive a meal plan based on low-fat, unrefined, plant based foods with the goal macronutrient intake of approximately 15% protein, <15 % fats and 70-75% of carbohydrates, and will additionally receive polyunsaturated fatty acid (PUFA n-3) supplement (daily dose 840 mg) to ensure daily recommended intake. Subjects in the control group will receive a meal plan in accordance with recommendations by the Task Force for the Management of Dyslipidaemias of the European Society of Cardiology

2018 Clinical Trials

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