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Urine Uric Acid

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263. Autosomal Dominant Polycystic Kidney Disease - Diet and Lifestyle Management

-protein diet (0.58 g/kg/d) or a very low protein diet (0.28 g/kg/ d supplemented with keto and amino acids). Patients were included in the study if they met the GFR criteria respective to Study A or Study B (as stated earlier), their mean arterial pressure was less than 125 mm Hg, and their dietary protein intake was greater than or equal to 0.9 g/kg body weight/d. The primary outcome for the MDRD study was GFR decline measured by 125 I-iothalamate clearance every 4 months. Klahr et al, 9 in 1995 (...) , the effect of increased ?uid intake (beyond thirst) on renal disease progression in humans with ADPKD is not known. The available data are limited and include a single post hoc analytical study, 36 two short-term interventional trials (o1 wk) without con- trol groups, 37,38 and a single long-term observational cohort study of 12 months. 39 A post hoc analysis of the well-known MDRD trial examined the relationship between GFR decline and urine volume (an indirect marker of ?uid intake). 36 During the MDRD

2015 KHA-CARI Guidelines

264. Heart failure - chronic

factors and to exclude with similar presentations. Possible tests include: Chest X-ray. Blood tests such as urea and electrolytes, estimated glomerular filtration rate (eGFR), full blood count, thyroid function tests, liver function tests, HbA1c, and fasting lipids. Urine dipstick for blood and protein. Lung function tests (peak flow and/or spirometry). Assess for and manage any underlying where appropriate. People with heart failure due to valve disease should be referred for specialist assessment

2019 NICE Clinical Knowledge Summaries

265. Effects of antioxidant-rich foods on altitude-induced oxidative stress and inflammation in elite endurance athletes: A randomized controlled trial. Full Text available with Trip Pro

(23 ± 5 years), ingested antioxidant-rich foods (n = 16), (> doubling their usual intake), or eucaloric control foods (n = 15) during a 3-week altitude training camp (2320 m). Fasting blood and urine samples were collected 7 days pre-altitude, after 5 and 18 days at altitude, and 7 days post-altitude. Change over time was compared between the groups using mixed models for antioxidant capacity [uric acid-free (ferric reducing ability of plasma (FRAP)], oxidative stress (8-epi-PGF2α

2019 PLoS ONE Controlled trial quality: uncertain

266. Biochemical metabolic levels and vitamin D receptor FokⅠ gene polymorphisms in Uyghur children with urolithiasis. Full Text available with Trip Pro

) and serum chlorine (Cl) (OR = 0.93, 95% CI: 0.88-0.97) were related to Uyghur children urolithiasis risk. A multiple logistic regression model showed CO2CP (OR = 1.17, 95% CI: 1.09-1.26), levels of uric acid (OR = 1.01, 95% CI: 1.00-1.01) and serum sodium (Na) (OR = 0.90, 95% CI: 0.82-0.99) were associated with pediatric urolithiasis. The risk of urolithiasis was increased with the F versus f allele overall (OR = 1.42; 95% CI: 1.01-2.00) and for males (OR = 1.52, 95% CI: 1.02-2.27). However, metabolic (...) levels did not differ by FokⅠ genotypes. In our population, CO2CP and levels of uric acid and serum Na as well as polymorphism of the F allele of the VDR FokⅠ may provide important clues to evaluate the risk of urolithiasis in Uyghur children.

2019 PLoS ONE

267. CUA guideline on the evaluation and medical management of the kidney stone patient

, Grade C Recommendation): 14-20 • Children ( 5.8 serum bicarbonate serum potassium Pure apatite stone Hypocitraturia Serum electrolytes Urine pH Ammonium chloride load test* Potassium citrate *Optional; PTH: parathyroid hormone; ?: high; ?N: at the high end of normal range; : low.CUAJ • November-December 2016 • Volume 10, Issues 11-12 E354 dion et al. Focus of treatment for uric acid stones should, therefore, primarily be to correct urine pH above 5.5 and increase urine volume rather than institute (...) excretion. This results in unbuffered hydrogen ions and a lowering of the urinary pH. 134 Based on the num- ber of metabolic syndrome traits, the risk of stone formation may go up two-fold. 135 Dietary and medical prophylaxis options are shown in Fig. 2. In patients with uric acid stones, alkalinization of the urine targeting a urine pH of 6.5 is the first-line therapy. Allopurinol may be used as adjunctive therapy in patients with hyperuricemia or hyperuricosuria (Level of Evidence 1-3, Grade B

2016 Canadian Urological Association

268. Can a Spot Urine Replace or Improve 24 Hour Urine Collections in Kidney Stone Patients

.), different crystals may precipitate. Therefore therapy is tailored to the individual, based on stone composition and the results of the 24-hour urine collection. The majority of the stones are calcium based (calcium oxalate, calcium phosphate) while the remaining are comprised of uric acid, struvite, cystine or other substances. While some stones can pass spontaneously, the majority will require some form of treatment, and more than 50% will require surgical intervention. Until the 1980s, treatment (...) : All Accepts Healthy Volunteers: No Sampling Method: Non-Probability Sample Study Population Patients receiving care at Vancouver General Hospital for their kidney stone disease. Criteria Inclusion Criteria: Patients who have been diagnosed as having calcium based urinary stones at least 19 years of age do not have any additional serious disease Exclusion Criteria: Patients who do not have calcium based urinary stones (such as: uric acid, cystine, struvite) less than 19 years of age have a serious

2010 Clinical Trials

269. Management of Ureteral Calculi

to SWL and may be better served by ureteroscopic management. 12 Moreover, in the case of cystine and calcium oxalate monohydrate, the frag- ments created by SWL may be large which can result in poor clearance. Uric acid stones, while fragile in the face of SWL, present a challenge with respect to localization for SWL treatment. Either the use of ultrasound or pyelography (IVP or retrograde) is required to target the stone. In addition, follow-up cannot be completed in the conventional fashion (...) with plain radiography, and requires the use of either ultra- sound or, more often, CT scanning to ensure the patient is successfully treated. In many instances the exact stone composition will not be known prior to treatment, or in the case of recurrent stone formers, it may have changed over time. 13 Non-contrast CT scans using dual energy can distinguish some types of stones in vivo. Uric acid stones can be differentiated from calcium stones; however, there is significant overlap in the attenua- tion

2015 Canadian Urological Association

270. Polycythaemia/erythrocytosis

but clinically normal haemoglobin. JAK2 V617F mutation — positive finding is definitive for polycythaemia vera. Negative finding does not rule it out as around 5% of cases involve other mutations. Serum uric acid (optional) — frequently elevated in polycythaemia vera. Abdominal ultrasound — to detect splenomegaly (suggestive of polycythaemia vera) where physical examination is equivocal. Differential diagnosis What else might it be? The differential diagnoses of polycythaemia vera include: Essential (...) , leading to secondary erythrocytosis. Examine the digits, measure oxygen saturation, and listen to the chest — clubbing of digits, oxygen saturation <92% in room air, and/or abnormal heart or breath sounds may suggest secondary erythrocytosis caused by underlying cardiopulmonary disease. Carry out urine dipstick analysis to identify possible renal causes of secondary erythrocytosis. Consider . Take blood samples (without a tourniquet if possible) for haemoglobin, mean corpuscular volume (MCV

2018 NICE Clinical Knowledge Summaries

271. Contrast-induced Nephropathy

bicarbonate versus N-acetylcysteine plus IV saline; 8 RCTs comparing a statin versus IV saline; 5 RCTs comparing a statin plus N-acetylcysteine versus N-acetylcysteine; 6 RCTs comparing statin versus statin, statin by dose, or statins plus other agents; 5 RCTs comparing an adenosine antagonist versus IV saline; 6 RCTs investigating hemodialysis or hemofiltration versus IV saline; 6 RCTs comparing ascorbic acid versus IV saline, and 3 RCTs comparing ascorbic acid to N-acetylcysteine. Although we found many (...) of CIN (RR, 0.93; 95% CI, 0.68 to 1.27). The SOE was low for a clinically important reduction in CIN that was not statistically significant when comparing IV sodium bicarbonate with IV saline in patients receiving LOCM (RR, 0.65; 95% CI, 0.33 to 1.25). The SOE was low for a clinically important reduction in CIN that was not statistically significant when comparing ascorbic acid with IV saline (RR, 0.72; 95% CI, 0.48 to 1.01). The SOE was low that use of hemodialysis versus IV saline to prevent CIN

2016 Effective Health Care Program (AHRQ)

272. Screening for Chronic Kidney Disease in Adult Males in Vojvodina: A Cross-sectional Study Full Text available with Trip Pro

, based on estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR), and exploring the determinants and awareness of CKD.This cross-sectional study included 3060 male examinees from the general population, over 18 years of age, whose eGFR and ACR were calculated, first morning urine specimen examined, arterial blood pressure measured and body mass index calculated. Standard biochemistry methods determined creatinine, urea, uric acid and glucose serum concentrations as well (...) as albumin and creatinine urine levels.Prevalence of CKD in the adult male population is 7.9%, highest in men over 65 years of age (46.7%), while in the other age groups it is 3.6-12.6%. The largest number of examinees with a positive CKD marker suffer from arterial hypertension (HTA) and diabetes mellitus (DM). Only 1.3% of examinees with eGFR<60 ml/min/1.73 m2 and/or ACR≥ 3 mg/mmol had been aware of positive CKD biomarkers.Obtained results show the prevalence of CKD in adult males is 7.9%, HTA and DM

2017 Journal of medical biochemistry

273. Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System

investigators and clinical researchers avoid experimental error and ensure high-quality measurements of these important biological species. Introduction Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced in virtually all eukaryotic cells. These molecules regulate several physiological processes including proliferation, migration, hypertrophy, differentiation, cytoskeletal dynamics, and metabolism, but when available in excess, they react with lipids, proteins, and nucleic acids (...) Free radical; neutral form of hydroxide ion (HO − ) Superoxide anion Free radical; dioxide (1-); product of 1 e − reduction of dioxygen O 3 Ozone Trioxygen; an allotrope of oxygen OCl − Hypochloride anion Salt of hypochlorous acid ROOH Hydroperoxide Organic peroxide, protonated peroxyl radical ROO· Peroxyl radical Free radical; lipid peroxyl radical when R is a lipid carbon RO· Alkoxyl radical Free radical; lipid alkoxyl radical when R is a lipid carbon Reactive nitrogen species ·NO Nitric oxide

2016 American Heart Association

274. Surgical Management of Stones: AUA/Endourology Society Guideline

or distal ureteral stones who require intervention (who were not candidates for or who failed MET), clinicians should recommend URS as first-line therapy. For patients who decline URS, clinicians should offer SWL. (Index Patients 2,3,5,6) Strong Recommendation; Evidence Level Grade B 12. URS is recommended for patients with suspected cystine or uric acid ureteral stones who fail MET or desire intervention. Expert Opinion 13. Routine stenting should not be performed in patients undergoing SWL. (Index (...) ' published in 2014. 6 The surgical management of patients with various stones is described below and divided into 13 respective patient profiles. Index Patients 1-10 are non-morbidly obese; non-pregnant adults (≥ 18 years of age) with stones not thought to be composed of uric acid or cystine; normal renal, coagulation and platelet function; normally positioned kidneys; intact lower urinary tracts without ectopic ureters; no evidence of sepsis; and no anatomic or functional obstruction distal to the stone

2016 American Urological Association

275. Screening and Management of Lipids

- treated patients results in a reduction in the risk of cardiovascular events. Therefore niacin should not be used in conjunction with statins for reduction in cardiovascular events. Rare cases of rhabdomyolysis have been associated with concomitant use of statins and niacin in doses > 1 g. Niacin patients should have baseline ALT and glucose and uric acid, with follow up ALT at 3 months or at dose escalations, and periodically thereafter. Niacin is available over the counter (OTC) as a dietary (...) controlled trials; B=controlled trials, no randomization; C=observational trials; D=opinion of expert panel. 2 UMHS Lipid Therapy Guideline, May 2014 Table 1. Secondary Causes of Hyperlipidemia Secondary Cause Elevated LDL-C Elevated Triglycerides Diet Saturated or trans fats, weight gain, anorexia Weight gain, very low-fat diets, high intake of refined carbohydrates, excessive alcohol intake Drugs Diuretics, cyclosporine, glucocorticoids, amiodarone Oral estrogens, glucocorticoids, bile acid

2016 University of Michigan Health System

277. Treatment Strategies for Patients with Renal Colic

Treatment Strategies for Patients with Renal Colic TITLE: Treatment Strategies for Patients with Renal Colic: A Review of the Comparative Clinical and Cost-Effectiveness DATE: 17 November 2014 CONTEXT AND POLICY ISSUES Urinary track calculi or urinary stones, formed from crystalized chemicals in the urine such as calcium oxalate, uric acid and cystine, occur in one of ten Canadians in their lifetime. 1 The obstruction of the urinary tract by calculi at the narrowest anatomical areas leads

2014 Canadian Agency for Drugs and Technologies in Health - Rapid Review

279. Acofide (acotiamide hydrochloride hydrate)

burning; and there is no evidence of structural disease (including at upper endoscopy) that is likely to explain the symptoms.” The cause of FD is not fully elucidated. The current assumption is that the symptoms are caused by the involvement of multiple factors including abnormal gastric emptying, gastric dysrhythmia, gastric hypersensitivity, hypersensitivity and motility disorder of the small intestine, impaired postprandial relaxation of the gastric fundus, vagus nerve disorder, enhanced acid (...) by elementary analysis, ultraviolet spectroscopy, infrared spectrophotometry (IR), water content, hydrochloric acid content, nuclear magnetic resonance spectrometry ( 1 H-, 13 C-NMR), mass spectrometry, and X-ray crystallography. 2.A.(1).2) Manufacturing process The drug substance is manufactured using ***************************************, ********************************, and ***************************** as the starting materials through ** **** processes and ** **** processes. The processes

2013 Pharmaceuticals and Medical Devices Agency, Japan

280. Topiloric/Uriadec (topiroxostat)

for the indications and dosage and administration as shown below. [Indication] Gout, hyperuricaemia [Dosage and administration] The usual adult initial dosage is 20 mg/dose of topiroxostat orally administered twice daily in the morning and evening. Thereafter, the dose should be gradually increased, as needed, while monitoring blood uric acid levels. The usual maintenance dosage should be 60 mg/dose twice daily. The dose may be adjusted according to the patient’s condition, up to 80 mg/dose twice daily. 4 Review (...) of topiroxostat orally administered twice daily in the morning and evening. Thereafter, the dosage should be gradually increased, as needed, while monitoring blood uric acid levels. The usual maintenance dosage should be 60 mg/dose twice daily. The dose may be adjusted according to the patient’s condition, up to 80 mg/dose twice daily. II. Summary of the Submitted Data and Outline of Review by the Pharmaceuticals and Medical Devices Agency (PMDA) A summary of the submitted data and an outline of the review

2013 Pharmaceuticals and Medical Devices Agency, Japan

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