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Urine Vanillylmandelic Acid

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1. Urine Vanillylmandelic Acid

Urine Vanillylmandelic Acid Urine Vanillylmandelic Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Vanillylmandelic Acid (...) Urine Vanillylmandelic Acid Aka: Urine Vanillylmandelic Acid , Urine VMA II. Physiology VMA is a metabolite III. Indications (other tests used more often) diagnosis or monitoring Suspected Multiple endocrine adenomatosis ry Carcinoma Evaluation for coexisting IV. Normal Levels Age 3-8 years: less than 2.3 mg per day Age 9-12 years: less than 3.4 mg per day Age 13-17 years: less than 3.9 mg per day Adults: less than 6.7 mg per day V. Causes of Increased Levels Ganglioma Images: Related links

2018 FP Notebook

2. Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo (PubMed)

Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo Vitiligo is an acquired skin disease characterized by depigmented areas of the skin. Increased release of catecholamines from autonomic nerve endings in microenvironment of melanocytes in affected skin might be involved in the aetiopathogenesis of vitiligo. Levels of catecholamines are considered as being related to onset or worsening of the disease. Therefore, in this study, the role (...) of catecholamines was evaluated in mapping disease stability and outcome of vitiligo patients undergoing melanocyte transfer.In this study, circulatory and urinary levels of catecholamine (CA) and vanillylmandelic acid (VMA) were determined in 45 individuals (30 vitiligo patients and 15 healthy controls) using ELISA.A significant increase for plasma and urinary catecholamines along with VMA was observed as compared to healthy controls. When the pre- and post-intervention levels were analyzed in responders

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2018 The Indian journal of medical research

3. The effects of seeds with hot and cold temperaments on serum thyroid hormones, corticosterone and urine vanillylmandelic acid concentrations of healthy rats. (PubMed)

The effects of seeds with hot and cold temperaments on serum thyroid hormones, corticosterone and urine vanillylmandelic acid concentrations of healthy rats. Hot and cold temperaments are the basic concepts of Iranian traditional medicine (ITM). Nevertheless, studies on the functional mechanisms of medicinal herbs based on hot and cold temperaments are not very extensive. This study aimed to evaluate the effects of diets containing hot or cold temperament seeds according to ITM on some hormonal (...) of the rats׳ serum free thyroxin (FT4), free triiodothyronin (FT3), triiodothyronin (T3), thyroxin (T4), corticosterone and urine vanillylmandelic acid (VMA) were analyzed.After 24 hours, a significant decrease in FT3 was observed in groups that were fed anise or fennel seeds. However, a significant increase in T3 was observed in the ajowan seed-fed group, and no changes in other parameters were observed in this group. On the 7th day, FT4 was significantly increased in fennel seed-fed group; T3

2014 Journal of Ethnopharmacology

4. Urine Vanillylmandelic Acid

Urine Vanillylmandelic Acid Urine Vanillylmandelic Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Vanillylmandelic Acid (...) Urine Vanillylmandelic Acid Aka: Urine Vanillylmandelic Acid , Urine VMA II. Physiology VMA is a metabolite III. Indications (other tests used more often) diagnosis or monitoring Suspected Multiple endocrine adenomatosis ry Carcinoma Evaluation for coexisting IV. Normal Levels Age 3-8 years: less than 2.3 mg per day Age 9-12 years: less than 3.4 mg per day Age 13-17 years: less than 3.9 mg per day Adults: less than 6.7 mg per day V. Causes of Increased Levels Ganglioma Images: Related links

2015 FP Notebook

5. Development of a new biochemical test to diagnose and monitor neuroblastoma in Vietnam: homovanillic and vanillylmandelic acid by gas chromatography-mass spectrometry. (PubMed)

Development of a new biochemical test to diagnose and monitor neuroblastoma in Vietnam: homovanillic and vanillylmandelic acid by gas chromatography-mass spectrometry. The aim of this study was to develop an accurate robust testing method to simultaneously measure urine levels of HVA and VMA using gas chromatography mass spectrometry (GCMS) and to establish age-specific reference intervals of HVA and VMA in random urines for Vietnamese children.The assay for urinary HVA and VMA was developed (...) based on a classical urinary organic acid profiling method. Briefly, this incorporated 3-phenyl butyric acid as the internal standard and liquid-liquid extraction with ethyl acetate followed by derivatization with BSTFA. The Agilent 7890A GC and 5975C Mass Selective Detector in single ion monitoring mode was used for analysis. Reference intervals were developed from random urine samples collected from 634 disease free Vietnamese children and compared to 50 known neuroblastoma patient samples

2014 Clinical biochemistry

6. Urine Catecholamine Levels as Diagnostic Markers for Neuroblastoma in a Defined Population: Implications for Ophthalmic Practice (PubMed)

elevated urinary catecholamine metabolites at the initial presentation. Urinary vanillylmandelic acid (VMA) levels were greater than twice the upper limit of normal in eight (57%) of 14 cases, whereas homovanillic acid (HVA) levels were greater than two times the upper limit of normal in 10 (71%) of the 14 cases. Three (75%) of the four cases without significantly elevated urinary VMA or HVA levels were diagnosed with stage IV disease, whereas one (25%) had stage II neuroblastoma.urinary catecholamine (...) Urine Catecholamine Levels as Diagnostic Markers for Neuroblastoma in a Defined Population: Implications for Ophthalmic Practice although elevated urinary catecholamine levels have been reported in 90-95% of patients with neuroblastoma, more recent studies of pediatric Horner syndrome caused by an underling neuroblastoma have reported normal values at presentation. The purpose of this population-based study is to report the percentage of cases of neuroblastoma with elevated urinary

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2010 Eye

7. Special Endocrine Testing

pituitary adenoma or ectopic source. Used in the diagnosis of non-classic CAH. Notes: For the investigation of adrenal insufficiency, concomitant am ACTH and cortisol should be performed before pursuit of ACTH stimulation testing. 24-hour urinary excretion of catecholamines and metanephrines MSP cost: $46.45 catecholamines $155.77 metanephrines Indications Non-Indications Used in the diagnosis of pheochromocytoma and functional paraganglioma. Urinary vanillylmandelic acid, although the end metabolite (...) , plasma and urine MSP cost: $170.92 Indications Non-Indications Investigation of secondary causes of hypertension: primary aldosteronism, renal artery stenosis. Not indicated for the initial investigation of syncope or hypotension caused by possible adrenal insufficiency. For adrenal insufficiency, screen with am cortisol and proceed to 250 µg ACTH stimulation test as indicated. Notes: For ambulatory patients meeting criteria for primary aldosteronism screening, order upright plasma aldosterone

2016 Clinical Practice Guidelines and Protocols in British Columbia

8. Neuroblastoma Treatment (PDQ®): Patient Version

of the abdomen called a . The picture can be printed to be looked at later. studies : A procedure in which a urine sample is checked to measure the amount of certain substances, vanillylmandelic acid (VMA) and homovanillic acid (HVA), that are made when catecholamines break down and are released into the urine. A higher than normal amount of VMA or HVA can be a sign of neuroblastoma. : An of the and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making (...) . The exam checks a person’s mental status, coordination, and ability to walk normally, and how well the muscles, senses, and reflexes work. This may also be called a neuro exam or a neurologic exam. Urine catecholamine studies : A procedure in which a urine sample is checked to measure the amount of certain substances, vanillylmandelic acid (VMA) and homovanillic acid (HVA), that are made when catecholamines break down and are released into the urine. A higher than normal amount of VMA or HVA can

2018 PDQ - NCI's Comprehensive Cancer Database

9. Neuroblastoma Treatment (PDQ®): Health Professional Version

. Individuals with Beckwith-Wiedemann syndrome and germline CDKN1C mutations. Individuals with Costello syndrome and HRAS mutations. Patients with neuroblastoma and a strong family history of neuroblastoma or clearly bilateral/multifocal neuroblastoma. Surveillance consists of the following:[ ] Abdominal ultrasonography. Quantitative, normalized assessment of urinary catecholamines, such as urine vanillylmandelic acid (VMA) and homovanillic acid (HVA), by gas chromatography and mass spectroscopy (can (...) be a random urine collection normalized for urine creatinine). Chest x-ray. Surveillance begins at birth or at diagnosis of neuroblastoma predisposition and continues every 3 months until age 6 years and then continues every 6 months until age 10 years. Patients with Costello syndrome may have elevated urinary catecholamines in the absence of a catecholamine-secreting tumor, so only very high levels or significantly rising levels should prompt further investigation beyond the ultrasonography and chest x

2018 PDQ - NCI's Comprehensive Cancer Database

11. Catecholamine excretion profiles identify clinical subgroups of neuroblastoma patients. (PubMed)

the profiles to clinical characteristics and outcome of patients with neuroblastoma.Four excretion profiles (A-D) were identified in vitro, which correlated with the relative protein expression of the catecholamine enzymes. These profiles were also identified in urine samples from patients with neuroblastoma and correlated with the presence of the catecholamine enzymes in the tumour. Strikingly, in 66% of the patients, homovanillic acid and vanillylmandelic acid excretions were discordant (...) relevance.A panel of 25 neuroblastoma cell lines was screened for catecholamine excretion. Detection of the catecholamine enzymes was performed using Western blot. Based on catecholamine enzymes presence and excreted catecholamine metabolites, excretion profiles were defined. The prevalence of these profiles was investigated in vivo using diagnostic urines from 301 patients with neuroblastoma and immunohistochemistry on primary tumours. The clinical relevance of the profiles was determined by linking

2019 European Journal of Cancer

12. Neuroblastoma Screening (PDQ®): Health Professional Version

is reviewed regularly and updated as necessary by the PDQ Screening and Prevention Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH). Summary of Evidence Note: Separate PDQ summaries on and are also available. Intervention Screening, usually at age 6 months, for urine vanillylmandelic acid and homovanillic acid (...) (e.g., phenylketonuria). Screening is performed through biochemical tests for metabolites of norepinephrine and dopamine (i.e., vanillylmandelic acid [VMA], and homovanillic acid [HVA]). Seventy-five percent to 90% of cases of neuroblastoma excrete these substances into the urine, which can be measured in urine specimens.[ ] There is no known optimal age for screening, but the most commonly discussed and studied age for a one-time screen has been 6 months. Screening at 12 months has also been

2017 PDQ - NCI's Comprehensive Cancer Database

13. Diagnosis and Treatment of Pheochromocytoma and Paraganglioma

at low rates or is episodic in nature. The superior sensitivity of urine metanephrines over catecholamines and vanillylmandelic acid (VMA) for diagnosis of PPGLs was first suggested from a meta-analysis by Manu and Runge ( ). This analysis was followed by reports revealing false-negative results for measurements of urine catecholamines and VMA and improved accuracy with measurements of urinary metanephrines ( – ). Initial evidence that measurements of plasma free metanephrines provide advantages (...) suggest measuring plasma or urine levels of metanephrines on follow-up to diagnose persistent disease. We suggest lifelong annual biochemical testing to assess for recurrent or metastatic disease. ( 2 |⊕⊕○○) 5.0 Surgery 5.1 We recommend minimally invasive adrenalectomy (eg, laparoscopic) for most adrenal pheochromocytomas. ( 1 |⊕⊕○○) We recommend open resection for large (eg, >6 cm) or invasive pheochromocytomas to ensure complete tumor resection, prevent tumor rupture, and avoid local recurrence. ( 1

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2014 The Endocrine Society

14. A Novel RET D898Y Germline Mutation in a Patient with Pheochromocytoma (PubMed)

a healthcare examination. Her mother and two sisters had previously undergone thyroidectomy for papillary thyroid carcinomas. The levels of vanillylmandelic acid and other catecholamines were elevated in 24-hour urine, and an imaging study revealed a right adrenal mass. She underwent laparoscopic adrenalectomy and the final pathologic diagnosis was pheochromocytoma. Mutation screening detected a RET p.D898Y mutation, both in the patient and in the patient's two sons and older sister. This is the first

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2018 Case reports in endocrinology

15. A rare presentation of pheochromocytoma in pregnancy: a case report (PubMed)

metanephrine, normetanephrine, and vanillylmandelic acid were assessed. Finally, the diagnosis of pheochromocytoma was confirmed. She underwent a cesarean section and adrenal mass excision at the 40th week of gestation. This timely diagnosis resulted in her proper management and good maternal and neonatal treatment outcomes.Our patient had pheochromocytoma during pregnancy. She had no complaints about hypertension before or during pregnancy until giving birth to her child; her only symptoms were a vague (...) which was managed by insulin administration. She also had a history of pulsatile bi-temporal headache for 2 years prior to her referral to us. She underwent complete abdominal and pelvic ultrasound imaging for her flank pain. This examination revealed a heterogeneous mass of 119 × 87 × 79 mm above her left kidney, highly suspicious of being an adrenal-originating tumor. Subsequently, we consulted an endocrinologist. She underwent abdominopelvic magnetic resonance imaging and her 24-hour urine

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2018 Journal of medical case reports

16. A Rare Case Report of Extra-adrenal Pheochromocytoma with Normal Blood Pressure: Is that Possible? (PubMed)

for pulmonary thromboembolism. Computed tomography (CT) chest confirmed the presence of old embolism and showed the 1.1 cm nodule in the left upper lobe. He suddenly collapsed and went into cardio-respiratory failure and attempts to resuscitate were futile. Results for pheochromocytoma workup received after the patient has passed away and it showed elevated levels of 24-hour urine metanephrine, normetanephrine, and Vanillylmandelic acid (VMA). In our patient, CT abdomen did not identify any mass

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2018 Cureus

17. Neuroblastoma Treatment (PDQ®): Health Professional Version

. Individuals with Beckwith-Wiedemann syndrome and germline CDKN1C mutations. Individuals with Costello syndrome and HRAS mutations. Patients with neuroblastoma and a strong family history of neuroblastoma or clearly bilateral/multifocal neuroblastoma. Surveillance consists of the following:[ ] Abdominal ultrasonography. Quantitative, normalized assessment of urinary catecholamines, such as urine vanillylmandelic acid (VMA) and homovanillic acid (HVA), by gas chromatography and mass spectroscopy (can (...) be a random urine collection normalized for urine creatinine). Chest x-ray. Surveillance begins at birth or at diagnosis of neuroblastoma predisposition and continues every 3 months until age 6 years and then continues every 6 months until age 10 years. Patients with Costello syndrome may have elevated urinary catecholamines in the absence of a catecholamine-secreting tumor, so only very high levels or significantly rising levels should prompt further investigation beyond the ultrasonography and chest x

2016 PDQ - NCI's Comprehensive Cancer Database

19. Phase 2 Study of ONC201 in Neuroendocrine Tumors

and/or presence of a detectable serum or urine biomarker (3-methoxytyramine, normetanephrine, metanephrines, homovanillic acid (HVA), vanillylmandelic acid (VMA), and dopamine, Varieties will include neuroblastoma, Ewing sarcoma, neuroectodermal tumor, clear call sarcoma, myoepithelial tumor, primitive neuroectodermal tumor (PNET), desmoplastic small round cell tumor, round cell sarcoma, and unresectable, metastatic or locally advanced , well-differentiated neuroendocrine tumors who have relapsed

2017 Clinical Trials

20. Catecholamines profiles at diagnosis: Increased diagnostic sensitivity and correlation with biological and clinical features in neuroblastoma patients. (PubMed)

Catecholamines profiles at diagnosis: Increased diagnostic sensitivity and correlation with biological and clinical features in neuroblastoma patients. Neuroblastoma (NBL) accounts for 10% of the paediatric malignancies and is responsible for 15% of the paediatric cancer-related deaths. Vanillylmandelic acid (VMA) and homovanillic acid (HVA) are most commonly analysed in urine of NBL patients. However, their diagnostic sensitivity is suboptimal (82%). Therefore, we performed in-depth analysis

2017 European Journal of Cancer

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