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Urine Vanillylmandelic Acid

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1. Urine Vanillylmandelic Acid

Urine Vanillylmandelic Acid Urine Vanillylmandelic Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Vanillylmandelic Acid (...) Urine Vanillylmandelic Acid Aka: Urine Vanillylmandelic Acid , Urine VMA II. Physiology VMA is a metabolite III. Indications (other tests used more often) diagnosis or monitoring Suspected Multiple endocrine adenomatosis ry Carcinoma Evaluation for coexisting IV. Normal Levels Age 3-8 years: less than 2.3 mg per day Age 9-12 years: less than 3.4 mg per day Age 13-17 years: less than 3.9 mg per day Adults: less than 6.7 mg per day V. Causes of Increased Levels Ganglioma Images: Related links

2018 FP Notebook

2. Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo (Full text)

Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo Vitiligo is an acquired skin disease characterized by depigmented areas of the skin. Increased release of catecholamines from autonomic nerve endings in microenvironment of melanocytes in affected skin might be involved in the aetiopathogenesis of vitiligo. Levels of catecholamines are considered as being related to onset or worsening of the disease. Therefore, in this study, the role (...) of catecholamines was evaluated in mapping disease stability and outcome of vitiligo patients undergoing melanocyte transfer.In this study, circulatory and urinary levels of catecholamine (CA) and vanillylmandelic acid (VMA) were determined in 45 individuals (30 vitiligo patients and 15 healthy controls) using ELISA.A significant increase for plasma and urinary catecholamines along with VMA was observed as compared to healthy controls. When the pre- and post-intervention levels were analyzed in responders

2018 The Indian journal of medical research

3. The effects of seeds with hot and cold temperaments on serum thyroid hormones, corticosterone and urine vanillylmandelic acid concentrations of healthy rats. (PubMed)

The effects of seeds with hot and cold temperaments on serum thyroid hormones, corticosterone and urine vanillylmandelic acid concentrations of healthy rats. Hot and cold temperaments are the basic concepts of Iranian traditional medicine (ITM). Nevertheless, studies on the functional mechanisms of medicinal herbs based on hot and cold temperaments are not very extensive. This study aimed to evaluate the effects of diets containing hot or cold temperament seeds according to ITM on some hormonal (...) of the rats׳ serum free thyroxin (FT4), free triiodothyronin (FT3), triiodothyronin (T3), thyroxin (T4), corticosterone and urine vanillylmandelic acid (VMA) were analyzed.After 24 hours, a significant decrease in FT3 was observed in groups that were fed anise or fennel seeds. However, a significant increase in T3 was observed in the ajowan seed-fed group, and no changes in other parameters were observed in this group. On the 7th day, FT4 was significantly increased in fennel seed-fed group; T3

2014 Journal of Ethnopharmacology

4. Urine Vanillylmandelic Acid

Urine Vanillylmandelic Acid Urine Vanillylmandelic Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Vanillylmandelic Acid (...) Urine Vanillylmandelic Acid Aka: Urine Vanillylmandelic Acid , Urine VMA II. Physiology VMA is a metabolite III. Indications (other tests used more often) diagnosis or monitoring Suspected Multiple endocrine adenomatosis ry Carcinoma Evaluation for coexisting IV. Normal Levels Age 3-8 years: less than 2.3 mg per day Age 9-12 years: less than 3.4 mg per day Age 13-17 years: less than 3.9 mg per day Adults: less than 6.7 mg per day V. Causes of Increased Levels Ganglioma Images: Related links

2015 FP Notebook

5. Development of a new biochemical test to diagnose and monitor neuroblastoma in Vietnam: homovanillic and vanillylmandelic acid by gas chromatography-mass spectrometry. (PubMed)

Development of a new biochemical test to diagnose and monitor neuroblastoma in Vietnam: homovanillic and vanillylmandelic acid by gas chromatography-mass spectrometry. The aim of this study was to develop an accurate robust testing method to simultaneously measure urine levels of HVA and VMA using gas chromatography mass spectrometry (GCMS) and to establish age-specific reference intervals of HVA and VMA in random urines for Vietnamese children.The assay for urinary HVA and VMA was developed (...) based on a classical urinary organic acid profiling method. Briefly, this incorporated 3-phenyl butyric acid as the internal standard and liquid-liquid extraction with ethyl acetate followed by derivatization with BSTFA. The Agilent 7890A GC and 5975C Mass Selective Detector in single ion monitoring mode was used for analysis. Reference intervals were developed from random urine samples collected from 634 disease free Vietnamese children and compared to 50 known neuroblastoma patient samples

2014 Clinical biochemistry

6. Special Endocrine Testing

pituitary adenoma or ectopic source. Used in the diagnosis of non-classic CAH. Notes: For the investigation of adrenal insufficiency, concomitant am ACTH and cortisol should be performed before pursuit of ACTH stimulation testing. 24-hour urinary excretion of catecholamines and metanephrines MSP cost: $46.45 catecholamines $155.77 metanephrines Indications Non-Indications Used in the diagnosis of pheochromocytoma and functional paraganglioma. Urinary vanillylmandelic acid, although the end metabolite (...) , plasma and urine MSP cost: $170.92 Indications Non-Indications Investigation of secondary causes of hypertension: primary aldosteronism, renal artery stenosis. Not indicated for the initial investigation of syncope or hypotension caused by possible adrenal insufficiency. For adrenal insufficiency, screen with am cortisol and proceed to 250 µg ACTH stimulation test as indicated. Notes: For ambulatory patients meeting criteria for primary aldosteronism screening, order upright plasma aldosterone

2016 Clinical Practice Guidelines and Protocols in British Columbia

7. Neuroblastoma Treatment (PDQ®): Health Professional Version

. Individuals with Costello syndrome and HRAS mutations. Individuals with neuroblastoma and a strong family history of neuroblastoma or clearly bilateral/multifocal neuroblastoma. Surveillance consists of the following:[ ] Abdominal ultrasonography. Quantitative, normalized assessment of urinary catecholamines, such as urine vanillylmandelic acid (VMA) and homovanillic acid (HVA), by gas chromatography and mass spectroscopy (can be a random urine collection normalized for urine creatinine). Chest x-ray (...) the primary tumor and sites of metastases.[ , ] MIBG scanning is also critical to assess response to therapy.[ ] About 90% of neuroblastoma cases are MIBG avid; fluorine F 18-fludeoxyglucose positron emission tomography (PET) scans are used to evaluate extent of disease in patients with tumors that are not MIBG avid.[ ] (Refer to the section of this summary for more information about imaging of neuroblastoma.) Urine catecholamine metabolites: Urinary excretion of the catecholamine metabolites VMA and HVA

2018 PDQ - NCI's Comprehensive Cancer Database

8. Neuroblastoma Treatment (PDQ®): Patient Version

(ultrasound) are bounced off the abdomen and make echoes. The echoes form a picture of the abdomen called a . The picture can be printed to be looked at later. studies : A test in which a urine sample is checked to measure the amount of certain substances, vanillylmandelic acid (VMA) and homovanillic acid (HVA), that are made when catecholamines break down and are released into the urine. A higher than normal amount of VMA or HVA can be a sign of neuroblastoma. : An of the and bones inside the chest. An x (...) . A history of the patient’s health habits and past illnesses and treatments will also be taken. : A series of questions and tests to check the brain, , and nerve function. The exam checks a person’s mental status, coordination, ability to walk normally, and how well the muscles, senses, and reflexes work. This may also be called a neuro exam or a neurologic exam. Urine catecholamine studies : A test in which a urine sample is checked to measure the amount of certain substances, vanillylmandelic acid (VMA

2018 PDQ - NCI's Comprehensive Cancer Database

10. European Society of Endocrinology Clinical Practice Guideline for long-term follow-up of patients operated on for a phaeochromocytoma or a paraganglioma

MN and 3MT every year to screen for local or metastatic recurrence or new tumours. (⊕○○○) Rationale. There is evidence that determination of plasma free or urinary fractionated MN is more sensitive than assaying catecholamine and vanillylmandelic acid for detection of PPGL ( , ). There is cross-sectional evidence that higher than normal levels of 3MT are associated with malignancy in PPGL ( , ). There is no evidence that MN and 3MT determinations allow earlier detection of recurrence or new (...) 1.1. We recommend defining malignancy of phaeochromocytoma and paraganglioma (PPGL) as the presence of metastasis in lymph node or other distant sites. R 1.2. We suggest screening for metastatic tumours by [ 18 F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT), if possible preoperatively: in patients with paragangliomas; in patients with phaeochromocytomas and elevated (i.e. above the reference) levels of 3-methoxytyramine (3MT) in plasma or urine; and in patients

2016 European Society of Endocrinology

11. Catecholamine excretion profiles identify clinical subgroups of neuroblastoma patients. (PubMed)

the profiles to clinical characteristics and outcome of patients with neuroblastoma.Four excretion profiles (A-D) were identified in vitro, which correlated with the relative protein expression of the catecholamine enzymes. These profiles were also identified in urine samples from patients with neuroblastoma and correlated with the presence of the catecholamine enzymes in the tumour. Strikingly, in 66% of the patients, homovanillic acid and vanillylmandelic acid excretions were discordant (...) relevance.A panel of 25 neuroblastoma cell lines was screened for catecholamine excretion. Detection of the catecholamine enzymes was performed using Western blot. Based on catecholamine enzymes presence and excreted catecholamine metabolites, excretion profiles were defined. The prevalence of these profiles was investigated in vivo using diagnostic urines from 301 patients with neuroblastoma and immunohistochemistry on primary tumours. The clinical relevance of the profiles was determined by linking

2019 European Journal of Cancer

12. Neuroblastoma Screening (PDQ®): Health Professional Version

is reviewed regularly and updated as necessary by the PDQ Screening and Prevention Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH). Summary of Evidence Note: Separate PDQ summaries on and are also available. Intervention Screening, usually at age 6 months, for urine vanillylmandelic acid and homovanillic acid (...) (e.g., phenylketonuria). Screening is performed through biochemical tests for metabolites of norepinephrine and dopamine (i.e., vanillylmandelic acid [VMA], and homovanillic acid [HVA]). Seventy-five percent to 90% of cases of neuroblastoma excrete these substances into the urine, which can be measured in urine specimens.[ ] There is no known optimal age for screening, but the most commonly discussed and studied age for a one-time screen has been 6 months. Screening at 12 months has also been

2017 PDQ - NCI's Comprehensive Cancer Database

13. A Rare Case Report of Extra-adrenal Pheochromocytoma with Normal Blood Pressure: Is that Possible? (Full text)

for pulmonary thromboembolism. Computed tomography (CT) chest confirmed the presence of old embolism and showed the 1.1 cm nodule in the left upper lobe. He suddenly collapsed and went into cardio-respiratory failure and attempts to resuscitate were futile. Results for pheochromocytoma workup received after the patient has passed away and it showed elevated levels of 24-hour urine metanephrine, normetanephrine, and Vanillylmandelic acid (VMA). In our patient, CT abdomen did not identify any mass

2018 Cureus

14. A rare presentation of pheochromocytoma in pregnancy: a case report (Full text)

metanephrine, normetanephrine, and vanillylmandelic acid were assessed. Finally, the diagnosis of pheochromocytoma was confirmed. She underwent a cesarean section and adrenal mass excision at the 40th week of gestation. This timely diagnosis resulted in her proper management and good maternal and neonatal treatment outcomes.Our patient had pheochromocytoma during pregnancy. She had no complaints about hypertension before or during pregnancy until giving birth to her child; her only symptoms were a vague (...) which was managed by insulin administration. She also had a history of pulsatile bi-temporal headache for 2 years prior to her referral to us. She underwent complete abdominal and pelvic ultrasound imaging for her flank pain. This examination revealed a heterogeneous mass of 119 × 87 × 79 mm above her left kidney, highly suspicious of being an adrenal-originating tumor. Subsequently, we consulted an endocrinologist. She underwent abdominopelvic magnetic resonance imaging and her 24-hour urine

2018 Journal of medical case reports

15. A Novel RET D898Y Germline Mutation in a Patient with Pheochromocytoma (Full text)

a healthcare examination. Her mother and two sisters had previously undergone thyroidectomy for papillary thyroid carcinomas. The levels of vanillylmandelic acid and other catecholamines were elevated in 24-hour urine, and an imaging study revealed a right adrenal mass. She underwent laparoscopic adrenalectomy and the final pathologic diagnosis was pheochromocytoma. Mutation screening detected a RET p.D898Y mutation, both in the patient and in the patient's two sons and older sister. This is the first

2018 Case reports in endocrinology

16. Diagnosis and Treatment of Pheochromocytoma and Paraganglioma

at low rates or is episodic in nature. The superior sensitivity of urine metanephrines over catecholamines and vanillylmandelic acid (VMA) for diagnosis of PPGLs was first suggested from a meta-analysis by Manu and Runge ( ). This analysis was followed by reports revealing false-negative results for measurements of urine catecholamines and VMA and improved accuracy with measurements of urinary metanephrines ( – ). Initial evidence that measurements of plasma free metanephrines provide advantages (...) suggest measuring plasma or urine levels of metanephrines on follow-up to diagnose persistent disease. We suggest lifelong annual biochemical testing to assess for recurrent or metastatic disease. ( 2 |⊕⊕○○) 5.0 Surgery 5.1 We recommend minimally invasive adrenalectomy (eg, laparoscopic) for most adrenal pheochromocytomas. ( 1 |⊕⊕○○) We recommend open resection for large (eg, >6 cm) or invasive pheochromocytomas to ensure complete tumor resection, prevent tumor rupture, and avoid local recurrence. ( 1

2014 The Endocrine Society

17. Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study (Full text)

. Blood and urine samples were collected pre-exposure, and 1-hour and 21-hour post-exposure to determine neural biomarker levels. Mixed-model regressions assessed associations between exposures and changes in biomarker levels.Results were expressed as percent change from daily pre-exposure biomarker levels. Exposure to coarse CAP was significantly associated with increased urinary levels of the stress-related biomarkers vanillylmandelic acid (VMA) and cortisol when compared with exposure to filtered

2017 Environment international Controlled trial quality: uncertain

18. Marker-Negative Pheochromocytoma Associated with Inferior Vena Cava Thrombosis (Full text)

of confluence with hepatic veins. Her routine laboratory investigations including 24-hour urine fractionated metanephrines, vanillylmandelic acid, and cortisol were normal. Right adrenalectomy with IVC thrombectomy was done. Perioperative period was uneventful. Histopathology of the mass turned out to be pheochromocytoma with thrombus revealing fibroadipose tissue with fibrin. Pheochromocytoma may present with IVC thrombus as well as normal serum and urinary markers. Thus, clinical suspicion is imperative

2017 Case reports in urology

19. Polychlorinated biphenyls and depression: cross-sectional and longitudinal investigation of a dopamine-related Neurochemical path in the German HELPcB surveillance program (Full text)

of depressive symptoms. As a surrogate for DA, we measured its metabolites homovanillic acid (HVA) and vanillylmandelic acid (VMA) in urine. Mediation analyses were performed to test whether the association between PCB exposure and severity of depressive symptoms is mediated by urinary concentration of DA metabolites HVA and VMA. The mediation was tested with the SPSS macro MEDIATE.We found a significant mediation over time for lower-chlorinated, higher-chlorinated and dioxin-like PCBs. The positive

2017 Environmental Health

20. Synchronous bilateral pheochromocytomas and paraganglioma with novel germline mutation in MAX: a case report (Full text)

and paraganglioma with novel MYC associated factor X (MAX) gene mutation.A 24-year-old female had hyperhidrosis and hypertension. Her urine test showed high normetanephrine and vanillylmandelic acid. Enhanced computed tomography revealed three enhanced masses in right adrenal gland, left adrenal gland, and left renal hilus. She was diagnosed with PPGL. Because 123I-metaiodobenzylguanidine scintigraphy indicated the accumulations in the left adrenal gland mass and the left renal hilus mass and not in the right

2017 Surgical Case Reports

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