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Urine Osmolality

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1. Mild water restriction with or without urea for the longterm treatment of SIADH: Can urine osmolality help the choice? (PubMed)

Mild water restriction with or without urea for the longterm treatment of SIADH: Can urine osmolality help the choice? Treatment options for chronic SIADH include water restriction (WR) and urea. The usefulness of urine osmolality to guide the choice of the treatment option is not clearly defined. We hypothesized that urine osmolality can indicate whether treatment with mild water restriction alone could be successful.Retrospective Review of clinical and biochemical (blood and urine) data (...) and increased to 136.5±1mEq/l and 490±151mOsm/kgH2O (P<0.001). Four of the eight patients had a permanent low solute intake which contributed to hyponatremia. Twelve patients needed 30g urea daily combined with mild WR. The SNa and Uosm were respectively 126±2mEq/l and 595±176mOsm/kgH2O and increased to 136.5±2mEq/l and 698±157mOsm/kgH2O (P<0.05). Uosm increased in most of the treated patients.About 30% of patients could be treated by moderate WR alone. All these patients presented an initial urine

2017 European journal of internal medicine

2. Prediction of need for intervention in posterior urethral valves: Use of urine osmolality. (PubMed)

Prediction of need for intervention in posterior urethral valves: Use of urine osmolality. Renal tubular dysfunction (RTD) causing obligate production of hypoosmolar urine in boys with posterior urethral valves (PUVs) has been described. It is not known how clinically significant this is. We hypothesize that a feedback loop is present in many PUV boys who suffer deterioration of their lower urinary tract (LUT). RTD results in hypoosmolar urine, obligate polyuria, and bladder stretch-injury (...) . The increasing back-pressure worsens RTD, thus exacerbating the injury. Coexisting renal dysplasia and acquired renal scarring exacerbate this. We compared the concentrating ability (random clinic urine osmolality) of PUV boys who had no LUT deterioration to those who required intervention, examining the confounding effect of renal impairment with a subgroup analysis comparing those with plasma creatinine ≤80μmol/l.A retrospective review of our PUV database was performed. Age, intervention, and highest

2017 Journal of Pediatric Surgery

3. Validation of Surrogates of Urine Osmolality in Population Studies. (PubMed)

Validation of Surrogates of Urine Osmolality in Population Studies. The importance of vasopressin and/or urine concentration in various kidney, cardiovascular, and metabolic diseases has been emphasized recently. Due to technical constraints, urine osmolality (Uosm), a direct reflect of urinary concentrating activity, is rarely measured in epidemiologic studies.We analyzed 2 possible surrogates of Uosm in 4 large population-based cohorts (total n = 4,247) and in patients with chronic kidney (...) disease (CKD, n = 146). An estimated Uosm (eUosm) based on the concentrations of sodium, potassium, and urea, and a urine concentrating index (UCI) based on the ratio of creatinine concentrations in urine and plasma were compared to the measured Uosm (mUosm).eUosm is an excellent surrogate of mUosm, with a highly significant linear relationship and values within 5% of mUosm (r = 0.99 or 0.98 in each population cohort). Bland-Altman plots show a good agreement between eUosm and mUosm with mean

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2017 American journal of nephrology

4. A Cross-Sectional Study on the Association between 24-h Urine Osmolality and Weight Status in Older Adults (PubMed)

A Cross-Sectional Study on the Association between 24-h Urine Osmolality and Weight Status in Older Adults Data on the association between hydration and body weight in the elderly are scarce. The objective of this work was to quantify the association between 24-h urine osmolality and weight status in the elderly. A cross-sectional study was conducted within the Nutrition UP 65 study. A quota sampling was implemented to achieve a nationally representative sample of Portuguese older adults (≥65 (...) years) according to age, sex, education and region. From a sample size of 1500 participants, 1315 were eligible for the present analysis, 57.3% were women and 23.5% were aged ≥80 years. Participants were grouped using tertiles of 24-h urine osmolality by sex. World Health Organization cutoffs were used to classify participants according to weight status. Multinomial multivariable logistic regression models were conducted to evaluate the association of tertiles of osmolality with weight status

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2017 Nutrients

5. Validity of Urine Specific Gravity when Compared to Plasma Osmolality as a Measure of Hydration Status in Male and Female NCAA Collegiate Athletes (PubMed)

Validity of Urine Specific Gravity when Compared to Plasma Osmolality as a Measure of Hydration Status in Male and Female NCAA Collegiate Athletes Sommerfield, LM, McAnulty, SR, McBride, JM, Zwetsloot, JJ, Austin, MD, Mehlhorn, JD, Calhoun, MC, Young, JO, Haines, TL, and Utter, AC. Validity of urine specific gravity when compared with plasma osmolality as a measure of hydration status in male and female NCAA collegiate athletes. J Strength Cond Res 30(8): 2219-2225, 2016-The purpose (...) of this study was to evaluate the response of urine specific gravity (Usg) and urine osmolality (Uosm) when compared with plasma osmolality (Posm) from euhydration to 3% dehydration and then a 2-hour rehydration period in male and female collegiate athletes. Fifty-six National Collegiate Athletic Association (NCAA) wrestlers (mean ± SEM); height 1.75 ± 0.01 m, age 19.3 ± 0.2 years, and body mass (BM) 78.1 ± 1.8 kg and 26 NCAA women's soccer athletes; height 1.64 ± 0.01 m, age 19.8 ± 0.3 years, and BM 62.2

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2016 Journal of strength and conditioning research / National Strength & Conditioning Association

6. The role of obesity in the relation between total water intake and urine osmolality in US adults, 2009-2012. (PubMed)

The role of obesity in the relation between total water intake and urine osmolality in US adults, 2009-2012. Adequate water intake is critical to physiologic and cognitive functioning. Although water requirements increase with body size, it remains unclear whether weight status modifies the relation between water intake and hydration status.We examined how the association between water intake and urine osmolality, which is a hydration biomarker, varied by weight status.NHANES cross-sectional (...) data (2009-2012) were analyzed in 9601 nonpregnant adults aged ≥20 y who did not have kidney failure. Weight status was categorized with the use of body mass index on the basis of measured height and weight (underweight or normal weight, overweight, and obesity). Urine osmolality was determined with the use of freezing-point depression osmometry. Hypohydration was classified according to the following age-dependent formula: ≥831 mOsm/kg - [3.4 × (age - 20 y)]. Total water intake was determined

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2016 American Journal of Clinical Nutrition

7. Urine Osmolality, Response to Tolvaptan, and Outcome in Autosomal Dominant Polycystic Kidney Disease: Results from the TEMPO 3:4 Trial. (PubMed)

Urine Osmolality, Response to Tolvaptan, and Outcome in Autosomal Dominant Polycystic Kidney Disease: Results from the TEMPO 3:4 Trial. The vasopressin-cAMP-osmolality axis is abnormal in autosomal dominant polycystic kidney disease (ADPKD). In the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes 3:4 Trial, a 3-year randomized, placebo-controlled trial in adults, the vasopressin V2 receptor antagonist tolvaptan slowed ADPKD progression (...) in patients with preserved GFR. Here, we investigated the determinants of baseline urine osmolality (Uosm) and its value as a severity marker of ADPKD, the factors influencing the response to tolvaptan, and whether change in Uosm associated with key trial end points. At baseline, lower Uosm independently associated with female sex, presence of hypertension, lower eGFR, higher total kidney volume (TKV), and higher age. Tolvaptan consistently reduced Uosm by 200-300 mOsm/kg over 36 months. The Uosm response

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2016 Journal of the American Society of Nephrology

8. Urine Osmolality

Urine Osmolality Urine Osmolality Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Osmolality Urine Osmolality Aka: Urine (...) Osmolality , Urine Osms II. Normal 50-1200 mOsm/kg III. Increased ( ) Dehydration High protein diet IV. Decreased Excessive hydration (oral or intravenous) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Urine Osmolality." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pathology and Laboratory Medicine About FPnotebook.com is a rapid access

2018 FP Notebook

9. Key influence of sex on urine volume and osmolality (PubMed)

Key influence of sex on urine volume and osmolality Demographics influence kidney stone risk and the type of stone that is more likely to form. Common kidney stone risk factors include having a low urine volume and a high urine concentration. The goal of the current study was to evaluate the effect of demographics on urinary concentration and osmole excretion.Twenty-four-hour urine samples were collected from non-Hispanic white sibships in Rochester, MN. Height, weight, blood pressure, serum (...) creatinine, and cystatin C were measured. Diet was assessed using the Viocare food frequency questionnaire. Effects of demographics and dietary elements on urine osmolality and volume were evaluated in bivariate and multivariable models, as well as models that included dietary interactions with age, sex, and weight.Samples were available from 709 individuals (mean age 66 ± 9 years, 59 % female). Across the age spectrum, males had higher urine osmolality (~140 mOsm/kg, p < 0.0001) and total osmole

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2016 Biology of sex differences

10. Is Abnormal Urine Protein/Osmolality Ratio Associated with Abnormal Renal Function in Patients Receiving Tenofovir Disoproxil Fumarate? (PubMed)

Is Abnormal Urine Protein/Osmolality Ratio Associated with Abnormal Renal Function in Patients Receiving Tenofovir Disoproxil Fumarate? Risk factors for and optimal surveillance of renal dysfunction in patients on tenofovir disoproxil fumarate (TDF) remain unclear. We investigated whether a urine protein-osmolality (P/O) ratio would be associated with renal dysfunction in HIV-infected persons on TDF.This retrospective, single-center study investigated the relationship between parameters

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2016 PloS one

11. Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis? (PubMed)

Urine and Plasma Osmolality in Patients with Autosomal Dominant Polycystic Kidney Disease: Reliable Indicators of Vasopressin Activity and Disease Prognosis? Vasopressin plays an essential role in osmoregulation, but has deleterious effects in patients with ADPKD. Increased water intake to suppress vasopressin activity has been suggested as a potential renoprotective strategy. This study investigated whether urine and plasma osmolality can be used as reflection of vasopressin activity in ADPKD (...) patients.We measured urine and plasma osmolality, plasma copeptin concentration, total kidney volume (TKV, by MRI) and GFR ((125)I-iothalamate). In addition, change in estimated GFR (eGFR) during follow-up was assessed.Ninety-four patients with ADPKD were included (56 males, age 40 ± 10, mGFR 77 ± 32 ml/min/1.73 m(2), TKV 1.55 (0.99-2.40) l. Urine osmolality, plasma osmolality and copeptin concentration were 420 ± 195, 289 ± 7 mOsmol/l and 7.3 (3.2-14.6) pmol/l, respectively. Plasma osmolality

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2015 American journal of nephrology

12. Antidiuretic hormone release associated with increased intracranial pressure independent of plasma osmolality (PubMed)

for completeness reduced the total number of studies to fourteen (N = 14). Twelve (N = 12) studies investigated human subjects in the hospital settings, and two (N = 2) studies investigated animals (rhesus monkeys and dog) under invasive experimental conditions. All fourteen studies included direct or indirect indicators of intracranial pressure (ICP), measurements of plasma ADH, and plasma osmolality or urine osmolality. Findings, in brief, reveal a stable and positive association between increased (...) Antidiuretic hormone release associated with increased intracranial pressure independent of plasma osmolality Introduce and evaluate a new model which explains the release of brain antidiuretic hormone (ADH) independent of plasma osmolality.Systematic review and critical analysis of the professional literature.Primary electronic database searches using key terms revealed 57,432 hits. Secondary searches with application of specific inclusion and exclusion criteria and manual inspection

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2018 Brain and behavior

13. Colloid Osmotic Pressure and Osmolality in Hyponatremia

and hemoglobin. These samples are repeated at 4 and 8 hours after start of the study. Amount of infused fluid as well as electrolytes are recorded. Urine volume is measured and urine samples are analyzed for the loss of electrolytes. Additional samples for guidance of treatment are collected every hour. Hopefully the addition of colloid osmotic pressure, osmolality and mass balance can be beneficial in the diagnosis of the reason for the disorder as well as for the treatment. Study Design Go to Layout table (...) Colloid Osmotic Pressure and Osmolality in Hyponatremia Colloid Osmotic Pressure and Osmolality in Hyponatremia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Colloid Osmotic Pressure and Osmolality

2018 Clinical Trials

14. Osmolality of Oral Supplements and Ileostomy Output

Osmolality of Oral Supplements and Ileostomy Output Osmolality of Oral Supplements and Ileostomy Output - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Osmolality of Oral Supplements and Ileostomy Output (...) Dietary Supplement: Isoosmolar Dietary Supplement: Hyperosmolar Not Applicable Detailed Description: Patients with an ileostomy may experience fluid and electrolyte imbalances sedondary to an unregulated intestinal loss of water and electrolytes. The osmolality of oral supplements may affect these losses. In a double-blinded, active comparator, cross-over intervention study, the investigators test the effects of substituting 800 ml of the usual fluid intake with an intake of either an isoosmolar (300

2017 Clinical Trials

15. Criterion values for urine-specific gravity and urine color representing adequate water intake in healthy adults (PubMed)

Criterion values for urine-specific gravity and urine color representing adequate water intake in healthy adults Growing evidence suggests a distinction between water intake necessary for maintaining a euhydrated state, and water intake considered to be adequate from a perspective of long-term health. Previously, we have proposed that maintaining a 24-h urine osmolality (UOsm) of ⩽500 mOsm/kg is a desirable target for urine concentration to ensure sufficient urinary output to reduce renal (...) health risk and circulating vasopressin. In clinical practice and field monitoring, the measurement of UOsm is not practical. In this analysis, we calculate criterion values for urine-specific gravity (USG) and urine color (UCol), two measures which have broad applicability in clinical and field settings. A receiver operating characteristic curve analysis performed on 817 urine samples demonstrates that a USG ⩾1.013 detects UOsm>500 mOsm/kg with very high accuracy (AUC 0.984), whereas a subject

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2017 European journal of clinical nutrition

16. Urine Concentrating Capacity, Vasopressin and Copeptin in ADPKD and IgA Nephropathy Patients with Renal Impairment. (PubMed)

at a similar level of kidney function, with consequently an enhanced AVP response to water deprivation with higher circulating AVP concentrations.15 ADPKD (eGFR<60) patients and 15 age-, sex- and eGFR-matched controls with IgA nephropathy (IgAN), underwent a water deprivation test to determine maximal urine concentrating capacity. Plasma and urine osmolality, urine aquaporin-2 (AQP2) and plasma AVP and copeptin (a surrogate marker for AVP) were measured at baseline and after water deprivation (average 16 (...) hours). In ADPKD patients, height adjusted total kidney volume (hTKV) was measured by MRI.Maximal achieved urine concentration was lower in ADPKD compared to IgAN controls (533±138 vs. 642±148 mOsm/kg, p = 0.046), with particularly a lower maximal achieved urine urea concentration (223±74 vs. 299±72 mmol/L, p = 0.008). After water deprivation, plasma osmolality was similar in both groups although change in plasma osmolality was more profound in ADPKD due to a lower baseline plasma osmolality

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2017 PLoS ONE

17. TOTAL BODY WATER IN ELDERLY ADULTS—ASSESSING HYDRATION STATUS BY BIOELECTRICAL IMPEDANCE ANALYSIS VS URINE OSMOLALITY (PubMed)

TOTAL BODY WATER IN ELDERLY ADULTS—ASSESSING HYDRATION STATUS BY BIOELECTRICAL IMPEDANCE ANALYSIS VS URINE OSMOLALITY 22332693 2012 04 03 2018 11 13 1532-5415 60 2 2012 Feb Journal of the American Geriatrics Society J Am Geriatr Soc Total body water in elderly adults--assessing hydration status by bioelectrical impedance analysis vs urine osmolality. 388-90 10.1111/j.1532-5415.2011.03814.x Powers James S JS Buchowski Maciej M Wang Li L Otoo-Boameh Antoinette A eng 1D31HP08823-10-00 PHS HHS (...) United States TL1 RR024978 RR NCRR NIH HHS United States KL2 RR024977 RR NCRR NIH HHS United States UL1 RRO 24975 PHS HHS United States KL2 TR000446 TR NCATS NIH HHS United States UL1 RR024975 RR NCRR NIH HHS United States Comparative Study Letter Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. United States J Am Geriatr Soc 7503062 0002-8614 IM Aged Aged, 80 and over Body Water Electric Impedance Female Humans Male Osmolar Concentration Urine Water-Electrolyte Balance 2012

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2012 Journal of the American Geriatrics Society

18. Urine Osmolality

Urine Osmolality Urine Osmolality Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Osmolality Urine Osmolality Aka: Urine (...) Osmolality , Urine Osms II. Normal 50-1200 mOsm/kg III. Increased ( ) Dehydration High protein diet IV. Decreased Excessive hydration (oral or intravenous) Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Urine Osmolality." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pathology and Laboratory Medicine About FPnotebook.com is a rapid access

2015 FP Notebook

19. Role of Bicarbonate Supplementation on Urine Uric Acid Crystals and Diabetic Tubulopathy in Adults with Type 1 Diabetes: A Brief Report. (PubMed)

± 9.3 years duration) without chronic kidney disease (eGFR ≥60 mL/min/1.73 m2 and albumin-to-creatinine ratio < 30 mg/g) received 2 doses of 1950 mg oral NaHCO3 over 24 hours. Fasting urine and serum were collected pre- and post-intervention. UA crystals were identified under polarized microscopy. Urine measurements included: osmolality, pH, UA, creatinine and kidney injury molecule-1 (KIM-1). NaHCO3 therapy increased mean ± SD urine pH from 6.1 ± 0.7 to 6.5 ± 0.7 (P < .0001). Prior to therapy, 31.0 (...) Role of Bicarbonate Supplementation on Urine Uric Acid Crystals and Diabetic Tubulopathy in Adults with Type 1 Diabetes: A Brief Report. Uricosuria and crystallization are increasingly recognized risk factors for diabetic tubulopathy. This pilot clinical trial aimed to determine the acute effect of urinary alkalinization using oral sodium bicarbonate (NaHCO3 ) on UA crystals in adults with type 1 diabetes (T1D). Adults with T1D, ages 18 to 65 years (n = 45, 60% female, HbA1c, 7.5 ± 1.2%, 20.2

2018 obesity & metabolism

20. Effects of sildenafil, metformin, and simvastatin on ADH‐independent urine concentration in healthy volunteers (PubMed)

20 mg thrice daily, metformin 500 mg thrice daily or simvastatin 40 mg once daily during 1 week. At baseline and at the end of treatment, a water loading test was performed. No significant increase in lowest urine osmolality was seen after the use of metformin or sildenafil (P = 0.66 and P = 0.09 respectively). Lowest urine osmolality increased modestly but significantly after the use of simvastatin (70 mOsm/kg to 85 mOsm/kg, P = 0.05). Our data suggest that only simvastatin has an effect (...) on urine osmolality in healthy volunteers. Validation studies are needed and, most importantly, these drugs should be tested in patients with NDI.© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

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2018 Physiological reports

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