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Urine Microalbumin

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1. The longitudinal effect of subclinical hypothyroidism on urine microalbumin-to-urine creatinine ratio in patients with type 2 diabetes mellitus. Full Text available with Trip Pro

The longitudinal effect of subclinical hypothyroidism on urine microalbumin-to-urine creatinine ratio in patients with type 2 diabetes mellitus. In patients with diabetes mellitus, the urinary microalbumin-to-urine creatinine ratio (UACR) can not only predict the occurrence of diabetic nephropathy but also can be a risk factor for cardiovascular disease and renal function damage. Current studies on subclinical hypothyroidism (SCH) and UACR are mainly cross-sectional studies, and the results

2019 BMC Endocrine Disorders

2. The Association Between the Metabolic Syndrome and Metabolic Syndrome Score and Urine Microalbumin/Urine Creatinine Ratio and Glomerular Filtration Rate in Korean Adults With Obesity. (Abstract)

The Association Between the Metabolic Syndrome and Metabolic Syndrome Score and Urine Microalbumin/Urine Creatinine Ratio and Glomerular Filtration Rate in Korean Adults With Obesity. This study assessed the association between metabolic syndrome (MetS) and metabolic syndrome score (MSS) and the levels of urine microalbumin-urine creatinine ratio (uACR) and glomerular filtration rate (GFR) in Korean adults with obesity.Analyses of data obtained during the 2012 Korean National Health

2017 Journal of Renal Nutrition

3. The relationship between vitamin D and estimated glomerular filtration rate and urine microalbumin/creatinine ratio in Korean adults Full Text available with Trip Pro

The relationship between vitamin D and estimated glomerular filtration rate and urine microalbumin/creatinine ratio in Korean adults The present study was conducted to assess the association between 25-hydroxyvitamin D [25(OH)D], estimated glomerular filtration rate (eGFR) and urine microalbumin/creatinine ratio (uACR) in Korean adults. Data on 4,948 adults aged ≥20 years from the Korean National Health and Nutrition Examination Survey V-3 (2012) were analyzed. After adjusting for the related

2017 Journal of clinical biochemistry and nutrition

4. Urine Microalbumin

Urine Microalbumin Urine Microalbumin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Microalbumin Urine Microalbumin Aka: Urine (...) Microalbumin , Microalbuminuria , Macroalbuminuria , Urine Microalbumin to Creatinine Ratio , Urine Albumin to Creatinine Ratio II. Indications Questionable efficacy as prognostic factor in (contrast with ) III. Protocol Nephropathy diagnosis needs 2 of 3 samples positive Typically performed as a Urine Albumin to Creatinine Ratio (random spot urine collection) Consider postural (especially in adolescents) Obtain overnight timed urine collection IV. Interpretation: Urine Albumin Normal (or mildly increased

2018 FP Notebook

5. Changes in Urine Microalbumin-to-Creatinine Ratio in Children with Sickle Cell Disease over Time Full Text available with Trip Pro

Changes in Urine Microalbumin-to-Creatinine Ratio in Children with Sickle Cell Disease over Time Approximately 20% of children with sickle cell disease (SCD) have microalbuminuria (MA). Very little is known about the progression of MA in children and young adults with SCD.In this study, we analyzed 5-year EMR data of 373 children [with ≥2 microalbumin-to-creatinine (MA/Cr) ratio measurements] followed at the Medical University of South Carolina to determine the rate, direction, magnitude

2016 Frontiers in pediatrics

6. Diagnostic Value of Urinary Microalbumin Level in Postpartum Acute Kidney Injury Full Text available with Trip Pro

Diagnostic Value of Urinary Microalbumin Level in Postpartum Acute Kidney Injury We aimed to explore the diagnostic value of urinary microalbumin (mALB) level in postpartum acute kidney injury.A total of 127 maternity patients were selected from December 2013 to January in 2016 in Binzhou Central Hospital, Binzhou, Shandong, China and divided into two groups: the kidney injury and normal kidney group. The dynamic changes and diagnostic value of urine microprotein in postpartum acute kidney (...) =0.001), and urinary microalbumin was 2.87 ± 1.24 mg/mmol·Cr. The difference was statistically significant (P=0.002). mALB/GFR, Cr, urinary mALB, and GFR were the independent risk factors of postpartum acute kidney injury. The area under the ROC curve for mALB/GFR was 0.759, whereas the area under the ROC curve for Cr was 0.681, which was smaller (P = 0.042). The area under the ROC curve of mALB was 0.785 (P=0.027), which was close to the area under the ROC curve of mALB/GFR.Urinary mALB test

2018 Iranian journal of public health

7. The ratio of urinary α1-microglobulin to microalbumin can be used as a diagnostic criterion for tubuloproteinuria Full Text available with Trip Pro

and interstitial disease, urinary α1-microglobin increased 10-300-fold above the upper limit of the normal range, the ratio of urinary α1-microglobulin to microalbumin was greater than 1, and the percentage of low-molecular-weight plasma proteins (LMWP) in urine was greater than 50% according to urine protein electrophoresis. There was close correlation between the ratio of urinary α1-microglobulin to microalbumin and the percentage of LMWP in urine according to urine protein electrophoresis (r = 0.797, p (...) The ratio of urinary α1-microglobulin to microalbumin can be used as a diagnostic criterion for tubuloproteinuria Low-molecular-weight proteinuria is one of the characteristic clinical manifestations of renal tubular and interstitial diseases. Low-molecular-weight proteinuria is defined as excessive urinary loss of α1-microglobulin, β2-microglobulin, or other low-molecular-weight plasma proteins. The current study examined the ratio of urinary α1-microglobulin to microalbumin in 24 Chinese

2018 Intractable & rare diseases research

8. Urine Microalbumin

Urine Microalbumin Urine Microalbumin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Microalbumin Urine Microalbumin Aka: Urine (...) Microalbumin , Microalbuminuria , Macroalbuminuria , Urine Microalbumin to Creatinine Ratio , Urine Albumin to Creatinine Ratio II. Indications Questionable efficacy as prognostic factor in (contrast with ) III. Protocol Nephropathy diagnosis needs 2 of 3 samples positive Typically performed as a Urine Albumin to Creatinine Ratio (random spot urine collection) Consider postural (especially in adolescents) Obtain overnight timed urine collection IV. Interpretation: Urine Albumin Normal (or mildly increased

2015 FP Notebook

9. Urine injury biomarkers are not associated with kidney transplant failure. (Abstract)

the association of donor urine injury biomarkers microalbumin, NGAL, KIM-1, IL-18, and L-FABP with graft failure (GF) and death-censored GF (dcGF) using Cox proportional hazard models (median follow-up 4 years). We examined if serum creatinine-defined donor AKI modified this association to assess the relationship between subclinical donor AKI (elevated biomarkers without creatinine-defined AKI) and graft failure. Through chart review of a sub-cohort (1137 recipients), we determined associations between donor (...) Urine injury biomarkers are not associated with kidney transplant failure. Kidneys transplanted from deceased-donors with serum creatinine-defined acute kidney injury (AKI) have similar allograft survival as non-AKI kidneys but are discarded at a higher rate. Urine injury biomarkers are sensitive markers of structural kidney damage and may more accurately predict graft outcomes.In the 2010-2013 multicenter Deceased Donor Study of 2430 kidney transplant recipients from 1298 donors, we assessed

2019 Transplantation

10. Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats Full Text available with Trip Pro

in USCs-Exo and urine-derived stem cell conditioned medium were investigated by enzyme-linked immunosorbent assay.Urine-derived stem cells were cultured and were verified by positive markers for CD29, CD73, CD90 and CD44 antigens, and negative markers for CD34, CD45 and HLA-DR. USCs-Exo were approximately 50-100 nm spherical vesicles, and the specific markers included CD9, CD63 and CD81. Intravenous injections of USCs-Exo could potentially reduce the urine volume and urinary microalbumin excretion (...) Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats Diabetic nephropathy is one of the most serious complications in patients with diabetes. At present, there are no satisfactory treatments available for diabetic nephropathy. Stem cells are currently the main candidates for the development of new treatments for diabetic nephropathy, as they may exert their therapeutic effects mainly through paracrine mechanisms. Exosomes derived

2016 Stem cell research & therapy

11. Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes. Full Text available with Trip Pro

Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes. Assessment of deceased-donor organ quality is integral to transplant allocation practices, but tools to more precisely measure donor kidney injury and better predict outcomes are needed. In this study, we assessed associations between injury biomarkers in deceased-donor urine and the following outcomes: donor AKI (stage 2 or greater), recipient delayed graft function (defined as dialysis in first week (...) post-transplant), and recipient 6-month eGFR. We measured urinary concentrations of microalbumin, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), IL-18, and liver-type fatty acid binding protein (L-FABP) from 1304 deceased donors at organ procurement, among whom 112 (9%) had AKI. Each biomarker strongly associated with AKI in adjusted analyses. Among 2441 kidney transplant recipients, 31% experienced delayed graft function, and mean±SD 6-month eGFR was 55.7±23.5

2015 Journal of the American Society of Nephrology

12. The Diagnostic Accuracy of a Urine Albumin-Creatinine Ratio Point-of-Care Test for Detection of Albuminuria in Primary Care (Abstract)

The Diagnostic Accuracy of a Urine Albumin-Creatinine Ratio Point-of-Care Test for Detection of Albuminuria in Primary Care Albuminuria is an important sign of chronic kidney disease and is detected routinely by measurement of urinary albumin-creatinine ratio (ACR). A Siemens CLINITEK test designed for use at the point of care is available that can semiquantitatively measure ACR.Diagnostic accuracy study evaluating a urinary ACR point-of-care test.The semiquantitative ACR test was evaluated (...) at the point of care in a representative primary care population (those with or at increased risk of chronic kidney disease) of 642 patients under standard operational conditions and compared with the reference standard of ACR measurement in the clinical laboratory.The point-of-care CLINITEK semiquantitative ACR test. This test uses dye-binding and catalytic assays for albumin and creatinine, respectively, on a Microalbumin 9 strip, which is read by the CLINITEK Status Analyzer, and ACR is calculated

2012 EvidenceUpdates

13. Management of Chronic Kidney Disease

in a diabetic patient), follow-up with more specific urine tests (eg, urine microalbumin with albumin-to-creatinine ratio, and urine microscopy) is recommended. Spot urine microalbumin with albumin-to-creatinine ratio. The preferred urine specimen to assess for microalbumin is the first voided urine in the morning. If an albumin-to- creatinine ratio of 30-300 mg/g is obtained, consider repeat testing once in 2 weeks to establish persistence. Potential transient or benign etiologies of albuminuria (...) the CKD-EPI equation) and urine studies for the presence or absence of albuminuria. [IC] • Ultrasound imaging for structural kidney disease may be helpful in certain populations. [IID] Treatment • Lifestyle modifications (dietary management, weight management, physical activity) are the initial components of treatment and secondary prevention. [IA] • Blockade of the renin angiotensin aldosterone system with either an angiotensin converting enzyme inhibitor (ACEI) or an angiotensin receptor blocker

2020 University of Michigan Health System

14. Management of Type 2 Diabetes Mellitus

= generally should not be performed. Level of evidence supporting a diagnostic method or an intervention: A=randomized controlled trials; B=controlled trials, no randomization; C=observational trials; D=opinion of expert panel. 2 UMHS Management of Type 2 Diabetes Mellitus June, 2017 Table 1. Diagnosis of Diabetes: Diagnostic Tests and Glucose Values Diagnostic Test Normal Pre-diabetes Diabetes Hemoglobin A1c (A1c) a 30 mg/gm, check UA to rule out asymptomatic UTI. • Repeat spot urine ratio twice within 6 (...) months. If 2 of 3 spot urine albumin/creatinine ratios > 30 mg/gm 1. Check creatinine, electrolytes and estimated glomerular filtration rate (eGFR) [ID g ]. 2. Begin ACE inhibitor or ARB [IA d ] (if electrolytes allow use of ACE inhibitor). Recheck creatinine and electrolytes within 1–2 weeks of initiating therapy. Neuropathy Perform foot exam: (1) visually inspect, (2) check pulses (each visit if patient has a history of neuropathy; otherwise annually), and (3) monofilament (annually), see Table 13

2020 University of Michigan Health System

15. Chronic kidney disease

retinopathy diabetes mellitus hypertension age >50 years childhood kidney disease smoking obesity black or Hispanic ethnicity family history of chronic kidney disease autoimmune disorders male sex long-term use of NSAIDs Diagnostic investigations serum creatinine urinalysis urine microalbumin renal ultrasound estimation of GFR renal biopsy plain abdominal radiograph abdominal CT abdominal MRI Treatment algorithm ACUTE Contributors Authors Assistant Professor of Medicine University of Arkansas for Medical (...) : Improving Global Outcomes (KDIGO). KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013 Jan;3(1):1-150. http://www.kdigo.org/clinical_practice_guidelines/pdf/CKD/KDIGO_2012_CKD_GL.pdf History and exam presence of risk factors fatigue oedema nausea with/without vomiting pruritus anorexia infection-related glomerular disease arthralgia enlarged prostate gland foamy-appearing urine cola-coloured urine rashes dyspnoea orthopnoea seizures

2018 BMJ Best Practice

16. Assessment of proteinuria

testing Newer dipsticks have been marketed that can report albumin-to-creatinine ratios in the microalbumin range, as well as total protein-to-creatinine ratios. Standardising the protein measurement to the quantity of creatinine in the urine helps to avoid errors introduced by diluted or concentrated urine samples. Measuring total protein also allows detection of tubular and overflow proteinuria. The reported sensitivity of these semi-quantitative dipsticks is 80% to 97% with a specificity of 33 (...) /Professionals/Kdoqi/guidelines_ckd/toc.htm http://www.ncbi.nlm.nih.gov/pubmed/11904577?tool=bestpractice.com Levey AS, de Jong PE, Coresh J, et al. The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney Int. 2011 Jul;80(1):17-28. http://www.ncbi.nlm.nih.gov/pubmed/21150873?tool=bestpractice.com Urine albumin measurement is an important component in screening for chronic kidney disease. The presence of proteinuria is an independent risk factor

2018 BMJ Best Practice

20. Chronic kidney disease

retinopathy diabetes mellitus hypertension age >50 years childhood kidney disease smoking obesity black or Hispanic ethnicity family history of chronic kidney disease autoimmune disorders male sex long-term use of NSAIDs Diagnostic investigations serum creatinine urinalysis urine microalbumin renal ultrasound estimation of GFR renal biopsy plain abdominal radiograph abdominal CT abdominal MRI Treatment algorithm ACUTE Contributors Authors Assistant Professor of Medicine University of Arkansas for Medical (...) : Improving Global Outcomes (KDIGO). KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013 Jan;3(1):1-150. http://www.kdigo.org/clinical_practice_guidelines/pdf/CKD/KDIGO_2012_CKD_GL.pdf History and exam presence of risk factors fatigue oedema nausea with/without vomiting pruritus anorexia infection-related glomerular disease arthralgia enlarged prostate gland foamy-appearing urine cola-coloured urine rashes dyspnoea orthopnoea seizures

2017 BMJ Best Practice

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