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1. Urine Leukocyte Esterase

Urine Leukocyte Esterase Urine Leukocyte Esterase Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Leukocyte Esterase Urine (...) Leukocyte Esterase Aka: Urine Leukocyte Esterase II. Mechanism Neutrophil s contain esterases Positive test suggests pyuria Dipstick requires 5 minutes to change color III. Normal Negative IV. Abnormal: Positive Vaginal contaminant V. Causes: False negative Leukocyte esterase on Urinalysis Inadequate time allowed for dipstick reading Increased present ( ) s present (Ketonuria) VI. Causes: Positive Leukocyte esterase and negative culture urealyticum Urinary tract foreign body Medications ( , Cytoxan

2018 FP Notebook

2. Leucocyte esterase dip-stick test as a point-of-care diagnostic for urogenital chlamydia in male patients: A multi-center evaluation in two STI outpatient clinics in Paramaribo and Amsterdam. Full Text available with Trip Pro

Leucocyte esterase dip-stick test as a point-of-care diagnostic for urogenital chlamydia in male patients: A multi-center evaluation in two STI outpatient clinics in Paramaribo and Amsterdam. Point-of-care (POC) tests are an important strategy to address the epidemic of sexually transmitted infections (STIs). The leucocyte esterase test (LET) can be used as a POC test for chlamydia. The aim of this study was to determine the diagnostic accuracy of the LET to detect urogenital chlamydia among (...) men at STI clinics in Paramaribo, Suriname and Amsterdam, the Netherlands.Recruitment of patients took place in 2008-2010 in Suriname and in 2009-2010 in the Netherlands. Urine of patients was examined with the LET. The reference test was a nucleic acid amplification test (NAAT).We included 412 patients in Suriname and 645 in the Netherlands. Prevalence of chlamydia in Suriname and the Netherlands was respectively 22.8 and 13.6 %. The sensitivity of the LET was 92.6 % (95 % CI = 85.3-97.0

2016 BMC Infectious Diseases

3. Leukocyte esterase, glucose and C-reactive protein in the diagnosis of prosthetic joint infections: a prospective study. Full Text available with Trip Pro

Leukocyte esterase, glucose and C-reactive protein in the diagnosis of prosthetic joint infections: a prospective study. Analysis of joint fluid is of paramount importance for the diagnosis of prosthetic joint infections. Different markers of inflammation and/or infection in joint fluid have been proposed for diagnosis of these infections. In this study we evaluated the performance of leucocyte esterase, C-reactive protein (CRP) and glucose assays in synovial fluids from 129 patients (...) with septic (n = 27) or aseptic (n = 102) prosthetic joint failure. Samples were collected in serum tubes and centrifuged to limit the presence of corpuscle interfering with the assays. Determinations of leucocyte esterase and glucose were carried out by means of enzymatic colorimetric reactions performed on strips for urine analysis. Tests were considered positive when graded + or ++ whereas traces or absence of colour were considered negative. CRP was measured using an automated turbidimetric method

2016 Clinical Microbiology and Infection

4. Urine Leukocyte Esterase

Urine Leukocyte Esterase Urine Leukocyte Esterase Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Leukocyte Esterase Urine (...) Leukocyte Esterase Aka: Urine Leukocyte Esterase II. Mechanism Neutrophil s contain esterases Positive test suggests pyuria Dipstick requires 5 minutes to change color III. Normal Negative IV. Abnormal: Positive Vaginal contaminant V. Causes: False negative Leukocyte esterase on Urinalysis Inadequate time allowed for dipstick reading Increased present ( ) s present (Ketonuria) VI. Causes: Positive Leukocyte esterase and negative culture urealyticum Urinary tract foreign body Medications ( , Cytoxan

2015 FP Notebook

5. Discrediting microscopic pyuria and leucocyte esterase as diagnostic surrogates for infection in patients with lower urinary tract symptoms: results from a clinical and laboratory evaluation. (Abstract)

midstream urine (MSU) samples for analysis, and routine microbiological cultures were used as our reference standard. We also scrutinised the performance of dipstick leucocyte esterase ≥ 'trace' in the detection of microscopic pyuria. The influence of sample handling and processing on test performance was examined in a series of laboratory studies. The effects of storage on leucocyte decay were determined using repeated microscopic assessments of individual urine samples, to plot temporal changes (...) marker of UTI were 0.40 (95% confidence interval [CI] 0.37-0.43) and 0.75 (95% CI 0.73-0.76), respectively. The dipstick was unable to identify significant microscopic pyuria (≥10 wbc/μL) in 60% of the samples: PPV 0.51 (95% CI 0.48-0.55); NPV 0.75 (95% CI 0.73-0.76). Microscopic pyuria performed poorly as a surrogate of UTI defined by bacterial culture. Whilst refrigeration and preservation did retard leucocyte loss (F = 11; DF = 2; P < 0.001), 40% of cells were still lost by 4 h. Centrifugation had

2013 BJU international

6. Asymptomatic bacteriuria in pregnant women attending Boo-Ali Hospital Tehran Iran: Urine analysis vs. urine culture Full Text available with Trip Pro

diagnostic cross-sectional study. One hundred twenty three mid-stream urine samples were inoculated into cultures and were processed by dipstick (nitrite test and leucocyte esterase test) and microscopic pus cell count. The sensitivity, specificity, positive predictive value and negative predictive value of nitrite test, leucocyte esterase test and microscopic pus cell count were compared with urine culture in diagnosis of asymptomatic bacteriuria by using SPSS version 19.Of 123 urine samples (...) , significant asymptomatic bacteriuria (≥104 cfu/Ml) was detected in 8 (6.5%) subjects. The sensitivity and specificity of nitrite test were 37% and 100% respectively. The sensitivity of pus cell count alone and leucocyte esterase test alone were 100% but the specificity of them were 64% and 65% respectively. We found high negative predictive value by Pus cell count and the leucocyte esterase test (100%) and low positive predictive value by them (16% and 17% respectively).Urine culture is the most useful

2017 Electronic physician

7. Cross-sectional study: Urine concentration should be taken into account when interpreting pyuria in infants

automated urinalysis of uncentrifuged urine, thus pyuria in dilute samples may have more significance than pyuria in concentrated urine samples. It may therefore be important to consider the possible impact of urine concentration on the significance of white cell counts (WCC) or leucocyte esterase (LE) assessment. Methods This was a retrospective study of routinely collected data from infants aged less than 3 months with suspected UTI, who presented to a busy US emergency department (ED) over 5 years (...) Cross-sectional study: Urine concentration should be taken into account when interpreting pyuria in infants Urine concentration should be taken into account when interpreting pyuria in infants | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts

2017 Evidence-Based Medicine

8. Accuracy of Automated Flow Cytometry-Based Leukocyte Counts To Rule Out Urinary Tract Infection in Febrile Children: a Prospective Cross-Sectional Study Full Text available with Trip Pro

children (1,247 episodes). Urine culture was used as the gold standard test for diagnosing UTI. The performance of screening tests to diagnose UTI were established using receiver operating characteristic (ROC) analysis. Among these 1,247 febrile episodes, 221 UTIs were diagnosed (17.7% [95% confidence interval {CI}, 15.6 to 19.8%]). The area under the ROC curve for flow cytometry white blood cell (WBC) counts (0.99 [95% CI, 0.98 to 0.99]) was significantly superior to that for red blood cell (0.74 [95 (...) % CI, 0.70 to 0.78]) and bacterial counts (0.89 [95% CI, 0.87 to 0.92]) (P < 0.001). Urinary WBC counts also had a significantly higher area under the ROC curve than that of the leukocyte esterase (LE) dipstick (0.92 [95% CI, 0.90 to 0.94]), nitrite dipstick (0.83 [95% CI, 0.80 to 0.87]), or the combination of positive LE and/or nitrite dipstick (0.91 [95% CI, 0.89 to 0.93]) test (P < 0.001). The presence of ≥35 WBC/μl of urine was the best cutoff point, yielding both a high sensitivity (99.5% [95

2016 Journal of clinical microbiology

9. Urine Testing in Long-Term Care

identified. Additional references of potential interest are provided in the appendix. OVERALL SUMMARY OF FINDINGS One non-randomized study 1 compared the validity of multi-reagent strips with standard urinalysis for the early detection of urinary tract infection (UTI) in long-term care (LTC) residents. Urine samples were tested for leukocyte esterase and nitrite. Dipstick tests that were positive for leukocyte esterase or nitrite were not specific indicators of a UTI and had high false negative rates (...) . The authors concluded that dipstick tests alone were not suitable for screening residents for UTI. A second non-randomized study 3 compared dipstick analysis for leukocyte esterase and nitrite with urine culture. The authors suggested using both dipsticks and determined that, when both dipstick tests were negative, the presence of pathogenic bacteria could be ruled out with a negative predictive value of 88%. One non-randomized study 2 aimed to identify clinical features that could be used to identify UTI

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

10. Safety of Intradetrusor OnabotulinumtoxinA (BTX-A) Injection in the Asymptomatic Patient With a Positive Urine Dip. Full Text available with Trip Pro

urine culture, recent antibiotic course, or absence of UD on the day of injection. A positive UD was defined using 7 different definitions with varying combinations of any level of positive blood, leukocyte esterase, or nitrite. Negative UDs were defined those excluded from the positive UD group. We compared multiple positive UD-defined groups to their respective negative UD cohorts with regards to outcomes and demographics.A total of 212 patients underwent 335 cycles of BTX-A injections over a 2 (...) Safety of Intradetrusor OnabotulinumtoxinA (BTX-A) Injection in the Asymptomatic Patient With a Positive Urine Dip. To evaluate differences in adverse events (AE) in asymptomatic patients with a positive urine dip (UD) at time of intradetrusor onabotulinumtoxinA (BTX-A) injection vsthose with a defined negative UD.All intradetrusor BTX-A injections were retrospectively reviewed at a single institution between 2016 and 2018. Exclusion criteria included an indwelling catheter, recent positive

2020 Urology

11. Clinical usefulness of iQ200/iChem Velocity workstation for screening of urine culture. Full Text available with Trip Pro

total of 1942 urine specimens were processed through both culture and iQ200/ iChem workstation. We analyzed the performance using two definition of positive urine culture; one or two potential uropathogens at a concentration of ≥105 CFU/ml and ≥ 104 CFU/ml. We assessed combinations of parameters (ASP; all small particles, WBC; leukocyte, BACT; bcteria, LE; leukocyte esterase) applying various cut-offs which can achieve the negative predictive value (NPV) ≥97% and culture reduction rate ≥ 50 (...) Clinical usefulness of iQ200/iChem Velocity workstation for screening of urine culture. Clinical microbiology laboratories are asked to process large numbers of urine specimens for culture, but only 20-40% of them are positive. Therefore, a rapid, reliable screening method is necessary to speed up the reporting of a negative result. In this study, we evaluated the iQ200/iChem workstation, which is a combination of digital imaging software and a strip reader to predict negative urine culture.A

2019 BMC Infectious Diseases

12. Fast and Sensitive: Automated Point-of-Care Urine Dips. (Abstract)

a positive leukocyte esterase, nitrites, or greater than 10 white blood cells per high-power field. Urine culture was used as the criterion standard for comparison.A total of 334 subjects' charts were reviewed. Sensitivity and specificity of the POC dip were 91.4% (95% confidence interval [CI], 76.9%-98.2%) and 63.9% (95% CI, 57.2%-69.3%); lab UA, 91.4% (95% CI, 76.9%-98.2%) and 63.9% (95% CI, 58.2%-69.3%); and lab dip, 88.6% (95% CI, 73.3%-96.8%) and 65.6% (95% CI, 59.9%-70.9%).Point-of-care dips (...) retrospective chart review was conducted on patients (aged birth through 18 years) presenting to a PED between January 2015 and December 2015. Eligible subjects included those that had a POC dip, laboratory urinalysis (lab UA), and urine culture performed during their PED visit. Subjects were selected, using a random number generator; 334 charts were selected. A positive POC dip was defined as having a positive leukocyte esterase or the presence of nitrites. A positive lab UA was defined as having

2017 Pediatric Emergency Care

13. Bladder Stimulation Technique for Clean Catch Urine Collection in Infants

the bladder stimulation technique. Three criteria are needed for each definition: Urinalysis result, number of organisms cultured and specific threshold for colony counts based on method of collection. Positive urinalysis: Bacteriuria, positive leukocyte esterase test, positive nitrite test and/or >/= 10 white blood cells per micro liter; negative urinalysis: do not meet criteria for positive urinalysis Secondary Outcome Measures : Time required for successful urine collection using the bladder (...) Bladder Stimulation Technique for Clean Catch Urine Collection in Infants Bladder Stimulation Technique for Clean Catch Urine Collection in Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Bladder

2017 Clinical Trials

14. The Importance of Urine Concentration on the Diagnostic Performance of the Urinalysis for Pediatric Urinary Tract Infection. (Abstract)

to 5.8) and 9.5 (95% CI 8.6 to 10.6) to 5.5 (95% CI 3.3 to 9.1) at a threshold of greater than or equal to 5 WBCs per high-power field and presence of leukocyte esterase, respectively. The negative likelihood ratios increased with increasing specific gravity for leukocyte esterase and microscopic pyuria.For the detection of pediatric urinary tract infection, the diagnostic performance of both dipstick leukocyte esterase and microscopic pyuria varies by urine concentration, and therefore the specific (...) The Importance of Urine Concentration on the Diagnostic Performance of the Urinalysis for Pediatric Urinary Tract Infection. The presence of leukocyte esterase by urine dipstick and microscopic pyuria are both indicators of possible urinary tract infection. The effect of urine concentration on the diagnostic performance of the urinalysis for pediatric urinary tract infection has not been studied. Our objective is to determine whether the urinalysis performance for detecting urinary tract

2017 Annals of Emergency Medicine

15. Cath or bag? Bag then cath? Urine testing options in the ED

of reducing the number of urine catheterizations being performed. Patients in the ED with a complaint of fever between the ages of 6-24 months were risk stratified (see attached table below from study). Patients determined to be at increased risk had urine bags placed by a nurse on arrival to an ED room. Urinalysis was performed at the discretion of the clinician after exam and full history obtained. If the urinalysis was positive for moderate or large leukocyte esterase or contained nitrites, the child (...) Cath or bag? Bag then cath? Urine testing options in the ED Cath or bag? Bag then cath? Urine testing options in the ED – PEMBlog Search for: Search for: Jane M. Lavelle, MD, Mercedes M. Blackstone, MD, Mary Kate Funari, MSN, RN, CPEN, Christine Roper, BSN, RN, CPEN, Patricia Lopez, MSN, CPNP-PC, Aileen Schast, PhD, April M. Taylor, MS, MHA, Catherine B. Voorhis, BS, Mira Henien, BS, Kathy N. Shaw, MD, MSCE Pediatrics, July 2016 The overall goal of this study was to investigate the possibility

2017 PEM Blog

16. Urine Concentration and Pyuria for Identifying UTI in Infants. Full Text available with Trip Pro

Urine Concentration and Pyuria for Identifying UTI in Infants. Varying urine white blood cell (WBC) thresholds have been recommended for the presumptive diagnosis of urinary tract infection (UTI) among young infants. These thresholds have not been studied with newer automated urinalysis systems that analyze uncentrifuged urine that might be influenced by urine concentration. Our objective was to determine the optimal urine WBC threshold for UTI in young infants by using an automated urinalysis (...) system, stratified by urine concentration.Retrospective cross-sectional study of infants aged <3 months evaluated for UTI in the emergency department with paired urinalysis and urine culture. UTI was defined as ≥50 000 colony-forming units/mL from catheterized specimens. Test characteristics were calculated across a range of WBC and leukocyte esterase (LE) cut-points, dichotomized into specific gravity groups (dilute <1.015; concentrated ≥1.015).Twenty-seven thousand infants with a median age of 1.7

2016 Pediatrics

17. Redefining Healthy Urine: A Cross-Sectional Exploratory Metagenomic Study of People With and Without Bladder Dysfunction. (Abstract)

with neuropathic bladder. Urine was originally collected by the usual method of bladder drainage and analyzed by urinalysis, culture and pyrosequencing. Urinalysis and culture values were stratified as leukocyte esterase (0, or 1 or greater), nitrite (positive or negative), pyuria (fewer than 5, or 5 or greater white blood cells per high power field), cloudy urine (positive or negative) and urine culture bacterial growth (less than 50,000, or 50,000 or greater cfu/ml). PathoScope was used for next generation (...) sequencing alignment, bacterial classification and microbial diversity characterization.Subjects with neuropathic bladder were significantly more likely to have positive leukocyte esterase and pyuria, cloudy urine and bacterial growth. Of 47 samples 23 showed bacterial growth on culture and in all samples bacteria were identified by pyrosequencing. Nonneuropathic bladder urine microbiomes included greater proportions of Lactobacillus crispatus in females and Staphylococcus haemolyticus in males

2016 Journal of Urology

18. The effectiveness of BD Vacutainer® Plus Urinalysis Preservative Tubes in preservation of urine for chemical strip analysis and particle counting Full Text available with Trip Pro

until the end of 48 hours in both storage conditions. Nitrite (Nit) was well preserved in BD UAP tubes for 24 hours but was stable only up to 8 hours at 4 °C. Bilirubin (Bil) had very high FN rates even at 4 hours in both conditions. The particle counting showed high FN rates for white blood cells (WBC) and red blood cells (RBC), whereas squamous epithelial cells (EC) were stable up to 8 hours in both conditions.Preanalytical requirements for both urine chemical strip analyses and particle counting (...) of storage in BD Vacutainer(®) Plus Urinalysis Preservative (BD UAP) tubes and compared with refrigeration at 4 °C. All analyses were peformed on H-800 and FUS-200 automatic modular urine analyzers (Dirui Industry, Changchun, China). The kappa coefficients (κ), false positive (FP) and false negative (FN) rates were evaluated. κ > 0.8 was accepted as good agreement.Haemoglobin (Hb), leucocyte esterase (LE), and protein (Pro) analyses should be performed within 4 hours, whereas glucose (Glc) was stable

2016 Biochemia medica

19. Urine culture guided antibiotic interventions: A pharmacist driven antimicrobial stewardship effort in the emergency department. (Abstract)

-pregnant and asymptomatic for urinary tract infection (UTI). 43% of 136 patients were treated with antibiotics, for a total of 426 antibiotic days. Pharmacist interventions for these patients resulted in 122/426 (29%) of potential antibiotic days saved. Factors found to significantly increase the odds of antibiotic prescribing in asymptomatic patients included presence of leukocyte esterase (OR=4.5, 95% CI: 1.2-17.2; p=0.03) or nitrites (OR=10.8, 95% CI: 1.7-68.1; p=0.01) in the urine and age≥75 (...) Urine culture guided antibiotic interventions: A pharmacist driven antimicrobial stewardship effort in the emergency department. Antibiotics are overprescribed for abnormal urine tests including asymptomatic bacteriuria (AB), contributing to rising antimicrobial resistance rates. Pharmacists reviewed urine cultures daily from emergency department (ED) encounters to assess antibiotic appropriateness. We studied antibiotic prescribing practices and assessed compliance to national guidelines

2016 American Journal of Emergency Medicine

20. Pyuria and Urine Cultures in Patients with Acute Renal Colic. (Abstract)

was performed. Patients without confirmed renal stone(s) or completed urinalysis were excluded. Hematuria is defined as ≥5 red blood cells per high power field (RBC/HPF) and pyuria as >10 white blood cells per high power field (WBC/HPF). A positive urine culture is defined as >100,000 colony forming units per milliliter. Student's t-test, chi square, or Fisher's exact tests were performed as appropriate, with significance set at 0.05.There were 339 patients who satisfied the inclusion and exclusion criteria (...) Pyuria and Urine Cultures in Patients with Acute Renal Colic. Renal colic caused by stone(s) is common in the emergency department. Often, urinalysis reveals white blood cells, but it is unknown how frequently pyuria is sterile or infectious.We sought to determine the incidence of pyuria in patients with renal colic and to correlate the incidence with a positive urine culture.A 1-year retrospective review of adult patients with renal colic presenting to three community emergency departments

2016 Journal of Emergency Medicine

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