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Urine Glucose

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1. Sotagliflozin for adult patients with Type 1 Diabetes Mellitus who have inadequate blood glucose control using insulin or insulin analogues

-glucose co-transporter 1 and 2 (SGLT1 and SGLT2) that reduces blood glucose levels via two mechanisms: inhibition of SGLT1 in the small intestine reduces glucose absorption, and inhibition of SGLT1 and SGLT2 in the kidneys reduces glucose reabsorption from the urine (23, 24). Comparators Sotagliflozin (200 mg and 400 mg) add-on to optimised insulin therapy is compared with: • placebo add-on to optimised insulin therapy (direct comparison); • empagliflozin and dapagliflozin add-on to optimised insulin (...) and CSII. SGLT2 inhibitors SGLT2 inhibitors reduce blood glucose by inhibiting SGLT2 in the kidneys, which reduces glucose reabsorption from the urine (25). Four SGLT2 inhibitors are approved in the EU for the treatment of T2D: canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin. As indicated above, this assess- ment includes an indirect comparison of sotagliflozin and the two SGLT2 inhibitors dapagliflozin (5 mg) and empagliflozin, for which there are published results from phase III

2019 EUnetHTA

2. Self-monitoring of blood glucose provides no important benefit for most people with type 2 diabetes

Self-monitoring of blood glucose provides no important benefit for most people with type 2 diabetes Self-monitoring of blood glucose provides no important benefit for most people with type 2 diabetes Discover Portal Discover Portal Self-monitoring of blood glucose provides no important benefit for most people with type 2 diabetes Published on 23 October 2018 doi: Patients with type 2 diabetes who monitor their blood glucose themselves may see small, short-term improvements in blood sugar (...) haemoglobin (HbA1c) at six months. This is just below the 0.4% threshold for a meaningful clinical difference in this measure of average 3-month sugar control. People who had poorer blood glucose control at the start saw a greater benefit. However, there was no difference between the self-monitoring and control groups by 12 months. The review supports current guideline recommendations that self-monitoring is not routinely used for people with type 2 diabetes controlled on diet or tablets. Share your views

2019 NIHR Dissemination Centre

3. Response to Dallosso et al. Self-monitoring of blood glucose versus self-monitoring of urine glucose in adults with newly diagnosed Type 2 diabetes receiving structured education: a cluster randomized controlled trial. (Abstract)

Response to Dallosso et al. Self-monitoring of blood glucose versus self-monitoring of urine glucose in adults with newly diagnosed Type 2 diabetes receiving structured education: a cluster randomized controlled trial. 25600996 2016 03 11 2018 12 02 1464-5491 32 8 2015 Aug Diabetic medicine : a journal of the British Diabetic Association Diabet. Med. Response to Dallosso et al. Self-monitoring of blood glucose versus self-monitoring of urine glucose in adults with newly diagnosed Type 2 (...) diabetes receiving structured education: a cluster randomized controlled trial. 1116 10.1111/dme.12695 Kerr D D William Sansum Diabetes Center - Research and Innovation, Santa Barbara, California, USA. eng Letter Comment England Diabet Med 8500858 0742-3071 IM Diabet Med. 2015 Mar;32(3):414-22 25308625 Blood Glucose Self-Monitoring methods Diabetes Mellitus, Type 2 complications Female Glycosuria diagnosis Humans Hyperglycemia diagnosis Male Monitoring, Ambulatory methods Patient Education as Topic

2016 Diabetic medicine : a journal of the British Diabetic Association Controlled trial quality: uncertain

4. Blood glucose monitoring

for these patients as well as a step-by-step plan to follow if the blood glucose is outside of these specified ranges . If the blood glucose level is outside of the parameters of 4-7mmol/L or the child is symptomatic, the advice of an experienced nurse or doctor should be sought . Symptoms of hypoglycaemia include pale pallor, lethargy, clammy skin, irritability, seizures Symptoms of hyperglycaemia include increase thirst, increased urination, irritability, abdominal pain, weight loss Acknowledge the child (...) Blood glucose monitoring Blood glucose monitoring | Great Ormond Street Hospital Google Tag Manager Navigation Search Search You are here Blood glucose monitoring Blood glucose monitoring . A normal blood glucose level is between approximately 4-7mmol/L . Certain conditions/disorders work within different parameters as dictated by local policies and/or condition specific, e.g. congenital hyperinsulinism ( ). Staff should report blood glucose levels in mmol/L rather than describing the level

2014 Publication 1593

5. Type 2 diabetes in adults: controlling your blood glucose by taking a second medicine ? what are your options?

for controlling your blood glucose to try to reduce the long-term risks of diabetes. It can help you if you are an adult with type 2 diabetes and: ? you have been taking a single medicine to control your blood glucose (sugar) level as measured by your haemoglobin A1c (HbA1c) level and ? your HbA1c level is higher than the target level you had agreed with your healthcare professional. (We use ‘healthcare professional’ in this decision aid to mean the doctor, nurse, pharmacist or other professional who (...) glucose by: ? making better use of your current medicine (for example, by having something to help you remember to take it regularly) or ? changing to a different medicine. What are the advantages and disadvantages of controlling your blood glucose? Advantages Controlling the symptoms of diabetes High blood glucose levels can cause symptoms such as feeling very thirsty, needing to pass urine a lot and feeling more tired than usual. Controlling blood glucose can stop these symptoms. Preventing some

2015 Health Information and Quality Authority

6. Self-monitoring of blood glucose versus self-monitoring of urine glucose in adults with newly diagnosed Type 2 diabetes receiving structured education: a cluster randomized controlled trial. Full Text available with Trip Pro

Self-monitoring of blood glucose versus self-monitoring of urine glucose in adults with newly diagnosed Type 2 diabetes receiving structured education: a cluster randomized controlled trial. To compare the effectiveness and acceptability of self-monitoring of blood glucose with self-monitoring of urine glucose in adults with newly diagnosed Type 2 diabetes.We conducted a multi-site cluster randomized controlled trial with practice-level randomization. Participants attended a structured group (...) education programme, which included a module on self-monitoring using blood glucose or urine glucose monitoring. HbA1c and other biomedical measures as well as psychosocial data were collected at 6, 12 and 18 months. A total of 292 participants with Type 2 diabetes were recruited from 75 practices.HbA1c levels were significantly lower at 18 months than at baseline in both the blood monitoring group [mean (se) -12 (2) mmol/mol; -1.1 (0.2) %] and the urine monitoring group [mean (se) -13 (2) mmol/mol

2015 Diabetic medicine : a journal of the British Diabetic Association Controlled trial quality: predicted high

7. Impact of different intravenous fluids on blood glucose levels in nondiabetic patients undergoing elective major noncardiac surgeries. Full Text available with Trip Pro

parameters, % oxygen saturation, and urine output were monitored at regular intervals. Capillary blood glucose (CBG) was measured half-hourly until end of surgery. If CBG level was more than 150 mg%, then calculated dose of human insulin (CBG/100) was given as IV bolus dose.Statistical analysis was done using SPSS 22.0 software (IBM Corporation, Armonk, New York, USA), paired t-test and Chi-square test.A significant increase of CBG level and was observed during intraoperative and immediate postoperative (...) Impact of different intravenous fluids on blood glucose levels in nondiabetic patients undergoing elective major noncardiac surgeries. Intravenous (IV) fluids are an integral part of perioperative management. Intraoperative hyperglycemia is associated with poor clinical outcomes in patients undergoing major surgeries even in nondiabetics.This study was conducted to observe the effect of different maintenance fluid regimens on intraoperative blood glucose levels in nondiabetic patients

2019 Anesthesia, essays and researches Controlled trial quality: uncertain

8. Effect of Pea Flour in Bread on Blood Glucose

; Medical history of diabetes mellitus, fasting blood glucose ≥6.1 mmol/L, HbA1c ≥6.0%, or use of insulin or oral medication to control blood sugar; Medical history of cardiovascular disease; Systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg; Fasting plasma total cholesterol >7.8 mmol/L; Fasting plasma HDL <0.9 mmol/L; Fasting plasma LDL >5.0 mmol/L; Fasting plasma triglycerides >2.3 mmol/L; Major surgery within the last 3 months; Medical history of inflammatory disease (ie (...) Effect of Pea Flour in Bread on Blood Glucose Effect of Pea Flour in Bread on Blood Glucose - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Pea Flour in Bread on Blood Glucose The safety

2018 Clinical Trials

9. Unusual high blood glucose in ketoacidosis as first presentation of type 1 diabetes mellitus Full Text available with Trip Pro

very high blood glucose (1687 mg/dL/93.6 mmol/L) and severe acidosis (pH <7) with proof of ketone bodies in serum and urine. Past history revealed a paranoid schizophrenia diagnosed 10 years ago and for which the patient was treated with risperidone for many years. Acute treatment with intravenous fluids, intravenous insulin infusion and sodium bicarbonate improved the symptoms. Further laboratory investigations confirmed diagnosis of autoimmune type 1 diabetes. After normalization of blood glucose (...) Unusual high blood glucose in ketoacidosis as first presentation of type 1 diabetes mellitus Diabetic ketoacidosis is a life-threatening complication of diabetes mellitus. It usually occurs in patients with type 1 diabetes where it is typically associated with only moderately increased blood glucose. Here, we report the case of a 52-year-old female patient who was admitted to the emergency unit with severely altered mental status but stable vital signs. Laboratory results on admission revealed

2018 Endocrinology, diabetes & metabolism case reports

10. Renal tubule insulin receptor modestly promotes elevated blood pressure and markedly stimulates glucose reabsorption Full Text available with Trip Pro

Renal tubule insulin receptor modestly promotes elevated blood pressure and markedly stimulates glucose reabsorption Although the cause of hypertension among individuals with obesity and insulin resistance is unknown, increased plasma insulin, acting in the kidney to increase sodium reabsorption, has been proposed as a potential mechanism. Insulin may also stimulate glucose uptake, but the contributions of tubular insulin signaling to sodium or glucose transport in the setting of insulin (...) glucosuria. Insulin receptor deletion significantly reduced SGLT2 expression and increased urinary glucose excretion and urine flow. These data demonstrate a direct role for insulin receptor-stimulated sodium and glucose transport and a functional interaction of insulin signaling with mineralocorticoids in vivo. These studies uncover a potential mechanistic link between preserved insulin sensitivity and renal glucose handling in obesity and insulin resistance.

2018 JCI insight

11. Appropriateness of Using Tests for Blood Glucose and Diabetic Complications in Clinical Practice: Experiences in a Hospital in Thailand Full Text available with Trip Pro

Appropriateness of Using Tests for Blood Glucose and Diabetic Complications in Clinical Practice: Experiences in a Hospital in Thailand BACKGROUND This study aimed to evaluate how the tests for blood glucose (BG) and diabetic complications have been utilized in a hospital in Thailand. MATERIAL AND METHODS Patient medical records having the results of BG, HbA1c, and/or urine microalbumin presented and the records of DM patients having the results of serum lipids, serum LDL-C, and/or serum (...) control in 58% of DM cases. In non-DM cases, the test results agreed, indicating normoglycemia in 17.32%, pre-diabetes in 20.47%, and diabetes in 21.78%. To prevent diabetic nephropathy, serum creatinine was frequently used, whereas urine microalbumin, the recommended test, was underutilized. The result of LDL-C from both direct measurement and calculation were used; however, based on the same guidelines, the results of measured LDL-C indicated risk of cardiovascular diseases in a higher percentage

2018 Medical science monitor : international medical journal of experimental and clinical research

12. Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice. Full Text available with Trip Pro

proximal tubule brush border. The lithium-10 and -40 diets did not affect body weight and resulted in blood lithium levels of respectively <0.25 mM and 0.48 mM. The Li-40 diet fully rescued the elevated non-fasting blood glucose levels. Importantly, glomerular filtration rate was not affected by lithium, while urine albumin and immunoglobulin G content were further elevated. While lithium did not worsen the glomerulosclerosis, proximal tubule function seemed affected by lithium, as urinary NGAL levels (...) Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice. Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulosclerosis in acute kidney injury. The effect of chronic GSK3 inhibition in diabetic nephropathy is not known. We tested the effect of lithium, the only clinical GSK3

2017 PLoS ONE

13. 15-minute Individual Consultation to Improve Blood Glucose Control in Pre-diabetes

15-minute Individual Consultation to Improve Blood Glucose Control in Pre-diabetes 15-minute Individual Consultation to Improve Blood Glucose Control in Pre-diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. 15-minute Individual Consultation to Improve Blood Glucose Control in Pre-diabetes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03483129 Recruitment Status : Active, not recruiting First Posted : March 30, 2018 Last Update Posted : August 7, 2018 Sponsor: Aberystwyth University

2018 Clinical Trials

14. SAFE-AP: Automatic Control of Blood Glucose Under Announced and Unannounced Exercise

SAFE-AP: Automatic Control of Blood Glucose Under Announced and Unannounced Exercise SAFE-AP: Automatic Control of Blood Glucose Under Announced and Unannounced Exercise - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. SAFE-AP: Automatic Control of Blood Glucose Under Announced and Unannounced Exercise (SAFE-AP3) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03577158 Recruitment Status : Recruiting First Posted : July 4

2018 Clinical Trials

15. A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation. Full Text available with Trip Pro

A randomized, double-blind clinical study to determine the effect of ANKASCIN 568 plus on blood glucose regulation. Diabetes is the fourth major cause of death in Taiwan. High blood glucose can lead to macrovascular diseases, small vessel diseases (retinopathy, kidney disease), and neuropathy. This study aimed to investigate whether Monascus-fermented products (ANKASCIN 568 plus) can regulate blood glucose and blood lipids. This study enrolled 39 patients with a fasting blood glucose level (...) between 100 mg/dL and 180 mg/dL, and a glycated hemoglobin (HbA1c) level of <9%. All patients were randomly divided into placebo (n=20) and experimental (n=19) groups. Each patient received two placebo capsules (maltodextrin) or ANKASCIN 568 plus capsules daily for 12 weeks. The patients were screened during follow-up 4 weeks after the administration of sample or placebo had been discontinued. Blood and urine samples were collected at the initial, 6th week, 12th week, and 16th week. The anthropometric

2017 Journal of food and drug analysis Controlled trial quality: uncertain

16. Effect of Peas in Chili on Blood Glucose and Appetite Control

Effect of Peas in Chili on Blood Glucose and Appetite Control Effect of Peas in Chili on Blood Glucose and Appetite Control - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Peas in Chili on Blood (...) General Hospital Research Centre Collaborators: Agriculture and Agri-Food Canada University of Manitoba Information provided by (Responsible Party): Dr. Heather Blewett, St. Boniface General Hospital Research Centre Study Details Study Description Go to Brief Summary: This study is part of a group of studies whose overall goal is to accurately define the physiochemical and structural effects of pea varieties and relate these to blood glucose attenuation and appetite related sensations in healthy human

2017 Clinical Trials

17. Effect of Peas in Muffins on Blood Glucose and Appetite Control

of diabetes mellitus, fasting blood glucose ≥6.1 mmol/L, HbA1c ≥6.0%, or use of insulin or oral medication to control blood sugar; Medical history of cardiovascular disease; Systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg; Fasting plasma total cholesterol >7.8 mmol/L; Fasting plasma HDL <0.9 mmol/L; Fasting plasma LDL >5.0 mmol/L; Fasting plasma triglycerides >2.3 mmol/L; Major surgery within the last 3 months; Medical history of inflammatory disease (ie. Systemic lupus (...) Effect of Peas in Muffins on Blood Glucose and Appetite Control Effect of Peas in Muffins on Blood Glucose and Appetite Control - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Peas in Muffins

2017 Clinical Trials

18. Mechanism of the blood pressure-lowering effect of sodium-glucose cotransporter 2 inhibitors in obese patients with type 2 diabetes Full Text available with Trip Pro

Mechanism of the blood pressure-lowering effect of sodium-glucose cotransporter 2 inhibitors in obese patients with type 2 diabetes Sodium-glucose cotransporter 2 (SGLT2) inhibitors are reported to have BP-lowering effect in addition to blood glucose-lowering effect, however, its mechanism is still unknown. This study aimed to investigate the mechanism of blood pressure (BP) lowering effects of SGLT2 inhibitors using 24-h urinary collection in obese type 2 diabetes patients.Twenty patients (...) with type 2 diabetes (age 48.2 ± 10.7 years, BMI 33.0 ± 4.9 kg/m2) were enrolled. Urine volume, 24-h urinary glucose and sodium excretion, and BP at baseline and 2 weeks and 6 months after administration were measured. Body weight, glycosylated hemoglobin, and BP were evaluated before and 1, 3, and 6 months after SGLT2 inhibitor administration. We evaluated the changes in urine volume and urinary excretion of glucose and sodium as well as correlations among urine volume and urinary sodium glucose

2017 BMC pharmacology & toxicology

19. Association of urinary citrate excretion, pH, and net gastrointestinal alkali absorption with diet, diuretic use, and blood glucose concentration Full Text available with Trip Pro

Association of urinary citrate excretion, pH, and net gastrointestinal alkali absorption with diet, diuretic use, and blood glucose concentration Urinary citrate (Ucit) protects against urinary stone formation. Acid base status and diet influence Ucit. However, the effect of demographics, diet, and glucose metabolism on Ucit excretion, urinary pH (U-pH) and net gastrointestinal alkali absorption (NAA) are not known. Twenty-four hour urine samples, blood glucose, creatinine, and cystatin C were (...) obtained from non-Hispanic white sibships in Rochester, MN (n = 446; 64.5 ± 9 years; 58% female). Diet was assessed by a food frequency questionnaire. The impact of blood glucose, demographics and dietary elements on Ucit excretion, U-pH, and NAA were evaluated in bivariate and multivariable models and interaction models that included age, sex, and weight. NAA significantly associated with Ucit and U-pH In multivariate models Ucit increased with age, weight, eGFRCys, and blood glucose, but decreased

2017 Physiological reports

20. Intake of Beta-glucan and Postprandial Regulation of Blood Glucose Metabolism in Healthy Subjects

Intake of Beta-glucan and Postprandial Regulation of Blood Glucose Metabolism in Healthy Subjects Intake of Beta-glucan and Postprandial Regulation of Blood Glucose Metabolism in Healthy Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Intake of Beta-glucan and Postprandial Regulation of Blood Glucose Metabolism in Healthy Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03293693 Recruitment Status : Completed First Posted : September 26, 2017 Last Update Posted : September 26, 2017

2017 Clinical Trials

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