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Urine Alkalinization

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1. The effect of early urine alkalinization on occurrence rhabdomyolysis and hospital stay in high dose doxylamine ingestion. (Abstract)

The effect of early urine alkalinization on occurrence rhabdomyolysis and hospital stay in high dose doxylamine ingestion. 29196111 2019 05 06 2019 05 06 1532-8171 36 7 2018 Jul The American journal of emergency medicine Am J Emerg Med The effect of early urine alkalinization on occurrence rhabdomyolysis and hospital stay in high dose doxylamine ingestion. 1170-1173 S0735-6757(17)30968-3 10.1016/j.ajem.2017.11.058 Kim Eun E Ewha Womans University Medical Center, Department of Emergency Medicine (...) 8MDF5V39QO Sodium Bicarbonate 95QB77JKPL Doxylamine IM Adult Antidotes administration & dosage Buffers Charcoal administration & dosage Doxylamine poisoning Drug Overdose therapy urine Drug Therapy, Combination Female Fluid Therapy methods statistics & numerical data Gastric Lavage statistics & numerical data Histamine H1 Antagonists poisoning Humans Infusions, Intravenous Injections, Intravenous Length of Stay statistics & numerical data Male Rhabdomyolysis chemically induced prevention & control urine

2019 The American journal of emergency medicine Controlled trial quality: uncertain

2. Recommended oral sodium bicarbonate administration for urine alkalinization did not affect the concentration of mitomycin-C in non-muscle invasive bladder cancer patients Full Text available with Trip Pro

Recommended oral sodium bicarbonate administration for urine alkalinization did not affect the concentration of mitomycin-C in non-muscle invasive bladder cancer patients Sodium bicarbonate has been reported to maximize the efficacy of intravesical instillation of mitomycin-C (IVI-MMC) therapy by urine alkalinization in non-muscle-invasive bladder cancer (NMIBC). This study aimed to analyze the changes in MMC concentration according to urinary pH and evaluate the efficacy of sodium bicarbonate (...) . No correlation was found between urinary pH and MMC concentration. Urine alkalinization by SB administration did not maintain the high concentration of urinary MMC.Urine alkalinization by sodium bicarbonate administration for IVI-MMC did not maintain the high concentration of active urinary MMC in NMIBC.

2017 Oncotarget

3. Is it safe to prescribe ascorbic acid for urinary acidification in stone-forming patients with alkaline urine? Full Text available with Trip Pro

Is it safe to prescribe ascorbic acid for urinary acidification in stone-forming patients with alkaline urine? To study the effect of ascorbic acid (AA) supplementation on urinary pH, metabolic stone workup parameters, and development of de novo urolithiasis in stone-forming patients.A retrospective review of the patients followed-up at a tertiary stone centre between September 2009 and October 2015 was performed. Patients with recurrent urolithiasis who received AA supplementation as a urinary (...) in patients with recurrent urolithiasis and alkaline urine pH. Prospective studies are needed to assess whether this reduction in urinary pH is associated with lower stone recurrence rates.

2017 Turkish journal of urology

4. Outcomes Associated with Reducing the Urine Alkalinization Threshold in Patients Receiving High-Dose Methotrexate. (Abstract)

Outcomes Associated with Reducing the Urine Alkalinization Threshold in Patients Receiving High-Dose Methotrexate. Urine alkalinization increases methotrexate (MTX) solubility and reduces the risk of nephrotoxicity. The objectives of this study were to determine whether a reduction in the urine pH threshold from 8 to 7 in patients receiving high-dose methotrexate (HDMTX) results in a shorter length of hospital stay, delayed MTX clearance, or higher rates of nephrotoxicity; and to determine (...) whether specific factors were associated with prolonged MTX clearance.Retrospective cohort study.Hematology service of a large university-affiliated teaching hospital in Ottawa, Canada.Sixty-five adults with 150 HDMTX exposures who had elective admissions for HDMTX between September 1, 2014, and December 18, 2015, were included. Thirty-four patients (with 79 HDMTX exposures) had their urine alkalinized to a pH of 8 or higher, and 31 patients (with 71 HDMTX exposures) had their urine alkalinized

2017 Pharmacotherapy

5. Urine Alkalinization

Urine Alkalinization Urine Alkalinization Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Urine Alkalinization Urine Alkalinization (...) Aka: Urine Alkalinization , Urinary Alkalinization , Alkaline Diuresis II. Indication: Drug Overdose with weak acid Phenobarbital or barbiturate All Class I antidysrhythmic Other channel blockers Cocaine s Chlorophenoxy Herbicides s (some) Diflunisal (Dolobid) III. Mechanism Enhances urinary excretion of weak acids Traps weak acids in ionized state (ion trapping) Prevents reabsorption by renal tubules IV. Preparation 100 to 150 meq (2-3 ampules) Dissolve in 1 liter D5W with 20-40 meq KCl Works out

2018 FP Notebook

6. PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization

PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. PrevenTion of Contrast (...) -inducEd nephroAThy With urinE Alkalinization (TEATE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02980003 Recruitment Status : Unknown Verified November 2016 by Raffaele De Caterina, G. d'Annunzio University. Recruitment status was: Recruiting First Posted : December 2, 2016 Last Update Posted

2016 Clinical Trials

7. The Effect of Urine Concentration and pH on the Growth of Escherichia Coli in Canine Urine In Vitro Full Text available with Trip Pro

at 37°C for 18 hours, and statistically compared.Significant differences were identified in the mean log CFU/mL among different combinations of pH and USG. The lowest log CFU/mL were observed in alkaline concentrated urine (pH 8.5 and USG 1.030).Escherichia coli in vitro growth was higher in neutral to acidic and diluted urine compared to alkaline and concentrated urine. The impact of non-alkalizing diluting diets on the incidence of E. coli lower urinary tract infections should be further (...) The Effect of Urine Concentration and pH on the Growth of Escherichia Coli in Canine Urine In Vitro Lower urinary tract infections are common in dogs, and Escherichia coli is the most common bacterial pathogen isolated. The literature has conflicting evidence regarding the inhibitory effects of urine concentration and pH on E. coli growth.To determine the effect of different pH and urine concentrations on E. coli growth in vitro.Voided urine samples from 10 apparently healthy spayed female dogs

2018 Journal of Veterinary Internal Medicine

8. Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes

Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes (Alk-UA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02502071 Recruitment Status : Completed First Posted

2015 Clinical Trials

9. Alkaline water improves exercise-induced metabolic acidosis and enhances anaerobic exercise performance in combat sport athletes. Full Text available with Trip Pro

Alkaline water improves exercise-induced metabolic acidosis and enhances anaerobic exercise performance in combat sport athletes. Hydration is one of the most significant issues for combat sports as athletes often use water restriction for quick weight loss before competition. It appears that alkaline water can be an effective alternative to sodium bicarbonate in preventing the effects of exercise-induced metabolic acidosis. Therefore, the main aim of the present study was to investigate (...) , in a double blind, placebo controlled randomized study, the impact of mineral-based highly alkaline water on acid-base balance, hydration status, and anaerobic capacity. Sixteen well trained combat sport athletes (n = 16), were randomly divided into two groups; the experimental group (EG; n = 8), which ingested highly alkaline water for three weeks, and the control group (CG; n = 8), which received regular table water. Anaerobic performance was evaluated by two double 30 s Wingate tests for lower

2018 PLoS ONE

10. Absorbance measurements of oxidation of homogentisic acid accelerated by the addition of alkaline solution with sodium hypochlorite pentahydrate Full Text available with Trip Pro

Absorbance measurements of oxidation of homogentisic acid accelerated by the addition of alkaline solution with sodium hypochlorite pentahydrate The urine of patients with alkaptonuria turns dark brown due to the oxidation of homogentisic acid (HGA) to benzoquinone acetic acid (BQA), and this is accelerated by the addition of alkali. We recently reported that alkaptonuric urine and HGA after the addition of alkali showed characteristic peaks at 406 and 430 nm. In order to improve (...) the sensitivity of our spectrometric method for the detection of HGA, we accelerated the oxidation of HGA to BQA using sodium hypochlorite pentahydrate (NaOCl·5H2O), which is a strong oxidant. In the present study, we measured the absorption spectra of alkaptonuric urine and HGA solution after the addition of sodium hydroxide (NaOH) or NaOH with NaOCl·5H2O and analyzed the oxidation reaction of HGA after alkalization using a liquid chromatography time-of-flight mass spectrometer (LC/TOF-MS) and nuclear

2018 Scientific reports

11. Furosemide Reduces BK-αβ4-mediated K+ Secretion in Mice on an Alkaline High K+ Diet. Full Text available with Trip Pro

Furosemide Reduces BK-αβ4-mediated K+ Secretion in Mice on an Alkaline High K+ Diet. Special high-K diets have cardioprotective effects and are often warranted in conjunction with diuretics such as furosemide for treating hypertension. However, it is not understood how a high-K diet (HK) influences the actions of diuretics on renal K+ handling. Furosemide acidifies the urine by increasing acid secretion via the Na+-H+ exchanger 3 (NHE3) in TAL and vacuolar H+-ATPase (V-ATPase) in the distal (...) nephron. We previously found that an alkaline urine is required for large conductance Ca2+-activated K+ (BK)-αβ4-mediated K+ secretion in mice on HK. We therefore hypothesized that furosemide could reduce BK-αβ4-mediated K+ secretion by acidifying the urine. Treating with furosemide (drinking water) for 11 days led to decreased urine pH in both wild-type (WT) and BK-β4-knockout mice (BK-β4-KO) with increased V-ATPase expression and elevated plasma aldosterone levels. However, furosemide decreased

2018 American Journal of Physiology. Renal physiology

12. The properties and pharmacological action of a base liberated by alkaline hydrolysis of normal urine, compared with those of a similar base found free in the urine of dogs with renal ischaemia Full Text available with Trip Pro

The properties and pharmacological action of a base liberated by alkaline hydrolysis of normal urine, compared with those of a similar base found free in the urine of dogs with renal ischaemia 16991714 2007 02 05 2018 11 13 0022-3751 105 2 1946 Sep 18 The Journal of physiology J. Physiol. (Lond.) The properties and pharmacological action of a base liberated by alkaline hydrolysis of normal urine, compared with those of a similar base found free in the urine of dogs with renal ischaemia. 138-51

1946 The Journal of physiology

13. The effect of mineral-based alkaline water on hydration status and the metabolic response to short-term anaerobic exercise Full Text available with Trip Pro

The effect of mineral-based alkaline water on hydration status and the metabolic response to short-term anaerobic exercise Previously it was demonstrated that mineralization and alkalization properties of mineral water are important factors influencing acid-base balance and hydration in athletes. The purpose of this study was to investigate the effects of drinking different types of water on urine pH, specific urine gravity, and post-exercise lactate utilization in response to strenuous (...) utilization rate in LM. In conclusion, the athletes hydrated with alkaline, low mineralized water demonstrated favourable changes in hydration status in response to high-intensity interval exercise with a significant decrease of specific urine gravity, increased urine pH and more efficient utilization of lactate after supramaximal exercise.

2017 Biology of Sport Controlled trial quality: uncertain

14. Evaluation of Correlation between Salivary Calcium, Alkaline Phosphatase and Osteoporosis- A Prospective, Comparative and Observational Study Full Text available with Trip Pro

Evaluation of Correlation between Salivary Calcium, Alkaline Phosphatase and Osteoporosis- A Prospective, Comparative and Observational Study Fixed and/or removable prosthodontics caters to the restorative needs of the largest count of geriatric patients whose rehabilitative procedures depend on the quality and quantity of available bone. The common diagnostic parameters for quantifying bone may involve an invasive blood examination, an expensive bone densitometry procedure or a urine analysis (...) . Sialometry involving the basic biochemistry of saliva analysis may be proposed as an alternative to the conventional investigative protocol and its usefulness may be attributed owing to its non invasive and simpler procedure.The aim of this study was to compare the salivary calcium and alkaline phosphatase among osteoporotic, osteopenic and normal edentulous subjects.A prospective, comparative and observational study was carried out on 80 selected edentulous subjects (40 males and 40 females) aged 55-75

2017 Journal of clinical and diagnostic research : JCDR

15. An association between time-varying serum alkaline phosphatase concentrations and mortality rate in patients undergoing peritoneal dialysis: a five-year cohort study Full Text available with Trip Pro

An association between time-varying serum alkaline phosphatase concentrations and mortality rate in patients undergoing peritoneal dialysis: a five-year cohort study The relationship between serum alkaline phosphatase (ALP) concentrations and mortality in peritoneal dialysis (PD) patients is rarely reported. We enrolled 667 PD patients in one PD centre in Taiwan to retrospectively examine the association between three ALP concentrations (baseline, time-averaged, time-dependent) and mortality (...) over a 5-year period (2011-2015). Baseline data collection included demographics, clinical, and laboratory parameters. Multivariable-adjusted Cox models were used to analyse the association. Four ALP quartiles were defined at the baseline: ≤62, 63-82, 83-118, and ≥119 U/L. Of 667 patients, 65 patients died, of which 8 patients died due to cardiovascular disease. Females were predominant in the higher ALP quartiles, and 24-h urine volume was significantly proportionately decreased in the higher ALP

2017 Scientific reports

16. Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase

Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase (APPIRED-III) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03050476 Recruitment Status : Recruiting First Posted : February 13

2017 Clinical Trials

17. Alkalinization by Urologists & Nephrologists

propose to follow patients in which an oral alkalinization is indicated: blood pressure, body weight, and a clinical evaluation of the extracellular compartment will be performed at the beginning and during the follow-up of participants. Initial recorded data will be: age, gender, prescription (indication, kind of alkali therapy, volume and duration), body weight, body length, a clinical appreciation of the extracellular compartment, blood pressure, comorbidities, drug therapy, blood and urine (...) Alkalinization by Urologists & Nephrologists Alkalinization by Urologists & Nephrologists - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Alkalinization by Urologists & Nephrologists (AlcalUN) The safety

2017 Clinical Trials

18. Generation of urine-derived induced pluripotent stem cells from a patient with phenylketonuria Full Text available with Trip Pro

episomal vectors carrying an OCT4, SOX2, KLF4, and miR-302-367 cluster. PKU-UiPSCs were verified as correct using alkaline phosphatase staining. Pluripotency markers were detected with real-time PCR and flow cytometry. Promoter methylation in two pluripotent genes, NANOG and OCT4, was analyzed using bisulphite sequencing. An embryoid body (EB) formation assay was also performed. An induced pluripotent stem cell line (iPSC) was generated from epithelial cells in urine from a patient with PKU. This cell (...) Generation of urine-derived induced pluripotent stem cells from a patient with phenylketonuria The aim of the study was to establish an induced pluripotent stem cell line from urine-derived cells (UiPSCs) from a patient with phenylketonuria (PKU) in order to provide a useful research tool with which to examine the pathology of this rare genetic metabolic disease. Urine-derived epithelial cells (UCs) from a 15-year-old male patient with PKU were isolated and reprogrammed with integration-free

2018 Intractable & rare diseases research

19. Role of Bicarbonate Supplementation on Urine Uric Acid Crystals and Diabetic Tubulopathy in Adults with Type 1 Diabetes: A Brief Report. Full Text available with Trip Pro

Role of Bicarbonate Supplementation on Urine Uric Acid Crystals and Diabetic Tubulopathy in Adults with Type 1 Diabetes: A Brief Report. Uricosuria and crystallization are increasingly recognized risk factors for diabetic tubulopathy. This pilot clinical trial aimed to determine the acute effect of urinary alkalinization using oral sodium bicarbonate (NaHCO3 ) on UA crystals in adults with type 1 diabetes (T1D). Adults with T1D, ages 18 to 65 years (n = 45, 60% female, HbA1c, 7.5 ± 1.2%, 20.2 (...) ± 9.3 years duration) without chronic kidney disease (eGFR ≥60 mL/min/1.73 m2 and albumin-to-creatinine ratio < 30 mg/g) received 2 doses of 1950 mg oral NaHCO3 over 24 hours. Fasting urine and serum were collected pre- and post-intervention. UA crystals were identified under polarized microscopy. Urine measurements included: osmolality, pH, UA, creatinine and kidney injury molecule-1 (KIM-1). NaHCO3 therapy increased mean ± SD urine pH from 6.1 ± 0.7 to 6.5 ± 0.7 (P < .0001). Prior to therapy, 31.0

2018 obesity & metabolism

20. Urine Cotinine Should Be Involved in Initial Evaluation of Tinnitus in Adolescents Full Text available with Trip Pro

of tinnitus increased with age (P<0.001) and was higher among girls (P=0.012). Blood tests and urinalysis showed significant correlation between tinnitus and red blood cell count, alkaline phosphatase levels, and urine cotinine (P=0.002, P<0.001, P=0.018, respectively). In multivariate analysis, the urine cotinine level was the only parameter associated with tinnitus (odds ratio, 1.000; 95% confidence interval, 0.999 to 1.000; P=0.038). Smoking was also significantly correlated with tinnitus (P=0.043 (...) Urine Cotinine Should Be Involved in Initial Evaluation of Tinnitus in Adolescents Smoking is associated with hearing loss, while the correlation between tinnitus and smoking is not fully elucidated. This study aimed to evaluate risk factors of tinnitus in adolescents in terms of smoking, and we identified a rectifiable parameter that can be serially monitored.A cross-sectional study was conducted using data from the Korea National Health and Nutrition Examination Survey, with 2,782

2018 Clinical and experimental otorhinolaryngology

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