How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

366 results for

Uric Acid Nephrolithiasis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

141. The Predictors of Successful Oral Dissolution Therapy in Radiolucent Renal Stones; A Prospective Evaluation

table for MeSH terms Calculi Urolithiasis Kidney Calculi Nephrolithiasis Pathological Conditions, Anatomical Urologic Diseases Kidney Diseases Urinary Calculi Citric Acid Sodium Citrate Allopurinol Uric Acid Potassium Citrate Anticoagulants Calcium Chelating Agents Chelating Agents Sequestering Agents Molecular Mechanisms of Pharmacological Action Antimetabolites Enzyme Inhibitors Gout Suppressants Antirheumatic Agents Free Radical Scavengers Antioxidants Protective Agents Physiological Effects (...) alkalinization Potassium citrate 20 mEq three times daily Hyperuricosuric patients (24-hours urine uric acid more than 750 mg/day in male and more than 650mg/day in females), will receive Allopurinol, a competitive inhibitor of xanthine oxidase, in a dose of 300 mg daily. Life style modification Adequate fluid intake in order to maintain urine volume between 2-3 L per day. Dietary recommendations In hyperuricosuric patients (24-hours urine uric acid more than 750 mg/day in male and more than 650mg/day

2015 Clinical Trials

142. Stone formation and management after bariatric surgery. (PubMed)

Stone formation and management after bariatric surgery. Obesity is a significant health concern and is associated with an increased risk of nephrolithiasis, particularly in women. The underlying pathophysiology of stone formation in obese patients is thought to be related to insulin resistance, dietary factors, and a lithogenic urinary profile. Uric acid stones and calcium oxalate stones are common in these patients. Use of surgical procedures for obesity (bariatric surgery) has risen over (...) the past two decades. Although such procedures effectively manage obesity-dependent comorbidities, several large, controlled studies have revealed that modern bariatric surgeries increase the risk of nephrolithiasis by approximately twofold. In patients who have undergone bariatric surgery, fat malabsorption leads to hyperabsorption of oxalate, which is exacerbated by an increased permeability of the gut to oxalate. Patients who have undergone bariatric surgery show characteristic 24 h urine parameters

2015 Nature reviews. Urology

143. Evaluation and medical management of kidney stones in children. (PubMed)

composition to those that form in adulthood. Approximately 75% to 80% of stones are composed of predominantly calcium oxalate, 5% to 10% are predominantly calcium phosphate, 10% to 20% are struvite and 5% are pure uric acid. The recurrence rate of nephrolithiasis in patients with stones that form during childhood is poorly defined. Ultrasound should be used as the initial imaging study to evaluate children with suspected nephrolithiasis, with noncontrast computerized tomography reserved for those in whom (...) . Potassium citrate is a potentially effective medication for children with calcium oxalate stones and concomitant hypocitraturia, as well as children with uric acid stones. However, long-term compliance with therapy and the effect on decreasing stone recurrence in children are unknown. Based largely on efficacy in adult populations, thiazide diuretics should be considered in the treatment of children with calcium based stones and persistent hypercalciuria refractory to reductions in salt intake.The

2014 Journal of Urology

146. Fragmentation of Urinary Calculi in Vitro by Burst Wave Lithotripsy. (PubMed)

at the surface nearest to the transducer until the stone was disintegrated. All natural and artificial stones were fragmented at the highest focal pressure of 6.5 MPa with a mean treatment duration of 36 seconds for uric acid stones to 14.7 minutes for cystine stones. At a frequency of 170 kHz the largest artificial stone fragments were less than 4 mm. Exposure at 285 and 800 kHz produced only fragments less than 2 mm and less than 1 mm, respectively.Stone comminution with burst wave lithotripsy is feasible (...) as a potential noninvasive treatment method for nephrolithiasis. Adjusting the fundamental ultrasound frequency allows for stone fragment size to be controlled.Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Full Text available with Trip Pro

2014 Journal of Urology

147. Recurrent exercise-induced acute renal failure in a young Pakistani man with severe renal hypouricemia and SLC2A9 compound heterozygosity. (PubMed)

Recurrent exercise-induced acute renal failure in a young Pakistani man with severe renal hypouricemia and SLC2A9 compound heterozygosity. Familial renal hypouricemia (RHUC) is a hereditary disease characterized by hypouricemia, high renal fractional excretion of uric acid (FE-UA) and can be complicated by acute kidney failure and nephrolithiasis. Loss-of-function mutations in the SLC22A12 gene cause renal hypouricemia type 1 (RHUC1), whereas renal hypouricemia type 2 (RHUC2) is caused

Full Text available with Trip Pro

2014 BMC Medical Genetics

148. Pathophysiological and physicochemical basis of ammonium urate stone formation in dolphins. (PubMed)

represent a continuum of stone risk. On analysis combining cases and controls in a single cohort we noted significant postprandial increases in urinary uric acid, sulfate and net acid excretion accompanied by increased urinary ammonium excretion and a commensurate increase in urine pH. The supersaturation index of ammonium urate increased more than twofold postprandially.These findings suggest that dolphins are susceptible to ammonium urate nephrolithiasis at least in part because a high dietary load (...) Pathophysiological and physicochemical basis of ammonium urate stone formation in dolphins. Nephrolithiasis is increasingly reported in bottle-nosed dolphins. All cases to date have been ammonium urate nephrolithiasis.A case-control study was performed in dolphins with and without evidence of nephrolithiasis to identify biomarkers and risk factors associated with stone formation in a managed population. Dolphins were sampled in fasting and postprandial states to study the effect of dietary

Full Text available with Trip Pro

2014 Journal of Urology

149. Evaluating the Effect of ALLN-177 to Reduce Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria

procedures History of enteric or idiopathic hyperoxaluria and at least one calcium oxalate kidney stone Hyperoxaluria >36mg of oxalate/24-hr May be taking drugs for the prevention of stone disease as long as there have been no changes in these medications for at least 3 months Exclusion Criteria: Uric acid ≥1.5g/24-hr Estimated glomerular filtration rate of < 60 mL/min Positive results from drug urine screen Requires daily vitamin C (defined as >10 days of >300 mg/day) Diagnosis of hypercalcemia (...) or hypothyroidism Obstructive uropathy, chronic urosepsis, renal failure, renal tubular acidosis, primary hyperparathyroidism, primary hyperoxaluria, pure uric acid and cystine stones, and/or medullary sponge kidney. Auto-immune disorder requiring high dose steroids or other immunosuppressant drugs. Subjects who are pregnant. Women of childbearing potential must have a negative pregnancy test prior to enrollment and must practice approved methods of birth control during the trial History of cancer diagnosis

2014 Clinical Trials

150. A Study In Healthy Elderly People To Evaluate Safety, Toleration, Pharmacokinetics and Pharmacodynamics of Multiple Oral Doses Of PF-06743649

Concentration (Tmax) [ Time Frame: up to 14 days ] Plasma Decay Half-Life (t1/2) [ Time Frame: up to 14 days ] Amount of drug recovered unchanged in urine during the dosing interval (Aetau) [ Time Frame: up to 14 days ] Percent of dose recovered unchanged in urine during the dosing interval(Aetau%) [ Time Frame: up to 14 days ] Renal clearance (CLr) [ Time Frame: up to 14 days ] Secondary Outcome Measures : Change from baseline in serum uric acid level [ Time Frame: up to 14 days ] Change from baseline (...) in serum levels of xanthine and hypoxanthine [ Time Frame: up to 14 days ] Urinary uric acid levels [ Time Frame: up to 14 days ] Urinary xanthine levels [ Time Frame: up to 14 days ] Urinary hypoxanthine levels [ Time Frame: up to 14 days ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study

2014 Clinical Trials

151. A Study In Healthy People To Evaluate Safety, Toleration, Pharmacokinetics And Pharmacodynamics Of Multiple Oral Doses Of PF-06743649

-Life (t1/2) [ Time Frame: up to 14 days ] Amount of drug recovered unchanged in urine during the dosing interval (Aetau) [ Time Frame: up to 14 days ] Percent of dose recovered unchanged in urine during the dosing interval(Aetau%) [ Time Frame: up to 14 days ] Renal clearance (CLr) [ Time Frame: up to 14 days ] Secondary Outcome Measures : Change from baseline in serum uric acid level [ Time Frame: up to 14 days ] Change from baseline in serum levels of xanthine and hypoxanthine [ Time Frame: up (...) to 14 days ] Urinary uric acid levels [ Time Frame: up to 14 days ] Urinary xanthine levels [ Time Frame: up to 14 days ] Urinary hypoxanthine levels [ Time Frame: up to 14 days ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using

2014 Clinical Trials

152. Extracorporeal Shockwave Lithotripsy (Overview)

for detecting and tracking calcified and otherwise radio-opaque stones, both in the kidney and the ureter. Conversely, it is usually poor for localizing radiolucent stones (eg, uric acid stones). To compensate for this shortcoming, intravenous contrast can be introduced or (more commonly) cannulation of the ureter with a catheter and retrograde instillation of contrast (ie retrograde pyelography) can be performed. Ultrasonographic localization allows for visualization of both radiopaque and radiolucent (...) , Gutierrez-Aceves J, et al. Lower pole I: a prospective randomized trial of extracorporeal shock wave lithotripsy and percutaneous nephrostolithotomy for lower pole nephrolithiasis-initial results. J Urol . 2001 Dec. 166(6):2072-80. . Anagnostou T, Tolley D. Management of ureteric stones. Eur Urol . 2004 Jun. 45(6):714-21. . Auge BK, Preminger GM. Update on shock wave lithotripsy technology. Curr Opin Urol . 2002 Jul. 12(4):287-90. . Chacko J, Moore M, Sankey N, Chandhoke PS. Does a slower treatment rate

2014 eMedicine.com

153. Ureteroscopy (Diagnosis)

treatment of ureteropelvic junction obstruction. J Urol . 1998 Nov. 160(5):1643-6; discussion 1646-7. . Teichman JM, Champion PC, Wollin TA, Denstedt JD. Holmium:YAG lithotripsy of uric acid calculi. J Urol . 1998 Dec. 160(6 Pt 1):2130-2. . Wollin TA, Teichman JM, Rogenes VJ, Razvi HA, Denstedt JD, Grasso M. Holmium:YAG lithotripsy in children. J Urol . 1999 Nov. 162(5):1717-20. . Bus MT, de Bruin DM, Faber DJ, Kamphuis GM, Zondervan PJ, Laguna Pes MP, et al. Optical diagnostics for upper urinary tract (...) patterns in urologic management of upper-tract transitional-cell carcinoma. J Endourol . 2005 Apr. 19(3):366-71. . Segura JW, Preminger GM, Assimos DG, Dretler SP, Kahn RI, Lingeman JE, et al. Nephrolithiasis Clinical Guidelines Panel summary report on the management of staghorn calculi. The American Urological Association Nephrolithiasis Clinical Guidelines Panel. J Urol . 1994 Jun. 151(6):1648-51. . Segura JW, Preminger GM, Assimos DG, Dretler SP, Kahn RI, Lingeman JE, et al. Ureteral Stones Clinical

2014 eMedicine.com

154. Radiographic Evaluation of the Pediatric Urinary Tract (Follow-up)

Baseline renal US is usually performed, though upper urinary tract abnormalities are rare in patients with classic bladder exstrophy. Renal abnormalities are much more common in patients with cloacal exstrophy. VUR is present in nearly all patients with exstrophic anomalies. After closure of the bladder, VCUG is useful to assess bladder capacity and to evaluate the competency of the bladder neck. Nephromegaly Renal vein thrombosis, uric acid nephropathy, , infection, and nephroblastomatosis are all (...) the end of their hospital stay. Approximately 50% of patients younger than 1 year who present with a febrile UTI have VUR, compared with 33% of patients older than 1 year. [ ] Of patients younger than 1 year with VUR, 50% will have evidence of renal lesions on dimercaptosuccinic acid (DMSA) scan; patients older than 1 year old with VUR have a 33% chance of having renal scarring. [ ] This has led some centers to use DMSA scanning as the initial test after a child has a febrile UTI. It is proposed

2014 eMedicine Pediatrics

155. Glycogen-Storage Disease Type I (Diagnosis)

the nucleic acid degradation pathway and resulting in increased uric acid, the end product. Hyperuricemia can reach levels that require use of xanthine oxidase inhibitors to prevent nephrolithiasis. Nephrolithiasis secondary to increased uric acid is a constant threat to patients with poorly controlled disease. Severe hypoglycemia stimulates epinephrine secretion, which activates lipoprotein lipase and the release of free fatty acids. These fatty acids are transported to the liver, where they are used (...) the substrate for glycolysis and produces lactate. Lactate exits the hepatocyte, causing clinically significant lactic acidemia in proportion to the degree of stimulus for glycogen breakdown. The accumulation of lactic acid in blood can cause true acidosis with a large anion gap, a characteristic of glycogen-storage disease type I. The immense increase in the intracellular phosphorylated intermediate compounds of glycolysis concurrently inhibits rephosphorylation of adenine nucleotides, activating

2014 eMedicine Pediatrics

156. Disorders of Bone Mineralization (Diagnosis)

not be needed. Approximately 800-1000 IU/day, plus good calcium intake, may be sufficient. Previous Next: Renal Causes Fanconi syndrome is a disorder of proximal renal tubular transport. Phosphate, amino acid, glucose, bicarbonate, and uric acid wasting characterize this disorder. Dysfunctions in tubular phosphate reabsorption via the sodium-phosphate cotransporter, endocytotic reabsorption of the vitamin D–vitamin D–binding protein complex mediated by megalin and cubilin, and acid-base regulation (...) ( DMP1 ), respectively. Degradation of matrix extracellular phosphoglycoprotein (MEPE) and DMP-1 and release of acidic serine-rich and aspartate-rich MEPE-associated motif (ASARM) peptides are chiefly responsible for the hypophosphatemic rickets mineralization defect and changes in osteoblast-osteoclast differentiation. [ ] In patients with oncogenic osteomalacia, intact and C-terminal fibroblast growth factor-23 (FGF-23) levels are elevated, and the tumors responsible for this disease show increased

2014 eMedicine Pediatrics

157. Gout (Follow-up)

, with its uricosuric effect, may reduce the serum concentration of uric acid. In one study, 500 mg/day for 2 months reduced uric acid by a mean of 0.5 mg/dL in patients without gout. [ ] However, gout patients appear to be less responsive to such a low dose of ascorbate. Vitamin C treatment should be avoided in patients with nephrolithiasis, urate nephropathy, or cystinuria. Kobylecki et al reported that each 10 µmol/L higher plasma vitamin C level was associated with a 2.3 µmol/L lower plasma urate (...) . Clinical spectrum and uric acid metabolism. Arch Intern Med . 1991 Apr. 151(4):726-32. . Meyers OL, Monteagudo FS. Gout in females: an analysis of 92 patients. Clin Exp Rheumatol . 1985 Apr-Jun. 3(2):105-9. . Macfarlane DG, Dieppe PA. Diuretic-induced gout in elderly women. Br J Rheumatol . 1985 May. 24(2):155-7. . Kramer HM, Curhan G. The association between gout and nephrolithiasis: the National Health and Nutrition Examination Survey III, 1988-1994. Am J Kidney Dis . 2002 Jul. 40(1):37-42

2014 eMedicine Surgery

158. Gout (Diagnosis)

(11):692-4. . Puig JG, Michan AD, Jimenez ML, et al. Female gout. Clinical spectrum and uric acid metabolism. Arch Intern Med . 1991 Apr. 151(4):726-32. . Meyers OL, Monteagudo FS. Gout in females: an analysis of 92 patients. Clin Exp Rheumatol . 1985 Apr-Jun. 3(2):105-9. . Macfarlane DG, Dieppe PA. Diuretic-induced gout in elderly women. Br J Rheumatol . 1985 May. 24(2):155-7. . Kramer HM, Curhan G. The association between gout and nephrolithiasis: the National Health and Nutrition Examination (...) , blurred vision, anterior uveitis (rare), scleritis Complications of gout include the following: Severe degenerative arthritis Secondary infections Urate or uric acid nephropathy Increased susceptibility to infection Urate nephropathy Renal stones Nerve or spinal cord impingement Fractures in joints with tophaceous gout See for more detail. Diagnosis Studies that may be helpful include the following: Joint aspiration and synovial fluid analysis Serum uric acid measurement (though hyperuricemia

2014 eMedicine Surgery

159. Diabetic Nephropathy (Diagnosis)

for uric acid stones. J Am Soc Nephrol . 2006 Jul. 17 (7):2026-33. . . Zelnick LR, Weiss NS, Kestenbaum BR, et al. Diabetes and CKD in the United States Population, 2009-2014. Clin J Am Soc Nephrol . 2017 Dec 7. 12 (12):1984-90. . Cheung CY, Ma MKM, Chak WL, Tang SCW. Cancer risk in patients with diabetic nephropathy: a retrospective cohort study in Hong Kong. Medicine (Baltimore) . 2017 Sep. 96 (38):e8077. . . Fan JZ, Wang R. Non-diabetic renal diseases in patients with type 2 diabetes: a single (...) to accumulation of extracellular matrix. The image below is a simple schema for the pathogenesis of diabetic nephropathy. Simple schema for the pathogenesis of diabetic nephropathy. Light microscopy findings show an increase in the solid spaces of the tuft, most frequently observed as coarse branching of solid (positive periodic-acid Schiff reaction) material (diffuse diabetic glomerulopathy). Large acellular accumulations also may be observed within these areas. These are circular on section and are known

2014 eMedicine.com

160. Gout (Diagnosis)

(11):692-4. . Puig JG, Michan AD, Jimenez ML, et al. Female gout. Clinical spectrum and uric acid metabolism. Arch Intern Med . 1991 Apr. 151(4):726-32. . Meyers OL, Monteagudo FS. Gout in females: an analysis of 92 patients. Clin Exp Rheumatol . 1985 Apr-Jun. 3(2):105-9. . Macfarlane DG, Dieppe PA. Diuretic-induced gout in elderly women. Br J Rheumatol . 1985 May. 24(2):155-7. . Kramer HM, Curhan G. The association between gout and nephrolithiasis: the National Health and Nutrition Examination (...) , blurred vision, anterior uveitis (rare), scleritis Complications of gout include the following: Severe degenerative arthritis Secondary infections Urate or uric acid nephropathy Increased susceptibility to infection Urate nephropathy Renal stones Nerve or spinal cord impingement Fractures in joints with tophaceous gout See for more detail. Diagnosis Studies that may be helpful include the following: Joint aspiration and synovial fluid analysis Serum uric acid measurement (though hyperuricemia

2014 eMedicine.com

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>