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Uric Acid Nephrolithiasis

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141. Urinary calcium and uric acid excretion in children with vesicoureteral reflux. (Abstract)

Urinary calcium and uric acid excretion in children with vesicoureteral reflux. Urolithiasis is relatively common in children, and identifiable predisposing factors for stone formation, including metabolic and structural derangements, can be established in most cases. Vesicoureteral reflux (VUR) is a common cause of kidney stone formation. The pathophysiological mechanism of urolithiasis in reflux is related to urinary tract infection and urinary stasis, both of which promote urinary crystal (...) formation, but metabolic causes, such as crystallurias (mostly hypercalciuria), may also be involved in this process. However, few studies on urinary calcium and uric acid excretion in children with VUR have been conducted. We have studied the frequency of hypercalciuria and hyperuricosuria in children with VUR and compared the results with those from a control group. The VUR group comprised 108 children with VUR (19 boys, 89 girls; age range 3 months to 12 years), and the control group comprised 110

2012 Pediatric Nephrology

142. The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers. Full Text available with Trip Pro

of nephrolithiasis and uric acid stones result from excessively low urine pH. Here we placed 9 healthy volunteers and 10 uric acid stone formers on fixed metabolic diets to study the diurnal pattern of urinary acidification. All showed clear diurnal trends in urinary acidification, but none of the patterns were affected by inhibitors of the gastric proton pump. Uric acid stone formers had similar patterns of change throughout the day but their urine pH was always lower compared to healthy volunteers. Uric acid (...) stone formers excreted more acid (normalized to acid ingestion), with the excess excreted primarily as titratable acid rather than ammonium. Urine base excretion was also lower in uric acid stone formers (normalized to base ingestion), along with lower plasma bicarbonate concentrations during part of the day. Thus, increased net acid presentation to the kidney and the preferential use of buffers, other than ammonium, result in much higher concentrations of undissociated uric acid throughout the day

2012 Kidney international Controlled trial quality: uncertain

143. Effect of Renal Function on Urinary Mineral Excretion and Stone Composition. (Abstract)

Effect of Renal Function on Urinary Mineral Excretion and Stone Composition. To determine the effect of renal function on urinary mineral stone excretion and composition of kidney stones in patients undergoing urologic intervention for nephrolithiasis.We performed a retrospective analysis of 158 patients with 193 kidney stones who underwent endourologic intervention for nephrolithiasis. The patients were grouped by the estimated glomerular filtration rate (eGFR). The kidney stone composition (...) and results of the 24-hour urinalysis were reported for each group. Statistical analysis was performed using the chi-square test, Kruskal-Wallis test, and analysis of variance.The kidney stone composition profile differed significantly between the groups, with uric acid stones associated with a lower eGFR and calcium phosphate stones associated with a greater eGFR. A lower eGFR correlated with lower urine pH, lower calcium excretion, and greater oxalate excretion. Excretion of uric acid and the body mass

2011 Urology

144. Uric acid and the kidney. Full Text available with Trip Pro

Hypertension blood Hypoxanthines blood Kidney Calculi blood prevention & control Kidney Diseases blood Kidney Failure, Chronic blood Swine Uremia complications Uric Acid blood Xanthenes blood Xanthine Oxidase antagonists & inhibitors 1973 9 1 1973 9 1 0 1 1973 9 1 0 0 ppublish 4805094 PMC1645432 Ann Intern Med. 1965 Apr;62:667-74 14274831 N Engl J Med. 1950 Aug 31;243(9):325-9 15439538 Q J Med. 1960 Jan;29:127-35 13818629 N Engl J Med. 1969 Feb 20;280(8):426-7 5763090 J Urol. 1969 May;101(5):637-42 5780596 (...) Uric acid and the kidney. 4805094 1975 05 29 2018 11 13 0035-9157 66 9 1973 Sep Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Uric acid and the kidney. 900-2 Cameron J S JS eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Hypoxanthines 0 Xanthenes 268B43MJ25 Uric Acid 63CZ7GJN5I Allopurinol EC 1.17.3.2 Xanthine Oxidase IM Aged Allopurinol therapeutic use Animals Diabetes Mellitus blood Gout blood Humans Hydrogen-Ion Concentration Hypercholesterolemia blood

1973 Proceedings of the Royal Society of Medicine

145. Adenine phosphoribosyltransferase deficiency presenting with supposed 'uric acid' stones: pitfalls of diagnosis. Full Text available with Trip Pro

Article England J R Soc Med 7802879 0141-0768 268B43MJ25 Uric Acid EC 2.4.2.- Pentosyltransferases EC 2.4.2.7 Adenine Phosphoribosyltransferase JAC85A2161 Adenine IM Adenine analogs & derivatives analysis Adenine Phosphoribosyltransferase deficiency Diagnosis, Differential Female Humans Infant Kidney Calculi diagnosis Pentosyltransferases deficiency Ureteral Calculi diagnosis Uric Acid analysis Urinary Calculi diagnosis 1978 11 1 1978 11 1 0 1 1978 11 1 0 0 ppublish 731641 PMC1436179 J Med Lab Technol (...) Adenine phosphoribosyltransferase deficiency presenting with supposed 'uric acid' stones: pitfalls of diagnosis. 731641 1979 03 13 2018 11 13 0141-0768 71 11 1978 Nov Journal of the Royal Society of Medicine J R Soc Med Adenine phosphoribosyltransferase deficiency presenting with supposed 'uric acid' stones: pitfalls of diagnosis. 791-5 Simmonds H A HA Potter C F CF Sahota A A Cameron J S JS Rose G A GA Barratt T M TM Williams D I DI Arkell D G DG Van Acker K J KJ eng Case Reports Journal

1978 Journal of the Royal Society of Medicine

146. Treatment of gout by reduction of uric acid production. Full Text available with Trip Pro

therapy Humans Kidney Calculi prevention & control Sulfinpyrazone therapeutic use Uracil therapeutic use Uric Acid biosynthesis Uricosuric Agents therapeutic use Xanthine Oxidase therapeutic use 1966 7 1 1966 7 1 0 1 1966 7 1 0 0 ppublish 5947580 PMC2453350 Arthritis Rheum. 1965 Oct;8(5):883-90 5859558 Arthritis Rheum. 1965 Oct;8(5):899-904 5323682 Arthritis Rheum. 1965 Oct;8(5):907-10 5323684 Cancer Res. 1964 May;24:671-3 14188472 Ann Rheum Dis. 1964 Nov;23:439-46 14229577 Am J Med. 1964 Dec;37:885 (...) Treatment of gout by reduction of uric acid production. 5947580 1966 10 23 2018 11 30 0003-4967 25 4 1966 Jul Annals of the rheumatic diseases Ann. Rheum. Dis. Treatment of gout by reduction of uric acid production. 353-5 Kersley G D GD eng Journal Article England Ann Rheum Dis 0372355 0003-4967 0 Uricosuric Agents 268B43MJ25 Uric Acid 56HH86ZVCT Uracil EC 1.11.1.6 Catalase EC 1.17.3.2 Xanthine Oxidase V6OFU47K3W Sulfinpyrazone IM Catalase therapeutic use Drug Synergism Enzyme Therapy Gout drug

1966 Annals of the Rheumatic Diseases

147. Effects of Allopurinol on Gouty and Non-Gouty Uric Acid Nephropathy Full Text available with Trip Pro

Sulfinpyrazone IM Allopurinol therapeutic use Blood Urea Nitrogen Enzyme Therapy Female Gout complications Humans Kidney Calculi drug therapy Kidney Diseases drug therapy Male Salicylates therapeutic use Sulfinpyrazone therapeutic use Uric Acid blood urine Xanthine Oxidase 1966 11 1 1966 11 1 0 1 1966 11 1 0 0 ppublish 5958697 PMC2453415 10.1136/ard.25.Suppl_6.673 (...) Effects of Allopurinol on Gouty and Non-Gouty Uric Acid Nephropathy 5958697 1967 04 13 2018 11 30 0003-4967 25 6 Suppl 1966 Nov Annals of the rheumatic diseases Ann. Rheum. Dis. Effects of allopurinol on gouty and non-gouty uric acid nephropathy. 673-80 10.1136/ard.25.Suppl_6.673 Ogryzlo M A MA Urowitz M B MB Weber H M HM Houpt J B JB eng Journal Article England Ann Rheum Dis 0372355 0003-4967 0 Salicylates 268B43MJ25 Uric Acid 63CZ7GJN5I Allopurinol EC 1.17.3.2 Xanthine Oxidase V6OFU47K3W

1966 Annals of the Rheumatic Diseases

148. Allopurinol in the Prophylaxis of Uric Acid Stones Full Text available with Trip Pro

complications Humans Hydrogen-Ion Concentration Kidney Calculi drug therapy Male Uric Acid urine Xanthine Oxidase 1966 11 1 1966 11 1 0 1 1966 11 1 0 0 ppublish 5958700 PMC2453421 10.1136/ard.25.Suppl_6.691 (...) Allopurinol in the Prophylaxis of Uric Acid Stones 5958700 1967 04 13 2018 11 30 0003-4967 25 6 Suppl 1966 Nov Annals of the rheumatic diseases Ann. Rheum. Dis. Allopurinol in the prophylaxis of uric acid stones. 691-3 10.1136/ard.25.Suppl_6.691 de Vries A A Frank M M Liberman U A UA Sperling O O eng Journal Article England Ann Rheum Dis 0372355 0003-4967 268B43MJ25 Uric Acid 63CZ7GJN5I Allopurinol EC 1.17.3.2 Xanthine Oxidase IM Allopurinol therapeutic use Enzyme Therapy Female Gout

1966 Annals of the Rheumatic Diseases

149. Anuria Due to Uric Acid Crystalluria: An Unusual Complication of Therapy in the Reticuloses Full Text available with Trip Pro

Abdominal Neoplasms Anuria Blood Genetic Diseases, X-Linked Humans Kidney Diseases Leukemia, Hairy Cell Lymphatic Diseases Lymphoma Lymphoma, Non-Hodgkin Neoplasms radiotherapy Peptide Nucleic Acids Potassium Severe Combined Immunodeficiency Urea Uric Acid Urinary Calculi ABDOMINAL NEOPLASMS ANURIA BLOOD KIDNEY DISEASES LYMPHOSARCOMA NEOPLASM RADIOTHERAPY POTASSIUM RETICULOENDOTHELIOSIS UREA URIC ACID URINARY CALCULI 1964 6 1 1964 6 1 0 1 1964 6 1 0 0 ppublish 14189678 PMC2071308 Am J Med Sci. 1953 Jun (...) Anuria Due to Uric Acid Crystalluria: An Unusual Complication of Therapy in the Reticuloses 14189678 1996 12 01 2018 12 01 0007-0920 18 1964 Jun British journal of cancer Br. J. Cancer ANURIA DUE TO URIC ACID CRYSTALLURIA: AN UNUSUAL COMPLICATION OF THERAPY IN THE RETICULOSES. 247-51 CONOLLY M E ME ELLIS H H eng Journal Article England Br J Cancer 0370635 0007-0920 0 Peptide Nucleic Acids 0 reticulose 268B43MJ25 Uric Acid 8W8T17847W Urea RWP5GA015D Potassium Reticuloendotheliosis, X-linked OM

1964 British journal of cancer

150. Kidney stone Full Text available with Trip Pro

Kidney stone Kidney stone disease - Wikipedia Kidney stone disease From Wikipedia, the free encyclopedia (Redirected from ) Kidney stone disease Other names Urolithiasis, kidney stone, renal calculus, nephrolith, kidney stone disease, A kidney stone, 8 millimeters (0.3 in) in , Symptoms Severe pain in the lower back or abdomen, blood in the urine, vomiting, nausea Causes and environmental factors Based on symptoms, , , , , Prevention Drinking fluids such that more than two liters of urine (...) the kidneys and bladder. Nephrolithiasis refers to the presence of such stones in the kidneys. Calyceal calculi are aggregations in either the or , parts of the kidney that pass urine into the ureter (the tube connecting the kidneys to the urinary bladder). The condition is called ureterolithiasis when a calculus is located in the ureter. Stones may also form or pass into the bladder, a condition referred to as . Size [ ] Radiograph showing a large staghorn calculus involving the and in a person

2012 Wikipedia

151. List of kidney stone formers Full Text available with Trip Pro

stone include , , , . and . Artists and musicians [ ] Arthur Sullivan wrote the comic opera in between bouts of excruciating pain from his kidney stones. In 1549, painter was treated for kidney stones by anatomist . Michelangelo appears to have suffered for many years from recurrent uric acid stones and may have died from obstructive . His condition may account for his artistic interest in kidneys. Five years after retiring because of ill-health, in 1612 Italian composer died from an attack (...) urinary incontinence, probably due to uric acid stones in the bladder. The distinguished mathematician and philosopher died from a combination of gout and the stone. Although he was a member of several distinguished societies, he had fallen into such disfavor that only one man came to his funeral. In the final years of his life, is known to have used , an herbal preparation of , to alleviate the pain of recurrent kidney stones. The eminent Italian anatomist and surgeon suffered severely from a stone

2012 Wikipedia

152. Investigation of Adipose Tissue Fatty Acid Composition in Men with Uronephrolithiasis and Metabolic Syndrome Full Text available with Trip Pro

Investigation of Adipose Tissue Fatty Acid Composition in Men with Uronephrolithiasis and Metabolic Syndrome BACKGROUND Fatty acids (FA) and their metabolites are closely related to some mechanisms involved in the development of uronephrolithiasis. The aim of this study was to evaluate the relationship between FA composition and type of kidney stones. MATERIAL AND METHODS Abdominal adipose tissue fatty acid methyl esters of 71 men with nephrolithiasis were identified by GC/MS, and the type (...) of kidney stones was identified using FTIR infrared spectroscopy. Patients were divided into groups according to diagnosis of metabolic syndrome (MS) and type of kidney stone. The composition of FA was compared within different groups of patients with different types of kidney stones and between the patients and healthy individuals (control group) (n=100). RESULTS Individuals with nephrolithiasis had a significantly higher level of monounsaturated fatty acids (MUFA) and a lower level of polyunsaturated

2018 Medical science monitor : international medical journal of experimental and clinical research

153. Nephrolithiasis: Acute Renal Colic (Diagnosis)

and type of calculus (eg, calcium oxalate, uric acid, cystine), respectively Microscopic urinalysis 24-Hour urine profile Imaging studies The following imaging studies are used in the evaluation of nephrolithiasis: Noncontrast abdominopelvic CT scan: The imaging modality of choice for assessment of urinary tract disease, especially acute renal colic Renal ultrasonography: To determine presence of a renal stone and the presence of hydronephrosis or ureteral dilation; used alone or in combination (...) population. [ ] The term nephrolithiasis specifically refers to calculi in the kidneys, but this article discusses both renal calculi (see the first image below) and ureteral calculi (ureterolithiasis; see the second image below). Ureteral calculi almost always originate in the kidneys, although they may continue to grow once they lodge in the ureter. Small renal calculus that would likely respond to extracorporeal shockwave lithotripsy. Distal ureteral stone observed through a small, rigid ureteroscope

2014 eMedicine.com

154. Nephrolithiasis (Diagnosis)

of calculus (eg, calcium oxalate, uric acid, cystine), respectively Microscopic urinalysis 24-Hour urine profile Imaging studies The following imaging studies are used in the evaluation of nephrolithiasis: Noncontrast abdominopelvic CT scan: The imaging modality of choice for assessment of urinary tract disease, especially acute renal colic Renal ultrasonography: To determine presence of a renal stone and the presence of hydronephrosis or ureteral dilation; used alone or in combination with plain (...) . [ ] The term nephrolithiasis specifically refers to calculi in the kidneys, but this article discusses both renal calculi (see the first image below) and ureteral calculi (ureterolithiasis; see the second image below). Ureteral calculi almost always originate in the kidneys, although they may continue to grow once they lodge in the ureter. Small renal calculus that would likely respond to extracorporeal shockwave lithotripsy. Distal ureteral stone observed through a small, rigid ureteroscope prior

2014 eMedicine.com

155. Nephrolithiasis (Treatment)

paramount whenever a UTI is suspected in conjunction with hydronephrosis or renal colic a septic patient. The vast majority of symptomatic urinary tract calculi are now treated with noninvasive or minimally invasive techniques. Open surgical excision of a stone from the urinary tract is now limited to isolated atypical cases. Guidelines are now available to assist the urologist in selecting surgical treatments. The 2005 AUA staghorn calculus guidelines recommend percutaneous nephrostolithotomy (...) %). [ ] Anatrophic nephrolithotomy Anatrophic nephrolithotomy was classically an open procedure indicated for large staghorn calculi. It involved accessing the kidney through an open approach, identifying the avascular plane of Brodel, which is a relatively avascular plane in the posterior kidney, and then making an incision through this plane and subsequently removing the calculus. During this procedure the renal artery is clamped, which raises the risk for ischemic injury, as well as reperfusion injury once

2014 eMedicine.com

156. Nephrolithiasis: Acute Renal Colic (Treatment)

with acute renal colic, especially in patients in whom narcotics cannot be used or in whom the pain is unusually resistant to standard medical treatment. Antibiotic therapy Antibiotic use in patients with kidney stones remains controversial. Overuse of the more effective agents leaves only highly resistant bacteria, but failure to adequately treat a UTI complicated by an obstructing calculus can result in potentially life-threatening urosepsis and pyonephrosis. Use antibiotics if a kidney stone (...) which are then tailored to sensitivities is also paramount whenever a UTI is suspected in conjunction with hydronephrosis or renal colic a septic patient. The vast majority of symptomatic urinary tract calculi are now treated with noninvasive or minimally invasive techniques. Open surgical excision of a stone from the urinary tract is now limited to isolated atypical cases. Guidelines are now available to assist the urologist in selecting surgical treatments. The 2005 AUA staghorn calculus

2014 eMedicine.com

157. Nephrolithiasis: Acute Renal Colic (Overview)

and type of calculus (eg, calcium oxalate, uric acid, cystine), respectively Microscopic urinalysis 24-Hour urine profile Imaging studies The following imaging studies are used in the evaluation of nephrolithiasis: Noncontrast abdominopelvic CT scan: The imaging modality of choice for assessment of urinary tract disease, especially acute renal colic Renal ultrasonography: To determine presence of a renal stone and the presence of hydronephrosis or ureteral dilation; used alone or in combination (...) population. [ ] The term nephrolithiasis specifically refers to calculi in the kidneys, but this article discusses both renal calculi (see the first image below) and ureteral calculi (ureterolithiasis; see the second image below). Ureteral calculi almost always originate in the kidneys, although they may continue to grow once they lodge in the ureter. Small renal calculus that would likely respond to extracorporeal shockwave lithotripsy. Distal ureteral stone observed through a small, rigid ureteroscope

2014 eMedicine.com

158. Nephrolithiasis (Overview)

of calculus (eg, calcium oxalate, uric acid, cystine), respectively Microscopic urinalysis 24-Hour urine profile Imaging studies The following imaging studies are used in the evaluation of nephrolithiasis: Noncontrast abdominopelvic CT scan: The imaging modality of choice for assessment of urinary tract disease, especially acute renal colic Renal ultrasonography: To determine presence of a renal stone and the presence of hydronephrosis or ureteral dilation; used alone or in combination with plain (...) . [ ] The term nephrolithiasis specifically refers to calculi in the kidneys, but this article discusses both renal calculi (see the first image below) and ureteral calculi (ureterolithiasis; see the second image below). Ureteral calculi almost always originate in the kidneys, although they may continue to grow once they lodge in the ureter. Small renal calculus that would likely respond to extracorporeal shockwave lithotripsy. Distal ureteral stone observed through a small, rigid ureteroscope prior

2014 eMedicine.com

159. Nephrolithiasis: Acute Renal Colic (Follow-up)

with acute renal colic, especially in patients in whom narcotics cannot be used or in whom the pain is unusually resistant to standard medical treatment. Antibiotic therapy Antibiotic use in patients with kidney stones remains controversial. Overuse of the more effective agents leaves only highly resistant bacteria, but failure to adequately treat a UTI complicated by an obstructing calculus can result in potentially life-threatening urosepsis and pyonephrosis. Use antibiotics if a kidney stone (...) which are then tailored to sensitivities is also paramount whenever a UTI is suspected in conjunction with hydronephrosis or renal colic a septic patient. The vast majority of symptomatic urinary tract calculi are now treated with noninvasive or minimally invasive techniques. Open surgical excision of a stone from the urinary tract is now limited to isolated atypical cases. Guidelines are now available to assist the urologist in selecting surgical treatments. The 2005 AUA staghorn calculus

2014 eMedicine.com

160. Nephrolithiasis (Follow-up)

paramount whenever a UTI is suspected in conjunction with hydronephrosis or renal colic a septic patient. The vast majority of symptomatic urinary tract calculi are now treated with noninvasive or minimally invasive techniques. Open surgical excision of a stone from the urinary tract is now limited to isolated atypical cases. Guidelines are now available to assist the urologist in selecting surgical treatments. The 2005 AUA staghorn calculus guidelines recommend percutaneous nephrostolithotomy (...) %). [ ] Anatrophic nephrolithotomy Anatrophic nephrolithotomy was classically an open procedure indicated for large staghorn calculi. It involved accessing the kidney through an open approach, identifying the avascular plane of Brodel, which is a relatively avascular plane in the posterior kidney, and then making an incision through this plane and subsequently removing the calculus. During this procedure the renal artery is clamped, which raises the risk for ischemic injury, as well as reperfusion injury once

2014 eMedicine.com

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