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Uric Acid Nephrolithiasis

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121. Understanding the Urine Electrolyte Profile of the Individual Renal Unit

, oxalate, potassium, magnesium, phosphate, uric acid, and urate. When an abnormality is detected on a 24-hour urine collection the assumption is that this is due to a global metabolic defect present in both kidneys. However, this may not be the case. It is possible there could be a relative imbalance with both kidneys having a defect, but to different degrees (or different defects in one or multiple electrolytes). It is also possible that one kidney has a dominant defect, but the contralateral kidney (...) in the concentrations of urine electrolytes, such as calcium. Condition or disease Intervention/treatment Kidney Calculi Nephrolithiasis Urolithiasis Procedure: Ureteral catheterization Detailed Description: Nephrolithiasis is common within the general population. Although the majority of patients with a symptomatic stone event will not require surgical intervention, the rate of recurrence is high. Therefore, reducing this rate of recurrence is important. Traditionally, this has been achieved with a combination

2016 Clinical Trials

122. Study to Evaluate the Efficacy and Safety of DS-1971a for the Treatment of Diabetic Peripheral Neuropathic Pain (DPNP)

disorders such as bipolar disorder, schizophrenia, or major depression. Abnormal liver function (aspartate aminotransferase/alanine aminotransferase (AST/ALT) > 2.5 × upper limit of normal (ULN), bilirubin > 1.5 ULN). Subjects with history of gout, and/or urate nephrolithiasis, and/or with abnormally low serum uric acid (below the lowest laboratory reference range both in men and women) at baseline. Other sources of pain that may confound assessment or self-evaluation of DPNP such as disseminated

2016 Clinical Trials

123. Influence of Hypocaloric Diet on Urinary Lithogenic Factors of Obese Patients With Kidney Stones

and requested total serum calcium, phosphate, sodium, potassium, urea, creatinine, uric acid, and PTH, pH venous blood, urine tests type I, culture of urine and urine tests of calcium, oxalate, phosphate, sodium, potassium, citrate, magnesium, creatinine, uric acid, cystine and computed tomography for evaluation of urinary calculus. In the second evaluation, 30 days after, anthropometric measures will be repeated, bioimpedance and nutritional assessment will be made with recommendation of daily ingestion (...) of 2500 ml of water and low-calorie diet of 16 Kcal/kg bw/day and requested total serum calcium, phosphate, sodium, potassium, urea, creatinine, uric acid, and PTH, pH venous blood, urine tests type I, culture of urine and urine tests of calcium, oxalate, phosphate, sodium, potassium, citrate, magnesium, creatinine, uric acid, cystine. Patients will be monitored monthly for 3 months with anthropometric measurements, bioimpedance and strengthening of nutritional recommendations. By the end of the third

2016 Clinical Trials

124. Bacterial Analysis of Kidney Stones Removed by Percutaneous Nephrolithotomy

characterized. Previous studies have found bacteria present in stones of patients without active infection and with negative pre-operative urine tests. There are various compositions of kidney stones, including calcium oxalate, calcium phosphate, struvite and uric acid, with calcium oxalate being the most common. It is well known that struvite stones are associated with active infection, however the role of bacteria in the formation of other types of kidney stones, including calcium oxalate, is not well (...) First Posted: April 15, 2016 Last Update Posted: May 2, 2018 Last Verified: November 2016 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Keywords provided by Dirk Lange, University of British Columbia: Kidney stones Renal Calculi Additional relevant MeSH terms: Layout table for MeSH terms Kidney Calculi Nephrolithiasis Urolithiasis Kidney Diseases Urologic Diseases Urinary Calculi Calculi Pathological Conditions, Anatomical

2016 Clinical Trials

125. Uromodulin in kidney health and disease. (PubMed)

estimated glomerular filtration rate (eGFR) and kidney size, possibly indicating greater kidney functional reserve. Greater uromodulin excretion is associated with markers of volume overload such as fractional excretion of uric acid, sodium and chloride, indicating a possible role in salt and water retention. Recent evidence also suggests that higher uromodulin levels are associated with lower risk of eGFR decline, death and possibly a lower risk of acute kidney injury. Higher levels of uromodulin (...) Uromodulin in kidney health and disease. Although uromodulin or Tamm-Horsfall protein was discovered over 60 years ago, its functional role in humans remains unclear. This review highlights new studies elucidating the clinical correlates of uromodulin, its association with kidney function decline, nephrolithiasis and urinary host defense.Uromodulin is evolutionarily conserved and has multiple functional roles. In large population studies, higher levels of uromodulin are associated with higher

2016 Current Opinion in Nephrology and Hypertension

126. Do Overweight and Obese Pediatric Stone Formers Have Differences in Metabolic Abnormalities Compared with Normal Weight Stone Formers? (PubMed)

%). Univariable and multivariable analyses revealed that overweight and obese children were more likely to have low urinary volume and elevated uric acid compared to normal-weight children.Although there is a link between stone formation and BMI in adults, no definitive conclusions have been proven in the pediatric literature. Our study indicates that stone-forming children who are overweight or obese have low urinary volume and elevated uric acid compared to normal-weight stone-forming children.Copyright © (...) Do Overweight and Obese Pediatric Stone Formers Have Differences in Metabolic Abnormalities Compared with Normal Weight Stone Formers? To determine if 24-hour urinary parameters in children with nephrolithiasis across 4 institutions were influenced by body mass index (BMI).The 24-hour urinary parameters obtained from children with nephrolithiasis between 2000 and 2013 were stratified by BMI percentile ≥85th and <85th (overweight and obese patients vs healthy weight, respectively). A total

2016 Urology

127. A Novel Homozygous SLC2A9 Mutation Associated with Renal-Induced Hypouricemia. (PubMed)

A Novel Homozygous SLC2A9 Mutation Associated with Renal-Induced Hypouricemia. Hereditary renal hypouricemia (RHUC) is a genetically heterogenous disorder characterized by defective uric acid (UA) reabsorption resulting in hypouricemia and increased fractional excretion of UA; acute kidney injury (AKI) and nephrolithiasis are recognized complications. Type 1 (RHUC1) is caused by mutations in the SLC22A12 gene, whereas RHUC2 is caused by mutations in the SLC2A9 gene. Patient ethnicity is diverse

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2016 American journal of nephrology

128. The Effect of Vitamin D Repletion on Kidney Stone Risk

Criteria: Known uric acid, cystine, or struvite stone disease Hypercalcemia (serum calcium >10.4 mg/dl within the past 12 months) Gross hematuria within the past 6 months Acute stone event within the past 1 month Recent stone intervention within the past 1 month Suspected or known secondary causes of hypercalciuria such as primary hyperparathyroidism, sarcoidosis, hyperthyroidism, or malignancy (except non-melanoma skin cancer) Addition or dose change of medicines potentially affecting urinary calcium (...) followed at Miriam Hospital Kidney Stone Clinic with history of nephrolithiasis, urinary calcium excretion between 150 and 400 mg/day, and 25-vitamin D deficiency/insufficiency (defined as serum level ≤ 30ng/ml). The intervention is oral ergocalciferol 50,000 IU per week for 12 weeks (repletion course). After that, the same repletion course will be repeated if serum 25-vitamin D remains ≤ 30ng/ml or drops to ≤ 30ng/ml anytime during the study. Otherwise, a maintenance dose of cholecalciferol 1,000 IU

2016 Clinical Trials

129. Vitamin D deficiency is prevalent among idiopathic stone formers, but does correction pose any risk? (PubMed)

that baseline 24-h urinary measures related to stone risk expressed as concentration ratios over urine creatinine (Cr), such as U. Calcium/Cr, U. Oxalate/Cr, U. Citrate/Cr, and U. Uric acid/Cr were not significantly different. VitD3 supplementation did significantly increase serum 25-OH vitD levels and U. Phosphate/Cr ratios, as well as reduce serum parathyroid hormone (PTH) concentrations. Following vitD3 supplementation, there was an overall rise in 24-h urine calcium excretion, but it failed to reach (...) Vitamin D deficiency is prevalent among idiopathic stone formers, but does correction pose any risk? While vitamin D (vitD) deficiency is thought to contribute to poor health in a variety of ways and should be corrected, there is still concern about giving vitD supplements to patients with a history of nephrolithiasis. The aim is to study the prevalence of vitD deficiency and the effect on stone risk of cholecalciferol (vitD3) supplementation in a cohort of idiopathic stone formers (ISF). We

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2016 Urolithiasis

130. Pegloticase for chronic gout. (PubMed)

%, 52% and 62%. Percent time without hyperuricemia (uric acid below 6 mg/dl) was 78%, 92%, 76% and 76% respectively. No between dose differences were noted. Most common adverse events (10% or more patients) included nephrolithiasis, arthralgia, anemia, dyspnea, headache, muscle spasms, nausea and pyrexia. 89% reported one or more gout flares during the study. Pain, patient/physician global, function, quality of life, tophus size/regression and radiographic progression were not reported (...) Pegloticase for chronic gout. Pegloticase is a potential new treatment option for patients with chronic gout intolerant to other urate-lowering therapies.To assess safety (adverse events, death) and efficacy (pain, function, frequency of flares, quality of life, uric acid level, radiographic damage) of pegloticase in various doses or as compared to placebo or other interventions for treatment of hyperuricemia in patients with chronic gout.We searched six databases: The Cochrane Central Register

2010 Cochrane

131. Gout

Gout Gout - NICE CKS Clinical Knowledge Summaries Share Gout: Summary Gout is a disorder of purine metabolism characterized by a raised uric acid level in the blood (hyperuricaemia) and the deposition of urate crystals in joints and other tissues. The natural history of gout can occur in three distinct phases: A long period of asymptomatic hyperuricaemia. A period during which acute attacks of gouty arthritis are followed by variable intervals (months to years) when there are no symptoms (...) if: The diagnosis is uncertain. There is an underlying systemic illness. Gout occurs during pregnancy or in a person under 30 years of age. There are persistent symptoms despite treatment. ULT is required but allopurinol and febuxostat are not tolerated, contraindicated or inadequate in lowering serum uric acid levels to target. Complications are present. The person is at risk of adverse effects of drug treatment. Have I got the right topic? Have I got the right topic? From age 16 years onwards. This CKS topic

2015 NICE Clinical Knowledge Summaries

132. Olodaterol inhalation solution (Striverdi Respimat)

) Chronic obstructive pulmonary disease 20 (1.8) 18 (1.6) 38 (1.7) Acute respiratory failure 0 (0.0) 5 (0.4) 5 (0.2) Pulmonary hypertension 1 (0.1) 1 (0.1) 2 (0.1) Respiratory failure 1 (0.1) 1 (0.1) 2 (0.1) Gastrointestinal disorders 5 (0.4) 7 (0.6) 12 (0.5) Gastritis 1 (0.1) 1 (0.1) 2 (0.1) Intestinal obstruction 1 (0.1) 1 (0.1) 2 (0.1) Esophagitis 1 (0.1) 1 (0.1) 2 (0.1) Renal and urinary disorders 3 (0.3) 3 (0.3) 6 (0.3) Nephrolithiasis 2 (0.2) 0 (0.0) 2 (0.1) Renal failure acute 1 (0.1) 2 (0.2) 3

2014 FDA - Drug Approval Package

133. Endocrine and Nutritional Management of the Post-Bariatric Surgery Patient

to maintain body composition and mobility, improve blood lipids and lipoproteins, and help to control food intake ( – ). Modular protein supplements can be sorted into four categories: 1) protein concentrates derived from a complete protein such as milk, soy, or eggs; 2) protein concentrates derived from collagen, either alone or in combination with a complete protein; 3) doses of one or more dispensable (nonessential) amino acids; and 4) hybrids of the complete or collagen-based proteins and amino acid (...) dose. Modular protein supplements are generally provided either as a substrate for protein synthesis or as a source of one or more amino acids that may be conditionally indispensable (conditionally essential) ( ). Hospitalization with initiation of parenteral nutrition support may be required ( ) in cases of severe protein deficiency, but there are no currently accepted guidelines or clinical studies guiding nutritional therapy after weight loss surgery. Nutritional support with parenteral

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2010 The Endocrine Society

134. Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days

Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: History of enteric or idiopathic hyperoxaluria or kidney stones Urinary oxalate ≥ 50 mg/24 hours Exclusion Criteria: Hyperuricosuria Glomerular filtration rate < 45 mL/min/1.73m2 Hypercalcemia or hyperthyroidism Autoimmune disorder requiring systemic steroids Acute renal colic, primary hyperoxaluria, pure uric acid and/or cysteine stones, renal (...) Hyperoxaluria Nephrolithiasis Hyperoxaluria Kidney Stones Dietary Hyperoxaluria Drug: ALLN-177 Drug: Placebo Phase 2 Detailed Description: This is a multicenter, randomized, double-blind, placebo controlled study to evaluate the efficacy of ALLN 177 compared with placebo in reducing the urinary excretion of oxalate in subjects with secondary hyperoxaluria and kidney stones. ALLN-177 is an orally administered form of oxalate decarboxylase. The goal of therapy with ALLN-177 is to reduce urinary oxalate

2015 Clinical Trials

135. Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones

urosepsis, renal failure, renal tubular acidosis, primary hyperparathyroidism, primary hyperoxaluria, pure uric acid and cystine stones, and/or medullary sponge kidney Treatment with cholestyramine Average daily dietary intake of oxalate <75 mg per day Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its (...) Posted : January 11, 2018 Sponsor: Allena Pharmaceuticals Information provided by (Responsible Party): Allena Pharmaceuticals Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the safety, tolerability, and efficacy of different doses of ALLN 177 for reducing urinary oxalate excretion in patients with secondary hyperoxaluria and recurrent kidney stones. Condition or disease Intervention/treatment Phase Secondary Hyperoxaluria Nephrolithiasis Kidney Stones

2015 Clinical Trials

136. Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia. (PubMed)

Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia. Spontaneous tumor lysis syndrome is a rare initial presentation of hematologic malignancy in children that typically presents with complications of electrolyte derangement, specifically hyperkalemia, hyperphosphatemia, and hyperuricemia. We report a case of a 5-year-old boy who presented to the emergency department with gross hematuria, abdominal pain, and vomiting and was ultimately diagnosed with uric acid (...) nephrolithiasis and acute renal failure secondary to spontaneous tumor lysis syndrome in the setting of T-cell acute lymphoblastic leukemia. Tumor lysis syndrome is considered an oncologic emergency, and in this case, the child required urgent treatment with potassium-binding agents, rasburicase, and hemodialysis. This case demonstrates that occult hematologic malignancy should be suspected in cases of nephrolithiasis and acute renal failure when found in conjunction with hyperuricemia despite a normal

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2015 Pediatrics

137. Prospective evaluation of urinary metabolic indices in severely obese adolescents after weight loss surgery. (PubMed)

total of 55 samples were analyzed from 14 severely obese adolescents and from 17 severely obese adolescents after bariatric surgery (RYGB, 10; SG, 7). Median body mass index was similar between the RYGB and SG groups. The median 24-hour excretion of oxalate was significantly elevated in the RYGB group. Calcium and uric acid excretion and the median supersaturation of calcium oxalate, calcium phosphate, and uric acid were similar among all groups.Elevated excretion of oxalate in the urine of severely (...) Prospective evaluation of urinary metabolic indices in severely obese adolescents after weight loss surgery. Observational studies in obese adults have found abnormal urinary metabolic indices that predispose to nephrolithiasis. Few studies have been performed in severely obese adolescents.To assess urinary stone risk factors in severely obese adolescents and in those undergoing 2 types of weight loss surgery.Children's hospital, United States.A prospective cross-sectional study was performed

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2015 Surgery for Obesity and Related Diseases

138. Effect of Potassium Citrate on Calcium Phosphate Stones in a Model of Hypercalciuria. (PubMed)

was collected at 6, 12, and 18 weeks. At 18 weeks, stone formation was visualized by radiography. Urine citrate, phosphate, oxalate, and pH levels were higher and urine calcium level was lower in rats fed potassium citrate. Furthermore, calcium oxalate and calcium phosphate supersaturation were higher with potassium citrate; however, uric acid supersaturation was lower. Both groups had similar numbers of exclusively calcium phosphate stones. Thus, potassium citrate effectively raises urine citrate levels (...) Effect of Potassium Citrate on Calcium Phosphate Stones in a Model of Hypercalciuria. Potassium citrate is prescribed to decrease stone recurrence in patients with calcium nephrolithiasis. Citrate binds intestinal and urine calcium and increases urine pH. Citrate, metabolized to bicarbonate, should decrease calcium excretion by reducing bone resorption and increasing renal calcium reabsorption. However, citrate binding to intestinal calcium may increase absorption and renal excretion of both

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2015 Journal of the American Society of Nephrology

139. Dietary Calcium Supplementation, Gut Permeability and Microbiota in Type 2 Diabetics

hormone, 25-dihydroxy vitamin D, calcium, fasting glucose, fasting insulin, fructosamine, hemoglobin, HbA1c, uric acid, triglycerides, cholesterol total and partial, lipopolysaccharide, inflammatory markers) will be evaluated at baseline and after 12 weeks. The statistical analysis will be performed with the use of SPSS software (SPSS Inc., Chicago, IL, 2008, version 17.0). Parametric or non-parametric tests will be applied, according to the distribution of variables (level of statistical significance (...) of recurrent nephrolithiasis Caffeine consumption of> 300 mg / day Pregnancy, lactation or postmenopausal Anemia Cardiovascular, infectious, inflammatory, thyroid, liver, kidney or intestinal disease Use of anti-inflammatory, antacids, antibiotics and laxatives drugs Major gastrointestinal surgery. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided

2015 Clinical Trials

140. The Predictors of Successful Oral Dissolution Therapy in Radiolucent Renal Stones; A Prospective Evaluation

table for MeSH terms Calculi Urolithiasis Kidney Calculi Nephrolithiasis Pathological Conditions, Anatomical Urologic Diseases Kidney Diseases Urinary Calculi Citric Acid Sodium Citrate Allopurinol Uric Acid Potassium Citrate Anticoagulants Calcium Chelating Agents Chelating Agents Sequestering Agents Molecular Mechanisms of Pharmacological Action Antimetabolites Enzyme Inhibitors Gout Suppressants Antirheumatic Agents Free Radical Scavengers Antioxidants Protective Agents Physiological Effects (...) alkalinization Potassium citrate 20 mEq three times daily Hyperuricosuric patients (24-hours urine uric acid more than 750 mg/day in male and more than 650mg/day in females), will receive Allopurinol, a competitive inhibitor of xanthine oxidase, in a dose of 300 mg daily. Life style modification Adequate fluid intake in order to maintain urine volume between 2-3 L per day. Dietary recommendations In hyperuricosuric patients (24-hours urine uric acid more than 750 mg/day in male and more than 650mg/day

2015 Clinical Trials

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