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Uric Acid Nephrolithiasis

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81. The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel Full Text available with Trip Pro

The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel 20750534 2011 03 29 2011 03 29 0007-1447 1 1159 1883 Mar 17 British medical journal Br Med J The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel. 495-7 Garrod A B AB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1883 3 17 0 0 1883 3 17 0 1 ppublish 20750534 PMC2372225

1883 British medical journal

82. The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel Full Text available with Trip Pro

The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel 20750542 2011 03 29 2011 03 29 0007-1447 1 1160 1883 Mar 24 British medical journal Br Med J The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel. 547-9 Garrod A B AB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1883 3 24 0 0 1883 3 24 0 1 ppublish 20750542 PMC2372237

1883 British medical journal

83. The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel Full Text available with Trip Pro

The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel 20750553 2011 03 29 2011 03 29 0007-1447 1 1161 1883 Mar 31 British medical journal Br Med J The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel. 601-3 Garrod A B AB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1883 3 31 0 0 1883 3 31 0 1 ppublish 20750553 PMC2372270

1883 British medical journal

84. The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel Full Text available with Trip Pro

The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel 20750571 2011 03 29 2011 03 29 0007-1447 1 1163 1883 Apr 14 British medical journal Br Med J The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel. 704-7 Garrod A B AB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1883 4 14 0 0 1883 4 14 0 1 ppublish 20750571 PMC2372354

1883 British medical journal

85. The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel Full Text available with Trip Pro

The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel 20750578 2011 03 29 2011 03 29 0007-1447 1 1164 1883 Apr 21 British medical journal Br Med J The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel. 751-3 Garrod A B AB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1883 4 21 0 0 1883 4 21 0 1 ppublish 20750578 PMC2372399

1883 British medical journal

86. The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel Full Text available with Trip Pro

The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel 20750562 2011 03 29 2011 03 29 0007-1447 1 1162 1883 Apr 07 British medical journal Br Med J The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel. 651-3 Garrod A B AB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1883 4 7 0 0 1883 4 7 0 1 ppublish 20750562 PMC2372306

1883 British medical journal

87. Effects of the association of potassium citrate and agropyrum repens in renal stone treatment: results of a prospective randomized comparison with potassium citrate. (Abstract)

Effects of the association of potassium citrate and agropyrum repens in renal stone treatment: results of a prospective randomized comparison with potassium citrate. To evaluate by a prospective randomized controlled study the efficacy of the association of potassium citrate and dry extract of couch grass (Agropyrum repens) (CalcoMEV) in renal stone treatment.50 patients with nephrolithiasis associated with one or more active metabolic alterations that constitute an indication to the use (...) ) and in the larger diameter of the stones (-3.6 +/- 0.9 mm vs. 0.0 +/- 0.8 mm), as well as a statistically significant reduction of uric acid urinary excretion (-164.7 +/- 45.3 vs -38 +/- 42 mg/24 h). No significant differences in the two groups were observed with respect to urinary citrate, oxalate and calcium urinary excretions and urinary pH.This prospective randomized study demonstrates the superiority of the association of potassium citrate and dry extract of couch grass, in combination with standard

2012 Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia Controlled trial quality: uncertain

88. NephMadness 2014 Part 6 - Kidney Stone Bracket

NephMadness 2014 Part 6 - Kidney Stone Bracket Renal Fellow Network: NephMadness 2014 Part 6 - Kidney Stone Bracket | | | | | Sunday, March 23, 2014 NephMadness 2014 Part 6 - Kidney Stone Bracket In the kidney stone bracket I think the most disappointed team must be XO inhibitors. Allopurinol has been around for a long time and is one of the mainstays of treatment for gout. More recently, febuxostat hit the scene and can also lower uric acid. The most interesting issue relating to uric acid (...) (for me) is the evidence linking elevated uric acid with risk of developing CKD. This idea is backed by experiments in rats. Raising the uric acid level in rats can induce glomerular hypertension and renal disease as noted by the development of arteriolosclerosis, glomerular injury and tubulointerstitial fibrosis. Some pilot studies in human suggest that lowering uric acid levels can slow the progression of renal disease. If these findings are significant large RCTs, the old man Allopurinol

2014 Renal Fellow Network

89. Uric Acid

is a metabolic-by-product of purine catabolism Uricase converts Uric Acid to allantoin in most mammals, but is dysfunctional in humans Uric Acid varies considerably with purine and intake, as well as III. Interpretation: Normal Uric Acid: 2-7 mg/dl IV. Interpretation: Increased (Hyperuricemia) See V. Interpretation: Decreased Medications High dose ASA s Renal tubule disease ( ) disease Protein or purine deficient diet Xanthine-oxidase deficiency Images: Related links to external sites (from Bing (...) Uric Acid Uric Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Uric Acid Uric Acid Aka: Uric Acid II. Physiology Uric Acid

2018 FP Notebook

90. Evaluation of the chemical composition of nephrolithiasis using dual-energy CT in Southern Chinese gout patients. Full Text available with Trip Pro

Evaluation of the chemical composition of nephrolithiasis using dual-energy CT in Southern Chinese gout patients. A study to evaluate the prevalence of uric acid (UA) nephrolithiasis with dual-energy CT (DECT) and explore the risk factors for kidney stones in primary gout patients.Eighty-four consecutive gout patients underwent urinary tract ultrasonography or DECT to confirm the existence of kidney stones. Urine and blood samples were also taken for laboratory analysis.Forty-one subjects (48.8 (...) %) had nephrolithiasis diagnosed; 38 had a kidney stone. Thirty-two of the 38 patients underwent a DECT scan, and 27 patients had nephrolithiasis in DECT. Among them, 63.0% (17/27) and 14.8% (4/21) of the patients had pure UA and UA-based mixed stone, respectively, and 22.2% (6/27) had a non-UA stone. Those with nephrolithiasis suffered from more frequent acute attacks and had longer disease durations of gout. At least one urine biochemical abnormality was found in 81% of patients. Forty-four (55.0

2019 BMC Nephrology

91. Renal Stones and Their Medical Management Full Text available with Trip Pro

Renal Stones and Their Medical Management Renal stones are common; in North America calcific stones far exceed uric acid and cystine stones in number. Patients with recurrent, complicated, or bilateral stones merit thoughtful investigation which should take into account what is known about the causes of stone.This review gives an outline of investigation and therapy for cystine and uric acid stones on the assumption that they can be dissolved and recurrences prevented. The challenge of calcific (...) stones is faced and the use of thiazide and allopurinol is discussed as a potentially useful approach to treatment.

1978 Canadian Family Physician

92. Complete deficiency of adenine phosphoribosyltransferase: a third case presenting as renal stones in a young child. Full Text available with Trip Pro

Complete deficiency of adenine phosphoribosyltransferase: a third case presenting as renal stones in a young child. We report a third case of 2, 8-dihydroxyadenine stones in a child with a complete lack of the adenine salvage enzyme--adenine phosphoribosyltransferase (APRT). The propositus, a 20-month-old girl of consanguineous Arab parents, presented with multiple urinary tract infections and supposed 'uric acid' stones in the right renal pelvis and left ureter. Both parents and one brother (...) were heterzygotes for the defect, in keeping with an autosomal recessive mode of inheritance. In contrast with the other purine salvage enzyme disorder of childhood with true uric acid stones (the Lesch-Nyhan syndrome), uric acid excretion was normal in all family members. As in our previous case, treatment with allopurinol, without alkali, has eliminated the urinary excretion of 2, 8-dihydroxyadenine: the stones were removed surgically. 2, 8-Dihydroxyadenine should be considered in any child

1979 Archives of Disease in Childhood

93. Uric Acid Nephrolithiasis

Acid Nephrolithiasis Aka: Uric Acid Nephrolithiasis , Urate Stones , Hyperuricosuria , Uric Acid Calculi From Related Chapters II. Epidemiology Represents 10% of s III. Evaluation See IV. Types Pure Uric Acid Calculi Mixed calcium and Uric Acid Calculi V. Causes Primary cause Acidic urine (pH <5.5) Other causes (confers 2 fold risk of calculi) Excessive dietary purine intake (meats) End Ileostomy Results in impaired ammonia and citrate excretion Results in lower pH and increased urinary ammonia (...) Increased crystallization VI. Labs AM spot urine for and Crystaluria stones form in acidic urine VII. Imaging Non-contrast XRay Pure Uric Acid Calculi are radiolucent May be visualized if mixed calcium and VIII. Management: Prevention of Uric Acid stone recurrence ral Restrict dietary intake of and protein Maintain : over 2.5 liters per day Alkalinize urine (especially if is low, acidic) Maintain >5.5 (6.5 - 7.0 preferred) Citrate 10-20 mEq orally three times daily with meals 500 mg, two tablets daily

2015 FP Notebook

94. Non-alcoholic fatty liver disease and the development of nephrolithiasis: A cohort study. Full Text available with Trip Pro

to the presence of NAFLD.During 1,054,887.6 person-year of follow-up, 16,442 participants developed nephrolithiasis. After adjusting for age, center, year of screening exam, smoking status, alcohol intake, physical activity, education level, body mass index, history of hypertension and diabetes, HOMA-IR, uric acid and C-reactive protein, male participants with NAFLD had a significantly increased risk of nephrolithiasis than those without NAFLD (adjusted HR 1.17, 95% CI 1.06-1.30). However, no association (...) Non-alcoholic fatty liver disease and the development of nephrolithiasis: A cohort study. Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation or precursor of metabolic syndrome, may increase nephrolithiasis, a renal manifestation of insulin resistance, but the prospective association between NAFLD and incident nephrolithiasis has not been evaluated. We examined the association of NAFLD with the development of nephrolithiasis in a large cohort of Korean men and women.We performed

2017 PLoS ONE

95. Comparison of potential dietary and urinary risk factors for ammonium urate nephrolithiasis in two bottlenose dolphin (Tursiops truncatus) populations. Full Text available with Trip Pro

biomarkers after a large meal. Urinary biomarkers and nephrolithiasis presence were assessed opportunistically in 15 long-term resident free-ranging dolphins living in Sarasota Bay, Florida. Additionally, the total purine contents of fish commonly consumed by each dolphin population were measured to evaluate potential dietary risk factors. Populations were compared for total dietary purine composition, recently fed status, nephrolithiasis presence, and differences in urinary biochemical, acid-base (...) , and physicochemical parameters via Wilcoxon rank sum analysis and least square means. Managed dolphins had higher urinary pH and ammonium ([Formula: see text]) in both pre- and postprandial conditions and higher urinary uric acid and saturation indices of NH4U in the postprandial condition compared with free-ranging dolphins ( Pā€‰< 0.05). The purine content was greater ( Pā€‰< 0.0001) in the diet consumed by managed dolphins [7 mmol/Mcal metabolizable energy (ME)] than in the free-ranging dolphin diet (4 mmol/Mcal

2018 American Journal of Physiology. Renal physiology

96. Kidney Stones - What's the diagnosis? - Answer

. The treatment in this case is to increase fluids and treat with a combination of sodium and potassium citrate. Even a small rise in urine pH would significantly reduce the risk of uric acid stones while the citrate and increased volume should reduce the calcium oxalate stone risk. Posted by Gearoid McMahon at Labels: , , No comments: Subscribe to: Interested in Contributing to the Renal Fellow Network? Email Matt or Gearoid NSMC Founding Member Get notified of new RFN posts by email Partner A nice (...) Kidney Stones - What's the diagnosis? - Answer Renal Fellow Network: Kidney Stones - What's the diagnosis? - Answer | | | | | Friday, July 19, 2013 Kidney Stones - What's the diagnosis? - Answer This was an interesting case and all those who responded correctly identified that the patient had bowel pathology. However, only one person figured out that the issue was an ileostomy. This patient had a low urine volume and an extremely low urinary citrate and sodium. The low citrate could indicated

2013 Renal Fellow Network

97. Kidney Stones - What's the diagnosis?

Kidney Stones - What's the diagnosis? Renal Fellow Network: Kidney Stones - What's the diagnosis? | | | | | Friday, July 12, 2013 Kidney Stones - What's the diagnosis? A 65yo man was reviewed in the clinic for assessment of kidney stones. He has a history of stones for at least 8 years and has been passing small calculi on a regular basis for the last few months. His 24 hour urine results are shown below (results are 24 hour total values unless otherwise specified): Volume, Liters 0.71 Sodium (...) , mmol/day 7 Supersaturation Calcium Oxalate 10.11 Potassium, mmol/day 45 Calcium, mg/day 78 Magnesium, mg/day 52 Oxalate, mg/day 28 Phosphate, mg/day 0.76 Citrate, mg/day 11 NH4, mmol/day 68 Supersaturation Calcium Phosphate 0.71 Chloride, mmol/day 48 Urine pH 5.6 Sulphate, mEq/day 39 Supersaturation Uric Acid 2.71 Urea Nitrogen, g/day 11 Uric Acid, mg/day 0.499 Protein Catabolic Rate 1.2 Creatinine 1292 He has a high risk for calcium oxalate and uric acid stones. His urine citrate and sodium

2013 Renal Fellow Network

98. Dietary and Pharmacologic Management to Prevent Recurrent Nephrolithiasis in Adults Full Text available with Trip Pro

that inhibit stone formation is low. Approximately 80% of adults with kidney stones have stones consisting primarily of calcium oxalate, calcium phosphate, or both. Other stones consist of struvite, uric acid, or cystine. The lifetime prevalence of nephrolithiasis is 13% for men and 7% for women ( ), with a 5-year recurrence rate after an initial event of 35% to 50% without treatment ( ). Stones are caused by an interaction between genetics and environmental exposure ( ). Efforts to prevent the recurrence (...) , Jungers P. Type 2 diabetes increases the risk for uric acid stones. J Am Soc Nephrol(2006)17(7):2026-33. 4) Bell DS. Beware the low urine pH--the major cause of the increased prevalence of nephrolithiasis in the patient with type 2 diabetes. Diabetes Obes Metab(2012)14(4):299-303. Amy E. Krambeck, John C. Lieske Mayo Clinic December 2, 2014 Comment We read with interest the recent Clinical Practice guidelines from the American College of Physicians (ACP) for the Prevention of Kidney Stones in Adults

2014 American College of Physicians

99. Recurrent nephrolithiasis in adults: comparative effectiveness of preventive medical strategies

recurrent kidney stones, and whether stone composition and pre- and post-treatment biochemistries predict treatment efficacy. Authors' conclusions Increased fluid intake, reduced soft drink consumption, thiazide diuretics, citrate pharmacotherapy, and allopurinol reduce risk of recurrent calcium stones. Effects of other dietary interventions appear mixed. We identified no RCTs for uric acid or cystine stones. Data regarding whether baseline or followup biochemistries predict treatment efficacy (...) Recurrent nephrolithiasis in adults: comparative effectiveness of preventive medical strategies Recurrent nephrolithiasis in adults: comparative effectiveness of preventive medical strategies Recurrent nephrolithiasis in adults: comparative effectiveness of preventive medical strategies Fink HA, Wilt TJ, Eidman KE, Garimella PS, MacDonald R, Rutks IR, Brasure M, Kane RL, Monga M Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA

2012 Health Technology Assessment (HTA) Database.

100. Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia. Full Text available with Trip Pro

Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia. Spontaneous tumor lysis syndrome is a rare initial presentation of hematologic malignancy in children that typically presents with complications of electrolyte derangement, specifically hyperkalemia, hyperphosphatemia, and hyperuricemia. We report a case of a 5-year-old boy who presented to the emergency department with gross hematuria, abdominal pain, and vomiting and was ultimately diagnosed with uric acid (...) nephrolithiasis and acute renal failure secondary to spontaneous tumor lysis syndrome in the setting of T-cell acute lymphoblastic leukemia. Tumor lysis syndrome is considered an oncologic emergency, and in this case, the child required urgent treatment with potassium-binding agents, rasburicase, and hemodialysis. This case demonstrates that occult hematologic malignancy should be suspected in cases of nephrolithiasis and acute renal failure when found in conjunction with hyperuricemia despite a normal

2015 Pediatrics

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