How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

851 results for

Uric Acid Nephrolithiasis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

81. Fucoidan elevates surface organic cation transporter 2 expression via upregulation of protein kinase A in uric acid nephropathy Full Text available with Trip Pro

Fucoidan elevates surface organic cation transporter 2 expression via upregulation of protein kinase A in uric acid nephropathy Uric acid nephropathy (UAN) is caused by excessive uric acid, and is a key risk factor for uric acid nephrolithiasis, gouty arthritis, renal diseases and cardiovascular diseases. The present study aimed to evaluate the protective effect of fucoidan, a sulfated polysaccharide component of brown algae, on UAN and to elucidate the underlying molecular mechanism. A rat (...) in the fucoidan treatment group. Periodic acid methenamine silver-Masson staining was performed and the results indicated that renal interstitial fibrosis was reduced among renal tissues from the fucoidan treatment group compared with the model group. Terminal deoxynucleotidyl-transferase-mediated dUTP nick end labelling staining revealed a lower proportion of apoptotic nuclei in the kidneys of the fucoidan treatment group compared with the model group. Protein kinase A (PKA) 2β and phosphorylated PKA 2β

2017 Experimental and therapeutic medicine

82. Epidemiology, pathophysiology, and management of uric acid urolithiasis: A narrative review Full Text available with Trip Pro

Epidemiology, pathophysiology, and management of uric acid urolithiasis: A narrative review An in-depth comprehension of the epidemiology as well as pathophysiology of uric acid urolithiasis is important for the identification, treatment, and prophylaxis of calculi in these patients. Persistently low urinary pH, hyperuricosuria, and low urinary volume are the most important factors in pathogenesis of uric acid urolithiasis. Other various causes of calculus formation comprises of chronic (...) diarrhea, renal hyperuricosuria, insulin resistance, primary gout, extra purine in the diet, neoplastic syndromes, and congenital hyperuricemia. Non-contrast-enhanced computed tomography is the radiologic modality of choice for early assessment of patients with renal colic. Excluding situations where there is acute obstruction, rising blood chemistry, severe infection, or unresolved pain, the initial management ought to be medical dissolution by oral chemolysis since this method has proved

2017 Journal of advanced research

83. Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level

Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03211403 Recruitment Status : Completed First Posted : July 7, 2017 Last Update Posted : March 21, 2018 Sponsor: Atridia Pty Ltd. Information provided

2017 Clinical Trials

84. Effects of the association of potassium citrate and agropyrum repens in renal stone treatment: results of a prospective randomized comparison with potassium citrate. (Abstract)

Effects of the association of potassium citrate and agropyrum repens in renal stone treatment: results of a prospective randomized comparison with potassium citrate. To evaluate by a prospective randomized controlled study the efficacy of the association of potassium citrate and dry extract of couch grass (Agropyrum repens) (CalcoMEV) in renal stone treatment.50 patients with nephrolithiasis associated with one or more active metabolic alterations that constitute an indication to the use (...) ) and in the larger diameter of the stones (-3.6 +/- 0.9 mm vs. 0.0 +/- 0.8 mm), as well as a statistically significant reduction of uric acid urinary excretion (-164.7 +/- 45.3 vs -38 +/- 42 mg/24 h). No significant differences in the two groups were observed with respect to urinary citrate, oxalate and calcium urinary excretions and urinary pH.This prospective randomized study demonstrates the superiority of the association of potassium citrate and dry extract of couch grass, in combination with standard

2012 Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia Controlled trial quality: uncertain

85. NephMadness 2014 Part 6 - Kidney Stone Bracket

NephMadness 2014 Part 6 - Kidney Stone Bracket Renal Fellow Network: NephMadness 2014 Part 6 - Kidney Stone Bracket | | | | | Sunday, March 23, 2014 NephMadness 2014 Part 6 - Kidney Stone Bracket In the kidney stone bracket I think the most disappointed team must be XO inhibitors. Allopurinol has been around for a long time and is one of the mainstays of treatment for gout. More recently, febuxostat hit the scene and can also lower uric acid. The most interesting issue relating to uric acid (...) (for me) is the evidence linking elevated uric acid with risk of developing CKD. This idea is backed by experiments in rats. Raising the uric acid level in rats can induce glomerular hypertension and renal disease as noted by the development of arteriolosclerosis, glomerular injury and tubulointerstitial fibrosis. Some pilot studies in human suggest that lowering uric acid levels can slow the progression of renal disease. If these findings are significant large RCTs, the old man Allopurinol

2014 Renal Fellow Network

86. Evaluation of the chemical composition of nephrolithiasis using dual-energy CT in Southern Chinese gout patients. Full Text available with Trip Pro

Evaluation of the chemical composition of nephrolithiasis using dual-energy CT in Southern Chinese gout patients. A study to evaluate the prevalence of uric acid (UA) nephrolithiasis with dual-energy CT (DECT) and explore the risk factors for kidney stones in primary gout patients.Eighty-four consecutive gout patients underwent urinary tract ultrasonography or DECT to confirm the existence of kidney stones. Urine and blood samples were also taken for laboratory analysis.Forty-one subjects (48.8 (...) %) had nephrolithiasis diagnosed; 38 had a kidney stone. Thirty-two of the 38 patients underwent a DECT scan, and 27 patients had nephrolithiasis in DECT. Among them, 63.0% (17/27) and 14.8% (4/21) of the patients had pure UA and UA-based mixed stone, respectively, and 22.2% (6/27) had a non-UA stone. Those with nephrolithiasis suffered from more frequent acute attacks and had longer disease durations of gout. At least one urine biochemical abnormality was found in 81% of patients. Forty-four (55.0

2019 BMC Nephrology

87. Uric Acid

is a metabolic-by-product of purine catabolism Uricase converts Uric Acid to allantoin in most mammals, but is dysfunctional in humans Uric Acid varies considerably with purine and intake, as well as III. Interpretation: Normal Uric Acid: 2-7 mg/dl IV. Interpretation: Increased (Hyperuricemia) See V. Interpretation: Decreased Medications High dose ASA s Renal tubule disease ( ) disease Protein or purine deficient diet Xanthine-oxidase deficiency Images: Related links to external sites (from Bing (...) Uric Acid Uric Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Uric Acid Uric Acid Aka: Uric Acid II. Physiology Uric Acid

2018 FP Notebook

88. Renal Stones and Their Medical Management Full Text available with Trip Pro

Renal Stones and Their Medical Management Renal stones are common; in North America calcific stones far exceed uric acid and cystine stones in number. Patients with recurrent, complicated, or bilateral stones merit thoughtful investigation which should take into account what is known about the causes of stone.This review gives an outline of investigation and therapy for cystine and uric acid stones on the assumption that they can be dissolved and recurrences prevented. The challenge of calcific (...) stones is faced and the use of thiazide and allopurinol is discussed as a potentially useful approach to treatment.

1978 Canadian Family Physician

89. Complete deficiency of adenine phosphoribosyltransferase: a third case presenting as renal stones in a young child. Full Text available with Trip Pro

Complete deficiency of adenine phosphoribosyltransferase: a third case presenting as renal stones in a young child. We report a third case of 2, 8-dihydroxyadenine stones in a child with a complete lack of the adenine salvage enzyme--adenine phosphoribosyltransferase (APRT). The propositus, a 20-month-old girl of consanguineous Arab parents, presented with multiple urinary tract infections and supposed 'uric acid' stones in the right renal pelvis and left ureter. Both parents and one brother (...) were heterzygotes for the defect, in keeping with an autosomal recessive mode of inheritance. In contrast with the other purine salvage enzyme disorder of childhood with true uric acid stones (the Lesch-Nyhan syndrome), uric acid excretion was normal in all family members. As in our previous case, treatment with allopurinol, without alkali, has eliminated the urinary excretion of 2, 8-dihydroxyadenine: the stones were removed surgically. 2, 8-Dihydroxyadenine should be considered in any child

1979 Archives of Disease in Childhood

90. Uric Acid Nephrolithiasis

Acid Nephrolithiasis Aka: Uric Acid Nephrolithiasis , Urate Stones , Hyperuricosuria , Uric Acid Calculi From Related Chapters II. Epidemiology Represents 10% of s III. Evaluation See IV. Types Pure Uric Acid Calculi Mixed calcium and Uric Acid Calculi V. Causes Primary cause Acidic urine (pH <5.5) Other causes (confers 2 fold risk of calculi) Excessive dietary purine intake (meats) End Ileostomy Results in impaired ammonia and citrate excretion Results in lower pH and increased urinary ammonia (...) Increased crystallization VI. Labs AM spot urine for and Crystaluria stones form in acidic urine VII. Imaging Non-contrast XRay Pure Uric Acid Calculi are radiolucent May be visualized if mixed calcium and VIII. Management: Prevention of Uric Acid stone recurrence ral Restrict dietary intake of and protein Maintain : over 2.5 liters per day Alkalinize urine (especially if is low, acidic) Maintain >5.5 (6.5 - 7.0 preferred) Citrate 10-20 mEq orally three times daily with meals 500 mg, two tablets daily

2015 FP Notebook

91. Non-alcoholic fatty liver disease and the development of nephrolithiasis: A cohort study. Full Text available with Trip Pro

to the presence of NAFLD.During 1,054,887.6 person-year of follow-up, 16,442 participants developed nephrolithiasis. After adjusting for age, center, year of screening exam, smoking status, alcohol intake, physical activity, education level, body mass index, history of hypertension and diabetes, HOMA-IR, uric acid and C-reactive protein, male participants with NAFLD had a significantly increased risk of nephrolithiasis than those without NAFLD (adjusted HR 1.17, 95% CI 1.06-1.30). However, no association (...) Non-alcoholic fatty liver disease and the development of nephrolithiasis: A cohort study. Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation or precursor of metabolic syndrome, may increase nephrolithiasis, a renal manifestation of insulin resistance, but the prospective association between NAFLD and incident nephrolithiasis has not been evaluated. We examined the association of NAFLD with the development of nephrolithiasis in a large cohort of Korean men and women.We performed

2017 PLoS ONE

92. Comparison of potential dietary and urinary risk factors for ammonium urate nephrolithiasis in two bottlenose dolphin (Tursiops truncatus) populations. Full Text available with Trip Pro

biomarkers after a large meal. Urinary biomarkers and nephrolithiasis presence were assessed opportunistically in 15 long-term resident free-ranging dolphins living in Sarasota Bay, Florida. Additionally, the total purine contents of fish commonly consumed by each dolphin population were measured to evaluate potential dietary risk factors. Populations were compared for total dietary purine composition, recently fed status, nephrolithiasis presence, and differences in urinary biochemical, acid-base (...) , and physicochemical parameters via Wilcoxon rank sum analysis and least square means. Managed dolphins had higher urinary pH and ammonium ([Formula: see text]) in both pre- and postprandial conditions and higher urinary uric acid and saturation indices of NH4U in the postprandial condition compared with free-ranging dolphins ( P < 0.05). The purine content was greater ( P < 0.0001) in the diet consumed by managed dolphins [7 mmol/Mcal metabolizable energy (ME)] than in the free-ranging dolphin diet (4 mmol/Mcal

2018 American Journal of Physiology. Renal physiology

93. Dietary and Pharmacologic Management to Prevent Recurrent Nephrolithiasis in Adults Full Text available with Trip Pro

that inhibit stone formation is low. Approximately 80% of adults with kidney stones have stones consisting primarily of calcium oxalate, calcium phosphate, or both. Other stones consist of struvite, uric acid, or cystine. The lifetime prevalence of nephrolithiasis is 13% for men and 7% for women ( ), with a 5-year recurrence rate after an initial event of 35% to 50% without treatment ( ). Stones are caused by an interaction between genetics and environmental exposure ( ). Efforts to prevent the recurrence (...) , Jungers P. Type 2 diabetes increases the risk for uric acid stones. J Am Soc Nephrol(2006)17(7):2026-33. 4) Bell DS. Beware the low urine pH--the major cause of the increased prevalence of nephrolithiasis in the patient with type 2 diabetes. Diabetes Obes Metab(2012)14(4):299-303. Amy E. Krambeck, John C. Lieske Mayo Clinic December 2, 2014 Comment We read with interest the recent Clinical Practice guidelines from the American College of Physicians (ACP) for the Prevention of Kidney Stones in Adults

2014 American College of Physicians

94. Kidney Stones - What's the diagnosis? - Answer

. The treatment in this case is to increase fluids and treat with a combination of sodium and potassium citrate. Even a small rise in urine pH would significantly reduce the risk of uric acid stones while the citrate and increased volume should reduce the calcium oxalate stone risk. Posted by Gearoid McMahon at Labels: , , No comments: Subscribe to: Interested in Contributing to the Renal Fellow Network? Email Matt or Gearoid NSMC Founding Member Get notified of new RFN posts by email Partner A nice (...) Kidney Stones - What's the diagnosis? - Answer Renal Fellow Network: Kidney Stones - What's the diagnosis? - Answer | | | | | Friday, July 19, 2013 Kidney Stones - What's the diagnosis? - Answer This was an interesting case and all those who responded correctly identified that the patient had bowel pathology. However, only one person figured out that the issue was an ileostomy. This patient had a low urine volume and an extremely low urinary citrate and sodium. The low citrate could indicated

2013 Renal Fellow Network

95. Kidney Stones - What's the diagnosis?

Kidney Stones - What's the diagnosis? Renal Fellow Network: Kidney Stones - What's the diagnosis? | | | | | Friday, July 12, 2013 Kidney Stones - What's the diagnosis? A 65yo man was reviewed in the clinic for assessment of kidney stones. He has a history of stones for at least 8 years and has been passing small calculi on a regular basis for the last few months. His 24 hour urine results are shown below (results are 24 hour total values unless otherwise specified): Volume, Liters 0.71 Sodium (...) , mmol/day 7 Supersaturation Calcium Oxalate 10.11 Potassium, mmol/day 45 Calcium, mg/day 78 Magnesium, mg/day 52 Oxalate, mg/day 28 Phosphate, mg/day 0.76 Citrate, mg/day 11 NH4, mmol/day 68 Supersaturation Calcium Phosphate 0.71 Chloride, mmol/day 48 Urine pH 5.6 Sulphate, mEq/day 39 Supersaturation Uric Acid 2.71 Urea Nitrogen, g/day 11 Uric Acid, mg/day 0.499 Protein Catabolic Rate 1.2 Creatinine 1292 He has a high risk for calcium oxalate and uric acid stones. His urine citrate and sodium

2013 Renal Fellow Network

96. Recurrent nephrolithiasis in adults: comparative effectiveness of preventive medical strategies

recurrent kidney stones, and whether stone composition and pre- and post-treatment biochemistries predict treatment efficacy. Authors' conclusions Increased fluid intake, reduced soft drink consumption, thiazide diuretics, citrate pharmacotherapy, and allopurinol reduce risk of recurrent calcium stones. Effects of other dietary interventions appear mixed. We identified no RCTs for uric acid or cystine stones. Data regarding whether baseline or followup biochemistries predict treatment efficacy (...) Recurrent nephrolithiasis in adults: comparative effectiveness of preventive medical strategies Recurrent nephrolithiasis in adults: comparative effectiveness of preventive medical strategies Recurrent nephrolithiasis in adults: comparative effectiveness of preventive medical strategies Fink HA, Wilt TJ, Eidman KE, Garimella PS, MacDonald R, Rutks IR, Brasure M, Kane RL, Monga M Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA

2012 Health Technology Assessment (HTA) Database.

97. Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia. Full Text available with Trip Pro

Renal Calculi: An Unusual Presentation of T-Cell Acute Lymphoblastic Leukemia. Spontaneous tumor lysis syndrome is a rare initial presentation of hematologic malignancy in children that typically presents with complications of electrolyte derangement, specifically hyperkalemia, hyperphosphatemia, and hyperuricemia. We report a case of a 5-year-old boy who presented to the emergency department with gross hematuria, abdominal pain, and vomiting and was ultimately diagnosed with uric acid (...) nephrolithiasis and acute renal failure secondary to spontaneous tumor lysis syndrome in the setting of T-cell acute lymphoblastic leukemia. Tumor lysis syndrome is considered an oncologic emergency, and in this case, the child required urgent treatment with potassium-binding agents, rasburicase, and hemodialysis. This case demonstrates that occult hematologic malignancy should be suspected in cases of nephrolithiasis and acute renal failure when found in conjunction with hyperuricemia despite a normal

2015 Pediatrics

98. Multiple Sclerosis and Nephrolithiasis: A Matched Case Comparative Study. Full Text available with Trip Pro

Multiple Sclerosis and Nephrolithiasis: A Matched Case Comparative Study. To compare stone composition and serum/urine biochemistries in stone formers with multiple sclerosis (MS) against stone formers without MS and to examine the association between mobility, methods of bladder emptying, and stone formation.In this retrospective case-control study, we identified patients diagnosed with MS and kidney stone disease who were seen at our institution between 2001 and 2016. For the first part (...) nephrolithotomy (PCNL; 25% vs 12%, P = 0.005) or a cystolithopaxy (16% vs 3%, P < 0.001) compared to their matched controls. In all, 61 patients had a complete 24-h urinary stone panel. There were no significant differences in urinary pH, volume, creatinine, calcium, citrate, oxalate, sodium, and uric acid as well as rates of hypocitraturia, hyperoxaluria, hypercalciuria, and hyperuricosuria among patients with MS. Use of intermittent straight catheterisation [ISC; odds ratio (OR) 3.50, 95% confidence

2017 BJU international

99. Association Between Sonographically Diagnosed Nephrolithiasis and Subclinical Coronary Artery Calcification in Adults. (Abstract)

of screening examination, physical activity, alcohol intake, smoking status, education level, body mass index, family history of cardiovascular disease, total energy intake, glucose concentration, systolic blood pressure, triglyceride concentration, high-density lipoprotein cholesterol concentration, uric acid concentration, and estimated glomerular filtration rate, the CAC score ratio was attenuated, but remained significant (CAC score ratio, 1.31; 95% CI, 1.00-1.71).Computed tomographic diagnosis (...) of nephrolithiasis was unavailable.Nephrolithiasis was associated with the presence of CAC in adults without known coronary heart disease, supporting the hypothesis that these 2 health conditions share a common pathophysiology.Copyright © 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

2017 American Journal of Kidney Diseases

100. Nephrolithiasis as a common urinary system manifestation of inflammatory bowel diseases; a clinical review and meta-analysis. Full Text available with Trip Pro

and nephrolithiasis or renal/kidney stones have been suggested to be a common manifestation of disease in forms of uric acid, calcium phosphate or calcium oxalate. We performed a meta-analysis on five clinical trials and reported that correlation between IBD and formation of stone in renal system is positive and significant (Fix-effect model; CI: 95%, P <0.001, and randomeffect model; CI: 95%, P = 0.03).Based on the reports of the clinical trials, calcium oxalate is more prevalent in Crohn's disease (CD) than (...) Nephrolithiasis as a common urinary system manifestation of inflammatory bowel diseases; a clinical review and meta-analysis. The extra-intestinal manifestations of inflammatory bowel disease (IBD) are common and involve other organs or systems for example; urinary system.For this review, we used a variety of sources by searching through Web of Science, PubMed, EMBASE, Scopus and directory of open access journals (DOAJ).Urinary complications may occur in up to 22% of patients

2017 Journal of nephropathology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>