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Uric Acid Nephrolithiasis

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61. Evaluating the Effect of ALLN-177 to Reduce Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria

or hypothyroidism Obstructive uropathy, chronic urosepsis, renal failure, renal tubular acidosis, primary hyperparathyroidism, primary hyperoxaluria, pure uric acid and cystine stones, and/or medullary sponge kidney. Auto-immune disorder requiring high dose steroids or other immunosuppressant drugs. Subjects who are pregnant. Women of childbearing potential must have a negative pregnancy test prior to enrollment and must practice approved methods of birth control during the trial History of cancer diagnosis (...) procedures History of enteric or idiopathic hyperoxaluria and at least one calcium oxalate kidney stone Hyperoxaluria >36mg of oxalate/24-hr May be taking drugs for the prevention of stone disease as long as there have been no changes in these medications for at least 3 months Exclusion Criteria: Uric acid ≥1.5g/24-hr Estimated glomerular filtration rate of < 60 mL/min Positive results from drug urine screen Requires daily vitamin C (defined as >10 days of >300 mg/day) Diagnosis of hypercalcemia

2014 Clinical Trials

62. Animal protein and the risk of kidney stones: a comparative metabolic study of animal protein sources. (Abstract)

), although the difference attained significance only compared to chicken (1.67, p = 0.02) but not to fish (1.79, p = 0.08).Consuming animal protein is associated with increased serum and urine uric acid in healthy individuals. The higher purine content of fish compared to beef or chicken is reflected in higher 24-hour urinary uric acid. However, as reflected in the saturation index, the stone forming propensity is marginally higher for beef compared to fish or chicken. Stone formers should be advised (...) Animal protein and the risk of kidney stones: a comparative metabolic study of animal protein sources. We compared the effect of 3 animal protein sources on urinary stone risk.A total of 15 healthy subjects completed a 3-phase randomized, crossover metabolic study. During each 1-week phase subjects consumed a standard metabolic diet containing beef, chicken or fish. Serum chemistry and 24-hour urine samples collected at the end of each phase were compared using mixed model repeated measures

2014 Journal of Urology Controlled trial quality: uncertain

63. Effect of being overweight on urinary metabolic risk factors for kidney stone formation. Full Text available with Trip Pro

into three categories: BMI ≤25.0 kg/m(2) (NW group), BMI 25-30 kg/m(2) (OW group) and BMI >30.0 kg/m(2) (obese group). Twenty-four hour urinary volume (U.Vol), pH (U.pH), calcium (U.Ca), oxalate (U.Ox), citrate (U.Cit), uric acid (U.UA), magnesium (U.Mg), sodium (U.Na) and potassium (U.K) excretions, along with stone composition and Psf, were then compared among the groups.A total of 2132 patients were studied, of whom 833 (39%) were NW, 863 (40.5%) were OW and 436 (20.5%) were obese. OW and obese KSF (...) ; P < 0.001 for trend), and lower U.pH (6.3 ± 0.5 versus 6.1 ± 0.5 versus 6.0 ± 0.6; P < 0.001 for trend) by both crude and multivariate adjusted analysis models were demonstrated in OW and obese KSF. Stone composition data (N = 640) showed a significantly higher incidence of uric acid stones in OW and obese groups (P for trend < 0.001). In addition, higher Psf for CaOx, UA and CaOx/UA stone types were detected in OW and obese compared with NW KSF.Similar to obese KSF, OW KSF show clear

2014 Transplantation

64. Inosine 5'-Monophosphate to Raise of Serum Uric Acid Level in Patients With Multiple System Atrophy: a Multi-center, Randomized Controlled, Double Blind, Parallel Assigned Clinical Trial

to week 24. Laboratory tests including serum uric acid level, urine analysis, and stone analysis are scheduled to be checked at time of week 2, 4, 6, 12, 18, and 24, respectively. A maximum limit of elevated serum uric acid level is 9 mg/dL, and thus reducing dose of administration may be considered in case of exceeding the limited level. Comparison of the extent of altered serum uric acid level, safety, and tolerability from baseline to week 24 will be analyzed after study termination. Study Design (...) any findings compatible to multiple system atrophy, such as cerebellar or putaminal atrophy, putaminal hyperintense rim or iron accumulation, hot cross bun sign or T2 high signal intensities on middle cerebellar peduncle, and decreased glucose metabolism on putamen or cerebellum. Total score of unified multiple system atrophy rating scale 30 or more at baseline screening. Serum uric acid level ≤ 6.0 mg/dL at baseline screening. Exclusion Criteria: Prior history of gout, nephrolithiasis, stroke

2018 Clinical Trials

65. Study of the Crystallization Inhibition Capacity of the Uric Acid in Urine in a Group of Lithiasic Patients After Intake of a Food Supplement

that uric stones account for between 10 and 15% of all cases and especially affects men over 50 years, while mixed lithiasis of calcium oxalate monohydrate and uric acid affects a 2.5% of all cases. Lithiasis generated by uric acid is a highly recurrent pathology, even repeating itself several times during the year, and is related to other pathologies such as diabetes and obesity. It is evident that the medical problem that lithiasis originates should not be treated only by eliminating the calculus (...) the development of stones of another composition (eg, Phosphate), which are much more difficult to treat. There are natural substances, such as theobromine (natural component of cocoa) that has been found to have the ability to inhibit the formation of uric acid crystals: this substance has been tested in laboratory experiments and therefore would be useful to prevent the formation of uric acid stones and / or mixed calcium oxalate monohydrate / uric acid stones. Theobromine corresponds to a phytocomponent

2018 Clinical Trials

66. Study of the Effects of the Consumption of Different Products Cocoa Derivatives at the Risk of Crystallization of Uric Acid in Urine of Volunteers.

. The "healing" of renal lithiasis inevitably goes through the elimination of the alterations related to the genesis of kidney calculus. It the case of uric acid lithiasis the most important are having urinary pH less than 5.5 and an elevated uricosuria, which can be corrected relatively easy by undergoing changes in dietary habits, and with pharmacological treatment with citrate -which produces and increase in pH- or with inhibitors of the xantino-oxidase as allopurinol. However, among the prophylactic (...) . ClinicalTrials.gov Identifier: NCT03512600 Recruitment Status : Completed First Posted : May 1, 2018 Last Update Posted : June 13, 2018 Sponsor: Devicare S.L. Information provided by (Responsible Party): Devicare S.L. Study Details Study Description Go to Brief Summary: The present study aims to assess the effectiveness of theobromine, -product present in high proportion in the cacao-, to prevent the development of uric acid kidney stones. Condition or disease Intervention/treatment Phase Lithiasis, Urinary

2018 Clinical Trials

67. Uric Acid Metabolism Was Altered In Isolated Colonic Crohn's Disease But Not Ulcerative Colitis. Full Text available with Trip Pro

Uric Acid Metabolism Was Altered In Isolated Colonic Crohn's Disease But Not Ulcerative Colitis. Patients with inflammatory bowel disease (IBD) have higher incidence of developing nephrolithiasis. Increased uric acid production induced by Saccharomyces cerevisiae exacerbates colitis in mice. We aimed to evaluate the association between serum uric acid level and disease activity in IBD population.Four hundred and thirty-five patients enrolled in Jinling Hospital from January 1, 2015 to August 31 (...) , 2017 were included in the retrospective study. Clinical parameters were collected and compared with non-IBD matched controls (n = 51). Serum uric acid to creatinine ratio (UA/Cr) was used as a biomarker for uric acid metabolism. Sixty-five active IBD patients were longitudinally studied to investigate the UA/Cr before and after therapy. Linear mixed models were estimated for Crohn's disease (CD) group to explore the relationship between UA/Cr and other parameters.Uric acid to creatinine ratio

2018 Journal of gastroenterology and hepatology

68. Antiurolithiatic Effect of Sirupeelai Samoola Kudineer: A Polyherbal Siddha Decoction on Ethylene Glycol-induced Renal Calculus in Experimental Rats Full Text available with Trip Pro

the present study, anti-urolithiatic effect of SK was evaluated in Sprague-Dawley rats using ethylene glycol through drinking water and intraperitoneal injection of sodium oxalate. Renal damage was confirmed by the increased production of thiobarbituric acid reactive substance (TBARS).Co-treatment with SK to urolithiatic rats for 21 days significantly prevented the elevation of renal and urinary stone biomarkers in plasma and renal tissue thereby preventing renal damage and the formation of renal calculi (...) formation and validates its clinical use.SK exhibited antilithiatic and diuretic potential in ethylene glycol and sodium oxalate induced urolithiasis in ratsElevated urinary stone markers (Calcium, oxalate, uric acid, magnesium and phosphates) in plasma and renal tubular enzymes (LDH, GGT, ALP, AST ALT) in urolithiatic rats were reversed by SK treatmentSK administration significantly reduced the level of renal stress markers like Urea, Creatinine, LPO and elevated SOD, GPx, GSH levels aiding

2017 Pharmacognosy magazine

69. Antiurolithiasis Activity of Bioactivity Guided Fraction of Bergenia ligulata against Ethylene Glycol Induced Renal Calculi in Rat Full Text available with Trip Pro

of urolithiasis and the curative effects of mother extract and DCM fraction were checked for the level of oxalate, calcium, creatinine, uric acid, and urea of both urine and serum. Treatment with mother extract and DCM fraction at a dose of 185 mg/kg and 7 mg/kg, respectively, in ethylene glycol induced rats resulted in a significant (p < 0.05) decrease in serum and urine markers. Histological study revealed lower number of calcium oxalate deposits with minimum damage in the kidneys of mother extract and DCM (...) Antiurolithiasis Activity of Bioactivity Guided Fraction of Bergenia ligulata against Ethylene Glycol Induced Renal Calculi in Rat Dried rhizome of Bergenia ligulata (pashanbhed) is commonly used as a traditional herbal medicine with a wide range of therapeutic applications including urolithiasis. Aqueous extract of B. ligulata was prepared through maceration followed by decoction (mother extract, 35.9% w/w). Further, polarity based fractions were prepared successively from mother extract which

2017 BioMed research international

70. Association of Metabolic Syndrome Traits and Severity of Kidney Stones: Results From a Nationwide Survey on Urolithiasis in Japan. (Abstract)

, the presence of metabolic syndrome traits was associated with significantly increased odds of having hypercalciuria, hyperuricosuria, hyperoxaluria, and hypocitraturia after adjustment for age and sex.Cross-sectional design, absence of dietary data, ill-defined diagnostic criteria for metabolic syndrome traits, and missing data for the majority of participants.Metabolic syndrome trait clustering is associated with greater severity of kidney stone disease; increased urinary calcium, uric acid, and oxalate (...) Association of Metabolic Syndrome Traits and Severity of Kidney Stones: Results From a Nationwide Survey on Urolithiasis in Japan. Although metabolic syndrome and its individual components have been associated with kidney stone disease, whether the clustering of metabolic syndrome traits increases the severity of kidney stone disease has not been examined in a large-scale study.Cross-sectional analysis.Data were obtained from 30,448 patients enrolled in the 6th Nationwide Survey on Urolithiasis

2013 American Journal of Kidney Diseases

71. Dyslipidemia and kidney stone risk. (Abstract)

Dyslipidemia and kidney stone risk. We studied the impact of dyslipidemia on 24-hour urinalysis and stone composition.We retrospectively identified patients with nephrolithiasis who underwent 24-hour urinalysis and lipid profile evaluation within 3 months. Patients were divided into groups based on total cholesterol, high density lipoprotein, nonhigh density lipoprotein and triglycerides. The groups were compared based on demographic data, diabetes, hypertension and each component of 24-hour (...) and uric acid with lower pH, and those with high nonhigh density lipoprotein had higher urinary sodium and uric acid. Regarding stone composition, high total cholesterol and triglycerides were significantly associated with a higher uric acid stone rate (p = 0.006 and <0.001, respectively). Linear regression showed a significant association of nonhigh density lipoprotein with higher urinary sodium (p = 0.011) and uric acid (p <0.001) as well as triglycerides and higher uric acid (p = 0.017), and lower

2013 Journal of Urology

72. The Efficiency and Safety of Sodium Bicarbonate on Uric Acid in Patients With Asymptomatic Hyperuricemia or Gout

, niacin, aspirin, estrogen, losartan, amlodipine, reserpine, vitamin C,fenofibrate,atorvastatin, sulfonylureas,biguanides,NSAIDs; Disease which influence serum uric acid, such as cancer, lymphoma, and etc. Severe disorders involving heart, liver, kidneys, brain, lungs,digestive tract, rheumatoid disease, blood, endocrine, infection, and etc; Blood donation or excessive loss of blood over the last 3 month. Contacts and Locations Go to No Contacts or Locations Provided More Information Go to Layout (...) The Efficiency and Safety of Sodium Bicarbonate on Uric Acid in Patients With Asymptomatic Hyperuricemia or Gout The Efficiency and Safety of Sodium Bicarbonate on Uric Acid in Patients With Asymptomatic Hyperuricemia or Gout - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

73. Lowering Uric Acid in Live Kidney Donors

of the patients for the treatment and follow up must be obtained and documented according to ICH GCP, and national/local regulations. Exclusion Criteria: Adverse reactions to allopurinol or other xanthine oxidase inhibitors Use of uric acid lowering therapy within 3 months History of gout, xanthinuria or other indications for uric acid lowering therapy such as cancer chemotherapy History of renal calculi History of coronary heart disease Heart failure with left ventricular ejection fraction <45% History (...) Lowering Uric Acid in Live Kidney Donors Lowering Uric Acid in Live Kidney Donors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Lowering Uric Acid in Live Kidney Donors (AL-DON) The safety and scientific

2017 Clinical Trials

74. Uric acid, an important screening tool to detect inborn errors of metabolism: a case series Full Text available with Trip Pro

phosphoribosyltransferase enzyme level confirmed the diagnosis of Lesch-Nyhan syndrome. CASE 4: A 9-year-old boy was investigated for lower abdominal pain, gross haematuria and right renal calculus. Low uric acid level in serum and increased fractional excretion of uric acid pointed towards hereditary renal hypouricaemia which was confirmed by genetic studies.Abnormal uric acid level in blood and urine is a valuable tool in screening for clinical conditions related to derangement of the nucleic acid metabolic pathway. (...) for haematuria and a calculus in the bladder. Xanthine crystals were seen in microscopic examination of urine sediment. Low uric acid concentrations in serum and low urinary fractional excretion of uric acid associated with high urinary excretion of xanthine and hypoxanthine were compatible with xanthine oxidase deficiency. CASE 2: An 8-month-old boy presented with intractable seizures, feeding difficulties, screaming episodes, microcephaly, facial dysmorphism and severe neuro developmental delay. Low uric

2017 BMC research notes

75. Fucoidan elevates surface organic cation transporter 2 expression via upregulation of protein kinase A in uric acid nephropathy Full Text available with Trip Pro

Fucoidan elevates surface organic cation transporter 2 expression via upregulation of protein kinase A in uric acid nephropathy Uric acid nephropathy (UAN) is caused by excessive uric acid, and is a key risk factor for uric acid nephrolithiasis, gouty arthritis, renal diseases and cardiovascular diseases. The present study aimed to evaluate the protective effect of fucoidan, a sulfated polysaccharide component of brown algae, on UAN and to elucidate the underlying molecular mechanism. A rat (...) in the fucoidan treatment group. Periodic acid methenamine silver-Masson staining was performed and the results indicated that renal interstitial fibrosis was reduced among renal tissues from the fucoidan treatment group compared with the model group. Terminal deoxynucleotidyl-transferase-mediated dUTP nick end labelling staining revealed a lower proportion of apoptotic nuclei in the kidneys of the fucoidan treatment group compared with the model group. Protein kinase A (PKA) 2β and phosphorylated PKA 2β

2017 Experimental and therapeutic medicine

76. Epidemiology, pathophysiology, and management of uric acid urolithiasis: A narrative review Full Text available with Trip Pro

Epidemiology, pathophysiology, and management of uric acid urolithiasis: A narrative review An in-depth comprehension of the epidemiology as well as pathophysiology of uric acid urolithiasis is important for the identification, treatment, and prophylaxis of calculi in these patients. Persistently low urinary pH, hyperuricosuria, and low urinary volume are the most important factors in pathogenesis of uric acid urolithiasis. Other various causes of calculus formation comprises of chronic (...) diarrhea, renal hyperuricosuria, insulin resistance, primary gout, extra purine in the diet, neoplastic syndromes, and congenital hyperuricemia. Non-contrast-enhanced computed tomography is the radiologic modality of choice for early assessment of patients with renal colic. Excluding situations where there is acute obstruction, rising blood chemistry, severe infection, or unresolved pain, the initial management ought to be medical dissolution by oral chemolysis since this method has proved

2017 Journal of advanced research

77. Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level

Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03211403 Recruitment Status : Completed First Posted : July 7, 2017 Last Update Posted : March 21, 2018 Sponsor: Atridia Pty Ltd. Information provided

2017 Clinical Trials

78. The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel Full Text available with Trip Pro

The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel 20750534 2011 03 29 2011 03 29 0007-1447 1 1159 1883 Mar 17 British medical journal Br Med J The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel. 495-7 Garrod A B AB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1883 3 17 0 0 1883 3 17 0 1 ppublish 20750534 PMC2372225

1883 British medical journal

79. The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel Full Text available with Trip Pro

The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel 20750542 2011 03 29 2011 03 29 0007-1447 1 1160 1883 Mar 24 British medical journal Br Med J The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel. 547-9 Garrod A B AB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1883 3 24 0 0 1883 3 24 0 1 ppublish 20750542 PMC2372237

1883 British medical journal

80. The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel Full Text available with Trip Pro

The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel 20750553 2011 03 29 2011 03 29 0007-1447 1 1161 1883 Mar 31 British medical journal Br Med J The Lumleian Lectures on Uric Acid: Its Physiology and its Relation to Renal Calculi and Gravel. 601-3 Garrod A B AB eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1883 3 31 0 0 1883 3 31 0 1 ppublish 20750553 PMC2372270

1883 British medical journal

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