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Uric Acid Nephrolithiasis

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361. The Clinical Impact of Accurate Cystine Calculi Characterization Using Dual-Energy Computed Tomography Full Text available with Trip Pro

The Clinical Impact of Accurate Cystine Calculi Characterization Using Dual-Energy Computed Tomography Dual-energy computed tomography (DECT) has recently been suggested as the imaging modality of choice for kidney stones due to its ability to provide information on stone composition. Standard postprocessing of the dual-energy images accurately identifies uric acid stones, but not other types. Cystine stones can be identified from DECT images when analyzed with advanced postprocessing (...) . This case report describes clinical implications of accurate diagnosis of cystine stones using DECT.

2015 Case Reports in Radiology

362. Treatment response in stone patients with low urine pH and hypocitraturia stratified by body mass index. (Abstract)

Treatment response in stone patients with low urine pH and hypocitraturia stratified by body mass index. Obesity has been shown to be a risk factor for kidney stone formation. Obesity leads to insulin resistance which subsequently leads to low urinary pH. Low urinary pH is typically treated with potassium citrate. We determined if the response to potassium citrate for the treatment of low urinary pH and hypocitraturia varied when patients were stratified by body mass index.We retrospectively (...) in these parameters from baseline. Similarly, we compared the rates of potassium citrate treatment failure.A total of 125 patients with hypocitraturia and low urinary pH were included in this study. Median patient age was 61 years, 80 patients were male and median body mass index was 30.4 kg/m(2). Patients with a higher body mass index tended to be younger (p=0.010), and had a lower urinary citrate but higher sodium, oxalate and uric acid levels. Urinary pH was similar across body mass index groups. pH values

2015 Journal of Urology

363. EAU Guidelines on Diagnosis and Conservative Management of Urolithiasis. (Abstract)

support spontaneous passage in the absence of complicating factors. These guidelines summarise current recommendations for imaging, pain management, conservative treatment, and MET for renal and ureteral stones. Oral chemolysis is an option for uric acid stones.To evaluate the optimal measures for diagnosis and conservative and medical treatment of urolithiasis.Several databases were searched for studies on imaging, pain management, observation, and MET for urolithiasis, with particular attention (...) EAU Guidelines on Diagnosis and Conservative Management of Urolithiasis. Low-dose computed tomography (CT) has become the first choice for detection of ureteral calculi. Conservative observational management of renal stones is possible, although the availability of minimally invasive treatment often leads to active treatment. Acute renal colic due to ureteral stone obstruction is an emergency that requires immediate pain management. Medical expulsive therapy (MET) for ureteral stones can

2015 European Urology

364. Study of FYU-981 in Hyperuricemia With or Without Gout

Inclusion Criteria: Hyperuricemic or gout patients Serum urate level: >= 7.0mg/dL in patients with history of gout, or >= 8.0mg/dL in patients with hypertension, diabetes or metabolic syndrome, or >= 9.0mg/dL Exclusion Criteria: Gouty arthritis within two weeks before start of study treatment Secondary hyperuricemia HbA1c: >= 8.4% Uric acid-overproduction type in the classification of hyperuricemia History of, clinically significant cardiac, hematologic and hepatic disease Kidney calculi or clinically (...) significant urinary calculi eGFR: < 30mL/min/1.73m^2 Systolic blood pressure: >= 180 mmHg Diastolic blood pressure: >= 110 mmHg Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02416167 Locations Layout table for location information Japan Japan Tokyo

2015 Clinical Trials

365. Dietary Calcium Supplementation, Gut Permeability and Microbiota in Type 2 Diabetics

hormone, 25-dihydroxy vitamin D, calcium, fasting glucose, fasting insulin, fructosamine, hemoglobin, HbA1c, uric acid, triglycerides, cholesterol total and partial, lipopolysaccharide, inflammatory markers) will be evaluated at baseline and after 12 weeks. The statistical analysis will be performed with the use of SPSS software (SPSS Inc., Chicago, IL, 2008, version 17.0). Parametric or non-parametric tests will be applied, according to the distribution of variables (level of statistical significance (...) of recurrent nephrolithiasis Caffeine consumption of> 300 mg / day Pregnancy, lactation or postmenopausal Anemia Cardiovascular, infectious, inflammatory, thyroid, liver, kidney or intestinal disease Use of anti-inflammatory, antacids, antibiotics and laxatives drugs Major gastrointestinal surgery. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided

2015 Clinical Trials

366. Does obesity or hyperuricemia influence lithogenic risk profile in children with urolithiasis? Full Text available with Trip Pro

profile in the urinary stone formers in our study, but there was an indication that higher serum uric acid may be associated with impairment in renal function, which in turn could influence the excretion of lithogenic parameters. (...) serum uric acid levels) and compared the groups.Among the children and adolescents with urolithiasis and hyperuricemia, there was a significantly lower excretion of crystallization inhibitors (citrates, magnesium). We also found significantly negative correlations between serum uric acid levels and the urine citrate/creatinine ratio (citrate/cr.; r = -0.30, p < 0.01), as well as the magnesium/cr. ratio (Mg/cr.; r = -0.33, p < 0.01). There was no statistically significant differences in the urinary

2015 Pediatric Nephrology

367. Regulation of Arginine-vasopressin (AVP)

test). A history of cardiac disease including arrhythmias; history of syncope or unexplained loss of consciousness; history of renal stones or renal failure; history of diabetes mellitus or diabetes insipidus. Subjects with hypertension (BP > 140/90). Current hyponatremia. Serum Ca2+ and uric acid levels that are above normal range. Serum creatinine outside of normal range for age. Creatinine clearance <70 ml/min using the Cockcroft-Gault equation (Cockcroft et al 1976) [(140-age)*(weight in kg (...) of consciousness; history of renal stones or renal failure; history of diabetes mellitus or diabetes insipidus. Serum Ca2+ and uric acid levels that are above normal range. Serum creatinine outside of normal range for age. Creatinine clearance <70 ml/min using the Cockcroft-Gault equation [(140-age)*(weight in kg)*(.85 if female)/(72*Cr)]. Subjects with hypertension (BP > 140/90). Current hyponatremia. Any medication that in the opinion of the PI could interfere with either the safety of the study

2015 Clinical Trials

368. RDEA3170 PK/PD Study

and 9 ] Single-dose Pharmacodynamic (PD) profile of RDEA3170 4.5 mg, 6 mg and 12 mg Urine uric acid excretion amount [ Time Frame: Days -1, 1, 5 and 9 ] Single-dose Pharmacodynamic (PD) profile of RDEA3170 4.5 mg, 6 mg and 12 mg Renal clearance of uric acid [ Time Frame: Days -1, 1, 5 and 9 ] Single-dose Pharmacodynamic (PD) profile of RDEA3170 4.5 mg, 6 mg and 12 mg Fractional excretion of uric acid [ Time Frame: Days -1, 1, 5 and 9 ] Single-dose Pharmacodynamic (PD) profile of RDEA3170 4.5 mg, 6 (...) mg and 12 mg Serum urate concentration [ Time Frame: Days -1, 1 and 7 ] Multiple-dose Pharmacodynamic (PD) profile of RDEA3170 12 mg Urine uric acid excretion amount [ Time Frame: Days -1, 1 and 7 ] Multiple-dose Pharmacodynamic (PD) profile of RDEA3170 12 mg Renal clearance of uric acid [ Time Frame: Days -1, 1 and 7 ] Multiple-dose Pharmacodynamic (PD) profile of RDEA3170 12 mg Fractional excretion of uric acid [ Time Frame: Days -1, 1 and 7 ] Multiple-dose Pharmacodynamic (PD) profile

2015 Clinical Trials

369. Effect of Vinegar Consumption on 24-hour Urinary Risk Factors Associated With Stone Formation

vinegar(the 0th day)and on the 7th,14th,21th and 28th day after drinking vinegar. ] To compare the change of 24-hour urinary risk factors associated with calcium oxalate urinary stone formation which include Ph, volume, creatinine, oxalate, citrate, phosphate, uric acid, calcium, magnesium, sodium and chloride of 24-hour urine between two groups on the 7th,14th,21th and 28th day after drinking vinegar. Secondary Outcome Measures : Change of blood biochemical parameters [ Time Frame: One day before (...) drinking vinegar(the 0th day)and on the 29th day after drinking vinegar. ] To compare the change of blood biochemical parameters which include fasting serum glucose, creatinine, urea, uric acid, high-density lipoprotein, low-density lipoprotein, triglycerides,serum total bile acid, cholesterol, sodium, potassium, calcium and chloride ions before grouping and on the 28th day after drinking vinegar. Other Outcome Measures: Change of blood oxidative stress markers [ Time Frame: One day before drinking

2015 Clinical Trials

370. Microalbuminuria and Allopurinol in Type 1 Diabetes

Go to Brief Summary: The objective is to determine if lowering serum uric acid by means of allopurinol in the course of kidney disease may be effective in preventing or improving albuminuria and renal function in Type 1 Diabetic patients. The study is a double blinded, randomised, placebo-controlled cross-over clinical trial. Condition or disease Intervention/treatment Phase Type 1 Diabetes Diabetic Nephropathy Drug: Allopurinol Drug: Placebo Phase 4 Study Design Go to Layout table for study (...) , Layout table for eligibility information Ages Eligible for Study: 18 Years to 75 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Albuminuria (≥30 mg/g) Uric Acid ≥ 0,265 mmol/l GFR (glomerular filtration rate) > 40 ml/min/1.73m2 Exclusion Criteria: History of gout or xanthinuria or other indications for uric acid lowering therapy such as cancer chemotherapy. Recurrent renal calculi. Current use of azathioprine, 6-mercaptopurine

2015 Clinical Trials

371. Hanging Bladder calculi Secondary to Misplaced Surgical Suture Full Text available with Trip Pro

tract infection, resistant to antibiotic therapy. Physical examination was unremarkable. Ultrasonography (US) showed an echogenic fixed intra-luminal lesion in the bladder. Cystoscopic evaluation was performed and confirmed presence of calculi forming around several permanent silk sutures fixed to the bladder wall. The patient undergone cystotomy and the calculi were resected. The stone analysis revealed 80% uric acid calculi. The final diagnosis was of bladder calculi due to remnant suture from (...) Hanging Bladder calculi Secondary to Misplaced Surgical Suture Bladder calculi, a rare condition in the pediatric population, occur most commonly as a result of either migration from the kidney or urinary stasis in the bladder. We report the case of a 3-year-old boy with recurrent urinary tract infections (UTI) secondary to bladder calculi formation on the sutures from a previous herniorrhaphy.A 3-year-old boy with previous history of herniorrhaphy presented with recurrent episodes of urinary

2015 Iranian Journal of Radiology

372. Melamine contamination in nutritional supplements - Is it an alarm bell for the general consumer, athletes, and ‘Weekend Warriors’? Full Text available with Trip Pro

in infants and young children. At the time over 294,000 infants were screened and diagnosed with urinary tract stones and sand-like calculi associated with melamine in milk products, of which 50,000 infants were hospitalised, and at least six associated deaths, recorded. The extent that melamine contamination occurs in nutritional supplements is not known. Therefore, the aim of this study was to determine whether commercially available nutritional and traditional supplement products contain melamine (...) guidelines of 200 μg/g as set by WHO and others. Melamine over exposure within the context of the nutritional supplements consumption in the products investigated should not be of concern to the consumer provided the recommended guidelines of daily product use are adhered to. Further investigation is warranted to determine, (i) the link of melamine as (part) substitute for the perceived total declared protein content on the product label, (ii) cyanuric and uric acid presence in the supplement products

2015 Nutrition journal

373. Metabolic disorders: stones as first clinical manifestation of significant diseases. (Abstract)

Metabolic disorders: stones as first clinical manifestation of significant diseases. Metabolic syndrome, type 2 diabetes, and primary hyperparathyroidism are metabolic disorders that should deserve a special focus in renal stone patients as a pathogenic link is established with some stone components. Indeed, an acidic urinary pH due to a decreased ammonium bioavailability explains the high prevalence of uric acid stones in patients with metabolic syndrome or diabetes and, primary (...) hyperparathyroidism induced hypercalciuria increases the risk of calcium phosphate stones.We report here four clinical cases of renal stone patients with metabolic disorders encountered in a daily practice. Clinical and metabolic findings altogether with stone analysis components presented here, illustrate relevant pathophysiological links.24 hours urine evaluation and stone analysis which includes both morphological typing and infrared spectroscopy, are key diagnostic steps for early recognition of metabolic

2015 World journal of urology

374. Effect of Potassium Citrate on Calcium Phosphate Stones in a Model of Hypercalciuria. Full Text available with Trip Pro

Effect of Potassium Citrate on Calcium Phosphate Stones in a Model of Hypercalciuria. Potassium citrate is prescribed to decrease stone recurrence in patients with calcium nephrolithiasis. Citrate binds intestinal and urine calcium and increases urine pH. Citrate, metabolized to bicarbonate, should decrease calcium excretion by reducing bone resorption and increasing renal calcium reabsorption. However, citrate binding to intestinal calcium may increase absorption and renal excretion of both (...) was collected at 6, 12, and 18 weeks. At 18 weeks, stone formation was visualized by radiography. Urine citrate, phosphate, oxalate, and pH levels were higher and urine calcium level was lower in rats fed potassium citrate. Furthermore, calcium oxalate and calcium phosphate supersaturation were higher with potassium citrate; however, uric acid supersaturation was lower. Both groups had similar numbers of exclusively calcium phosphate stones. Thus, potassium citrate effectively raises urine citrate levels

2015 Journal of the American Society of Nephrology

375. Stone formation and management after bariatric surgery. (Abstract)

Stone formation and management after bariatric surgery. Obesity is a significant health concern and is associated with an increased risk of nephrolithiasis, particularly in women. The underlying pathophysiology of stone formation in obese patients is thought to be related to insulin resistance, dietary factors, and a lithogenic urinary profile. Uric acid stones and calcium oxalate stones are common in these patients. Use of surgical procedures for obesity (bariatric surgery) has risen over (...) the past two decades. Although such procedures effectively manage obesity-dependent comorbidities, several large, controlled studies have revealed that modern bariatric surgeries increase the risk of nephrolithiasis by approximately twofold. In patients who have undergone bariatric surgery, fat malabsorption leads to hyperabsorption of oxalate, which is exacerbated by an increased permeability of the gut to oxalate. Patients who have undergone bariatric surgery show characteristic 24 h urine parameters

2015 Nature reviews. Urology

376. ABCG2: The molecular mechanisms of urate secretion and gout. Full Text available with Trip Pro

ABCG2: The molecular mechanisms of urate secretion and gout. The human propensity for high levels of serum uric acid (SUA) is a trait that has defied explanation. Is it beneficial? Is it pathogenic? Its role in the human diseases like gout and kidney stones was discovered over a century ago [Richette P, Bardin T. Lancet 375: 318-328, 2010; Rivard C, Thomas J, Lanaspa MA, Johnson RJ. Rheumatology (Oxford) 52: 421-426, 2013], but today emerging new genetic and epidemiological techniques have (...) revived an age-old debate over whether high uric acid levels (hyperuricemia) independently increase risk for diseases like hypertension and chronic kidney disease [Feig DI. J Clin Hypertens (Greenwich) 14: 346-352, 2012; Feig DI, Madero M, Jalal DI, Sanchez-Lozada LG, Johnson RJ. J Pediatr 162: 896-902, 2013; Feig DI, Soletsky B, Johnson RJ. JAMA 300: 924-932, 2008; Wang J, Qin T, Chen J, Li Y, Wang L, Huang H, Li J. PLoS One 9: e114259, 2014; Zhu P, Liu Y, Han L, Xu G, Ran JM. PLoS One 9: e100801

2015 American Journal of Physiology. Renal physiology

377. Prospective evaluation of urinary metabolic indices in severely obese adolescents after weight loss surgery. Full Text available with Trip Pro

Prospective evaluation of urinary metabolic indices in severely obese adolescents after weight loss surgery. Observational studies in obese adults have found abnormal urinary metabolic indices that predispose to nephrolithiasis. Few studies have been performed in severely obese adolescents.To assess urinary stone risk factors in severely obese adolescents and in those undergoing 2 types of weight loss surgery.Children's hospital, United States.A prospective cross-sectional study was performed (...) total of 55 samples were analyzed from 14 severely obese adolescents and from 17 severely obese adolescents after bariatric surgery (RYGB, 10; SG, 7). Median body mass index was similar between the RYGB and SG groups. The median 24-hour excretion of oxalate was significantly elevated in the RYGB group. Calcium and uric acid excretion and the median supersaturation of calcium oxalate, calcium phosphate, and uric acid were similar among all groups.Elevated excretion of oxalate in the urine of severely

2015 Surgery for Obesity and Related Diseases

378. The Mineral Water of Vichy and the Urinary Alkalization: A Study of the Dose

ingredient in Vichy water, along with calcium and magnesium carbonates. Bicarbonates alkalinize urine, which is fundamental in preventing and/or diluting uric acid crystals. These are the main component of the uric acid stones or even oxalate stones, which generally " use " a crystal of uric acid as nucleus for stone formation. Cystine stones can also be treated by alkalinizing urine. Any disorder leading to a low urinary pH ( < 5.5 ) may predispose to stone formation. In this context , the solution (...) of uric acid and the prevention and treatment of uric acid stones can be obtained by alkalization of the urine . The ideal alkalization is achieved when a urinary pH of 6-6.5 can be reached. The aim of this study is to evaluate the quantity of daily intake of the Vichy water necessary to obtain this alkalization of the urine. There are no data available in the literature about the relationship between the absolute quantity of Vichy water taken and the urinary pH ; nor about the possible influence

2015 Clinical Trials

379. Study of FYU-981 in Hyperuricemia With or Without Gout

, diabetes or metabolic syndrome, or >= 9.0mg/dL Exclusion Criteria: Gouty arthritis within two weeks before start of study treatment Secondary hyperuricemia HbA1c: >= 8.4% Uric acid-overproduction type in the classification of hyperuricemia History of, clinically significant cardiac, hematologic and hepatic disease Kidney calculi or clinically significant urinary calculi eGFR: < 60mL/min/1.73m^2 Systolic blood pressure: >= 180 mmHg Diastolic blood pressure: >= 110 mmHg Contacts and Locations Go

2015 Clinical Trials

380. Preventive treatment of calcium oxalate crystal deposition with immortal flowers. (Abstract)

of the experiments, liver, kidney and body weights of the animals were determined; biochemical analysis were conducted on urine, blood and plasma samples. Histopathological changes in kidney tissues were examined and statistical analysis were evaluated.HS extract showed the highest preventive effect at 156mg/kg dose (stone formation score: 1.16), whereas a number of kidney stones were maximum in sodium oxalate group (stone formation score: 2.66). Helichrysum extracts decreased urine oxalate and uric acid levels (...) Preventive treatment of calcium oxalate crystal deposition with immortal flowers. A number of medicinal plants are used for their diuretic, urolithiatic and anti-inflammatory effects on urinary system problems in Turkey and the most common traditional remedy for kidney stones is the tea of immortal flowers. The aim of this study is to evaluate the preventive effect of infusions prepared from capitulums of Helichrysum graveolens (M.Bieb.) Sweet (HG) and Helichrysum stoechas ssp. barellieri (Ten

2015 Journal of Ethnopharmacology

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