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Uric Acid

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161. Heritability and Genome-Wide Association Analyses of Serum Uric Acid in Middle and Old-Aged Chinese Twins Full Text available with Trip Pro

Heritability and Genome-Wide Association Analyses of Serum Uric Acid in Middle and Old-Aged Chinese Twins Serum uric acid (SUA), as the end product of purine metabolism, has proven emerging roles in human disorders. Here based on a sample of 379 middle and old-aged Chinese twin pairs, we aimed to explore the magnitude of genetic impact on SUA variation by performing sex-limitation twin modeling analyses and further detect specific genetic variants related to SUA by conducting a genome-wide (...)  < 0.05), including PTGR2, ENTPD5, well-known SLC2A9, etc. Enrichment analysis identified one pathway of transmembrane transport of small molecules and 20 GO gene sets involving in ion transport, transmembrane transporter activity, hydrolase activity acting on acid anhydrides, etc. In conclusion, SUA shows moderate heritability in women and low heritability in men in the Chinese population and genetic variations are significantly involved in functional genes and regulatory domains that mediate SUA

2018 Frontiers in endocrinology

162. Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population Full Text available with Trip Pro

Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population Oxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Reactive oxygen species are reported to suppress osteoblast generation and differentiation and enhance osteoclast development and activity. Increasing evidence suggests favorable effect of serum uric acid (UA) on bone metabolism due to its antioxidant properties. Therefore, we

2018 Therapeutics and clinical risk management

163. Letter to the Editor: When Claiming a U-shaped Association between Uric Acid Levels and Major Adverse Cardiac Events, Perhaps Show the Evidence? Full Text available with Trip Pro

Letter to the Editor: When Claiming a U-shaped Association between Uric Acid Levels and Major Adverse Cardiac Events, Perhaps Show the Evidence? 29349941 2018 11 13 1598-6357 33 6 2018 02 05 Journal of Korean medical science J. Korean Med. Sci. Letter to the Editor: When Claiming a U-shaped Association between Uric Acid Levels and Major Adverse Cardiac Events, Perhaps Show the Evidence? e50 10.3346/jkms.2018.33.e50 Abraham Ivo I 0000-0003-0490-4421 Center for Health Outcomes

2018 Journal of Korean medical science

164. The association between elevated serum uric acid levels and islet β-cell function indexes in newly diagnosed type 2 diabetes mellitus: a cross-sectional study Full Text available with Trip Pro

The association between elevated serum uric acid levels and islet β-cell function indexes in newly diagnosed type 2 diabetes mellitus: a cross-sectional study Serum uric acid (UA) has been reported as a risk factor for type 2 diabetes mellitus (T2DM). However, whether serum UA is associated with insulin resistance and insulin secretion, and the effect of gender on it in the case of the existed association, both remain undefined.A cross-sectional study was designed and performed, which enrolled

2018 PeerJ

165. The relationship between subclinical hypothyroidism and serum levels of uric acid and creatinine in children aged 2–14 years Full Text available with Trip Pro

The relationship between subclinical hypothyroidism and serum levels of uric acid and creatinine in children aged 2–14 years Hypothyroidism is a clinical syndrome that can lead to elevated levels of serum creatinine and uric acid by causing impaired renal function. Although many studies have been carried out on the relationship between overt hypothyroidism and renal function, few studies have been conducted on subclinical hypothyroidism and renal function, especially in pediatric patients (...) . For this reason, we studied this issue in children, so as to provide a background for more useful research and future education.This case-control study was performed on 107 children aged 2-14 years, 56 children with subclinical hypothyroidism in the case group, and 51 healthy children in the control group presenting to Ayatollah Mousavi Hospital in Zanjan and private clinics of Zanjan city. Thyroid stimulating hormone, triiodothyronine, thyroxine, creatinine, and uric acid were measured in both groups

2018 Annals of pediatric endocrinology & metabolism

166. High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke Full Text available with Trip Pro

High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke Objective We aimed to evaluate the association between serum uric acid levels at the onset and prognostic outcome in patients with acute ischaemic stroke. Methods We retrospectively analysed the outcomes of 1166 patients with ischaemic stroke who were hospitalized in our centre during August 2008 to November 2012. Correlations of serum uric acid levels (...) and prognostic outcomes were analysed. Results Men had higher serum uric acid levels and better neurological functional outcomes compared with women. There was a strong negative correlation between serum uric acid levels and unfavourable neurological functional outcomes. Generalized estimated equation analysis showed that a higher serum uric acid level (>237 µmol/L) was a protective factor for neurological functional outcome in male, but not female, patients. Among five trial of ORG 10172 in acute stroke

2018 The Journal of international medical research

167. Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression Full Text available with Trip Pro

Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD.A total of 32 (...) radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM.The present study suggests a significant association between altered WM

2018 Psychiatry investigation

168. Association between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging Study Full Text available with Trip Pro

Association between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging Study Serum uric acid level is a risk factor for cardiovascular disease (CVD). However, whether it is an independent risk factor or not remains controversial. We analyzed the association between serum uric acid level and cardiovascular risk. In total, 973 nonhypertensive and nondiabetic participants in the I-Lan Longitudinal Aging Study were eligible (...) for this study. Subjects were divided into tertiles according to uric acid levels. The 10-year cardiovascular risk was calculated using Framingham risk score (FRS). Study subjects in the highest tertile of serum uric acid level were older, more likely to be male, and had higher systolic blood pressure, body mass index, carotid artery intima-media thickness and serum triglyceride, high-sensitivity C-reactive protein, and low-density lipoprotein cholesterol levels and lower serum high-density lipoprotein

2018 Scientific reports

169. Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells Full Text available with Trip Pro

Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells High levels of uric acid (UA) are associated with type-2 diabetes and cardiovascular disease. Recent pieces of evidence attributed to UA a causative role in the appearance of diabetes and vascular damage. However, the molecular mechanisms by which UA induces these alterations have not been completely elucidated so far. Among the mechanisms underlying insulin resistance

2018 Frontiers in endocrinology

170. The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice. Full Text available with Trip Pro

The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice. Gouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints. Despite many treatment options for gout, there is a substantial need for alternative treatments for patients unresponsive to current therapies. Tyrosine kinase inhibitors have demonstrated therapeutic benefit in experimental models of antibody-dependent arthritis and in rheumatoid arthritis (...) the efficiency of local intra-articular injections of imatinib-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles in this model of acute gout. Treatment with low doses of this long-acting imatinib:PLGA formulation was able to reduce ankle swelling in a therapeutic protocol. Altogether, these results raise the possibility that tyrosine kinase inhibitors might have utility in the treatment of acute gout in humans.

2017 PLoS ONE

171. A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: A pilot study. Full Text available with Trip Pro

A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: A pilot study. Uric acid has been linked with increased risk of chronic disease such as cardiovascular disease and this association has been attributed to a pro-inflammatory effect. Indeed, observational studies have shown that high uric acid is associated with high level of pro-inflammatory cytokines in the blood. However, whether high uric acid directly affects (...) inflammation or rather represents a parallel defensive antioxidant mechanism in response to pathology that causes inflammation is unknown. To determine whether acute increase or decrease uric acid levels affects inflammation in healthy individuals, a randomized, placebo-controlled, double blind clinical study of uric acid or rasburicase with 20 healthy volunteers in each treatment-placebo group was conducted at the National Institute on Aging (NIA) Clinical Research Unit (CRU) at Harbor Hospital

2017 PLoS ONE Controlled trial quality: uncertain

172. Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells. Full Text available with Trip Pro

Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells. The airway epithelium is a physical and immunological barrier that protects the pulmonary system from inhaled environmental insults. Uric acid has been detected in the respiratory tract and can function as an antioxidant or damage associated molecular pattern. We have demonstrated that human airway epithelial cells are a source of uric acid. Our hypothesis is that uric acid (...) production by airway epithelial cells is induced by environmental stimuli associated with chronic respiratory diseases. We therefore examined how airway epithelial cells regulate uric acid production.Allergen and cigarette smoke mouse models were performed using house dust mite (HDM) and cigarette smoke exposure, respectively, with outcome measurements of lung uric acid levels. Primary human airway epithelial cells isolated from clinically diagnosed patients with asthma and chronic obstructive pulmonary

2017 PLoS ONE

173. Serum uric acid and prevalence of age-related hearing loss in the Japanese population: Baseline data from the Aidai Cohort Study in Yawatahama. Full Text available with Trip Pro

Serum uric acid and prevalence of age-related hearing loss in the Japanese population: Baseline data from the Aidai Cohort Study in Yawatahama. This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.Copyright © 2017. Published by Elsevier Inc.

2018 Experimental Gerontology

174. The effect of uric acid lowering treatment on albuminuria and renal function in Type 1 diabetes: a randomized clinical trial. (Abstract)

The effect of uric acid lowering treatment on albuminuria and renal function in Type 1 diabetes: a randomized clinical trial. 29315768 2018 12 17 2018 12 17 1464-5491 35 3 2018 03 Diabetic medicine : a journal of the British Diabetic Association Diabet. Med. The effect of uric acid lowering treatment on albuminuria and renal function in Type 1 diabetes: a randomized clinical trial. 392-393 10.1111/dme.13577 Pilemann-Lyberg S S 0000-0001-6546-9502 Medical Research Laboratory, Department (...) Controlled Trial Research Support, Non-U.S. Gov't England Diabet Med 8500858 0742-3071 0 Renal Agents 268B43MJ25 Uric Acid 63CZ7GJN5I Allopurinol AYI8EX34EU Creatinine IM Albuminuria drug therapy Allopurinol therapeutic use Creatinine urine Cross-Over Studies Diabetes Mellitus, Type 1 drug therapy Diabetic Nephropathies drug therapy Double-Blind Method Female Glomerular Filtration Rate drug effects Humans Male Middle Aged Renal Agents therapeutic use Uric Acid metabolism 2018 1 10 6 0 2018 12 18 6 0 2018

2018 Diabetic Medicine Controlled trial quality: uncertain

175. Effect of immediate and prolonged GLP-1 receptor agonist administration on uric acid and its kidney clearance: post-hoc analyses of four clinical trials. Full Text available with Trip Pro

Effect of immediate and prolonged GLP-1 receptor agonist administration on uric acid and its kidney clearance: post-hoc analyses of four clinical trials. To determine the effects of glucagon-like peptide (GLP)-1 receptor agonists (RA) on uric acid (UA) levels and kidney UA clearance.This study involved post-hoc analyses of 4 controlled clinical trials, which assessed actions of GLP-1RA administration on kidney physiology. The immediate effects of GLP-1RA exenatide infusion vs placebo were

2018 obesity & metabolism Controlled trial quality: uncertain

176. Effects of a DASH Diet Intervention on Serum Uric Acid in African Americans with Hypertension. Full Text available with Trip Pro

Effects of a DASH Diet Intervention on Serum Uric Acid in African Americans with Hypertension. To examine whether partial replacement of a diet typical of the average American diet with Dietary Approaches to Stop Hypertension (DASH)-related foods in the home environment lowers the serum uric acid (UA) level in individuals with hypertension.We conducted an ancillary study of a randomized trial of African American adults with controlled hypertension from an urban clinic. Participants were

2018 Arthritis care & research Controlled trial quality: uncertain

177. Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan. (Abstract)

Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan. High serum uric acid (SUA) is associated with the dyslipidemia, but whether hyperuricemia predicts an increase in serum low-density lipoprotein (LDL) cholesterol is unknown. This study is to evaluate whether an elevated SUA predicts the development of high LDL cholesterol as well as hypertriglyceridemia.This is a retrospective 5-year cohort study of 6476

2018 International journal of cardiology

178. LDL-oxidation, serum uric acid, kidney function and pulse-wave velocity: Data from the Brisighella Heart Study cohort. (Abstract)

LDL-oxidation, serum uric acid, kidney function and pulse-wave velocity: Data from the Brisighella Heart Study cohort. Serum uric acid (SUA) and oxidized LDL (oxLDL) may be associated with arterial aging. The aim of our study was to evaluate the relationship between SUA, oxLDL and arterial stiffness in subjects with normal renal function and in patients with mild or moderate renal impairment.From the database of the 2012 Brisighella Heart Study, we compared age-matched adult, non-smoker

2018 International journal of cardiology

179. Intestinal tract is an important organ for lowering serum uric acid in rats. Full Text available with Trip Pro

Intestinal tract is an important organ for lowering serum uric acid in rats. The kidney was recognized as a dominant organ for uric acid excretion. The main aim of the study demonstrated intestinal tract was an even more important organ for serum uric acid (SUA) lowering. Sprague-Dawley rats were treated normally or with antibiotics, uric acid, adenine, or inosine of the same molar dose orally or intraperitoneally for 5 days. Rat's intestinal tract was equally divided into 20 segments except (...) the cecum. Uric acid in serum and intestinal segment juice was assayed. Total RNA in the initial intestinal tract and at the end ileum was extracted and sequenced. Protein expression of xanthine dehydrogenase (XDH) and urate oxidase (UOX) was tested by Western blot analysis. The effect of oral UOX in lowering SUA was investigated in model rats treated with adenine and an inhibitor of uric oxidase for 5 days. SUA in the normal rats was 20.93±6.98 μg/ml, and total uric acid in the intestinal juice

2017 PLoS ONE

180. Effect and Mechanism of ShiZhiFang on Uric Acid Metabolism in Hyperuricemic Rats. Full Text available with Trip Pro

Effect and Mechanism of ShiZhiFang on Uric Acid Metabolism in Hyperuricemic Rats. To explore the effect and mechanism of ShiZhiFang on uric acid metabolism.40 rats were divided into normal group, model group, ShiZhiFang group, and benzbromarone group. The hyperuricemic rat model was induced by yeast gavage at 15 g/kg and potassium oxonate intraperitoneal injection at 600 mg/kg for two weeks. During the next two weeks, ShiZhiFang group rats were given ShiZhiFang by gavage, and benzbromarone (...) group rats were given benzbromarone by gavage. The serum uric acid, creatinine, blood urea nitrogen, XOD activity, urinary uric acid, urinary β2-MG, and histopathological changes were observed in the rats of each group after treatment.The hyperuricemic model was established successfully and did not show the increase of serum creatinine and blood urea nitrogen. Compared with the model group, the serum uric acid, serum XOD activity, and urinary β2-MG were significantly decreased (p < 0.05), and 24 h

2018 Evidence-based Complementary and Alternative Medicine (eCAM)

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