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Uric Acid

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121. Uric Acid Metabolism Was Altered In Isolated Colonic Crohn's Disease But Not Ulcerative Colitis. (PubMed)

Uric Acid Metabolism Was Altered In Isolated Colonic Crohn's Disease But Not Ulcerative Colitis. Patients with inflammatory bowel disease (IBD) have higher incidence of developing nephrolithiasis. Increased uric acid production induced by Saccharomyces cerevisiae exacerbates colitis in mice. We aimed to evaluate the association between serum uric acid level and disease activity in IBD population.Four hundred and thirty-five patients enrolled in Jinling Hospital from January 1, 2015 to August 31 (...) , 2017 were included in the retrospective study. Clinical parameters were collected and compared with non-IBD matched controls (n = 51). Serum uric acid to creatinine ratio (UA/Cr) was used as a biomarker for uric acid metabolism. Sixty-five active IBD patients were longitudinally studied to investigate the UA/Cr before and after therapy. Linear mixed models were estimated for Crohn's disease (CD) group to explore the relationship between UA/Cr and other parameters.Uric acid to creatinine ratio

2018 Journal of gastroenterology and hepatology

122. Uric acid is linked to cardiometabolic risk factors in overweight and obese youths. (PubMed)

Uric acid is linked to cardiometabolic risk factors in overweight and obese youths. Observational studies have indicated that high levels of serum uric acid are associated with the risk of cardiovascular disease. The aim of the present study is to investigate the association of uric acid with individual cardiometabolic risk factors, as well as their degree of clustering, in overweight and moderate obese youth.Three hundred and thirty-three Caucasians of both sexes (149 women), from 5-18 years (...) of age from those who underwent an assessment of overweight/obesity. Anthropometric parameters, office and 24-h blood pressure measurements and metabolic profile, including HDL-cholesterol, triglycerides, insulin, HOMA index and uric acid were assessed.Uric acid was significantly higher in boys than in girls. A positive significant association between uric acid, and office, daytime and night-time SBP, insulin and triglycerides was observed. When boys and girls were grouped by sex-specific uric acid

2018 Journal of Hypertension

123. Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach. (PubMed)

Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach. Recent investigations showed single associations between uric acid levels, functional parameters, exacerbations and mortality in COPD patients. The aim of this study was to describe the role of uric acid within the network of multiple relationships between function, exacerbation and comorbidities.We used baseline data from the German COPD cohort COSYCONET which were (...) evaluated by standard multiple regression analyses as well as path analysis to quantify the network of relations between parameters, particularly uric acid.Data from 1966 patients were analyzed. Uric acid was significantly associated with reduced FEV1, reduced 6-MWD, higher burden of exacerbations (GOLD criteria) and cardiovascular comorbidities, in addition to risk factors such as BMI and packyears. These associations remained significant after taking into account their multiple interdependences

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2018 Respiratory research

124. Common gene variants interactions related to uric acid transport are associated with knee osteoarthritis susceptibility. (PubMed)

Common gene variants interactions related to uric acid transport are associated with knee osteoarthritis susceptibility. The presence of genetic variants in uric acid (UA) transporters can be associated with hyperuricemia, and therefore with an increased risk of monosodium urate (MSU) crystal precipitation. The inflammatory process triggered by these crystals leads to cartilage damage, which, in turn, could promote knee osteoarthritis (KOA).To determine whether genetic polymorphisms of the UA

2018 Connective Tissue Research

125. Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension. (PubMed)

Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension. The endothelial dysfunction-arterial stiffness-atherosclerosis continuum plays an important pathophysiological role in hypertension. The aim of this study was to investigate the cross-sectional association between serum uric acid (SUA) and vascular markers related to this continuum, and to assess the longitudinal association between SUA and endothelial function

2018 International journal of cardiology

126. Role of Bicarbonate Supplementation on Urine Uric Acid Crystals and Diabetic Tubulopathy in Adults with Type 1 Diabetes: A Brief Report. (PubMed)

Role of Bicarbonate Supplementation on Urine Uric Acid Crystals and Diabetic Tubulopathy in Adults with Type 1 Diabetes: A Brief Report. Uricosuria and crystallization are increasingly recognized risk factors for diabetic tubulopathy. This pilot clinical trial aimed to determine the acute effect of urinary alkalinization using oral sodium bicarbonate (NaHCO3 ) on UA crystals in adults with type 1 diabetes (T1D). Adults with T1D, ages 18 to 65 years (n = 45, 60% female, HbA1c, 7.5 ± 1.2%, 20.2

2018 obesity & metabolism

127. The effect of uric acid lowering treatment on albuminuria and renal function in Type 1 diabetes: a randomized clinical trial. (PubMed)

The effect of uric acid lowering treatment on albuminuria and renal function in Type 1 diabetes: a randomized clinical trial. 29315768 2018 12 17 2018 12 17 1464-5491 35 3 2018 03 Diabetic medicine : a journal of the British Diabetic Association Diabet. Med. The effect of uric acid lowering treatment on albuminuria and renal function in Type 1 diabetes: a randomized clinical trial. 392-393 10.1111/dme.13577 Pilemann-Lyberg S S 0000-0001-6546-9502 Medical Research Laboratory, Department (...) Controlled Trial Research Support, Non-U.S. Gov't England Diabet Med 8500858 0742-3071 0 Renal Agents 268B43MJ25 Uric Acid 63CZ7GJN5I Allopurinol AYI8EX34EU Creatinine IM Albuminuria drug therapy Allopurinol therapeutic use Creatinine urine Cross-Over Studies Diabetes Mellitus, Type 1 drug therapy Diabetic Nephropathies drug therapy Double-Blind Method Female Glomerular Filtration Rate drug effects Humans Male Middle Aged Renal Agents therapeutic use Uric Acid metabolism 2018 1 10 6 0 2018 12 18 6 0 2018

2018 Diabetic Medicine

128. Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study. (PubMed)

Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study. Reports are conflicting on whether serum uric acid (sUA) levels are independently associated with increased cardiovascular (CV) death risk.This post hoc analysis assessed the relationship between sUA levels and CV death risk score in 7531 patients from the cross-sectional, multinational EURIKA study (NCT00882336). Patients had at least one CV risk factor but no clinical CV disease. Ten

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2018 International journal of cardiology

129. Assessment of the association between serum uric acid levels and the incidence of hypertension in nonmetabolic syndrome subjects: A prospective observational study. (PubMed)

Assessment of the association between serum uric acid levels and the incidence of hypertension in nonmetabolic syndrome subjects: A prospective observational study. The purpose of this study was to examine the association between serum uric acid (sUA) and the incidence of hypertension in nonmetabolic syndrome (non-MetS) subjects.This was a prospective observational study including 23,525 subjects who had been followed up for at least 5 years. A logistic regression model was used to assess

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2018 Medicine

130. Uric acid is associated with long-term adverse cardiovascular outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention. (PubMed)

Uric acid is associated with long-term adverse cardiovascular outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Evidence links uric acid (UA) with the promotion of cardiovascular disease. We assessed the prognostic value of UA on long-term major adverse outcomes (MACE) in patients with acute coronary syndrome (ACS), undergoing percutaneous coronary intervention (PCI).As primary endpoint, we assessed the association of UA (continuous

2018 Atherosclerosis

131. Elevated serum uric acid levels are associated with endothelial dysfunction in HIV patients receiving highly-active antiretroviral therapy. (PubMed)

Elevated serum uric acid levels are associated with endothelial dysfunction in HIV patients receiving highly-active antiretroviral therapy. Elevated serum uric acid (SUA) levels may be associated with endothelial dysfunction. Increased rates of metabolic syndrome (MS) and elevated SUA levels were described in human immunodeficiency virus (HIV) infected patients. We investigated whether SUA levels are associated with endothelial dysfunction in HIV positive patients receiving highly-active

2018 Atherosclerosis

132. Serum uric acid levels in patients with amyotrophic lateral sclerosis: a meta-analysis. (PubMed)

Serum uric acid levels in patients with amyotrophic lateral sclerosis: a meta-analysis. The pathogenic mechanism of ALS remains unclear. However, increasing evidence has indicated that uric acid (UA) may play a protective role in the pathogenesis of ALS. The aim of this study was to evaluate the association between serum UA levels and ALS. A comprehensive literature search in PubMed, Embase, Web of Science, and Cochrane Library was conducted up to 31st August, 2017, using keywords. A random

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2018 Scientific reports

133. LDL-oxidation, serum uric acid, kidney function and pulse-wave velocity: Data from the Brisighella Heart Study cohort. (PubMed)

LDL-oxidation, serum uric acid, kidney function and pulse-wave velocity: Data from the Brisighella Heart Study cohort. Serum uric acid (SUA) and oxidized LDL (oxLDL) may be associated with arterial aging. The aim of our study was to evaluate the relationship between SUA, oxLDL and arterial stiffness in subjects with normal renal function and in patients with mild or moderate renal impairment.From the database of the 2012 Brisighella Heart Study, we compared age-matched adult, non-smoker

2018 International journal of cardiology

134. Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan. (PubMed)

Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan. High serum uric acid (SUA) is associated with the dyslipidemia, but whether hyperuricemia predicts an increase in serum low-density lipoprotein (LDL) cholesterol is unknown. This study is to evaluate whether an elevated SUA predicts the development of high LDL cholesterol as well as hypertriglyceridemia.This is a retrospective 5-year cohort study of 6476

2018 International journal of cardiology

135. Serum uric acid and cancer mortality and incidence: a systematic review and meta-analysis.

Serum uric acid and cancer mortality and incidence: a systematic review and meta-analysis. Elevated serum uric acid (SUA) is a marker of chronic inflammation and has been suggested to be associated with increased risk of cancer, but its antioxidant capacity would justify an anticancer effect. Previous meta-analyses did not include all available results. We conducted a systematic review of prospective studies on SUA level and risk of all cancers and specific cancers, a conducted a meta-analysis

2018 European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

136. Mediators of the Effects of Gender on Uric Acid Nephrolithiasis: A Novel Application of Structural Equation Modeling (PubMed)

Mediators of the Effects of Gender on Uric Acid Nephrolithiasis: A Novel Application of Structural Equation Modeling Numerous epidemiological studies have shown that male patients with uric acid nephrolithiasis outnumber female patients. To our knowledge, no research exists evaluating the reasons gender affects the development of uric acid nephrolithiasis. We hereby used a novel application of structural equation modeling to analyze the mediators of the effects of gender on uric acid (...) nephrolithiasis. In 1,098 patients with nephrolithiasis between 2012 and 2016, male gender was found to have a statistically significant positive indirect effect on the development of uric acid nephrolithiasis, which was mediated by lower urine pH (estimate: 0.010, standard error: 0.005, critical ratio: 2.135, 95% confidence interval: 0.002-0.023, P = 0.017), lower estimated glomerular filtration rate (estimate: 0.014, standard error: 0.005, critical ratio: 2.993, 95% confidence interval: 0.006-0.025, P

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2018 Scientific reports

137. Letter to the Editor: When Claiming a U-shaped Association between Uric Acid Levels and Major Adverse Cardiac Events, Perhaps Show the Evidence? (PubMed)

Letter to the Editor: When Claiming a U-shaped Association between Uric Acid Levels and Major Adverse Cardiac Events, Perhaps Show the Evidence? 29349941 2018 11 13 1598-6357 33 6 2018 02 05 Journal of Korean medical science J. Korean Med. Sci. Letter to the Editor: When Claiming a U-shaped Association between Uric Acid Levels and Major Adverse Cardiac Events, Perhaps Show the Evidence? e50 10.3346/jkms.2018.33.e50 Abraham Ivo I 0000-0003-0490-4421 Center for Health Outcomes

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2018 Journal of Korean medical science

138. Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population (PubMed)

Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population Oxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Reactive oxygen species are reported to suppress osteoblast generation and differentiation and enhance osteoclast development and activity. Increasing evidence suggests favorable effect of serum uric acid (UA) on bone metabolism due to its antioxidant properties. Therefore, we

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2018 Therapeutics and clinical risk management

139. Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis (PubMed)

Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis Whether uric acid levels were associated with the progression of chronic kidney disease (CKD) remained controversial. This meta-analysis was aimed to assess the effect of lowering serum uric acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD indirectly.Pubmed, Embase, the Cochrane library, CBM were searched for randomized (...) controlled trials (RCTs) that assessed the efficiency of lowering serum uric acid therapy on the progression of CKD without language restriction. Summary estimates of weighted mean differences (WMDs) and relative risk (RR) were obtained by using random-effect or fixed-effect models. Sensitivity analyses were performed to identify the source of heterogeneity.A total of 12 randomized controlled trials with 832 CKD participants were included in the analysis. Pooled estimate for eGFR was in favor of lowering

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2018 Renal failure

140. Uric acid levels are associated with endothelial dysfunction and severity of coronary atherosclerosis during a first episode of acute coronary syndrome (PubMed)

Uric acid levels are associated with endothelial dysfunction and severity of coronary atherosclerosis during a first episode of acute coronary syndrome The role of serum uric acid in coronary artery disease has been extensively investigated. It was suggested that serum uric acid level (SUA) is an independent predictor of endothelial dysfunction and related to coronary artery lesions. However, the relationship between SUA and severity of coronary atherosclerosis evaluated via endothelial

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2018 Purinergic signalling

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