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Uric Acid

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121. Effect of Consumption of Cocoa-Derived Products on Uric Acid Crystallization in Urine of Healthy Volunteers Full Text available with Trip Pro

Effect of Consumption of Cocoa-Derived Products on Uric Acid Crystallization in Urine of Healthy Volunteers The purpose of this study was to determine the effects of consumption of different cocoa-derived products on uric acid crystallization in urine of 20 healthy volunteers. Participants were requested to select the specific diet that they wished to follow during the 12 h prior to collection of urine. The only restriction was that the diet could not include any product with cocoa, coffee (...) , or caffeine. On the first day, each volunteer followed their selected diet, and an overnight 12 h urine sample was collected as the baseline urine. After seven days on an unrestricted diet, each volunteer repeated the same diet with 20 g of milk chocolate, chocolate powder, or dark chocolate during breakfast and another 20 g during dinner. Overnight 12 h urine samples were then collected. Urine volume, pH, oxalate, creatinine, uric acid, theobromine, and a uric acid crystallization test were determined

2018 Nutrients

122. Uric acid enhances alteplase-mediated thrombolysis as an antioxidant Full Text available with Trip Pro

Uric acid enhances alteplase-mediated thrombolysis as an antioxidant Uric acid (UA) therapy may prevent early ischemic worsening after acute stroke in thrombolysis patients. The aim of this study was to examine the influence of UA on the thrombolytic efficacy of alteplase in human blood samples by measuring thrombolysis under flow conditions using a newly developed microchip-based flow-chamber assay. Human blood samples from healthy volunteers were exposed to UA, alteplase, or a combination

2018 Scientific reports

123. Cognition, Olfaction and Uric Acid in Early de novo Parkinson’s Disease Full Text available with Trip Pro

Cognition, Olfaction and Uric Acid in Early de novo Parkinson’s Disease Cognitive impairment is one of the nonmotor symptoms in Parkinson's disease (PD), and olfactory dysfunction is used as a marker to detect premotor stages of PD. Serum uric acid (sUA) levels have been found to be a risk factor for PD. Our objective in this study was to examine whether sUA levels are associated with cognitive changes and olfactory dysfunction in early de novo PD patients.The study participants included 196

2018 Journal of movement disorders

124. Association between post-transplant uric acid level and renal allograft fibrosis: Analysis using Banff pathologic scores from renal biopsies Full Text available with Trip Pro

Association between post-transplant uric acid level and renal allograft fibrosis: Analysis using Banff pathologic scores from renal biopsies Several experimental studies implicate uric acid in renal injury and fibrosis. The objective of this study was to examine the association between uric acid level and allograft fibrosis after kidney transplantation. 241 adult patients who underwent kidney transplantation between 2003 and 2014 were divided into three groups according to the sex specific (...) tertiles of mean uric acid level within the first post-transplant year. The renal biopsies performed during 1 to 5 post-transplant year were analyzed to compare the degree of interstitial fibrosis and tubular atrophy (IF/TA). Mean interval between kidney transplantation and biopsy was similar between groups (23.7 ± 15.3 vs. 30.0 ± 18.6 vs. 27.5 ± 18.5 months, P = 0.072). The higher tertile uric acid level was, the more advanced grade of IF/TA was shown (P = 0.001). Multivariate analysis identified uric

2018 Scientific reports

125. Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver Full Text available with Trip Pro

Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver The prevalence of fatty liver disease (FLD) is increasing. To clarify risk factors for developing FLD, we analyzed a database from healthy Japanese adults who had annual medical check-ups in 2004 and reexamined in 2009. We used the fatty liver index (FLI) to classify participants as FLD (FLI ≥60), borderline FLD (30≤ FLI <60), and normal liver (FLI <30). Subjects with hepatitis B or C virus infection (...) and subjects with FLD at the baseline were excluded. The cumulative incidence of FLD from normal liver and from borderline FLD over five years were 0.65% (52/8,025) and 12.9% (244/1,888), respectively. After multiple adjustments, higher serum uric acid (SUA) (OR:1.92; 95% CI:1.40-2.63) and increased SUA change (OR:3.734; 95% CI:2.57-5.42) became risk factors for developing FLD from normal liver, as well as younger age and higher body mass index. The risk factors for developing FLD from borderline FLD were

2018 Scientific reports

126. Uric acid levels are independent of anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn’s disease: A reappraisal of the role of S. cerevisiae in this setting Full Text available with Trip Pro

Uric acid levels are independent of anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn’s disease: A reappraisal of the role of S. cerevisiae in this setting 30027793 2018 10 30 2018 11 14 2150-5608 9 1 2018 Virulence Virulence Uric acid levels are independent of anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease: A reappraisal of the role of S. cerevisiae in this setting. 1224-1229 10.1080/21505594.2018.1496779 Sendid B B 0000-0003-1577-7325 a Inserm, Univ. Lille, CHU (...) Research International Center , Lille , France. b CHU Lille, Parasitologie-Mycologie , Institut de Microbiologie , Lille , France. eng Letter Multicenter Study Randomized Controlled Trial United States Virulence 101531386 2150-5594 0 Antibodies, Fungal 0 Immunoglobulin A 0 Immunoglobulin G 268B43MJ25 Uric Acid IM Adult Antibodies, Fungal blood immunology Cohort Studies Crohn Disease blood immunology pathology surgery Female Humans Immunoglobulin A immunology Immunoglobulin G blood immunology Male

2018 Virulence

127. Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study Full Text available with Trip Pro

Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study We aimed to evaluate the association of serum uric acid on admission with long-term outcome of critically ill patients.We conducted a retrospective cohort study using data extracted from the Medical Information Mart for Intensive Care III database. The primary endpoint was 90-day mortality. Propensity score matching (PSM) was performed, and multivariate Cox regression analysis (...) was used to adjust for potential confounders. Receiver operating characteristic (ROC) curves were also used to assess the mortality predictions.A total of 2,123 patients were included finally with a PSM cohort consisting of 556 90-day non-survivors matched 1:1 with 556 90-day survivors. No statistically significant difference of median admission uric acid was observed between the two groups (survivors 5.50 mg/dL vs non-survivors 5.60 mg/dL, p=0.536). ROC area under the curve was 0.511 (95% confidence

2018 Therapeutics and clinical risk management

128. Synthesis of Heart/Dumbbell-Like CuO Functional Nanostructures for the Development of Uric Acid Biosensor Full Text available with Trip Pro

Synthesis of Heart/Dumbbell-Like CuO Functional Nanostructures for the Development of Uric Acid Biosensor It is always demanded to prepare a nanostructured material with prominent functional properties for the development of a new generation of devices. This study is focused on the synthesis of heart/dumbbell-like CuO nanostructures using a low-temperature aqueous chemical growth method with vitamin B12 as a soft template and growth directing agent. CuO nanostructures are characterized (...) by scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) techniques. CuO nanostructures are heart/dumbbell like in shape, exhibit high crystalline quality as demonstrated by XRD, and have no impurity as confirmed by XPS. Apparently, CuO material seems to be porous in structure, which can easily carry large amount of enzyme molecules, thus enhanced performance is shown for the determination of uric acid. The working linear range of the biosensor is 0.001 mM

2018 Materials

129. Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Verinurad, a Selective Uric Acid Reabsorption Inhibitor Full Text available with Trip Pro

Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Verinurad, a Selective Uric Acid Reabsorption Inhibitor BACKGROUND AND OBJECTIVE: Verinurad (RDEA3170) is a high-affinity, selective URAT1 transporter inhibitor in development for treating gout and asymptomatic hyperuricemia. This Phase I, single-dose study investigated the pharmacokinetics, pharmacodynamics, and safety of verinurad in adults with renal impairment and controls with normal renal function.Males aged 18-85

2018 Clinical drug investigation

130. Comparison of serum uric acid levels between prostate cancer patients and a control group Full Text available with Trip Pro

Comparison of serum uric acid levels between prostate cancer patients and a control group The aim of this study is to investigate whether the uric acid levels, measured in the serum of patients with a new prostate cancer diagnosis, differ from those in the healthy subjects.The study included 117 patients who applied to our clinic due to a high prostate specific antigen (PSA) with prostate cancer diagnosis from 2013-2016 and 114 patients applying in the same period for other reasons. The serum (...) uric acid levels and inflammatory markers like c-reactive protein (CRP) and neutrophil count were compared between the groups.The age distribution of the patients in the prostate cancer and control group was 67.6 ±9.4 and 62 ±8.5 years, respectively. The uric acid levels were identified as 5.05 ±1.14 and 6.04 ±1.12 in the prostate cancer and control group, respectively. Additionally, inflammatory markers like CRP and neutrophil count were identified to be high in the prostate cancer group (p <0.05

2018 Central European journal of urology

131. The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout Full Text available with Trip Pro

The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout The objective of the study was to evaluate the effect of lesinurad, a selective uric acid uptake inhibitor, alone and in combination with the xanthine oxidase inhibitor allopurinol, on serum uric acid and urinary urate excretion in patients with gout and hyperuricemia. A phase 1b, multicenter, open-label, multiple-dose study was carried out in patients with gout with serum uric acid ≥8 mg/dL (...) following washout of urate-lowering therapy. Patients were treated with allopurinol 300 mg/day alone in week 1; lesinurad 400 or 600 mg/day was added in week 2, followed by lesinurad 400 or 600 mg/day alone in week 3. Serum uric acid and urine uric acid were evaluated each week. Safety was assessed throughout the study. Lesinurad 400 or 600 mg/day added to allopurinol 300 mg/day reduced serum uric acid by 60% and 72%, respectively, versus allopurinol alone (37%) or lesinurad 400 mg/day (44%) or 600 mg

2018 Journal of clinical pharmacology

132. Hypertension in Children: Role of Obesity, Simple Carbohydrates, and Uric Acid Full Text available with Trip Pro

Hypertension in Children: Role of Obesity, Simple Carbohydrates, and Uric Acid Over the past 60 years there has been a dramatic increase in the prevalence of overweight in children and adolescents, ranging from 4% in 1975 to 18% in 2016. Recent estimates indicate that overweight or obese children and adolescents are more than 340 million. Obesity is often associated with hypertension, which is an important cardiovascular risk factor. Recent studies show that the presence of hypertension (...) , particularly fructose, both in adults and in children. Excessive intake of fructose leads to increased serum uric acid (SUA) and high SUA values are independently associated with the presence of hypertension and weaken the efficacy of lifestyle modifications in children. The present review intends to provide an update of existing data regarding the relationship between BP, simple carbohydrates (particularly fructose), and uric acid in pediatric age. In addition, we analyze the national policies that have

2018 Frontiers in public health

133. Accuracy of the HumaSensplus point-of-care uric acid meter using capillary blood obtained by fingertip puncture Full Text available with Trip Pro

Accuracy of the HumaSensplus point-of-care uric acid meter using capillary blood obtained by fingertip puncture The uric acid (UA) level in patients with gout is a key factor in disease management and is typically measured in the laboratory using plasma samples obtained after venous puncture. This study aimed to assess the reliability of immediate UA measurement with capillary blood samples obtained by fingertip puncture with the HumaSensplus point-of-care meter.UA levels were measured using

2018 Arthritis research & therapy

134. Predictive Value of Serum Creatinine, Blood Urea Nitrogen, Uric Acid, and β2-Microglobulin in the Evaluation of Acute Kidney Injury after Orthotopic Liver Transplantation Full Text available with Trip Pro

Predictive Value of Serum Creatinine, Blood Urea Nitrogen, Uric Acid, and β2-Microglobulin in the Evaluation of Acute Kidney Injury after Orthotopic Liver Transplantation As a major complication after orthotopic liver transplantation (OLT), the occurrence of acute kidney injury (AKI) is frequently defined by serum creatinine (Cr); however, the accuracy of commonly used blood urea nitrogen (BUN), uric acid (UA), and β2-microglobulin (β2-MG) remains to be explored. This retrospective study

2018 Chinese medical journal

135. Synovial fluid uric acid level aids diagnosis of gout Full Text available with Trip Pro

Synovial fluid uric acid level aids diagnosis of gout Examination of urate crystal in synovial fluid (SF) remains the gold standard for diagnosis of gout, but is not universally available. SF uric acid (UA) level may be measured by the uricase method with an automated analyzer. The present study aimed to evaluate the utility of SF to serum UA ratio (SSR) for diagnosis of gout. A cross-sectional study was conducted at the National Center for Rheumatic Diseases, Nepal. Patients presenting

2018 Biomedical reports

136. Association Between Uric Acid and Metabolic Syndrome in Elderly Women Full Text available with Trip Pro

Association Between Uric Acid and Metabolic Syndrome in Elderly Women To investigate the relationship between uric acid and metabolic syndrome (MetS) in elderly women.A total of 468 women aged ≥60 years participating in a health examination were enrolled. The association between uric acid and MetS and its individual variables was evaluated by univariate and multivariate logistic regression models.A dose-response relationship was observed for the prevalence of MetS and uric acid quartiles (...) . Subjects in the second, third and fourth quartile of uric acid had a 2.23-fold, 2.25-fold and 4.41-fold increased risk, respectively, of MetS than those in the first uric acid quartile (p for trend <0.001). Furthermore, each 1 mg/dl increment of serum uric acid level had a 1.38-fold increased risk of MetS (OR 1.38; 95% CI, 1.14-1.69; p=0.001).Our present study demonstrated that elevated uric acid was positively associated with the prevalence of MetS in elderly women. Further random control trials

2018 Open Medicine

137. Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion Full Text available with Trip Pro

Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion In patients with cerebral infarction (CI), elevated serum uric acid (UA) level may exacerbate the occurrence and development of carotid atherosclerosis (AS). Our study intended to explore the underlying mechanism. We enrolled 86 patients with CI, and divided them into four groups: Non-AS, AS-mild, AS-moderate, and AS-severe groups; the levels of UA and oxidative

2018 Bioscience reports

138. Association between urinary sodium excretion and uric acid, and its interaction on the risk of prehypertension among Chinese young adults Full Text available with Trip Pro

Association between urinary sodium excretion and uric acid, and its interaction on the risk of prehypertension among Chinese young adults High uric acid (UA) level and high salt intake are reportedly associated with cardiovascular disease. This study investigated the association between UA and urinary sodium excretion, as well as its interaction on the risk of prehypertension. A total of 1869 participants without hypertension were recruited from a previously established cohort in Shaanxi

2018 Scientific reports

139. Development and Validation of a Simple High Performance Liquid Chromatography/UV Method for Simultaneous Determination of Urinary Uric Acid, Hypoxanthine, and Creatinine in Human Urine Full Text available with Trip Pro

Development and Validation of a Simple High Performance Liquid Chromatography/UV Method for Simultaneous Determination of Urinary Uric Acid, Hypoxanthine, and Creatinine in Human Urine Uric acid and hypoxanthine are produced in the catabolism of purine. Abnormal urinary levels of these products are associated with many diseases and therefore it is necessary to have a simple and rapid method to detect them. Hence, we report a simple reverse phase high performance liquid chromatography (HPLC/UV (...) ) technique, developed and validated for simultaneous analysis of uric acid, hypoxanthine, and creatinine in human urine. Urine was diluted appropriately and eluted with C-18 column 100 mm × 4.6 mm with a C-18 precolumn 25 mm × 4.6 mm in series. Potassium phosphate buffer (20 mM, pH 7.25) at a flow rate of 0.40 mL/min was employed as the solvent and peaks were detected at 235 nm. Tyrosine was used as the internal standard. The experimental conditions offered a good separation of analytes without

2018 International Journal of Analytical Chemistry

140. Relationship between Serum Uric Acid and Vascular Function and Structure Markers and Gender Difference in a Real-World Population of China-From Beijing Vascular Disease Patients Evaluation Study (BEST) Study Full Text available with Trip Pro

Relationship between Serum Uric Acid and Vascular Function and Structure Markers and Gender Difference in a Real-World Population of China-From Beijing Vascular Disease Patients Evaluation Study (BEST) Study The study was done to establish the relationship between serum uric acid (UA) and vascular function and structure parameters including carotid femoral pulse wave velocity (CF-PWV), carotid radial pulse wave velocity (CR-PWV), cardio ankle vascular index (CAVI), ankle brachial index (ABI

2018 Journal of atherosclerosis and thrombosis

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