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Uric Acid

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101. Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study (PubMed)

Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study We aimed to evaluate the association of serum uric acid on admission with long-term outcome of critically ill patients.We conducted a retrospective cohort study using data extracted from the Medical Information Mart for Intensive Care III database. The primary endpoint was 90-day mortality. Propensity score matching (PSM) was performed, and multivariate Cox regression analysis (...) was used to adjust for potential confounders. Receiver operating characteristic (ROC) curves were also used to assess the mortality predictions.A total of 2,123 patients were included finally with a PSM cohort consisting of 556 90-day non-survivors matched 1:1 with 556 90-day survivors. No statistically significant difference of median admission uric acid was observed between the two groups (survivors 5.50 mg/dL vs non-survivors 5.60 mg/dL, p=0.536). ROC area under the curve was 0.511 (95% confidence

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2018 Therapeutics and clinical risk management

102. Association between post-transplant uric acid level and renal allograft fibrosis: Analysis using Banff pathologic scores from renal biopsies (PubMed)

Association between post-transplant uric acid level and renal allograft fibrosis: Analysis using Banff pathologic scores from renal biopsies Several experimental studies implicate uric acid in renal injury and fibrosis. The objective of this study was to examine the association between uric acid level and allograft fibrosis after kidney transplantation. 241 adult patients who underwent kidney transplantation between 2003 and 2014 were divided into three groups according to the sex specific (...) tertiles of mean uric acid level within the first post-transplant year. The renal biopsies performed during 1 to 5 post-transplant year were analyzed to compare the degree of interstitial fibrosis and tubular atrophy (IF/TA). Mean interval between kidney transplantation and biopsy was similar between groups (23.7 ± 15.3 vs. 30.0 ± 18.6 vs. 27.5 ± 18.5 months, P = 0.072). The higher tertile uric acid level was, the more advanced grade of IF/TA was shown (P = 0.001). Multivariate analysis identified uric

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2018 Scientific reports

103. Uric Acid and Cognitive Function in Older Individuals (PubMed)

Uric Acid and Cognitive Function in Older Individuals Hyperuricemia has been recognized as an independent cardiovascular risk factor in epidemiological studies. However, uric acid can also exert beneficial functions due to its antioxidant properties, which may be particularly relevant in the context of neurodegenerative diseases. In this paper, we critically revise the evidence on the relationship between serum uric acid levels and cognitive function in older individuals, focusing (...) on the etiology of cognitive impairment (Alzheimer's disease, Parkinson's dementia, and vascular dementia) and on the interactive connections between uric acid, dementia, and diet. Despite high heterogeneity in the existing studies, due to different characteristics of studied populations and methods of cognitive dysfunction assessment, we conclude that serum uric acid may modulate cognitive function in a different way according to the etiology of dementia. Current studies indeed demonstrate that uric acid may

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2018 Nutrients

104. Effect of a Health Belief Model-based education program on patients’ belief, physical activity, and serum uric acid: a randomized controlled trial (PubMed)

Effect of a Health Belief Model-based education program on patients’ belief, physical activity, and serum uric acid: a randomized controlled trial We aimed to investigate the effect of a Health Belief Model (HBM)-based education program on the perception scores of 5 HBM domains, physical activity, and serum uric acid (SUA) among asymptomatic hyperuricemia (AHU) patients in a randomized controlled trial.One hundred and ninety-three AHU patients were involved in this prospective experimental

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2018 Patient preference and adherence

105. Serum uric acid predicts incident metabolic syndrome in the elderly in an analysis of the Brisighella Heart Study (PubMed)

Serum uric acid predicts incident metabolic syndrome in the elderly in an analysis of the Brisighella Heart Study Several epidemiological studies report a positive correlation between hyperuricemia and metabolic syndrome (MetS) in adults, which hyperuricemic subjects seem to more easily develop. We aimed to verify if serum uric acid (SUA) concentrations were positively associated with MetS prevalence and middle-term (4-year) incidence in older overall healthy subjects. We also purposed

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2018 Scientific reports

106. Uric acid and cognitive decline: a double-edge sword? (PubMed)

Uric acid and cognitive decline: a double-edge sword? This narrative review aims to highlight recent findings on the relation between uric acid level and cognitive decline or dementia.The antioxidant properties of uric acid, which have supported the hypothesis that uric acid may be neuroprotective, have been questioned by preclinical data. Studies investigating the relation between serum uric acid (SUA) level and Alzheimer disease are mostly cross-sectional, and results are often inconclusive (...) . Similarly, data for an association between uric acid level and cognitive performance are inconsistent. There is some evidence that low SUA level might be associated with Parkinson disease, but studies are limited by methodological heterogeneity and risk of bias. Patients with gout may have decreased risk for Alzheimer disease, but the impact of treatment is unclear. Recent data suggest an increased risk of vascular dementia with high SUA level via increased cerebrovascular burden in older patients

2018 Current Opinion in Rheumatology

107. Elevated serum uric acid predicts the development of moderate coronary artery calcification independent of conventional cardiovascular risk factors. (PubMed)

Elevated serum uric acid predicts the development of moderate coronary artery calcification independent of conventional cardiovascular risk factors. Hyperuricemia was frequently noted in subjects with a high risk of cardiovascular disease (CVD). This study aimed to elucidate whether serum uric acid (SUA) is associated with development of moderate coronary artery calcification in generally healthy adults.A total of 9297 subjects underwent multidetector CT for the evaluation of CAC at least two

2018 Atherosclerosis

108. Uric acid and risk of new-onset metabolic syndrome, impaired fasting glucose and diabetes mellitus in a general Italian population: data from the Pressioni Arteriose Monitorate E Loro Associazioni study. (PubMed)

Uric acid and risk of new-onset metabolic syndrome, impaired fasting glucose and diabetes mellitus in a general Italian population: data from the Pressioni Arteriose Monitorate E Loro Associazioni study. Although several data suggest that serum uric acid (SUA) predicts future development of metabolic abnormalities, the evidence is not conclusive in Mediterranean populations.A total of 3200 individuals were randomly selected from the residents of Monza (North Italy) to be representative of its

2018 Journal of Hypertension

109. The effects of apples and apple juice on acute plasma uric acid concentration: a randomized controlled trial. (PubMed)

The effects of apples and apple juice on acute plasma uric acid concentration: a randomized controlled trial. The consumption of large amounts of fructose from added sugars results in the hepatic production and export of uric acid into the circulation.Our aim was to test whether fructose present in fruit is of sufficient quantity or in a form that will increase uric acid concentration.Seventy-three participants were randomly assigned to 1 of 3 groups to ingest small (205 g) and large (410 g (...) ) servings of apple segments, small (170 mL) and large (340 mL) servings of apple juice, or a glucose and a fructose control beverage. Within each group, participants ingested both treatments in a crossover design. The fructose control and the large servings of apple and juice contained 26.7 g fructose. Test foods were ingested within 10 min. Blood samples were taken at baseline and at 30 and 60 min after intake.Plasma uric acid concentrations increased after the intake of all fructose-containing

2018 American Journal of Clinical Nutrition

110. Effect of immediate and prolonged GLP-1 receptor agonist administration on uric acid and its kidney clearance: post-hoc analyses of four clinical trials. (PubMed)

Effect of immediate and prolonged GLP-1 receptor agonist administration on uric acid and its kidney clearance: post-hoc analyses of four clinical trials. To determine the effects of glucagon-like peptide (GLP)-1 receptor agonists (RA) on uric acid (UA) levels and kidney UA clearance.This study involved post-hoc analyses of 4 controlled clinical trials, which assessed actions of GLP-1RA administration on kidney physiology. The immediate effects of GLP-1RA exenatide infusion vs placebo were

2018 obesity & metabolism

111. Effects of a DASH Diet Intervention on Serum Uric Acid in African Americans with Hypertension. (PubMed)

Effects of a DASH Diet Intervention on Serum Uric Acid in African Americans with Hypertension. To examine whether partial replacement of a diet typical of the average American diet with Dietary Approaches to Stop Hypertension (DASH)-related foods in the home environment lowers the serum uric acid (UA) level in individuals with hypertension.We conducted an ancillary study of a randomized trial of African American adults with controlled hypertension from an urban clinic. Participants were

2018 Arthritis care & research

112. Serum uric acid and prevalence of age-related hearing loss in the Japanese population: Baseline data from the Aidai Cohort Study in Yawatahama. (PubMed)

Serum uric acid and prevalence of age-related hearing loss in the Japanese population: Baseline data from the Aidai Cohort Study in Yawatahama. This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.Copyright © 2017. Published by Elsevier Inc.

2018 Experimental Gerontology

113. Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study

Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03425305 Recruitment Status : Active, not recruiting First Posted : February 7, 2018 Last Update Posted : February 7, 2018 Sponsor: University College, London Collaborators

2018 Clinical Trials

114. Detection of uric acid crystal deposition by ultrasonography and dual-energy computed tomography: A cross-sectional study in patients with clinically diagnosed gout. (PubMed)

Detection of uric acid crystal deposition by ultrasonography and dual-energy computed tomography: A cross-sectional study in patients with clinically diagnosed gout. The aim of our study was to compare the performance of ultrasonography (US) and dual-energy computed tomography (DECT) in detecting the crystal deposition at lower extremity joints in patients with gout. The correlation of imaging findings with microscopic findings was further assessed whenever aspiration is available.We recruited

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2018 Medicine

115. Preoperative serum uric acid predicts incident acute kidney injury following cardiac surgery. (PubMed)

Preoperative serum uric acid predicts incident acute kidney injury following cardiac surgery. Acute kidney injury (AKI) following cardiac surgery is a frequent complication and several risk factors increasing its incidence have already been characterized. This study evaluates the influence of preoperative increased serum uric acid (SUA) levels in comparison with other known risk factors on the incidence of AKI following cardiac surgery.During a period of 5 month, 247 patients underwent elective (...) coronary artery bypass grafting, valve replacement/ repair or combined bypass and valve surgery. Datas were prospectively analyzed. Primary endpoint was the incidence of AKI as defined by the AKI criteria comparing patients with preoperative serum uric acid (SUA) levels below versus above the median. Multivariate logistic regression analysis was used to identify independent predictors of postoperative AKI.Thirty (12.1%) of the 247 patients developed postoperative AKI, 24 of 30 (80%) had preoperative

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2018 BMC Nephrology

116. Uric acid and progression of chronic kidney disease. (PubMed)

Uric acid and progression of chronic kidney disease. The association between serum uric acid levels and human disease has garnered intense interest over the last decade including chronic kidney disease. Animal studies have provided evidence for a potential mechanistic role of uric acid in promoting progression of chronic kidney disease. Epidemiologic studies have also suggested an association between elevated serum uric acid levels and worsening renal function in the general population as well (...) as in patients with chronic kidney disease. However, there is currently insufficient evidence to recommend the use of uric acid-lowering therapy to delay progression of chronic kidney disease in this patient population. Adequately powered, randomized, placebo-controlled trials are required to more precisely evaluate the risk and benefits of uric acid-lowering therapy in pediatric patients.

2018 Pediatric Nephrology

117. The systems biology of uric acid transporters: the role of remote sensing and signaling. (PubMed)

The systems biology of uric acid transporters: the role of remote sensing and signaling. Uric acid homeostasis in the body is mediated by a number of SLC and ABC transporters in the kidney and intestine, including several multispecific 'drug' transporters (e.g., OAT1, OAT3, and ABCG2). Optimization of uric acid levels can be viewed as a 'systems biology' problem. Here, we consider uric acid transporters from a systems physiology perspective using the framework of the 'Remote Sensing (...) and Signaling Hypothesis.' This hypothesis explains how SLC and ABC 'drug' and other transporters mediate interorgan and interorganismal communication (e.g., gut microbiome and host) via small molecules (e.g., metabolites, antioxidants signaling molecules) through transporters expressed in tissues lining body fluid compartments (e.g., blood, urine, cerebrospinal fluid).The list of uric acid transporters includes: SLC2A9, ABCG2, URAT1 (SLC22A12), OAT1 (SLC22A6), OAT3 (SLC22A8), OAT4 (SLC22A11), OAT10

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2018 Current Opinion in Nephrology and Hypertension

118. EuBIVAS: Within- and Between-Subject Biological Variation Data for Electrolytes, Lipids, Urea, Uric Acid, Total Protein, Total Bilirubin, Direct Bilirubin, and Glucose. (PubMed)

EuBIVAS: Within- and Between-Subject Biological Variation Data for Electrolytes, Lipids, Urea, Uric Acid, Total Protein, Total Bilirubin, Direct Bilirubin, and Glucose. The European Federation of Clinical Chemistry and Laboratory Medicine European Biological Variation Study (EuBIVAS) has been established to deliver rigorously determined data describing biological variation (BV) of clinically important measurands. Here, EuBIVAS-based BV estimates of serum electrolytes, lipids, urea, uric acid (...) , when relevant, to determine BV estimates with CIs.The within-subject BV (CVI) estimates of all measurands, except for urea and LDL cholesterol, were lower than estimates available in an online BV database, with differences being most pronounced for HDL cholesterol, glucose, and direct bilirubin. Significant differences in CVI for men and women/women <50 years of age were evident for uric acid, triglycerides, and urea. The CVA obtained for sodium and magnesium exceeded the EuBIVAS-based APS

2018 Clinical Chemistry

119. Association of serum uric acid levels with primary open-angle glaucoma: a 5-year case-control study. (PubMed)

Association of serum uric acid levels with primary open-angle glaucoma: a 5-year case-control study. It has been hypothesised that uric acid (UA) has a protective effect against oxidative damage in the central nervous system. Therefore, we investigated serum UA concentrations in patients with primary open-angle glaucoma (POAG) and explored the relationship between serum UA concentration and glaucoma severity.This prospective, cross-sectional, case-control study was conducted in 163 POAG

2018 Acta ophthalmologica

120. Unaccounted for Regression to the Mean Renders Conclusion of Article Titled "Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor Tofogliflozin" Unsubstantiated. (PubMed)

Unaccounted for Regression to the Mean Renders Conclusion of Article Titled "Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor Tofogliflozin" Unsubstantiated. 29660244 2018 08 09 2018 12 02 1463-1326 20 8 2018 08 Diabetes, obesity & metabolism Diabetes Obes Metab Unaccounted for regression to the mean renders conclusion of article titled "Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor tofogliflozin" unsubstantiated. 2039-2040 10.1111/dom (...) , Bloomington, Indiana. eng R25 DK099080 DK NIDDK NIH HHS United States R25 HL124208 HL NHLBI NIH HHS United States Letter Research Support, N.I.H., Extramural Comment 2018 05 03 England Diabetes Obes Metab 100883645 1462-8902 0 Benzhydryl Compounds 0 Glucosides 0 Glycated Hemoglobin A 0 Hypoglycemic Agents 0 Sodium-Glucose Transporter 2 268B43MJ25 Uric Acid P8DD8KX4O4 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol IM Diabetes Obes

2018 obesity & metabolism

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