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Uric Acid

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61. Association of the ESR1 polymorphism with menopause and MLXIPL genetic variant influence serum uric acid levels in Slovak midlife women. (Abstract)

Association of the ESR1 polymorphism with menopause and MLXIPL genetic variant influence serum uric acid levels in Slovak midlife women. This study examines associations between the ESR1 (XbaI, PvuII) and the MLXIPL (rs3812316) gene polymorphisms, and uric acid (UA) levels in Slovak midlife women, subdivided according to their menopause status.We assessed a total of 362 women from 38 to 65 years of age. Women were recruited from different localities in the western and middle parts of Slovakia

2019 Menopause

62. Targeted renal knockdown of Na<sup>+</sup>/H<sup>+</sup> exchanger regulatory factor <i>Sip1</i> produces uric acid nephrolithiasis in <i>Drosophila</i>. (Abstract)

Targeted renal knockdown of Na+/H+ exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila. Nephrolithiasis is one of the most common kidney diseases, with poorly understood pathophysiology, but experimental study has been hindered by lack of experimentally tractable models. Drosophila melanogaster is a useful model organism for renal diseases because of genetic and functional similarities of Malpighian (renal) tubules with the human (...) in rosy mutant flies (which model human xanthinuria) and by the xanthine oxidase inhibitor allopurinol, suggesting that the calculi were of uric acid. This was confirmed by direct biochemical assay for urate. Stones rapidly dissolved when the tubule was bathed in alkaline media, suggesting that Sip1 knockdown was acidifying the tubule. SIP1 was shown to collocate with Na+/H+ exchanger isoform 2 (NHE2) and with moesin in stellate cells. Knockdown of NHE2 specifically to the stellate cells also

2019 American Journal of Physiology. Renal physiology

63. Serum Uric Acid Measurement in Women With Hypertensive Disorders of Pregnancy. (Abstract)

Serum Uric Acid Measurement in Women With Hypertensive Disorders of Pregnancy. A 27-year-old asymptomatic primigravid woman at 36 weeks of gestation is evaluated in the labor and delivery unit with new-onset hypertension of 145/92 mm Hg (with similar measurements 4 hours apart). A spot urine protein/creatinine ratio is 0.35, serum transaminases and creatinine level are normal, and uric acid is 6.0 mg/dL (upper limit of normal for adult woman is 6.0 mg/dL but typically 4-5 mg/dL in the third

2019 Obstetrics and Gynecology

64. Elevated serum uric acid is associated with peripheral endothelial dysfunction in women. (Abstract)

Elevated serum uric acid is associated with peripheral endothelial dysfunction in women. Both elevated serum uric acid (SUA) and peripheral endothelial dysfunction (PED) are associated independently with cardiovascular disease (CVD). However, the association between SUA and PED is yet to be established. We hypothesized that high normal range of SUA is associated with PED.We performed a retrospective cross-sectional analysis of patients who were referred to Mayo Clinic between 2006 and 2014

2019 Atherosclerosis

65. Serum uric acid level and subclinical coronary atherosclerosis in asymptomatic individuals: An observational cohort study. (Abstract)

Serum uric acid level and subclinical coronary atherosclerosis in asymptomatic individuals: An observational cohort study. There are limited data on the association between serum uric acid (SUA) level and subclinical coronary atherosclerosis. This study investigated the influence of SUA level on subclinical coronary atherosclerosis, as detected by coronary computed tomography angiography (CCTA), in an asymptomatic population.We evaluated 6431 asymptomatic individuals (mean age 53.6 ± 7.6 years

2019 Atherosclerosis

66. Prognostic impact of elevated serum uric acid levels on long-term outcomes in patients with chronic heart failure: A post-hoc analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) trial. (Abstract)

Prognostic impact of elevated serum uric acid levels on long-term outcomes in patients with chronic heart failure: A post-hoc analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) trial. The prognostic impact of hyperuricemia on long-term clinical outcomes in patients with chronic heart failure (HF) has been investigated in observational registries and clinical trials, but the results have been often inconclusive. We examined (...) the prognostic impact of elevated serum uric acid levels on long-term clinical outcomes in the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) trial.CLINICALTRIALS.NCT00336336.We assessed the rates of all-cause death, cardiovascular death, cardiovascular hospitalization and the composite of all-cause death or cardiovascular hospitalization over a median follow-up of 3.9 years among 6683 ambulatory patients with chronic HF.Patients in the 3rd serum uric

2019 Metabolism: clinical and experimental Controlled trial quality: uncertain

67. The relationship between serum uric acid and lipid profile in Bangladeshi adults. Full Text available with Trip Pro

The relationship between serum uric acid and lipid profile in Bangladeshi adults. Although the link between elevated uric acid and metabolic syndrome has been reported in some studies; the relationship of serum uric acid (SUA) with lipid profile has not well studied or little is known so far. This study was conducted to assess the relationship between SUA and lipid profile among the general adults in Bangladesh.In total, 280 blood samples were collected from general adult participants (male, n

2019 BMC Cardiovascular Disorders

68. A Model of Uric Acid Transport in the Rat Proximal Tubule. (Abstract)

A Model of Uric Acid Transport in the Rat Proximal Tubule. The objective of this study was to investigate theoretically the mechanisms underlying uric acid transport in the proximal tubule (PT) of rat kidneys, and their modulation by factors including Na+, parathyroid hormone (PTH), Angiotensin II, and SGLT2 inhibitors. To that end, we incorporated the transport of uric acid and its conjugate anion urate in our mathematical model of water and solute transport in the rat PT. The model accounts (...) of uric acid transport in the rat PT; this model provides a framework to gain greater insight into the numerous solutes and coupling mechanisms that affect the renal handing of uric acid.

2019 American Journal of Physiology. Renal physiology

69. Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase 1 study in healthy volunteers. Full Text available with Trip Pro

Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase 1 study in healthy volunteers. Myeloperoxidase activity can contribute to impaired vascular endothelial function and fibrosis in chronic inflammation-related cardiovascular disease. Here, we investigated the safety, tolerability and pharmacokinetics of the myeloperoxidase inhibitor, AZD4831.In this randomized, single-blind, placebo-controlled (...) concentration-time curve (AUC) increased proportionally with dose (AUC0-∝ slope estimate 1.060; 95% confidence interval [CI] 0.9943, 1.127). Increases in maximum plasma concentration were slightly more than dose proportional (slope estimate 1.201; 95% CI 1.071, 1.332). Food intake reduced AZD4831 absorption rate but did not substantially affect overall exposure or plasma half-life (n = 4). Serum uric acid concentrations decreased by 71.77 (95% CI 29.15, 114.39) and 84.42 (58.90, 109.94) μmol L-1

2019 British journal of clinical pharmacology Controlled trial quality: uncertain

70. Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease? (Abstract)

Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease? Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease in Western countries with potential progression to nonalcoholic steatohepatitis (NASH) and cirrhosis, is associated with cardiovascular disease (CVD) mortality. Several studies have reported a relationship between uric acid and NAFLD/NASH and it seems that serum uric acid (SUA) is a significant

2019 Current vascular pharmacology

71. Medical dissolution therapy for the treatment of uric acid nephrolithiasis. (Abstract)

Medical dissolution therapy for the treatment of uric acid nephrolithiasis. Uric acid (UA) nephrolithiasis represents 10% of kidney stones in the US with low urine pH and high saturation of UA as the main risk factors for stone development. Dissolution therapy for UA kidney stones via urinary alkalization has been described as a treatment option. We present our experience in treating UA nephrolithiasis with medical dissolution therapy.A retrospective review was performed of UA stone patients

2019 World journal of urology

72. Uric Acid is an Independent Risk Factor for Decline in Kidney Function, Cardiovascular Event and Mortality in Patients With Type 1 Diabetes. (Abstract)

Uric Acid is an Independent Risk Factor for Decline in Kidney Function, Cardiovascular Event and Mortality in Patients With Type 1 Diabetes. Previous studies have provided inconclusive results on the role of uric acid (UA) in risk prediction. Here we aimed to improve the power and precision of the predictive value of UA for the risk of decline in kidney function, cardiovascular events (CVEs), and mortality in patients with type 1 diabetes (T1D).Plasma UA was measured in 670 patients with T1D

2019 Diabetes Care

73. Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity. (Abstract)

Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity. Some evidence suggests a relationship between thyroid dysfunction and uric acid (UA) metabolism, but the potential influential role of thyroid hormones on UA metabolism is still debated. This report was designed to evaluate the influential role of levothyroxine (L-T4) replacement therapy on circulating levels of UA in patients with recent onset post

2019 Internal and emergency medicine

74. Blockade of ERK1/2 by U0126 alleviates uric acid induced EMT and tubular cell injury in the rats with hyperuricemic nephropathy. (Abstract)

Blockade of ERK1/2 by U0126 alleviates uric acid induced EMT and tubular cell injury in the rats with hyperuricemic nephropathy. Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are serine/threonine kinases and function as regulators of cellular proliferation and differentiation. Recently, we demonstrated that inhibition of ERK1/2 alleviates the development and progression of hyperuricemia nephropathy (HN). However, its potential roles in uric acid-induced tubular epithelial-mesenchymal

2019 American Journal of Physiology. Renal physiology

75. Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure. Full Text available with Trip Pro

Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure. Elevated serum uric acid (SUA) is associated with poor prognosis in patients with cardiovascular disease, yet it is still not decided whether the role of SUA is causal or only reflects an underlying disease. The purpose of the study was to investigate if SUA was an independent predictor of 5-year all-cause mortality in a propensity score matched cohort of chronic heart failure (HF

2019 BMC Cardiovascular Disorders

76. Serum uric acid and resistance to antihypertensive treatment: data from the European Lacidipine Study on Atherosclerosis. (Abstract)

Serum uric acid and resistance to antihypertensive treatment: data from the European Lacidipine Study on Atherosclerosis. Whether increased serum uric acid (SUA) favours resistance to antihypertensive drugs is not clear.The European Lacidipine Study on Atherosclerosis (ELSA) was a randomized, double-blind, multicenter trial comparing the effects of a 4-year treatment with either lacidipine or atenolol on progression of carotid atherosclerosis in patients with moderate hypertension. SUA

2019 Journal of Hypertension Controlled trial quality: uncertain

77. Long-term Recurrence Rates in Uric Acid Stone Formers With or Without Medical Management. (Abstract)

Long-term Recurrence Rates in Uric Acid Stone Formers With or Without Medical Management. To determine if medical therapy affects long-term clinical outcomes in uric acid stone formers (UASF).We identified 53 UASF who had complete stone clearance following stone procedure by computed tomography (CT) and had ≥1 postoperative 24-hour urine collection and a clinical follow-up ≥6 months with a surveillance CT scan. Patients were divided into "adherent to medical therapy" (compliance with potassium

2019 Urology

78. Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen-progestin therapy in hypertensive postmenopausal women. (Abstract)

Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen-progestin therapy in hypertensive postmenopausal women. The aim was to assess the effect of estrogen-progestin therapy (EPT) on serum levels of uric acid (SUA) and its precursors: xanthine (X) and hypoxanthine (HX) and on uric acid (UA) renal excretion in hypertensive postmenopausal women treated with an angiotensin-converting enzyme

2019 Current medical research and opinion Controlled trial quality: uncertain

79. Distinct Uric Acid Trajectories Are Associated With Different Risks of Incident Hypertension in Middle-Aged Adults. (Abstract)

Distinct Uric Acid Trajectories Are Associated With Different Risks of Incident Hypertension in Middle-Aged Adults. To identify common uric acid (UA) trajectories in middle-aged adults and to examine their association with the risk of hypertension.This prospective cohort included 5758 participants who were aged between 30 and 60 years without hypertension on or before June 1, 2011. Latent mixture modeling was used to identify UA trajectories from June 1, 2005, through June 1, 2011

2019 Mayo Clinic Proceedings

80. Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Stu (Abstract)

Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Stu Elevated serum uric acid (SUA) is increasingly recognized as a risk factor for kidney disease in adults with diabetes, but data in youth are limited. We hypothesized that elevated SUA predicts development of elevated urinary albumin excretion

2019 Diabetes Care

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