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Uric Acid

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41. The relationship between serum uric acid and lipid profile in Bangladeshi adults. (PubMed)

The relationship between serum uric acid and lipid profile in Bangladeshi adults. Although the link between elevated uric acid and metabolic syndrome has been reported in some studies; the relationship of serum uric acid (SUA) with lipid profile has not well studied or little is known so far. This study was conducted to assess the relationship between SUA and lipid profile among the general adults in Bangladesh.In total, 280 blood samples were collected from general adult participants (male, n

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2019 BMC Cardiovascular Disorders

42. A Model of Uric Acid Transport in the Rat Proximal Tubule. (PubMed)

A Model of Uric Acid Transport in the Rat Proximal Tubule. The objective of this study was to investigate theoretically the mechanisms underlying uric acid transport in the proximal tubule (PT) of rat kidneys, and their modulation by factors including Na+, parathyroid hormone (PTH), Angiotensin II, and SGLT2 inhibitors. To that end, we incorporated the transport of uric acid and its conjugate anion urate in our mathematical model of water and solute transport in the rat PT. The model accounts (...) of uric acid transport in the rat PT; this model provides a framework to gain greater insight into the numerous solutes and coupling mechanisms that affect the renal handing of uric acid.

2019 American Journal of Physiology. Renal physiology

43. Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study. (PubMed)

Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study. To estimate the current prevalence of cardiovascular disease risk factors (CRFs) and renal disorders across serum uric acid (SUA) quartiles, and evaluate the relationships between SUA and CRFs and renal diseases in Shanghai population.Observational, cross-sectional study.Data were obtained from the physical check-up

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2019 BMJ open

44. Precipitation of Soluble Uric Acid is Necessary for in vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes. (PubMed)

Precipitation of Soluble Uric Acid is Necessary for in vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes. To investigate the effects of soluble uric acid (UA) on expression and activation of the NODlike receptor (NLR) pyrin domain containing protein 3 (NLRP3) inflammasome in human monocytes to elucidate the role of hyperuricemia in the pathogenesis of gout.Primary human monocytes and the THP-1 human monocyte cell line were used to determine the effects of short- and long

2019 Journal of Rheumatology

45. Prognostic value of serum uric acid in patients with acute heart failure: A meta-analysis. (PubMed)

Prognostic value of serum uric acid in patients with acute heart failure: A meta-analysis. Conflicting results have been reported on the prognostic significance of serum uric acid (SUA) in patients with acute heart failure (AHF). This meta-analysis aimed to determine the prognostic significance of SUA level in patients with AHF.We made a comprehensive literature search in Pubmed and Embase databases from inception to April 6, 2018. All available observational studies or post hoc analysis

2019 Medicine

46. Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase 1 study in healthy volunteers. (PubMed)

Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase 1 study in healthy volunteers. Myeloperoxidase activity can contribute to impaired vascular endothelial function and fibrosis in chronic inflammation-related cardiovascular disease. Here, we investigated the safety, tolerability and pharmacokinetics of the myeloperoxidase inhibitor, AZD4831.In this randomized, single-blind, placebo-controlled (...) concentration-time curve (AUC) increased proportionally with dose (AUC0-∝ slope estimate 1.060; 95% confidence interval [CI] 0.9943, 1.127). Increases in maximum plasma concentration were slightly more than dose proportional (slope estimate 1.201; 95% CI 1.071, 1.332). Food intake reduced AZD4831 absorption rate but did not substantially affect overall exposure or plasma half-life (n = 4). Serum uric acid concentrations decreased by 71.77 (95% CI 29.15, 114.39) and 84.42 (58.90, 109.94) μmol L-1

2019 British journal of clinical pharmacology

47. Association of maternal uric acid and cystatin C serum concentrations with maternal and neonatal cardiovascular risk markers and neonatal body composition: The Ulm SPATZ Health Study. (PubMed)

Association of maternal uric acid and cystatin C serum concentrations with maternal and neonatal cardiovascular risk markers and neonatal body composition: The Ulm SPATZ Health Study. In utero exposure to cardiometabolic risk factors may determine health related outcomes at birth and in later life. The aim of this analysis was to describe the relationship of maternal serum uric acid (SUA) and cystatin C with maternal and neonatal cardiometabolic risk markers and with birth weight and risk

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2018 PLoS ONE

48. Accumulation of uric acid in the epidermis forms the white integument of Samia ricini larvae. (PubMed)

Accumulation of uric acid in the epidermis forms the white integument of Samia ricini larvae. The white color in the larval integument of the silkworm Bombyx mori is considered the result of uric acid accumulation in its epidermal cells. Larvae of the eri silkworm Samia ricini (Lepidoptera; Saturniidae) also have a white and opaque integument, but little is known about its coloration mechanism. In this study, we first performed a feeding assay of S. ricini larvae using allopurinol, an inhibitor (...) of xanthine oxidase, which catalyzes the degradation of xanthine to uric acid. This treatment induced a clear translucent integument phenotype, indicating that the larval color of S. ricini is also determined by uric acid accumulation. Next, to investigate the genetic basis that controls uric acid accumulation in S. ricini larvae, we isolated and characterized the S. ricini homolog of mammalian biogenesis of lysosome-related organelles complex 1, subunit 2 (BLOS2), which is known to play a crucial role

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2018 PLoS ONE

49. Association between post-transplant serum uric acid levels and kidney transplantation outcomes. (PubMed)

Association between post-transplant serum uric acid levels and kidney transplantation outcomes. Serum uric acid (UA) level has been reported to be associated with chronic allograft nephropathy and graft failure in patients who undergo kidney transplantation (KT). However, the role of serum UA level in renal graft survival remains controversial.This study aimed to investigate the effect of mean serum UA level during two different post-KT periods on long-term renal graft outcomes in a large

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2018 PLoS ONE

50. Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Stu (PubMed)

Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Stu Elevated serum uric acid (SUA) is increasingly recognized as a risk factor for kidney disease in adults with diabetes, but data in youth are limited. We hypothesized that elevated SUA predicts development of elevated urinary albumin excretion

2019 Diabetes Care

51. Serum uric acid and resistance to antihypertensive treatment: data from the European Lacidipine Study on Atherosclerosis. (PubMed)

Serum uric acid and resistance to antihypertensive treatment: data from the European Lacidipine Study on Atherosclerosis. Whether increased serum uric acid (SUA) favours resistance to antihypertensive drugs is not clear.The European Lacidipine Study on Atherosclerosis (ELSA) was a randomized, double-blind, multicenter trial comparing the effects of a 4-year treatment with either lacidipine or atenolol on progression of carotid atherosclerosis in patients with moderate hypertension. SUA

2019 Journal of Hypertension

52. Distinct Uric Acid Trajectories Are Associated With Different Risks of Incident Hypertension in Middle-Aged Adults. (PubMed)

Distinct Uric Acid Trajectories Are Associated With Different Risks of Incident Hypertension in Middle-Aged Adults. To identify common uric acid (UA) trajectories in middle-aged adults and to examine their association with the risk of hypertension.This prospective cohort included 5758 participants who were aged between 30 and 60 years without hypertension on or before June 1, 2011. Latent mixture modeling was used to identify UA trajectories from June 1, 2005, through June 1, 2011

2019 Mayo Clinic Proceedings

53. Effect of thiazolidinedione therapy on the risk of uric acid stones. (PubMed)

Effect of thiazolidinedione therapy on the risk of uric acid stones. The most important variable leading to uric acid stones is low urine pH. Major causal conditions associated with low urine pH are metabolic syndrome and diabetes. In the study by Maalouf et al., treatment of uric acid stone formers with pioglitazone led to small but significant increases in urine pH. Pioglitazone will not supplant alkali administration to prevent uric acid stones, but the study helps confirm that insulin (...) resistance is an important cause of low urine pH that causes uric acid stones.Published by Elsevier Inc.

2019 Kidney International

54. Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen-progestin therapy in hypertensive postmenopausal women. (PubMed)

Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen-progestin therapy in hypertensive postmenopausal women. The aim was to assess the effect of estrogen-progestin therapy (EPT) on serum levels of uric acid (SUA) and its precursors: xanthine (X) and hypoxanthine (HX) and on uric acid (UA) renal excretion in hypertensive postmenopausal women treated with an angiotensin-converting enzyme

2019 Current medical research and opinion

55. Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study. (PubMed)

Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study. Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate estimated glomerular filtration rate (eGFR). We aimed to clarify the relationship between SUA levels and kidney

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2019 BMC Nephrology

56. Predictive value of serum uric acid levels for adverse perinatal outcomes in preeclampsia. (PubMed)

Predictive value of serum uric acid levels for adverse perinatal outcomes in preeclampsia. Preeclampsia is a multisystem disorder associated with pregnancy and is a common cause of perinatal morbidity. The aim of this study was to determine whether elevated serum uric acid levels, alone or in combination with other laboratory factors could predict preeclampsia in women with adverse perinatal outcomes.We conducted a prospective observational study of women who were admitted to Soonchunhyang (...) University Cheonan Hospital from January 2016 to December 2016. Demographic, clinical and laboratory data were collected for each pregnancy at the time of delivery. Women were grouped according to status (preeclampsia or normotensive), and a logistic regression analysis was used to determine the relationship between serum uric acid levels and adverse outcomes.The mean age of the study participants was 31.3 ± 5.0 years. In patients with preeclampsia, serum uric acid level was associated with the severity

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2019 Medicine

57. Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease. (PubMed)

Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease. Serum concentrations of bilirubin, albumin, and uric acid (UA) play important roles in controlling oxidative stress. Until now, there are few researches related to the relationship between oxidative stress and Crohn's disease (CD); furthermore, no such study has been reported from China. Our aim was to evaluate serum bilirubin, albumin, and UA levels in CD patients and relate them to disease activity.Seventy

2019 Medicine

58. Association of urinary metal profiles with serum uric acid: a cross-sectional study of traffic policemen in Wuhan, China. (PubMed)

Association of urinary metal profiles with serum uric acid: a cross-sectional study of traffic policemen in Wuhan, China. Serum uric acid (SUA) is both a strong antioxidant and one of the key risk factors of cardiovascular diseases (CVDs). We aimed to investigate the associations of urinary metal profile with SUA in traffic policemen in Wuhan, China.A cross-sectional study was carried out in traffic policemen.A seriously polluted Chinese city.A total of 186 traffic policemen were recruited

2019 BMJ open

59. Long-term Recurrence Rates in Uric Acid Stone Formers With or Without Medical Management. (PubMed)

Long-term Recurrence Rates in Uric Acid Stone Formers With or Without Medical Management. To determine if medical therapy affects long-term clinical outcomes in uric acid stone formers (UASF).We identified 53 UASF who had complete stone clearance following stone procedure by computed tomography (CT) and had ≥1 postoperative 24-hour urine collection and a clinical follow-up ≥6 months with a surveillance CT scan. Patients were divided into "adherent to medical therapy" (compliance with potassium

2019 Urology

60. Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity. (PubMed)

Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity. Some evidence suggests a relationship between thyroid dysfunction and uric acid (UA) metabolism, but the potential influential role of thyroid hormones on UA metabolism is still debated. This report was designed to evaluate the influential role of levothyroxine (L-T4) replacement therapy on circulating levels of UA in patients with recent onset post

2019 Internal and emergency medicine

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