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Uric Acid

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181. The association between time-mean serum uric acid levels and the incidence of chronic kidney disease in the general population: a retrospective study. Full Text available with Trip Pro

The association between time-mean serum uric acid levels and the incidence of chronic kidney disease in the general population: a retrospective study. Investigations on the role of the time-mean serum uric acid (SUA) value in determining the risk of chronic kidney disease (CKD) are limited. We investigated whether the time-mean SUA value indicates the risk of CKD, and explored associations of the baseline and time-mean SUA levels with kidney function decline and incident CKD in a healthy

2018 BMC Nephrology

182. Common gene variants interactions related to uric acid transport are associated with knee osteoarthritis susceptibility. (Abstract)

Common gene variants interactions related to uric acid transport are associated with knee osteoarthritis susceptibility. The presence of genetic variants in uric acid (UA) transporters can be associated with hyperuricemia, and therefore with an increased risk of monosodium urate (MSU) crystal precipitation. The inflammatory process triggered by these crystals leads to cartilage damage, which, in turn, could promote knee osteoarthritis (KOA).To determine whether genetic polymorphisms of the UA

2018 Connective Tissue Research

183. Gender-related differences in serum uric acid in treated hypertensive patients from central and east European countries: findings from the Blood Pressure control rate and CArdiovascular Risk profilE study. Full Text available with Trip Pro

Gender-related differences in serum uric acid in treated hypertensive patients from central and east European countries: findings from the Blood Pressure control rate and CArdiovascular Risk profilE study. Hyperuricemia has been associated with high blood pressure (BP) values, diabetes mellitus, metabolic syndrome and chronic kidney disease (CKD). In the present study, we assessed the gender-related relationships between serum uric acid (SUA) and cardionephrometabolic variables in central

2018 Journal of Hypertension

184. Preoperative serum uric acid predicts incident acute kidney injury following cardiac surgery. Full Text available with Trip Pro

Preoperative serum uric acid predicts incident acute kidney injury following cardiac surgery. Acute kidney injury (AKI) following cardiac surgery is a frequent complication and several risk factors increasing its incidence have already been characterized. This study evaluates the influence of preoperative increased serum uric acid (SUA) levels in comparison with other known risk factors on the incidence of AKI following cardiac surgery.During a period of 5 month, 247 patients underwent elective (...) coronary artery bypass grafting, valve replacement/ repair or combined bypass and valve surgery. Datas were prospectively analyzed. Primary endpoint was the incidence of AKI as defined by the AKI criteria comparing patients with preoperative serum uric acid (SUA) levels below versus above the median. Multivariate logistic regression analysis was used to identify independent predictors of postoperative AKI.Thirty (12.1%) of the 247 patients developed postoperative AKI, 24 of 30 (80%) had preoperative

2018 BMC Nephrology

185. The systems biology of uric acid transporters: the role of remote sensing and signaling. Full Text available with Trip Pro

The systems biology of uric acid transporters: the role of remote sensing and signaling. Uric acid homeostasis in the body is mediated by a number of SLC and ABC transporters in the kidney and intestine, including several multispecific 'drug' transporters (e.g., OAT1, OAT3, and ABCG2). Optimization of uric acid levels can be viewed as a 'systems biology' problem. Here, we consider uric acid transporters from a systems physiology perspective using the framework of the 'Remote Sensing (...) and Signaling Hypothesis.' This hypothesis explains how SLC and ABC 'drug' and other transporters mediate interorgan and interorganismal communication (e.g., gut microbiome and host) via small molecules (e.g., metabolites, antioxidants signaling molecules) through transporters expressed in tissues lining body fluid compartments (e.g., blood, urine, cerebrospinal fluid).The list of uric acid transporters includes: SLC2A9, ABCG2, URAT1 (SLC22A12), OAT1 (SLC22A6), OAT3 (SLC22A8), OAT4 (SLC22A11), OAT10

2018 Current Opinion in Nephrology and Hypertension

186. This is in Reply to Letter by Dr. Chanaka N. Kahathuduwa, et al. titled 'Unaccounted for regression to the mean renders conclusion of article titled "Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor Tofogliflozin" unsubstantiate (Abstract)

This is in Reply to Letter by Dr. Chanaka N. Kahathuduwa, et al. titled 'Unaccounted for regression to the mean renders conclusion of article titled "Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor Tofogliflozin" unsubstantiate 29749099 2018 08 09 2018 12 02 1463-1326 20 8 2018 08 Diabetes, obesity & metabolism Diabetes Obes Metab This is in reply to the Letter by Kahathuduwa et al. titled "Unaccounted for regression to the mean renders conclusion of article titled (...) 'Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor Tofogliflozin' unsubstantiated". 2041-2042 10.1111/dom.13347 Ouchi Motoshi M Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan. Oba Kenzo K Department of Internal Medicine, Oarai Coast Core Clinic, Ibaraki, Japan. Suganami Hideki H 0000-0001-9130-0137 Clinical Data Science Department, Kowa Company, Ltd., Tokyo, Japan. Yoshida Akihiro A Medical Information and Product

2018 obesity & metabolism

187. Impact of serum uric acid on incident hypertension in a worksite population of Japanese men. (Abstract)

Impact of serum uric acid on incident hypertension in a worksite population of Japanese men. Higher levels of serum uric acid are associated with an increased risk of cardiovascular diseases, which may be confounded by comorbidities. We investigated the effects of serum uric acid on the risk of hypertension in Japanese men at a worksite.We evaluated a total of 2335 Japanese male workers without hypertension who ranged in age from 18 to 64 years at a worksite in 2009. These men were followed (...) for 6 years from 2009 to 2015.During the follow-up period, 380 individuals developed hypertension. The odds ratio for the incident hypertension was estimated according to quartiles of serum uric acid levels of 5.1 or less, 5.2-5.8, 5.9-6.6, and at least 6.7 mg/dl. The multivariable-adjusted risk of incident hypertension was significantly higher in the highest serum uric acid quartile than in the lowest: odds ratio 1.00 (reference) for the lowest quartile, 1.34 (0.91-1.97) for the second quartile

2018 Journal of Hypertension

188. Urinary excretion of uric acid is negatively associated with albuminuria in patients with chronic kidney disease: a cross-sectional study. Full Text available with Trip Pro

Urinary excretion of uric acid is negatively associated with albuminuria in patients with chronic kidney disease: a cross-sectional study. Increasing evidence has shown that albuminuria is related to serum uric acid. Little is known about whether this association may be interrelated via renal handling of uric acid. Therefore, we aim to study urinary uric acid excretion and its association with albuminuria in patients with chronic kidney disease (CKD).A cross-sectional study of 200 Chinese CKD (...) patients recruited from department of nephrology of Huadong hospital was conducted. Levels of 24 h urinary excretion of uric acid (24-h Uur), fractional excretion of uric acid (FEur) and uric acid clearance rate (Cur) according to gender, CKD stages, hypertension and albuminuria status were compared by a multivariate analysis. Pearson and Spearman correlation and multiple regression analyses were used to study the correlation of 24-h Uur, FEur and Cur with urinary albumin to creatinine ratio (UACR

2018 BMC Nephrology

189. Elevated serum uric acid predicts the development of moderate coronary artery calcification independent of conventional cardiovascular risk factors. (Abstract)

Elevated serum uric acid predicts the development of moderate coronary artery calcification independent of conventional cardiovascular risk factors. Hyperuricemia was frequently noted in subjects with a high risk of cardiovascular disease (CVD). This study aimed to elucidate whether serum uric acid (SUA) is associated with development of moderate coronary artery calcification in generally healthy adults.A total of 9297 subjects underwent multidetector CT for the evaluation of CAC at least two

2018 Atherosclerosis

190. Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study. Full Text available with Trip Pro

Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study. Reports are conflicting on whether serum uric acid (sUA) levels are independently associated with increased cardiovascular (CV) death risk.This post hoc analysis assessed the relationship between sUA levels and CV death risk score in 7531 patients from the cross-sectional, multinational EURIKA study (NCT00882336). Patients had at least one CV risk factor but no clinical CV disease. Ten

2018 International journal of cardiology

191. Association of serum uric acid levels with primary open-angle glaucoma: a 5-year case-control study. (Abstract)

Association of serum uric acid levels with primary open-angle glaucoma: a 5-year case-control study. It has been hypothesised that uric acid (UA) has a protective effect against oxidative damage in the central nervous system. Therefore, we investigated serum UA concentrations in patients with primary open-angle glaucoma (POAG) and explored the relationship between serum UA concentration and glaucoma severity.This prospective, cross-sectional, case-control study was conducted in 163 POAG

2018 Acta ophthalmologica

192. Uric acid and risk of new-onset metabolic syndrome, impaired fasting glucose and diabetes mellitus in a general Italian population: data from the Pressioni Arteriose Monitorate E Loro Associazioni study. (Abstract)

Uric acid and risk of new-onset metabolic syndrome, impaired fasting glucose and diabetes mellitus in a general Italian population: data from the Pressioni Arteriose Monitorate E Loro Associazioni study. Although several data suggest that serum uric acid (SUA) predicts future development of metabolic abnormalities, the evidence is not conclusive in Mediterranean populations.A total of 3200 individuals were randomly selected from the residents of Monza (North Italy) to be representative of its

2018 Journal of Hypertension

193. Uric acid is associated with long-term adverse cardiovascular outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention. (Abstract)

Uric acid is associated with long-term adverse cardiovascular outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Evidence links uric acid (UA) with the promotion of cardiovascular disease. We assessed the prognostic value of UA on long-term major adverse outcomes (MACE) in patients with acute coronary syndrome (ACS), undergoing percutaneous coronary intervention (PCI).As primary endpoint, we assessed the association of UA (continuous

2018 Atherosclerosis

194. Assessment of the association between serum uric acid levels and the incidence of hypertension in nonmetabolic syndrome subjects: A prospective observational study. Full Text available with Trip Pro

Assessment of the association between serum uric acid levels and the incidence of hypertension in nonmetabolic syndrome subjects: A prospective observational study. The purpose of this study was to examine the association between serum uric acid (sUA) and the incidence of hypertension in nonmetabolic syndrome (non-MetS) subjects.This was a prospective observational study including 23,525 subjects who had been followed up for at least 5 years. A logistic regression model was used to assess

2018 Medicine

195. Inosine 5'-Monophosphate to Raise of Serum Uric Acid Level in Patients With Multiple System Atrophy: a Multi-center, Randomized Controlled, Double Blind, Parallel Assigned Clinical Trial

Inosine 5'-Monophosphate to Raise of Serum Uric Acid Level in Patients With Multiple System Atrophy: a Multi-center, Randomized Controlled, Double Blind, Parallel Assigned Clinical Trial Inosine 5'-Monophosphate to Raise of Serum Uric Acid Level in Patients With Multiple System Atrophy: a Multi-center, Randomized Controlled, Double Blind, Parallel Assigned Clinical Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration (...) or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Inosine 5'-Monophosphate to Raise of Serum Uric Acid Level in Patients With Multiple System Atrophy: a Multi-center, Randomized Controlled, Double Blind, Parallel Assigned Clinical Trial The safety and scientific validity of this study is the responsibility of the study sponsor

2018 Clinical Trials

196. Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid

Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03648996 Recruitment Status : Recruiting First Posted : August 28, 2018 Last

2018 Clinical Trials

197. Effects of Acute Fructose Loading on Levels of Serum Uric Acid - a Pilot Study. Full Text available with Trip Pro

Effects of Acute Fructose Loading on Levels of Serum Uric Acid - a Pilot Study. Fructose intake may lead to hyperuricaemia, which is associated with increased risk and progression of kidney disease. We aimed to explore the acute effects of fructose loading from different sources, with and without a pizza, on levels of serum uric acid in patients with chronic kidney disease (CKD), type 2 diabetes (T2D) without CKD, and in healthy subjects (HS).The study included six HS, and three CKD stage 4-5 (...) and seven T2D patients. Drinks consumed were blueberry drink (17.5 g fructose), Coca-Cola (18 g fructose) and fructose drink (35 g fructose). The drinks were also combined with pizza, in total six interventions. Serum samples were collected fasting and 30, 60, 90 and 120 minutes after intake and also 240 minutes after drink + pizza, and analysed for fructose, uric acid and triglycerides. Postprandial responses were explored using repeated-measure ANOVA.Baseline serum uric acid levels were increased

2018 European journal of clinical investigation

198. Detection of uric acid crystal deposition by ultrasonography and dual-energy computed tomography: A cross-sectional study in patients with clinically diagnosed gout. Full Text available with Trip Pro

Detection of uric acid crystal deposition by ultrasonography and dual-energy computed tomography: A cross-sectional study in patients with clinically diagnosed gout. The aim of our study was to compare the performance of ultrasonography (US) and dual-energy computed tomography (DECT) in detecting the crystal deposition at lower extremity joints in patients with gout. The correlation of imaging findings with microscopic findings was further assessed whenever aspiration is available.We recruited

2018 Medicine

199. Joint effects of uric acid and lymphocyte count on adverse outcomes in elderly patients with rheumatic heart disease undergoing valve replacement surgery. (Abstract)

Joint effects of uric acid and lymphocyte count on adverse outcomes in elderly patients with rheumatic heart disease undergoing valve replacement surgery. Increased uric acid and decreased lymphocyte count are common in elderly patients or those with heart failure, which were prognostic markers. We aimed to investigate the joint effect of uric acid and lymphocyte count for risk stratification in elderly patients with rheumatic heart disease undergoing valve replacement surgery.Uric acid (...) to lymphocyte ratio was calculated as serum uric acid (mg/dL)/lymphocyte count (×109/L). Univariate and multivariate analyses were performed to investigate the association of uric acid to lymphocyte ratio, with adverse events in 949 elderly patients with rheumatic heart disease undergoing valve replacement surgery. For clinical use, the uric acid to lymphocyte ratio was classified into 3 groups by the tertile, and a cutoff was also selected according to the receiver operator characteristic curve.Uric acid

2018 Journal of Thoracic and Cardiovascular Surgery

200. Unaccounted for Regression to the Mean Renders Conclusion of Article Titled "Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor Tofogliflozin" Unsubstantiated. Full Text available with Trip Pro

Unaccounted for Regression to the Mean Renders Conclusion of Article Titled "Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor Tofogliflozin" Unsubstantiated. 29660244 2018 08 09 2018 12 02 1463-1326 20 8 2018 08 Diabetes, obesity & metabolism Diabetes Obes Metab Unaccounted for regression to the mean renders conclusion of article titled "Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor tofogliflozin" unsubstantiated. 2039-2040 10.1111/dom (...) , Bloomington, Indiana. eng R25 DK099080 DK NIDDK NIH HHS United States R25 HL124208 HL NHLBI NIH HHS United States Letter Research Support, N.I.H., Extramural Comment 2018 05 03 England Diabetes Obes Metab 100883645 1462-8902 0 Benzhydryl Compounds 0 Glucosides 0 Glycated Hemoglobin A 0 Hypoglycemic Agents 0 Sodium-Glucose Transporter 2 268B43MJ25 Uric Acid P8DD8KX4O4 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol IM Diabetes Obes

2018 obesity & metabolism

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