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Uric Acid

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1. Who let the Gout Out? Targeting Uric Acid Levels in Treating Gout

Who let the Gout Out? Targeting Uric Acid Levels in Treating Gout Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca May (...) 19, 2020 Who let the Gout Out? Targeting Uric Acid Levels in Treating Gout Clinical Question: To prevent gout recurrence, should we dose urate lowering therapies (like allopurinol) to target uric acid levels? Bottom Line: Best evidence finds that increasing doses of allopurinol to achieve a specific serum urate target (example <360 µmol/L) does not reduce gout flares, pain, or function, compared to standard allopurinol dosing. Febuxostat increases cardiovascular and overall mortality and should

2020 Tools for Practice

2. The influence of serum uric acid on renal function in patients with calcium or uric acid stone: A population-based analysis. Full Text available with Trip Pro

The influence of serum uric acid on renal function in patients with calcium or uric acid stone: A population-based analysis. To determine the influence of serum uric acid (UA) levels on renal impairment in patients with UA stone.We retrospectively analyzed 463 patients with calcium oxalate and/or calcium phosphate stones (CaOx/CaP), and 139 patients with UA stones. The subjects were divided into the serum UA-high (UA ≥ 7.0 mg/dL) or the UA-low group (UA < 7.0 mg/dL). The control group comprised

2017 PLoS ONE

3. Level of uric acid and uric acid/creatinine ratios in correlation with stage of Parkinson disease. Full Text available with Trip Pro

Level of uric acid and uric acid/creatinine ratios in correlation with stage of Parkinson disease. This study aims to investigate relationship between the level of uric acid (UA) and UA/creatinine ratios (UA/Cr) to the stage of Parkinson disease (PD).A total of 120 cases of PD patients who were admitted in our hospital between 2013 and 2015 were enrolled into this study; these 120 cases of PD patients were divided into 3 groups, according to Hoehn-Yahr (H-Y) classification: early stage (1-2

2018 Medicine

4. Zurampic (lesinurad) - To treat high blood uric acid levels associated with gout

Zurampic (lesinurad) - To treat high blood uric acid levels associated with gout Zurampic Tablets U.S. Department of Health and Human Services Search FDA Submit search Zurampic Tablets Zurampic Tablets Company: Ardea Biosciences, Inc. Application No.: 207988 Approval Date: 12/22/2015 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created

2015 FDA - Drug Approval Package

5. Prednisone lowers serum uric acid levels in patients with decompensated heart failure by increasing renal uric acid clearance. (Abstract)

Prednisone lowers serum uric acid levels in patients with decompensated heart failure by increasing renal uric acid clearance. Clinical studies have shown that large doses of prednisone could lower serum uric acid (SUA) in patients with decompensated heart failure (HF); however, the optimal dose of prednisone and underlying mechanisms are unknown. Thirty-eight patients with decompensated HF were randomized to receive standard HF care alone (n = 10) or with low-dose (15 mg/day, n = 8), medium (...) -dose (30 mg/day, n = 10), or high-dose prednisone (60 mg/day, n = 10), for 10 days. At the end of the study, only high-dose prednisone significantly reduced SUA, whereas low- and medium-dose prednisone and standard HF care had no effect on SUA. The reduction in SUA in high-dose prednisone groups was associated with a significant increase in renal uric acid clearance. In conclusion, prednisone can reduce SUA levels by increasing renal uric acid clearance in patients with decompensated HF.

2017 Canadian journal of physiology and pharmacology Controlled trial quality: uncertain

6. Serum uric acid levels are associated with homeostasis model assessment in obese nondiabetic patients: HOMA and uric acid Full Text available with Trip Pro

Serum uric acid levels are associated with homeostasis model assessment in obese nondiabetic patients: HOMA and uric acid Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid. The aim of this study was to evaluate whether there is a correlation between serum uric acid levels with homeostatic model assessment (HOMA) 1 in nondiabetic patients.We evaluated 88 nondiabetic patients, in whom uric acid levels were measured, in all of them HOMA (...) of β-cell function (HOMA 1B) and HOMA of insulin resistance (HOMA 1IR) scores were performed. Uric acid and the HOMA 1 values were correlated using the Pearson coefficient.We did not find any correlation between uric acid levels with both HOMA 1B (r = 0.102, p = 0.343), nor with HOMA 1IR (r = 0.158, p = 0.117). When patients were analyzed by sex, we found a significant correlation with HOMA 1IR (0.278, p = 0.01), but not with HOMA 1B (0.138, p = 0.257) in women. We found a correlation with HOMA 1B

2017 Therapeutic advances in endocrinology and metabolism

7. Uric acid and blood pressure: exploring the role of uric acid production in the Maastricht study. (Abstract)

Uric acid and blood pressure: exploring the role of uric acid production in the Maastricht study. Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure (BP). We, therefore, investigated the association between serum uric acid concentration and 24-h urinary uric acid excretion, as proxy for uric acid production, with ambulatory 24-h blood pressure (...) and hypertension.Cross-sectional analyses were conducted among 2555 individuals [52% men, mean age 60.0 ± 8.2 years; 27% type 2 diabetes (by design)] from The Maastricht Study. Multivariable regression analyses were performed to investigate the association of serum uric acid and 24-h urinary uric acid excretion with 24-h pulse pressure, 24-h mean arterial pressure (MAP), and hypertension.After adjustment for traditional hypertension risk factors, serum uric acid concentration (per SD of 81 μmol/l) was associated

2017 Journal of Hypertension

8. Effect of phytic acid on postprandial serum uric acid level in healthy volunteers: a randomized, double-blind, crossover study. Full Text available with Trip Pro

Effect of phytic acid on postprandial serum uric acid level in healthy volunteers: a randomized, double-blind, crossover study. Phytic acid, a constituent of various plants, has been related to health benefits. Phytic acid has been shown to inhibit purine nucleotide metabolism in vitro and suppress elevation of plasma uric acid levels after purine administration in animal models. This study investigated the effect of phytic acid on postprandial serum uric acid (SUA) in humans. This randomized (...) , double-blind, crossover design study included 48 healthy subjects with normal fasting SUA. Subjects consumed a control drink and a phytic acid drink with purine-rich food, and serum and urine uric acid levels were measured for 360 min after purine loading. Phytic acid lowered the incremental area under the curve (0-360 min) and incremental maximum concentration of SUA after purine loading (p < 0.05); tended to lower cumulative urinary uric acid excretion (0-360 min) after purine loading (p < 0.10

2019 Nucleosides, nucleotides & nucleic acids Controlled trial quality: uncertain

9. Increased production and reduced urinary buffering of acid in uric acid stone formers is ameliorated by pioglitazone. (Abstract)

Increased production and reduced urinary buffering of acid in uric acid stone formers is ameliorated by pioglitazone. Idiopathic uric acid nephrolithiasis is characterized by an overly acidic urine pH caused by the combination of increased acid production and inadequate buffering of urinary protons by ammonia. A large proportion of uric acid stone formers exhibit features of the metabolic syndrome. We previously demonstrated that thiazolidinediones improved the urinary biochemical profile (...) in an animal model of the metabolic syndrome. In this proof-of-concept study, we examined whether the thiazolidinedione pioglitazone can also ameliorate the overly acidic urine in uric acid stone formers. Thirty-six adults with idiopathic uric acid nephrolithiasis were randomized to pioglitazone 30 mg/day or matching placebo for 24 weeks. At baseline and study end, participants underwent collection of blood and 24-hour urine in an inpatient research unit while consuming a fixed metabolic diet, followed

2019 Kidney International Controlled trial quality: uncertain

10. Net Acid Excretion and Urinary Organic Anions in Idiopathic Uric Acid Nephrolithiasis. Full Text available with Trip Pro

Net Acid Excretion and Urinary Organic Anions in Idiopathic Uric Acid Nephrolithiasis. Idiopathic uric acid nephrolithiasis, which is closely associated with obesity and the metabolic syndrome, is increasing in prevalence. Unduly acidic urine pH, the quintessential pathophysiologic feature of this disease, is in part explained by inadequate excretion of the principal urinary buffer ammonium. The role of net acid excretion in the pathogenesis of uric acid nephrolithiasis is incompletely (...) understood.We compared acid-base parameters of patients with idiopathic uric acid nephrolithiasis with matched control subjects under controlled diets in an inpatient metabolic unit. Measurements included fasting blood and 24-hour urine chemistries and 24-hour urine metabolomic analysis. Comparisons between groups included analysis of covariance models controlling for urine pH or body mass index.Subjects with idiopathic uric acid nephrolithiasis had lower urine pH (5.5 versus 5.9; P<0.001) and higher net

2019 Clinical Journal of the American Society of Nephrology

11. Relationship of Interleukin-1β Blockade With Incident Gout and Serum Uric Acid Levels: Exploratory Analysis of a Randomized Controlled Trial. (Abstract)

Relationship of Interleukin-1β Blockade With Incident Gout and Serum Uric Acid Levels: Exploratory Analysis of a Randomized Controlled Trial. Although studies have shown that interleukin-1β (IL-1β) inhibitors can shorten gout attacks, whether they can prevent gout attacks is unclear.To examine the relationship among canakinumab, a monoclonal antibody targeting IL-1β; serum uric acid levels; and the incidence of gout attacks.Secondary exploratory analysis of a randomized controlled trial (...) . (ClinicalTrials.gov: NCT01327846).Many clinical sites in 39 countries.10 059 patients with a prior myocardial infarction and a high-sensitivity C-reactive protein (hsCRP) level of at least 19.1 nmol/L.Random allocation to canakinumab (50 mg, 150 mg, or 300 mg) versus placebo, administered subcutaneously every 3 months.Rates of gout attacks were compared across patients with different baseline concentrations of serum uric acid (≤404.5 µmol/L, 404.6 to 535.3 µmol/L, and ≥535.4 µmol/L) and in different intervention

2018 Annals of Internal Medicine Controlled trial quality: predicted high

12. Inhibition of uric acid or IL-1β ameliorates respiratory syncytial virus immunopathology and development of asthma. (Abstract)

Inhibition of uric acid or IL-1β ameliorates respiratory syncytial virus immunopathology and development of asthma. Respiratory syncytial virus (RSV) affects most infants early in life and is associated with increased asthma risk. The specific mechanism remains unknown.To investigate the role of uric acid (UA) and IL-1β in RSV immunopathology and asthma predisposition.Tracheal aspirates from human infants with and without RSV were collected and analyzed for pro-IL-1β mRNA and protein

2020 Allergy

13. Body mass index and serum uric acid level: Individual and combined effects on blood pressure in middle-aged and older individuals in China. Full Text available with Trip Pro

Body mass index and serum uric acid level: Individual and combined effects on blood pressure in middle-aged and older individuals in China. Few studies on the individual and combined analysis between serum uric acid (SUA) and body mass index (BMI) and blood pressure (BP) were conducted in individuals aged ≥45 years. We aimed to assess the extent to which BMI and SUA and their interaction affect BP in Chinese middle-aged and older adults.Data were selected from the China Health and Retirement

2020 Medicine

14. Impact of serum uric acid on renal function after bariatric surgery: a retrospective study. (Abstract)

Impact of serum uric acid on renal function after bariatric surgery: a retrospective study. Despite a known negative association between serum uric acid level (SUA) and renal function, this correlation in patients after bariatric surgery remains unknown.To assess correlation between postoperative SUA and estimated glomerular filtration rate (eGFR) at 12 months after bariatric surgery.A single tertiary referral center.A total of 252 patients (age = 40.5 ± 11.2; body mass index = 39.0 ± 5.5 kg/m2

2020 Surgery for Obesity and Related Diseases

15. Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study. Full Text available with Trip Pro

Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study. Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH) D is still unclear in the eastern Chinese population.We did a population-based observational

2020 BMC Endocrine Disorders

16. A cross-sectional study on uric acid levels among Chinese adolescents. Full Text available with Trip Pro

A cross-sectional study on uric acid levels among Chinese adolescents. The prevalence of hyperuricemia is increasing in adults, while the prevalence among adolescents is seldom reported.A cross-sectional survey by multistage, stratified sampling method was carried out in Shandong Province during 2017-2018. A total of 9371 adolescents aged from 13 to 19 years were randomly sampled and analyzed in this survey.The overall mean serum uric acid (sUA) concentration was 6.08 ± 1.57 mg/dL and overall

2020 Pediatric Nephrology

17. Sex differences in uric acid and NT-pro BNP assessments during coronary severity. Full Text available with Trip Pro

Sex differences in uric acid and NT-pro BNP assessments during coronary severity. To investigate the correlation between uric acid (UA) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels and coronary artery severity in acute coronary syndrome patients of different sexes.A total of 134 patients with acute coronary syndrome (ACS) were investigated. According to sex, there were 96 cases in male group and 38 cases in female group. According to the number of diseased vessels, the degree

2020 Medicine

18. Serum uric acid to creatinine ratio and metabolic syndrome in postmenopausal Chinese women. Full Text available with Trip Pro

Serum uric acid to creatinine ratio and metabolic syndrome in postmenopausal Chinese women. This study aimed to investigate the association between Serum Uric Acid (UA) to Creatinine (Cr) Ratio (UA/Cr) and metabolic syndrome (MetS) in postmenopausal women.A total of 455 patients with MetS and 457 age- and gender- matched controls were included in the present retrospective study. Serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density

2020 Medicine

19. Higher serum uric acid levels are associated with reduced risk of hip osteoporosis in postmenopausal women with rheumatoid arthritis. Full Text available with Trip Pro

Higher serum uric acid levels are associated with reduced risk of hip osteoporosis in postmenopausal women with rheumatoid arthritis. Although the positive correlation between serum uric acid (UA) levels and bone mineral density (BMD) has been reported in the general population, there are little data regarding the effect of serum UA levels on bone loss in patients with rheumatoid arthritis (RA).We investigated whether increased serum UA levels were associated with a reduced risk of osteoporosis

2020 Medicine

20. Α higher ratio of serum uric acid to serum creatinine could predict the risk of total and cause specific mortality- insight from a US national survey. (Abstract)

Α higher ratio of serum uric acid to serum creatinine could predict the risk of total and cause specific mortality- insight from a US national survey. The link between serum uric acid to serum creatinine ratio (SUA/SCr) and mortality has not been studied yet.We prospectively evaluated the association between SUA/SCr and risk of total and cause specific [cardiovascular disease (CVD) and cancer] mortality by applying on the National Health and Nutrition Examination Surveys (NHANES, 1999-2010

2020 International journal of cardiology

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