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Upper Respiratory Infection

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3. Is there evidence backing the use of guaifensin for cough secondary to upper respiratory infection (URI)?

Is there evidence backing the use of guaifensin for cough secondary to upper respiratory infection (URI)? Chiefs’ Inquiry Corner – 8/12/19 – Clinical Correlations Search Chiefs’ Inquiry Corner – 8/12/19 August 12, 2019 2 min read Clinicians frequently recommend symptomatic management for cough, specifically over-the-counter (OTC) medications, but the data doesn’t necessarily back it up. A 2014 Cochrane review of OTC medications for acute cough in adults and children found that among the 29

2019 Clinical Correlations

4. CRACKCast E168 – Pediatric Respiratory Emergencies: Upper Airway Obstruction and Infections

CRACKCast E168 – Pediatric Respiratory Emergencies: Upper Airway Obstruction and Infections CRACKCast E168 – Pediatric Respiratory Emergencies: Upper Airway Obstruction and Infections - CanadiEM CRACKCast E168 – Pediatric Respiratory Emergencies: Upper Airway Obstruction and Infections In , , by Adam Thomas April 9, 2018 This episode of CRACKCast Covers Rosen’s Chapter 167, Pediatric Upper Airway Emergencies. Stridor is a very common presentation and this episode will help out with diagnosis (...) and management. Shownotes – Rosen’s In Perspective: Big categories for upper airway obstruction: Infectious, congenital, foreign body (IN THE AIRWAY OR ESOPHAGUS!) Congenital causes: Think of progressive stridor or feeding difficulties. In addition to the onset and duration of symptoms, ask about: DROOLING NECK STIFFNESS/TORTICOLLIS EXACERBATING FACTORS CHOKING EPISODES Try to think out loud with the team: Is this resp distress or resp failure? Respiratory failure is identified by the presence of extreme

2018 CandiEM

5. Written information for patients (or parents of child patients) to reduce the use of antibiotics for acute upper respiratory tract infections in primary care. (PubMed)

Written information for patients (or parents of child patients) to reduce the use of antibiotics for acute upper respiratory tract infections in primary care. Acute upper respiratory tract infections (URTIs) are frequently managed in primary care settings. Although many are viral, and there is an increasing problem with antibiotic resistance, antibiotics continue to be prescribed for URTIs. Written patient information may be a simple way to reduce antibiotic use for acute URTIs.To assess

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2016 Cochrane

6. CRACKCast E075 – Upper Respiratory Tract Infections

CRACKCast E075 – Upper Respiratory Tract Infections CRACKCast E075 - Upper Respiratory Tract Infections - CanadiEM CRACKCast E075 – Upper Respiratory Tract Infections In , by Adam Thomas May 4, 2017 This episode of CRACKCast covers Rosen’s Chapter 75, Upper Respiratory Tract Infections (URTI). This spectrum of disease involves a range of management strategies, all the way from supportive care to life-saving interventions. Shownotes – Rosens in Perspective For these questions, see “CC E023 (...) albicans [6] What are the potential complications of deep space neck/face infections? List 5. Airway Obstruction Trismus Lemierre’s syndrome Carotid aneurysm Cavernous sinus thrombosis Retropharyngeal abscess Empyema/pneumonia Sepsis/ acute respiratory distress syndrome Necrotizing fasciitis Mediastinitis Peri-myocarditis Osteomyelitis of the mandible, cervicothoracic necrotizing fasciitis [7] When do the sinuses typically develop? Fully develop by age 10. [8] What the pathophysiology of sinusitis

2017 CandiEM

7. Predictive Value of Respiratory Viral Detection in the Upper Respiratory Tract for Infection of the Lower Respiratory Tract with Hematopoietic Stem Cell Transplantation. (PubMed)

Predictive Value of Respiratory Viral Detection in the Upper Respiratory Tract for Infection of the Lower Respiratory Tract with Hematopoietic Stem Cell Transplantation. Hematopoietic cell transplant (HCT) recipients are frequently infected with respiratory viruses (RVs) in the upper respiratory tract (URT) but the concordance between URT and lower respiratory tract (LRT) RV detection is not well characterized.HCT candidates and recipients with respiratory symptoms and LRT and URT RV testing (...) %); respiratory syncytial virus was highly concordant (92%). Likelihood of LRT detection was increased with URT detection (OR 73.7; 95%CI 26.7-204) and in CMV+ recipients (OR 3.70, 95%CI 1.30-10.0).High rates of discordance were observed for certain RVs. BAL sampling may provide useful diagnostic information to guide management in symptomatic HCT candidates and recipients.© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved

2019 Journal of Infectious Diseases

8. Nasopharyngeal polymicrobial colonization during health, viral upper respiratory infection and upper respiratory bacterial infection. (PubMed)

Nasopharyngeal polymicrobial colonization during health, viral upper respiratory infection and upper respiratory bacterial infection. We sought to understand how polymicrobial colonization varies during health, viral upper respiratory infection (URI) and acute upper respiratory bacterial infection to understand differences in infection-prone vs. non-prone patients.Nasopharyngeal (NP) samples were collected from 74 acute otitis media (AOM) infection-prone and 754 non-prone children during 2094 (...) healthy visits, 673 viral URI visits and 631 AOM visits. Three otopathogens Streptococcus pneumoniae (Spn), Nontypeable Haemophilus influenzae (NTHi), and Moraxella catarrhalis (Mcat) were identified by culture.NP colonization rates of multiple otopathogens during health were significantly lower than during viral URI, and during URI they were lower than at onset of upper respiratory bacterial infection in both AOM infection-prone and non-prone children. AOM infection-prone children had higher

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2017 Journal of Infection

9. Antibiotic Prescribing and Respiratory Viral Testing for Acute Upper Respiratory Infections Among Adult Patients at an Ambulatory Cancer Center. (PubMed)

Antibiotic Prescribing and Respiratory Viral Testing for Acute Upper Respiratory Infections Among Adult Patients at an Ambulatory Cancer Center. Outpatient antibiotic prescribing for acute upper respiratory infections (URI) is a high priority target for antimicrobial stewardship that has not been described for cancer patients.We conducted a retrospective cohort study of adult patients at an ambulatory cancer center with ICD-10 diagnosis code consistent with URI from October 1, 2015 to September (...) 30, 2016. We obtained antimicrobial prescribing, respiratory viral testing, and other clinical data at first encounter for the URI through day 14. We used generalized estimating equations to test associations of baseline factors with antibiotic prescribing.Of 341 charts reviewed, 251 (74%) patients were eligible for analysis. Nearly one-third (32%) of patients were prescribed antibiotics for URI. Respiratory viruses were detected among 85 (75%) of 113 patients tested. Antibiotic prescribing (p

2019 Clinical Infectious Diseases

10. Procalcitonin Testing to Guide Antibiotic Therapy in Acute Upper and Lower Respiratory Tract Infections. (PubMed)

Procalcitonin Testing to Guide Antibiotic Therapy in Acute Upper and Lower Respiratory Tract Infections. Is the use of procalcitonin for guiding antibiotic decisions in patients with acute upper and lower respiratory tract infections associated with improved clinical outcomes compared with usual care?Among patients with varying types and severity of acute respiratory infection, using procalcitonin to guide decisions about antibiotics is associated with lower rates of antibiotic exposure

2018 JAMA

11. Intensified Therapy with Inhaled Corticosteroids and Long-Acting beta2-Agonists at the Onset of Upper Respiratory Tract Infection to Prevent Chronic Obstructive Pulmonary Disease Exacerbations. A Multicenter, Randomized, Double-Blind, Placebo-controlled T

Intensified Therapy with Inhaled Corticosteroids and Long-Acting beta2-Agonists at the Onset of Upper Respiratory Tract Infection to Prevent Chronic Obstructive Pulmonary Disease Exacerbations. A Multicenter, Randomized, Double-Blind, Placebo-controlled T The efficacy of intensified combination therapy with inhaled corticosteroids (ICS) and long-acting β2-agonists (LABA) at the onset of upper respiratory tract infection (URTI) symptoms in chronic obstructive pulmonary disease (COPD

2018 EvidenceUpdates

12. Improvements in throat function and qualities of sore throat from locally applied flurbiprofen 8.75 mg in spray or lozenge format: findings from a randomized trial of patients with upper respiratory tract infection in the Russian Federation (PubMed)

Improvements in throat function and qualities of sore throat from locally applied flurbiprofen 8.75 mg in spray or lozenge format: findings from a randomized trial of patients with upper respiratory tract infection in the Russian Federation To assess the speed of relief provided by flurbiprofen 8.75 mg spray and lozenge and their effect on many of the different qualities and characteristics of throat pain and discomfort, and the many articulations of the broad term "sore throat" (ST).Four (...) hundred and forty adults with recent-onset, moderate-to-severe ST due to upper respiratory tract infection (URTI) were randomized to a single dose of either flurbiprofen 8.75 mg spray (n=218) or flurbiprofen 8.75 mg lozenge (n=222). Throat swabs for bacterial culture were taken at baseline. ST relief was assessed at 1 minute, 1 and 2 hours post-dose using the Sore Throat Relief Rating Scale. The change from baseline at 1 and 2 hours post-dose in difficulty swallowing and swollen throat was assessed

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2018 EvidenceUpdates

13. Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol. (PubMed)

Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol. This review aims to determine the best available evidence related to the effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection (URTI). The objective is to examine the analgesic properties of amylmetacresol

2017 JBI database of systematic reviews and implementation reports

14. Effects of massage for children with upper respiratory tract infection: a systematic review and meta-analysis

Effects of massage for children with upper respiratory tract infection: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

15. Does antibiotic therapy as a treatment for lower and upper respiratory tract infections promote recurrence? A systematic review of randomized test meta-analyses in the PubMed and Cochrane databases

Does antibiotic therapy as a treatment for lower and upper respiratory tract infections promote recurrence? A systematic review of randomized test meta-analyses in the PubMed and Cochrane databases Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears

2019 PROSPERO

16. Oral vitamin C supplements to prevent and treat acute upper respiratory tract infections [Cochrane protocol]

Oral vitamin C supplements to prevent and treat acute upper respiratory tract infections [Cochrane protocol] Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

17. Assessing the potential of upper respiratory tract point-of-care testing: a systematic review of the prognostic significance of upper respiratory tract microbes. (PubMed)

for respiratory infections (RTIs).To investigate the relationship between upper respiratory tract microbial detection and disease prognosis, including effects of antimicrobial use.MEDLINE and Embase databases.Quantitative studies reporting microbiological and prognostic data from patients of all age groups presenting with RTI.Patients presenting to healthcare or research settings with RTI.Upper respiratory tract swab.Systematic review and meta-analysis.Searches identified 5156 articles, of which 754 were (...) Assessing the potential of upper respiratory tract point-of-care testing: a systematic review of the prognostic significance of upper respiratory tract microbes. Microbial point-of-care testing (POCT) has potential to revolutionise clinical care. Understanding prognostic value of microbes identified from the upper respiratory tract (a convenient sampling site) is a necessary first step to understand potential for upper respiratory tract POCTs in assisting antimicrobial treatment decisions

2019 Clinical Microbiology and Infection

18. Peri-operative respiratory adverse events in children with upper respiratory tract infections allowed to proceed with anaesthesia: The French national study. (PubMed)

Peri-operative respiratory adverse events in children with upper respiratory tract infections allowed to proceed with anaesthesia: The French national study. Peri-operative respiratory adverse events (PRAEs) in paediatric patients with upper respiratory tract infections (URTIs) remain inadequately explored in patients allowed to proceed to anaesthesia and surgery.To determine the incidence and risk factors of PRAE in children with URTI allowed to proceed to anaesthesia.Multicentre cohort study

2018 European Journal of Anaesthesiology

19. Laryngeal Mask Airway Versus Other Airway Devices for Anesthesia in Children With an Upper Respiratory Tract Infection: A Systematic Review and Meta-analysis of Respiratory Complications. (PubMed)

Laryngeal Mask Airway Versus Other Airway Devices for Anesthesia in Children With an Upper Respiratory Tract Infection: A Systematic Review and Meta-analysis of Respiratory Complications. There is an association between upper respiratory tract infection (URTI) and an increased incidence of perioperative respiratory adverse events (PRAEs), which is a major risk for morbidity during pediatric anesthesia. The aim of the present study was to compare the risk of PRAEs among different airway devices (...) management in children with a URTI remains obscure given that there are few data of perioperative respiratory complications during anesthesia. This systematic review demonstrates that LMA use during anesthesia in children with URTI did not result in decrease of the most feared PRAEs. However, LMA was better than ETT in reducing cough. Further research is needed to define the risks more clearly because cough and laryngospasm have similar triggers, and both bronchospasm and laryngospasm trigger cough.

2018 Anesthesia and Analgesia

20. Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections. (PubMed)

Flumazenil reduces respiratory complications during anesthesia emergence in children with preoperative upper respiratory tract infections. Despite its benignity, upper respiratory infections (URIs) 1 increase the risk of postoperative respiratory complications during the perioperative and postoperative periods. Flumazenil could improve the symptoms of respiratory obstruction.To evaluate the effect of flumazenil on the occurrence of respiratory complications during anesthesia emergence (...) and postoperative respiratory complications were recorded by one anesthesiologist unaware of the grouping.All patients underwent surgery uneventfully. The incidence of postoperative respiratory complications in post-anesthesia care unit (PACU) was higher in group I compared with the other 3 groups (IF: 17%; I: 41%; NF: 5%; N: 10%; P = .0147). During the PACU period, significant differences among groups were seen for cough (IF: 15%; I: 20%; NF: 2%; N: 0%; P = .004), secretion (IF: 17%; I: 29%; NF: 5%; N: 7%; P

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2018 Medicine

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