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Unintentional Weight Loss Causes

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161. Pain (PDQ®): Health Professional Version

. (Refer to the section of this summary for more information). Is the pain acute or chronic? Is it secondary to cancer, cancer treatment, other causes, or a combination? Is it somatic, visceral, neuropathic, or mixed? Is there an incidental component? Is there breakthrough pain? Determining whether the pain requires pharmacologic and/or other modalities of treatment. Pain is often multifactorial in nature, so factors that may modulate pain expression, such as psychological distress and substance use (...) , with exacerbations rated as high as 7. Causes of Cancer Pain: Cancer, Cancer Treatments, and Comorbidities A study evaluating the characteristics of patients (N = 100) with advanced cancer presenting to a palliative care service found the primary tumor as the chief cause of pain in 68% of patients.[ ] Most pain was somatic, and pain was as likely to be continuous as intermittent. Pain can be caused by cancer therapies, including surgery, radiation therapy, chemotherapy, targeted therapy, supportive care

2016 PDQ - NCI's Comprehensive Cancer Database

162. Composite Resin and Amalgam Dental Filling Materials: A Review of Safety, Clinical Effectiveness and Cost-effectiveness

health technologies, for which little information can be found, but which may in future prove to be effective. While CADTH has taken care in the preparation of the report to ensure that its contents are accurate, complete and up to date, CADTH does not make any guarantee to that effect. CADTH is not liable for any loss or damages resulting from use of the information in the report. Copyright: This report contains CADTH copyright material. It may be copied and used for non-commercial purposes (...) review failed to draw any conclusions about filling longevity due to various limitations in the included studies. 14 A probable cause of these limitations in the review might be the inclusion of low quality trials and pooling the results from trials of heterogeneous designs, both interventional randomized controlled trials (RCTs) and observational studies, without reporting stratified results by trial design or quality. Second, the use and handling proprieties of composite are operator sensitive

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

163. Addison's disease

disorders — unintentional weight loss, nausea, vomiting, and vague abdominal pain may be confused with symptoms of an eating disorder. For more information, see the CKS topic on . Type 1 diabetes mellitus — fatigue, unexplained weight loss, and thirst may occur in either condition. However, blood glucose is usually normal or low in adrenal failure. For more information, see the CKS topic on . Chronic fatigue syndrome — fatigue is a predominant feature in many people with Addison's disease. For more (...) areas, recent scars, pressure points, areas of friction, palmar creases, and mucous membranes. Gastrointestinal symptoms — weight loss; loss of appetite and premature satiety; nausea and vomiting; abdominal pain; cravings for salt, soy sauce, or liquorice. Musculoskeletal symptoms — muscle weakness and cramps; joint pains. Cardiovascular symptoms — postural dizziness due to hypotension (blood pressure decrease of 20 mmHg between sitting and standing measurements). Other symptoms — headache, low

2016 NICE Clinical Knowledge Summaries

164. Psychological, social and biological determinants of ill health (pSoBid)

potential explanatory variables. There are social gradients in a range of biological and psychosocial variables which indicate that living in a deprived environment may increase the propensity to develop chronic disease, through as yet unknown mechanisms. A potential underlying cause of increased prevalence of disease is chronic inflammation (Steptoe et al., 2002; Owen et al., 2003). This has been observed to be more common in deprived than affluent populations, linked to coronary heart disease (Ross (...) consistent gradients. These gradients have been shown for all-cause mortality, but also for a wide range of diseases, especially coronary heart disease, diabetes, respiratory diseases, arthritis, poor birth outcomes, and for accidents and violent deaths (Marmot and Wilkinson, 1999). The inverse relationship between socioeconomic position/status and health is one of the most consistent epidemiological findings. The social distribution of physiological risk is partly a reflection of the social patterning

2013 Glasgow Centre for Population Health

165. Diagnosis and Treatment of Peripheral Artery Diseases

. † Upper extremity exertional pain, particularly if associated with dizziness or vertigo. † Any transient or permanent neurological symptom. † History of hypertension or renal failure. † Post-prandial abdominal pain and diarhoea, particularly if related to eating and associated with weight loss. † Erectile dysfunction. This cannot be an exhaustive list, and a review of symptoms should include all domains. It is important to emphasize that history is a cornerstone of the vascular evaluation. One should (...) or procedure. Class IIa Weight of evidence/opinion is in favour of usefulness/ef?cacy. Should be considered Class IIb Usefulness/ef?cacy is less well established by evidence/opinion. May be considered Class III Evidence or general agreement that the given treatment or procedure is not useful/effective, and in some cases may be harmful. Is not recommended ESC Guidelines 2855 Downloaded from https://academic.oup.com/eurheartj/article-abstract/32/22/2851/434690 by guest on 02 April 2019patient, and, where

2011 European Society of Cardiology

166. Efficacy of Complementary and Alternative Medicine Therapies for Posttraumatic Stress Disorder

psychotherapies may provoke emotional responses, and some patients may have difficulty managing these reactions, or may choose not to engage in therapies that can cause emotional (albeit short-term) discomfort. Thus, the current V A/DoD Clinical Practice Guideline recommends careful screening of patients’ suitability for these modalities and recommends against their use with certain patients (e.g., those with current substance abuse, psychosis, or health problems for which intense physiological arousal (...) that nearly 27 percent of patients will prematurely discontinue SSRIs due to treatment failure or adverse side effects, including sexual dysfunction, weight gain, and sleep disturbance. 26 Finally, existing studies suggest that medications alone are often not sufficient to relieve symptoms, and there is some evidence that men are less likely than women to benefit from pharmacological PTSD treatments. 27 Therefore, current evidence-based treatments for PTSD are not always appropriate, well-tolerated

2011 Veterans Affairs Evidence-based Synthesis Program Reports

167. Cardiovascular disease prevention

for policy: a national framework for action 7 Recommendations for practice 19 2 Public health need and practice 31 CVD in England and the UK 31 Risk factors for CVD 32 How these risk factors cause many other illnesses 33 T ackling the risk factors 33 Government policy 34 3 Considerations 36 Introduction 36 Population versus individual approach 37 Population-based approaches: health inequalities 39 Population-level approaches: cost effectiveness 40 Epidemiology 40 Primordial prevention 42 Single risk (...) consumption. It aims to reduce the high incidence of cardiovascular disease. This, in turn, will help prevent other major causes of death and illness, such as type 2 diabetes and many cancers. Who is it for? National government NHS and local authorities Industry Commissioners, managers and practitioners working in the above and in the wider public, private, voluntary and community sectors Members of the public Cardiovascular disease prevention (PH25) © NICE 2019. All rights reserved. Subject to Notice

2010 National Institute for Health and Clinical Excellence - Clinical Guidelines

168. Family Practice Notebook Updates 2018

are late findings and their absence does not exclude limb threatening pressures Emergency fasciotomy delayed >4-6 hours may result in permanent injury or even limb loss (hemeonc, pharm, coags, adverse) Consider if ingestion within 1-2 hours (may be effective with s up to 8 hours) Intentional : Observe for bleeding for 24 hours (or per poison control) before medically cleared to psychiatry Unintentional : If small quantity (e.g. one extra dose) may discharge home with bleeding precautions Risk (...) to live in their home or community Specific approaches to common problems include , , aspiration, , behavior changes (gi, prevent, hemeonc, bowel) Screening options include every 10 years or (guiaic-based or FIT immunochemical) annually Although and are other screening options, they have significant disadvantages For average risk patients, screening starts at age 50 years and ends at 75-85 years old The only significantly effective lifestyle changes that have impact on CRC are weight loss

2019 FP Notebook

169. Entospletinib and Obinutuzumab in Treating Patients With Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Non-Hodgkin Lymphoma

: Unintentional weight loss > 10% within the previous 6 months prior to screening Extreme fatigue (unable to work or perform usual activities) Fevers of greater than 100.5 Fahrenheit (F) for >= 2 weeks without evidence of infection Night sweats without evidence of infection Evidence of progressive marrow failure as manifested by the development of, or worsening of anemia or thrombocytopenia Massive (i.e., > 6 cm below the left costal margin), progressive or symptomatic splenomegaly Massive nodes or clusters (...) Refractory Chronic Lymphocytic Leukemia Refractory Small Lymphocytic Lymphoma Richter Syndrome Splenomegaly Thrombocytopenia Weight Loss Drug: Entospletinib Other: Laboratory Biomarker Analysis Biological: Obinutuzumab Other: Pharmacological Study Phase 1 Phase 2 Detailed Description: PRIMARY OBJECTIVES: I. To evaluate the safety and tolerability of entospletinib administered in combination with obinutuzumab in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL

2017 Clinical Trials

170. Effects of Anamorelin on Cancer-Related-Fatigue in Patients With Advanced Cancer

to screening CRP must be >/= 3mg/l* in the absence of any other more likely cause of increased CRP like an infection or an autoimmune disorder. No evidence of moderate to severe depression as determined by a HADS depression score of unintentional weight loss ranging from >/= 2 - 25%) for at least 48 hours prior to study

2017 Clinical Trials

171. Spine Pain INtervention to Enhance Care Quality And Reduce Expenditure

delivered by a trained provider) History of spine surgery or spine injections/ablation in the past 6 months Severe, active psychosis or major depression inhibiting ability to physically participate in intervention Red Flag Symptoms (fever, night sweats, unintentional weight loss, bowel or bladder dysfunction, neurologic weakness, history of intravenous drug use) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact (...) , 2018 See Sponsor: Brigham and Women's Hospital Collaborator: Stanford University Information provided by (Responsible Party): Niteesh K. Choudhry, MD, PhD, Brigham and Women's Hospital Study Details Study Description Go to Brief Summary: Low back and neck pain are among the leading causes of medical visits, lost productivity and disability. There is an urgent need to identify effective and efficient ways of helping subjects with acute spine pain while guiding practitioners towards high-value care

2017 Clinical Trials

172. Complete transmural migration of a retained surgical sponge: an atypical case in image mimicking intussusception: A case report. (PubMed)

Complete transmural migration of a retained surgical sponge: an atypical case in image mimicking intussusception: A case report. Intraluminal migration of a retained surgical sponge causing intestinal obstruction and fistula is extremely rare occurrence.A case of a 35-year-old male, who complaining a diffuse abdominal pain beginning three days earlier. He also complained of occasional vomiting, nonspecific abdominal pain, and an unintentional 15 kg weight loss during the past 2 years. However

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2017 Medicine

173. Individualized Exercise Program Plus Behavioral Change Enhancement Strategies for Managing Fatigue in Frail Older People

: To detect the change from baseline frailty level at mid-term programme (wk 8 after commences of the programme),and then 1 week, 6 month and 12 months months after the completion of the programme ] Fried Frailty Index includes: i) an unintentional loss of 10% of body weight in the past year; ii) exhaustion: by answering 'Yes' to either 'I felt that everything I did was an effort', or 'I could not get going in the last week'; iii) a slow walk time: with an average walking speed in the lowest quintile (...) that their mobility and balance is good enough to join the exercise training; and in a frail state with exhaustion as determined using the Fried Frailty Index (FFI), including: i) an unintentional loss of 10% of body weight in the past year; ii) exhaustion: by answering 'Yes' to either 'I felt that everything I did was an effort', or 'I could not get going in the last week'; iii) a slow walk time: with an average walking speed in the lowest quintile stratified by median body height; iv) reduced grip strength

2017 Clinical Trials

174. Protocol GELLC-7: Ibrutinib Followed by Ibrutinib Consolidation in Combination With Ofatumumab

margin) or progressive or symptomatic splenomegaly. Massive nodes (i.e. > 10 cm in longest diameter) or progressive or symptomatic lymphadenopathy. Progressive lymphocytosis with an increase of > 50% over a 2-month period, or lymphocyte doubling time (LDT) of less than 6 months. A minimum of any one of the following disease-related symptoms: unintentional weight loss ≥ 10% within the previous 6 months, significant fatigue (i.e., ECOG PS 2; cannot work or unable to perform usual activities), fevers (...) . Females of child bearing potential are defined as sexually mature women without prior hysterectomy or who have had any evidence of menses in the past 12 months. However, women who have been amenorrheic for 12 or more months are still considered to be of childbearing potential if the amenorrhea is possibly due to other causes, including prior chemotherapy, anti-estrogens, or ovarian suppression Exclusion Criteria: Prior treatment for CLL or SLL. Any serious medical condition, laboratory abnormality

2017 Clinical Trials

176. The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty. (PubMed)

recommendations were developed: strong, conditional, and no recommendation.Strong recommendations were (1) use a validated measurement tool to identify frailty; (2) prescribe physical activity with a resistance training component; and (3) address polypharmacy by reducing or deprescribing any inappropriate/superfluous medications. Conditional recommendations were (1) screen for, and address modifiable causes of fatigue; (2) for persons exhibiting unintentional weight loss, screen for reversible causes

2017 Journal of the American Medical Directors Association

177. Metabolic syndrome and insulin resistance are associated with frailty in older adults: a prospective cohort study. (PubMed)

individuals aged ≥60, who were free of diabetes at 2008-10 and were followed up for 3.5 years. At baseline, MS was ascertained according to the harmonised definition, and IR with the Homoeostatic Model Assessment for IR index (HOMA-IR). Frailty was defined as having three or more of the Fried's criteria: exhaustion, low physical activity, slow walking, unintentional weight loss and low grip strength. Statistical analyses were performed with logistic regression, and adjusted for the main confounders.in (...) Metabolic syndrome and insulin resistance are associated with frailty in older adults: a prospective cohort study. diabetes increases the risk of frailty that is a leading cause of disability and premature mortality in older people. Metabolic syndrome (MS) and insulin resistance (IR) are strong risk factors for diabetes and could, thus, lead to frailty. However, the association between MS or IR and frailty has barely been investigated.data were obtained from a cohort of 1,499 community-dwelling

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2017 Age and ageing

178. Primary Care Corner with Geoffrey Modest MD: SPRINT Trial: Elderly Subgroup Study of Lower Blood Pressure Goal

or LVEF <35%, clinical dementia, prevalent stroke , unintentional weight loss of >10%, an SBP of <110 mmHg after standing for 1 minute , or residing in a nursing home Not surprisingly, the NNT was much lower in this trial than the overall SPRINT trial, given the higher event rate of this older group And, reassuringly re: orthostatic hypotension, this subgroup analysis is pretty convincing that there was no increase, but they did exclude anyone with a standing SBP <110 But, a few caveats here (...) patients had SBP difference of 10.8 mm Hg, less fit 11.3 and fit 13.5 mmHg) Primary composite outcome (nonfatal MI, acute coronary syndrome, nonfatal stroke, nonfatal acute decompensated heart failure, death from cardiovascular cause): 102 events in intensive group (2.59%/yr) vs 148 (3.85%/yr) on standard therapy, a 34% reduction [HR 0.66 (0.51-0.85)]. Number-needed-to-treat for 3.14 years was 27 Secondary outcome (all-cause mortality): 73 deathsin intensive group vs 107 on standard therapy, a 33

2016 Evidence-Based Medicine blog

179. First Line Therapy of Advanced Stage Follicular Lymphoma in Patients Not Eligible for Standard Immunochemotherapy

, drenching night sweats, or unintentional weight loss of >10% of normal body weight over a period of 6 months or less) Hematopoietic insufficiency (at least one of the following: granulocytopenia <1500 cells/μl, Hb < 10 g/dl, thrombocytopenia <100.000 cells/μl) Compressive syndrome Pleural/peritoneal effusion Symptomatic nodal or extranodal manifestations At least one bi-dimensionally measurable lesion (> 1.5 cm in its largest dimension by CT scan or MRI) Adequate hematologic function (unless (...) is superior to single agent OBINUTUZUMAB in medically non-fit, 'compromised' patients in terms of anti-lymphoma activity (primary objective), side effects, and quality of life. For the assessment of the anti-lymphoma activity the "event free survival (EFS)" will be applied as primary endpoint. EFS is defined as the time from the day of randomization to the date of first documented disease progression, death by any cause, or institution of a new anti-lymphoma treatment. Condition or disease Intervention

2017 Clinical Trials

180. Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)

and Cognitive Frailty) [ Time Frame: 20 years - once every 3-4 years ] Physical frailty was assessed by scores (1 = present, 0 = absent) for five components (shrinking, weakness, slowness, exhaustion, and low Physical Activity (PA)) proposed by Fried et al (3), with the following operational modifications: (i) Shrinking was defined by unintentional weight loss of 4 kg or more in the past 6 months, or BMI less than 18.5 kg/m2, or calf circumference of 31 cm or less. (ii) Weakness was assessed by knee (...) /learning, visuospatial ability, language, attention, and executive functioning. All domains are calculated by weighted averages of age and education adjusted scores. Tests: (i) Digit Span forward and backwards tasks (9); (ii) Rey's Auditory Verbal Learning Test (10); (iii) Story Memory Test (11); (iv) Brief Visuospatial Memory Test - Revised (12); (v) Boston Naming Test (13); (vi) Clock Reading Test; (viii) Colour Trials 1 and 2 (14); (ix) Block Design task (9). Frailty (Measuring the physical

2017 Clinical Trials

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