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Unintentional Weight Loss Causes

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141. Modification of lifestyle and nutrition interventions for management of early chronic kidney disease

) people should be encouraged to reduce their BMI to lower their risk of chronic kidney disease and end-stage renal disease (grade D). Maintenance of a health body weight (BMI 18.5–24.9 kg/m2; waist circumference 1.0 g/kg/day) is not recommended. No evidence was identified to show that phosphate restriction affects the progression of CKD. 3.7.2 For patients with stage 1-4 CKD and hypertension a reduction in sodium 30kg/m2 or unintentional weight loss of >10% in six months) should be referred (...) diabetes mellitus, hypertension, obesity and smoking (reviewed in Early CKD Guideline 2). Modification of lifestyle habits (e.g. healthy diet, physical exercise, smoking cessation, moderate alcohol consumption and weight loss in obese people) may therefore be of value in retarding the progression of CKD. In addition, restriction of dietary protein [1] and augmentation of fluid intake [2] have been recommended as a treatment for retarding CKD progression for over 50 years. The objective of the current

2013 KHA-CARI Guidelines

142. Diagnosis and Treatment of Overactive Bladder (Non-Neurogenic) in Adults: AUA/SUFU Guideline

in a diagnostic process to document symptoms and signs that characterize OAB and exclude other disorders that could be the cause of the patient’s symptoms; the minimum requirements for this process are a careful history, physical exam, and urinalysis. Clinical Principle 2. In some patients, additional procedures and measures may be necessary to validate an OAB diagnosis, exclude other disorders and fully inform the treatment plan. At the clinician’s discretion, a urine culture and/or post-void residual (...) epidemiologic differences across racial/ethnic groups. Patient-Reported Outcomes (PROs) and OAB. Since OAB is a symptom-based diagnosis, the quality of life (QOL) impact of the symptoms is a critical aspect of the condition. The degree of bother caused by OAB symptoms directly affects OAB care-seeking, treatment intensity and satisfaction with treatment. Therefore, assessment of patient-reported outcomes (PROs) can be a critical component of OAB management. Numerous questionnaire instruments have been

2014 Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction

143. Diagnosis and Treatment of Non-Neurogenic Overactive Bladder (OAB) in Adults: AUA/SUFU Guideline

existed. See text and algorithm for definitions and detailed diagnostic, management and treatment frameworks. Guideline Statements Diagnosis 1. The clinician should engage in a diagnostic process to document symptoms and signs that characterize OAB and exclude other disorders that could be the cause of the patient's symptoms; the minimum requirements for this process are a careful history, physical exam, and urinalysis. Clinical Principle 2. In some patients, additional procedures and measures may (...) , but the majority of patients have symptoms for years. 15,16 To date, no population-based studies have directly examined epidemiologic differences across racial/ethnic groups. Patient-Reported Outcomes (PROs) and OAB. Since OAB is a symptom-based diagnosis, the quality of life (QOL) impact of the symptoms is a critical aspect of the condition. The degree of bother caused by OAB symptoms directly affects OAB care-seeking, treatment intensity and satisfaction with treatment. Therefore, assessment of patient

2014 American Urological Association

144. Treatment and recommendations for homeless people with Opioid Use Disorders

-medical interventions for this population. The recommendations in this document specify what experienced providers and recipients of homeless services believe works best, with the realistic understanding that limited resources, fragmented health care delivery systems, and loss to follow-up often compromise adherence to optimal clinical practices. We hope these recommendations provide helpful guidance to health care professionals, and that they will contribute to improvements in both quality of care (...) providers and recipients gave generously of their time to formulate guidance for practitioners less experienced in the care of patients whose comorbidities and limited resources, both financial and social, are among the causes and consequences of homelessness. In addition, the Advisory Committee would like to thank the following individuals for reviewing and commenting on draft recommendations prior to publication: ? Diana Amodia MD, Medical Director, BAART Turk Street Clinic, San Francisco, California

2014 National Health Care for the Homeless Council

145. Guidelines for Insertion and Maintenance of Central Venous Access Devices in Children and Young People

of microorganisms causing catheter- related infection are the insertion site and the device hub. The microorganisms causing infections are usually Gram-positive bacteria residing on the patient’s skin, most often coagulase-negative staphylococci and Staphylococcus aureus. In addition, metastatic colonization of the device from a distant site of infection (Gastrointestinal and urinary tract, wound etc.) may occur. Figure 1. Sources of microbial contamination in patients with an IV catheter. Extraluminal sources (...) the area and the depth of the reservoir. It must sit flush against the skin surface. The length of the needle required may vary as the child gains or loses weight. The length of the needle used should be recorded on the patient’s documentation • Do not rock or tilt the needle as it may damage the septum • General observations of patients with these devices are outlined in Table 214 GENERAL PRINCIPLES FOR MANAGEMENT OF CVAD Dressing: A dressing will assist in anchoring the device during day to day

2014 Regulation and Quality Improvement Authority

146. Costs and impacts on the economy and productivity due to mental ill health

) in 2010 (Figure 1). 33 The DALY is calculated as the sum of the years of life lost due to premature mortality (YLL) in the population and the equivalent ‘healthy’ years lost due to disability (YLD) for incident cases of the health condition: one DALY is one year of healthy life lost due to premature death, prolonged illness or disability, or a combination of these factors. 34 Figure 1 provides a relative weighting of diseases by DALYs with cancer being the major disease group causing the greatest (...) group, Australia, 2003 34 Cause YLD % total YLL %total DALY %total Cancers 87,463 6.5% 411,953 32.2% 499,416 19.0% Cardiovascular disease 104,429 7.7% 369,365 28.9% 473,794 18.0% Mental disorders 327,391 24.2% 23,154 1.8% 350,545 13.3% Neurological and sense disorders 258,638 19.1% 54,127 4.2% 312,765 11.9% Chronic respiratory disorders 115,398 8.5% 71,339 5.6% 186,737 7.1% Diabetes mellitus 111,536 8.2% 32,295 2.5% 143,831 5.5% Unintentional injuries 41,263 3.0% 84,599 6.6% 125,862 4.8% Total

2013 Sax Institute Evidence Check

147. South Australian gastroenteropancreatic neuroendocrine tumours pathway

of hospital stay and poor coping skills. Each of these issues affects morbidity outcomes. Regular screening and ongoing monitoring for depression by health professionals as part of long-term follow-up care is required. Referral to a psychologist or psychiatrist may be appropriate. Body image Body image is the way a person feels about their appearance. Some cancer treatments can cause physical changes to a patient’s body, such as hair loss, scars from surgery, loss of a body part, changes to the skin (...) , weight gain or weight loss. Physical changes can result in poor body image. Patients should be provided with individualised and accurate information about any expected physical changes before treatment. Support and counselling by a specialist psychologist, psychiatrist or social worker may assist patients to make appropriate treatment decisions that incorporate the potential effect on their appearance. Sexuality Sexuality encompasses not only the physical aspects of sexual function, but also refers

2014 Clinical Practice Guidelines Portal

148. Australian and New Zealand Society for Geriatric Medicine position statement 22. Frailty in older people

, the FRAIL scale has recently been validated as predictive of mortality and disability in community- dwelling older Australian men 14 and women 15 . Slow gait speed in itself is strongly linked to functional decline and disability and has been used in isolation as a frailty measure 16 . The most well-known and widely used phenotype was defined by Fried et al. in 2001 and identifies frailty as the presence of = 3 of 5 criteria: unintentional weight loss of = 10lbs in the preceding year, self-reported (...) phenotypic tool is the Fried model which defines someone as frail if they meet 3 or more of 5 criteria: weight loss, exhaustion, weak grip strength, slow walking speed and low physical activity. The multidimensionality of frailty is embraced by tools such as the Edmonton Frailty Scale which derives a maximum score of 17 from assessments across 10 different domains. 4. Frailty can be conceptualised as the failure of a complex system. Deficits accumulate with the passage of time leading to a loss

2014 Clinical Practice Guidelines Portal

149. Chemical Exposures During Pregnancy

birth outcomes; pregnancy loss, preterm birth, low birth weight, congenital defects, childhood morbidity, obesity, cognitive dysfunction, impaired immune system development, asthma, early puberty, adult disease and mortality (cardiovascular effects and cancer). 5 In addition, impairment of fertility and fecundity in women 6 and impairment of testicular development and reproductive function in males, have been associated with fetal exposure to everyday chemicals in the environment. 7 Although (...) and choices during the planning and maintenance of pregnancy and breastfeeding. Examples of this are; refraining from smoking and drinking, and eating a balanced diet during pregnancy. 3. Increasing concerns over chemical exposure In recent years there has been increasing concern over the potential for exposure of environmental chemicals to the mother and baby to cause adverse health effects in the child. 4 Epidemiological research has linked exposure to some of these chemicals in pregnancy with adverse

2013 Royal College of Obstetricians and Gynaecologists

150. Heart Disease and Stroke Statistics?2016 Update

are health behaviors, including diet quality, PA, and body weight. However, each of the cardiovascular health metrics can be improved and deserves major focus. Health Behaviors (Chapters 3 to 6) Based on comparable risk assessment methods, poor lifestyle behaviors and lifestyle-related risk factors are the foremost causes of death and disability in the United States and in the world. Smoking/Tobacco Use (Chapter 3) Although tobacco use has declined substantially in the United States, it remains (...) socioeconomic status but increased among those of lower socioeconomic status. In addition, the overall prevalence of severe obesity in US youth continued to increase, especially among adolescent boys. Overweight and obesity predispose individuals to most major risk factors, including physical inactivity, hypertension, hyperlipidemia, and diabetes mellitus. Excess body weight is among the leading causes of death and disability in the United States and globally, with burdens expected to increase in coming

2014 American Heart Association

151. Preventing and Addressing Abuse and Neglect of Older Adults: Person-Centred, Collaborative, System-Wide Approaches

a liability nor discharge from liability. While every effort has been made to ensure the accuracy of the contents at the time of publication, neither the authors nor the Registered Nurses’ Association of Ontario (RNAO) give any guarantee as to the accuracy of the information contained in them nor accept any liability, with respect to loss, damage, injury or expense arising from any such errors or omission in the contents of this work. Copyright With the exception of those portions of this document (...) . The scope of this guideline includes harms caused by the main forms of abuse and neglect. These are physical abuse, emotional/psychological abuse, sexual abuse, financial abuse/exploitation and neglect. This guideline also includes education and policy/organization/system recommendations that address resident-to-resident aggressive behaviour G . Harms inflicted by one resident (often an older adult with cognitive impairment who is living in a long-term care facility G ) upon another resident

2014 Registered Nurses' Association of Ontario

152. Working with Families to Promote Safe Sleep for Infants 0-12 Months of Age

sleeping environment it may be plausible, but inconclusive, that the infant died from asphyxia. Such a case often leads the investigating team and coroner to conclude that they cannot determine the cause of death. 18 REGISTERED NURSES’ ASSOCIATION OF ONTARIO BACKGROUND Working with Families to Promote Safe Sleep for Infants 0-12 Months of Age Death by Asphyxia Versus Unexplained Death Two types of deaths can occur in a sleeping environment perceived as unsafe: death by asphyxia (an unintentional injury (...) to ensure the accuracy of the contents at the time of publication, neither the authors nor the Registered Nurses’ Association of Ontario (RNAO) give any guarantee as to the accuracy of the information contained in them nor accept any liability, with respect to loss, damage, injury or expense arising from any such errors or omission in the contents of this work. Copyright With the exception of those portions of this document for which a specific prohibition or limitation against copying appears

2014 Registered Nurses' Association of Ontario

153. Malnutrition

factors such as: distance to grocery stores the availability and affordability of public transit. Older adults who experience: Unintentional weight loss Loss of appetite Difficulty eating or drinking (coughing, choking, or pain) Older adults who have normal digestion but difficulty eating because of cancer, neurological problems, gastrointestinal problems, or trauma to their gut might also consider tube feeding. This document does not describe the pros and cons of the use of tube feeding. Depending (...) on your priorities, you may or may not decide to make a change. The choice is up to you because... There are several options to limit weight loss These options can cause benefits or harms. It is difficult to predict how they will work for you . You are more likely to stick to a lifestyle change that you chose to make yourself Opting for an intervention or ""watchful waiting"" are both acceptable option We recommend that... The decision take into account the person’s values and priorities The decision

2014 Cancer Council Australia

154. Power Threat Meaning Framework: innovative and important? #PTMFramework

solved the problem of psychiatric diagnosis; the DSM is, after all, not a static document. No decent mental health professional would say that the aetiology of mental health disorders is understood. We are in a reverse-therapeutic gap of sorts: we know what might work for certain conditions; but we don’t know the causes yet. And, just because biomarkers for psychiatric diagnoses have not yet been located, that does not mean they do not exist, or that we should stop looking for them. It is also (...) strange that both evidence-based medicine and outdated philosophies such as psychoanalysis and Foucauldian discourse are given the same weight in the Framework. Evidence-based medicine is just that: statistics have shown that it is effective for a high enough percentage of people to be useful. The same sorts of statistics can never be gathered for psychoanalysis. In terms of narratives, I agree that they can be useful. Looking at what happened can be helpful, up to a point. Many of us, however, find

2018 The Mental Elf

155. Eikenella corrodens endocarditis and liver abscess in a previously healthy male, a case report. (PubMed)

Eikenella corrodens endocarditis and liver abscess in a previously healthy male, a case report. Eikenella corrodens is one of the HACEK bacteria constituting part of the normal flora of the oropharynx, however, still an uncommon pathogen. We report a case of a large Eikenella corrodens liver abscess with simultaneously endocarditis in a previously healthy male.A 49-year-old Danish man was admitted because of one-month malaise, fever, cough and unintentional weight loss. On admission (...) slowly improved. He was discharged after 1.5 months of hospitalisation. On follow-up 2 months later, the patient was asymptomatic with normalized biochemistry and ultrasound showed complete regression of the abscess.This is the first case of documented Eikenella corrodens concurrent liver abscess and endocarditis. The case report highlights that Eikenella corrodens should be considered as a cause of liver abscess. Empirical treatment of pyogenic liver abscess will most often cover Eikenella corrodens

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2018 BMC Infectious Diseases

156. Impact of Dietary Intervention on Tumor Immunity: the DigesT Trial

-melanomatous skin cancer or curatively resected cervical cancer. Body Mass Index (BMI) < 20 Kg/m2. Anamnesis of alcohol abuse. Unintentional weight loss ≥ 5% in the last three months, unless the patient has a BMI > 25 Kg/m2 at study enrollment. Intentional weight loss is permitted if < 10% in the last three months and patient BMI is > 22 kg/m2. Severe heart, liver, pulmonary, kidney comorbidities. Current status of pregnancy or lactation, where pregnancy is defined as the state of a female after conception (...) fraction (LVEF) to less than 50%, as assessed by multigated radionuclide scintigraphic scan (MUGA) or echocardiography. Previous episodes of symptomatic hypotension causing unconsciousness. Baseline fasting plasma glucose ≤ 65 mg/dl. Ongoing therapy with systemic corticosteroids, or systemic corticosteroid therapy ≤ 2 weeks before study enrollment, or who have not recovered from side effects of such treatment. The following uses of corticosteroids are permitted: topical applications (e.g. for rash

2018 Clinical Trials

157. A Study of BNC105P Combined With Ibrutinib

leukemia and patients with Richter's transformation of CLL/SLL are NOT eligible. Active disease meeting at least 1 of the IWCLL 2008 criteria for requiring treatment: i) A minimum of any one of the following constitutional symptoms: Unintentional weight loss >10% within the previous 6 months prior to screening. Extreme fatigue (unable to work or perform usual activities). Fevers of greater than 100.5 F for ≥2 weeks without evidence of infection. Night sweats without evidence of infection. ii) Evidence (...) are not exclusions). Thrombotic events (pulmonary embolism; deep venous thrombosis) within 6 month prior to start of therapy. History of Human Immunodeficiency Virus (HIV) infection or active hepatitis B or C. Intravenous immunoglobulin (IVIG) can cause a false positive hepatitis B serology. If patients receiving routine IVIG have core antibody or surface antigen positivity without evidence of active viremia (negative hepatitis B DNA) they may still participate in the study, but should have hepatitis serologies

2018 Clinical Trials

158. Reducing SB in ALF and Its Affect on Cognitive Impairment, QoL, and Physical Functioning

cause of dependence and disability worldwide. With the nation's fastest growing demographic being adults over 65, the Lewy Body Dementia Association states that the current cost puts it higher than either heart disease or cancer; as the financial burden was estimated at $818 billion in 2015. Functional limitations such as a slower gait, muscle weakness (ex. grip strength), unintentional weight loss and self-reported exhaustion adds pressure on healthcare services. Older adults transitioning (...) benefits may come from the lower end of the PA spectrum; and there are no current guidelines for how long older adults should be sedentary. Research shows that large amounts of sedentary behaviour (SB) leads to an increased risk of all-cause mortality, independent from not meeting the PA guidelines (Ekelund et al., 2016). SB is defined as any waking behaviour characterized by an energy expenditure less than or equal to 1.5 metabolic equivalents while in a sitting or reclining posture. Alzheimer's

2018 Clinical Trials

159. Ibrutinib lead-in Followed by Venetoclax Plus Ibrutinib in Patients With RR CLL

or symptomatic lymphadenopathy Progressive lymphocytosis with an increase of ≥ 50% over a 2-month period, or lymphocyte doubling time of less than 6 months Disease-related symptoms as defined by any of the following: (a) Unintentional weight loss ≥ 10% within the previous 6 months. (b) Significant fatigue (i.e., ECOG PS 2 or worse; cannot work or unable to perform usual activities). (c) Fevers ≥38.0° C for 2 or more weeks without evidence of infection. (d) Night sweats for ≥ 1 month without evidence (...) . Progression-free survival (PFS) [ Time Frame: Day 169, 337, 505, 673, 841, yearly up to five years, end of trial treatment plus unscheduled (if progression is suspected) ] PFS is defined as the time from registration until progression according the iwCLL criteria or death from any cause, whichever occurs first. Patients not having an event at the time of analysis as well as patients starting a new antileukemic therapy in the absence of an event will be censored at the date of their last tumor assessment

2018 Clinical Trials

160. Safety and Efficacy of REGN2477+REGN1033 in Patients With Sporadic Inclusion Body Myositis

. Any condition that precludes adequate intake of energy and protein; malnutrition; presence of an eating disorder. Unintentional weight loss of ≥10% in the past 6 months (patient-reported) Hospitalization for heart failure in last year or New York Heart Association Class 4 History of hypertrophic cardiomyopathy Any drugs known to influence muscle mass and performance such as anabolic steroids or growth hormone within 6 weeks prior to screening Unable to fit on the site's DXA scanner table, within (...) . Ability to climb 4 steps of stairs unassisted (may use handrails) Willing and able to comply with clinic visits and study-related procedures Key Exclusion Criteria: Other neurological conditions (eg, hemiplegia post stroke, Parkinson's) or musculo-skeletal conditions (eg, severe osteoarthritis) causing mobility impairment Mini-Mental State Examination (MMSE) score <24 Ongoing, chronic, high-dose (>20 mg prednisone equivalent per day), systemic corticosteroid therapy within 6 weeks prior to screening

2018 Clinical Trials

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