How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

549 results for

Unintentional Weight Loss Causes

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

181. Massive splenomegaly due to B-cell lymphoma: A case report Full Text available with Trip Pro

of disseminated diffuse large B - cell lymphoma, clinical stage IV, with massive splenomegaly. A 53 - year old man complaining of unintentional major weight loss, palpable abdominal mass in the left hemiabdomen and cervical lymphadenopathy, was admited to Department of abdominal surgery, UMC Ljubljana. Abdominal CT scan showed massive spleen, enlarged retroperitoneal and upper mediastinal lymph nodes and cervical lymphadenopathy. Splenectomy was performed and spleen was sent on histological analysis (...) Massive splenomegaly due to B-cell lymphoma: A case report Massive splenomegaly is indicated by spleen weight exceeding 1000 g and largest spleen dimension greater than 20 cm Poulin et al. (1998). In many cases, splenectomy is the treatment of choice for massive splenomegaly because it releases the pressure on adjacent organs and also provides a definitive histopathological diagnosis of the underlying cause Iriyama et al. (2010), Radhakrishnan (2018).Herein we present a clinical case

2018 International journal of surgery case reports

182. Eikenella corrodens endocarditis and liver abscess in a previously healthy male, a case report. Full Text available with Trip Pro

Eikenella corrodens endocarditis and liver abscess in a previously healthy male, a case report. Eikenella corrodens is one of the HACEK bacteria constituting part of the normal flora of the oropharynx, however, still an uncommon pathogen. We report a case of a large Eikenella corrodens liver abscess with simultaneously endocarditis in a previously healthy male.A 49-year-old Danish man was admitted because of one-month malaise, fever, cough and unintentional weight loss. On admission (...) slowly improved. He was discharged after 1.5 months of hospitalisation. On follow-up 2 months later, the patient was asymptomatic with normalized biochemistry and ultrasound showed complete regression of the abscess.This is the first case of documented Eikenella corrodens concurrent liver abscess and endocarditis. The case report highlights that Eikenella corrodens should be considered as a cause of liver abscess. Empirical treatment of pyogenic liver abscess will most often cover Eikenella corrodens

2018 BMC Infectious Diseases

183. Ibrutinib and Obinutuzumab With or Without Venetoclax in Treating Older Patients With Untreated Chronic Lymphocytic Leukemia

nodes (>= 10 cm) or progressive or symptomatic lymphadenopathy Autoimmune anemia and/or thrombocytopenia that is poorly responsive to standard therapy Symptomatic or functional extranodal involvement (e.g. skin, kidney, lung, spine) Constitutional symptoms, which include any of the following: Unintentional weight loss of 10% or more within 6 months Significant fatigue Fevers > 100.5 degrees Fahrenheit (F) for 2 weeks or more without evidence of infection Night sweats >= 1 month without evidence (...) Given PO Other Names: ABT-0199 ABT-199 ABT199 GDC-0199 RG7601 Venclexta Outcome Measures Go to Primary Outcome Measures : Progression-free survival (PFS) [ Time Frame: From randomization date until the earlier of disease progression or death from any cause, assessed up to 10 years ] PFS will be compared between the experimental and control treatment strategy groups using a stratified log-rank test (stratified on Rai stage, intermediate versus [vs.] high, and del(17p13.1) by fluorescence in situ

2018 Clinical Trials

184. Ibrutinib lead-in Followed by Venetoclax Plus Ibrutinib in Patients With RR CLL

or symptomatic lymphadenopathy Progressive lymphocytosis with an increase of ≥ 50% over a 2-month period, or lymphocyte doubling time of less than 6 months Disease-related symptoms as defined by any of the following: (a) Unintentional weight loss ≥ 10% within the previous 6 months. (b) Significant fatigue (i.e., ECOG PS 2 or worse; cannot work or unable to perform usual activities). (c) Fevers ≥38.0° C for 2 or more weeks without evidence of infection. (d) Night sweats for ≥ 1 month without evidence (...) . Progression-free survival (PFS) [ Time Frame: Day 169, 337, 505, 673, 841, yearly up to five years, end of trial treatment plus unscheduled (if progression is suspected) ] PFS is defined as the time from registration until progression according the iwCLL criteria or death from any cause, whichever occurs first. Patients not having an event at the time of analysis as well as patients starting a new antileukemic therapy in the absence of an event will be censored at the date of their last tumor assessment

2018 Clinical Trials

185. Safety and Efficacy of REGN2477+REGN1033 in Patients With Sporadic Inclusion Body Myositis

. Any condition that precludes adequate intake of energy and protein; malnutrition; presence of an eating disorder. Unintentional weight loss of ≥10% in the past 6 months (patient-reported) Hospitalization for heart failure in last year or New York Heart Association Class 4 History of hypertrophic cardiomyopathy Any drugs known to influence muscle mass and performance such as anabolic steroids or growth hormone within 6 weeks prior to screening Unable to fit on the site's DXA scanner table, within (...) . Ability to climb 4 steps of stairs unassisted (may use handrails) Willing and able to comply with clinic visits and study-related procedures Key Exclusion Criteria: Other neurological conditions (eg, hemiplegia post stroke, Parkinson's) or musculo-skeletal conditions (eg, severe osteoarthritis) causing mobility impairment Mini-Mental State Examination (MMSE) score <24 Ongoing, chronic, high-dose (>20 mg prednisone equivalent per day), systemic corticosteroid therapy within 6 weeks prior to screening

2018 Clinical Trials

186. Impact of Dietary Intervention on Tumor Immunity: the DigesT Trial

-melanomatous skin cancer or curatively resected cervical cancer. Body Mass Index (BMI) < 20 Kg/m2. Anamnesis of alcohol abuse. Unintentional weight loss ≥ 5% in the last three months, unless the patient has a BMI > 25 Kg/m2 at study enrollment. Intentional weight loss is permitted if < 10% in the last three months and patient BMI is > 22 kg/m2. Severe heart, liver, pulmonary, kidney comorbidities. Current status of pregnancy or lactation, where pregnancy is defined as the state of a female after conception (...) fraction (LVEF) to less than 50%, as assessed by multigated radionuclide scintigraphic scan (MUGA) or echocardiography. Previous episodes of symptomatic hypotension causing unconsciousness. Baseline fasting plasma glucose ≤ 65 mg/dl. Ongoing therapy with systemic corticosteroids, or systemic corticosteroid therapy ≤ 2 weeks before study enrollment, or who have not recovered from side effects of such treatment. The following uses of corticosteroids are permitted: topical applications (e.g. for rash

2018 Clinical Trials

187. A Study of BNC105P Combined With Ibrutinib

leukemia and patients with Richter's transformation of CLL/SLL are NOT eligible. Active disease meeting at least 1 of the IWCLL 2008 criteria for requiring treatment: i) A minimum of any one of the following constitutional symptoms: Unintentional weight loss >10% within the previous 6 months prior to screening. Extreme fatigue (unable to work or perform usual activities). Fevers of greater than 100.5 F for ≥2 weeks without evidence of infection. Night sweats without evidence of infection. ii) Evidence (...) are not exclusions). Thrombotic events (pulmonary embolism; deep venous thrombosis) within 6 month prior to start of therapy. History of Human Immunodeficiency Virus (HIV) infection or active hepatitis B or C. Intravenous immunoglobulin (IVIG) can cause a false positive hepatitis B serology. If patients receiving routine IVIG have core antibody or surface antigen positivity without evidence of active viremia (negative hepatitis B DNA) they may still participate in the study, but should have hepatitis serologies

2018 Clinical Trials

188. Exocrine pancreatic dysfunction is common in hepatocyte nuclear factor 1β-associated renal disease and can be symptomatic Full Text available with Trip Pro

elastase-1 deficiency is a common feature of HNF1B-associated renal disease even when diabetes is not present and pancreatic exocrine deficiency may be more symptomatic than previously suggested. Faecal elastase-1 should be measured in all patients with known HNF1B-associated disease complaining of chronic abdominal pain, loose stools or unintentional weight loss. The discovery of a low faecal elastase-1 concentration in individuals with developmental kidney disease of uncertain cause should prompt (...) %) patients with HNF1B-associated renal disease. A total of 8/29 (28%) had a measurement suggestive of exocrine pancreatic insufficiency at  <200 μg/g stool; of these, 3 suffered with abdominal pain, loose stools and/or unintentional weight loss. All three experienced symptomatic improvement and weight gain after commencing pancreatic enzyme replacement therapy. Faecal elastase-1 was low in 7/15 (47%) HNF1B patients without diabetes compared with 11/14 (79%) of those with diabetes (P  =  0.1).Faecal

2018 Clinical kidney journal

189. Human IL-15 (rhIL-15) and Obinutuzumab for Relapsed and Refractory Chronic Lymphocyte Leukemia

of the following: Unintentional weight loss greater than or equal to 10% within the previous 6 months. Significant fatigue (ie, ECOG performance scale 2 or worse; cannot work or unable to perform usual activities). Fevers 38.0 degree C for 2 or more weeks without evidence of infection. Night sweats for greater than or equal to 1 month without evidence of infection. greater than or equal to 18 years of age on day of signing informed consent NOTE: Because no dosing or adverse event data are currently available (...) and for the duration of study treatment, and for at least 18 months after the last dose of obinutuzumab. The effects of rhIL-15 and obinutuzumab on the developing human fetus are unknown. Additionally, CD20-depleting agents are known to produce opportunistic infections, causing fetal B-cell depletion in animal studies, and may be teratogenic. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately. NOTE

2018 Clinical Trials

190. Evaluation of Nursing Facility Resident Safety During Implementation of the INTERACT Quality Improvement Program. (Abstract)

analysis data, and monthly telephonic support.Minimum data set (MDS) data for unintentional weight loss, malnutrition, hip fracture, pneumonia, wound infection, septicemia, urinary tract infection, and falls with injury for the intervention year and the year prior; unintentional weight loss, dehydration, changes in rates of falls, pressure ulcers, severe pain, and unexpected deaths obtained from the NFs participating in the intervention through monthly telephone calls.No adverse effects on resident (...) nonsignificant reduction in hospitalizations.NFs with adequate on-site medical, radiography, laboratory, and pharmacy services, and capability for online training and data input were eligible.264 NFs randomized into intervention and comparison groups stratified by previous INTERACT use and self-reported hospital readmission rates.NFs randomized to the intervention group received INTERACT materials, access to online training and a series of training webinars, feedback on hospitalization rates and root-cause

2018 Journal of the American Medical Directors Association Controlled trial quality: uncertain

191. Reducing SB in ALF and Its Affect on Cognitive Impairment, QoL, and Physical Functioning

cause of dependence and disability worldwide. With the nation's fastest growing demographic being adults over 65, the Lewy Body Dementia Association states that the current cost puts it higher than either heart disease or cancer; as the financial burden was estimated at $818 billion in 2015. Functional limitations such as a slower gait, muscle weakness (ex. grip strength), unintentional weight loss and self-reported exhaustion adds pressure on healthcare services. Older adults transitioning (...) benefits may come from the lower end of the PA spectrum; and there are no current guidelines for how long older adults should be sedentary. Research shows that large amounts of sedentary behaviour (SB) leads to an increased risk of all-cause mortality, independent from not meeting the PA guidelines (Ekelund et al., 2016). SB is defined as any waking behaviour characterized by an energy expenditure less than or equal to 1.5 metabolic equivalents while in a sitting or reclining posture. Alzheimer's

2018 Clinical Trials

192. Malnutrition

factors such as: distance to grocery stores the availability and affordability of public transit. Older adults who experience: Unintentional weight loss Loss of appetite Difficulty eating or drinking (coughing, choking, or pain) Older adults who have normal digestion but difficulty eating because of cancer, neurological problems, gastrointestinal problems, or trauma to their gut might also consider tube feeding. This document does not describe the pros and cons of the use of tube feeding. Depending (...) on your priorities, you may or may not decide to make a change. The choice is up to you because... There are several options to limit weight loss These options can cause benefits or harms. It is difficult to predict how they will work for you . You are more likely to stick to a lifestyle change that you chose to make yourself Opting for an intervention or ""watchful waiting"" are both acceptable option We recommend that... The decision take into account the person’s values and priorities The decision

2014 Cancer Council Australia

193. Treatment and recommendations for homeless people with Opioid Use Disorders

-medical interventions for this population. The recommendations in this document specify what experienced providers and recipients of homeless services believe works best, with the realistic understanding that limited resources, fragmented health care delivery systems, and loss to follow-up often compromise adherence to optimal clinical practices. We hope these recommendations provide helpful guidance to health care professionals, and that they will contribute to improvements in both quality of care (...) providers and recipients gave generously of their time to formulate guidance for practitioners less experienced in the care of patients whose comorbidities and limited resources, both financial and social, are among the causes and consequences of homelessness. In addition, the Advisory Committee would like to thank the following individuals for reviewing and commenting on draft recommendations prior to publication: ? Diana Amodia MD, Medical Director, BAART Turk Street Clinic, San Francisco, California

2014 National Health Care for the Homeless Council

194. Diagnosis and Treatment of Overactive Bladder (Non-Neurogenic) in Adults: AUA/SUFU Guideline

in a diagnostic process to document symptoms and signs that characterize OAB and exclude other disorders that could be the cause of the patient’s symptoms; the minimum requirements for this process are a careful history, physical exam, and urinalysis. Clinical Principle 2. In some patients, additional procedures and measures may be necessary to validate an OAB diagnosis, exclude other disorders and fully inform the treatment plan. At the clinician’s discretion, a urine culture and/or post-void residual (...) epidemiologic differences across racial/ethnic groups. Patient-Reported Outcomes (PROs) and OAB. Since OAB is a symptom-based diagnosis, the quality of life (QOL) impact of the symptoms is a critical aspect of the condition. The degree of bother caused by OAB symptoms directly affects OAB care-seeking, treatment intensity and satisfaction with treatment. Therefore, assessment of patient-reported outcomes (PROs) can be a critical component of OAB management. Numerous questionnaire instruments have been

2014 Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction

195. Diagnosis and Treatment of Non-Neurogenic Overactive Bladder (OAB) in Adults: AUA/SUFU Guideline

existed. See text and algorithm for definitions and detailed diagnostic, management and treatment frameworks. Guideline Statements Diagnosis 1. The clinician should engage in a diagnostic process to document symptoms and signs that characterize OAB and exclude other disorders that could be the cause of the patient's symptoms; the minimum requirements for this process are a careful history, physical exam, and urinalysis. Clinical Principle 2. In some patients, additional procedures and measures may (...) , but the majority of patients have symptoms for years. 15,16 To date, no population-based studies have directly examined epidemiologic differences across racial/ethnic groups. Patient-Reported Outcomes (PROs) and OAB. Since OAB is a symptom-based diagnosis, the quality of life (QOL) impact of the symptoms is a critical aspect of the condition. The degree of bother caused by OAB symptoms directly affects OAB care-seeking, treatment intensity and satisfaction with treatment. Therefore, assessment of patient

2014 American Urological Association

196. Preventing and Addressing Abuse and Neglect of Older Adults: Person-Centred, Collaborative, System-Wide Approaches

a liability nor discharge from liability. While every effort has been made to ensure the accuracy of the contents at the time of publication, neither the authors nor the Registered Nurses’ Association of Ontario (RNAO) give any guarantee as to the accuracy of the information contained in them nor accept any liability, with respect to loss, damage, injury or expense arising from any such errors or omission in the contents of this work. Copyright With the exception of those portions of this document (...) . The scope of this guideline includes harms caused by the main forms of abuse and neglect. These are physical abuse, emotional/psychological abuse, sexual abuse, financial abuse/exploitation and neglect. This guideline also includes education and policy/organization/system recommendations that address resident-to-resident aggressive behaviour G . Harms inflicted by one resident (often an older adult with cognitive impairment who is living in a long-term care facility G ) upon another resident

2014 Registered Nurses' Association of Ontario

197. Working with Families to Promote Safe Sleep for Infants 0-12 Months of Age

sleeping environment it may be plausible, but inconclusive, that the infant died from asphyxia. Such a case often leads the investigating team and coroner to conclude that they cannot determine the cause of death. 18 REGISTERED NURSES’ ASSOCIATION OF ONTARIO BACKGROUND Working with Families to Promote Safe Sleep for Infants 0-12 Months of Age Death by Asphyxia Versus Unexplained Death Two types of deaths can occur in a sleeping environment perceived as unsafe: death by asphyxia (an unintentional injury (...) to ensure the accuracy of the contents at the time of publication, neither the authors nor the Registered Nurses’ Association of Ontario (RNAO) give any guarantee as to the accuracy of the information contained in them nor accept any liability, with respect to loss, damage, injury or expense arising from any such errors or omission in the contents of this work. Copyright With the exception of those portions of this document for which a specific prohibition or limitation against copying appears

2014 Registered Nurses' Association of Ontario

198. Psychological, social and biological determinants of ill health (pSoBid)

potential explanatory variables. There are social gradients in a range of biological and psychosocial variables which indicate that living in a deprived environment may increase the propensity to develop chronic disease, through as yet unknown mechanisms. A potential underlying cause of increased prevalence of disease is chronic inflammation (Steptoe et al., 2002; Owen et al., 2003). This has been observed to be more common in deprived than affluent populations, linked to coronary heart disease (Ross (...) consistent gradients. These gradients have been shown for all-cause mortality, but also for a wide range of diseases, especially coronary heart disease, diabetes, respiratory diseases, arthritis, poor birth outcomes, and for accidents and violent deaths (Marmot and Wilkinson, 1999). The inverse relationship between socioeconomic position/status and health is one of the most consistent epidemiological findings. The social distribution of physiological risk is partly a reflection of the social patterning

2013 Glasgow Centre for Population Health

199. South Australian gastroenteropancreatic neuroendocrine tumours pathway

of hospital stay and poor coping skills. Each of these issues affects morbidity outcomes. Regular screening and ongoing monitoring for depression by health professionals as part of long-term follow-up care is required. Referral to a psychologist or psychiatrist may be appropriate. Body image Body image is the way a person feels about their appearance. Some cancer treatments can cause physical changes to a patient’s body, such as hair loss, scars from surgery, loss of a body part, changes to the skin (...) , weight gain or weight loss. Physical changes can result in poor body image. Patients should be provided with individualised and accurate information about any expected physical changes before treatment. Support and counselling by a specialist psychologist, psychiatrist or social worker may assist patients to make appropriate treatment decisions that incorporate the potential effect on their appearance. Sexuality Sexuality encompasses not only the physical aspects of sexual function, but also refers

2014 Clinical Practice Guidelines Portal

200. Guidelines for Insertion and Maintenance of Central Venous Access Devices in Children and Young People

of microorganisms causing catheter- related infection are the insertion site and the device hub. The microorganisms causing infections are usually Gram-positive bacteria residing on the patient’s skin, most often coagulase-negative staphylococci and Staphylococcus aureus. In addition, metastatic colonization of the device from a distant site of infection (Gastrointestinal and urinary tract, wound etc.) may occur. Figure 1. Sources of microbial contamination in patients with an IV catheter. Extraluminal sources (...) the area and the depth of the reservoir. It must sit flush against the skin surface. The length of the needle required may vary as the child gains or loses weight. The length of the needle used should be recorded on the patient’s documentation • Do not rock or tilt the needle as it may damage the septum • General observations of patients with these devices are outlined in Table 214 GENERAL PRINCIPLES FOR MANAGEMENT OF CVAD Dressing: A dressing will assist in anchoring the device during day to day

2014 Regulation and Quality Improvement Authority

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>