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Unintentional Weight Loss Causes

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181. Spine Pain INtervention to Enhance Care Quality And Reduce Expenditure

delivered by a trained provider) History of spine surgery or spine injections/ablation in the past 6 months Severe, active psychosis or major depression inhibiting ability to physically participate in intervention Red Flag Symptoms (fever, night sweats, unintentional weight loss, bowel or bladder dysfunction, neurologic weakness, history of intravenous drug use) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact (...) , 2018 See Sponsor: Brigham and Women's Hospital Collaborator: Stanford University Information provided by (Responsible Party): Niteesh K. Choudhry, MD, PhD, Brigham and Women's Hospital Study Details Study Description Go to Brief Summary: Low back and neck pain are among the leading causes of medical visits, lost productivity and disability. There is an urgent need to identify effective and efficient ways of helping subjects with acute spine pain while guiding practitioners towards high-value care

2017 Clinical Trials

182. Complete transmural migration of a retained surgical sponge: an atypical case in image mimicking intussusception: A case report. (PubMed)

Complete transmural migration of a retained surgical sponge: an atypical case in image mimicking intussusception: A case report. Intraluminal migration of a retained surgical sponge causing intestinal obstruction and fistula is extremely rare occurrence.A case of a 35-year-old male, who complaining a diffuse abdominal pain beginning three days earlier. He also complained of occasional vomiting, nonspecific abdominal pain, and an unintentional 15 kg weight loss during the past 2 years. However

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2017 Medicine

183. Individualized Exercise Program Plus Behavioral Change Enhancement Strategies for Managing Fatigue in Frail Older People

: To detect the change from baseline frailty level at mid-term programme (wk 8 after commences of the programme),and then 1 week, 6 month and 12 months months after the completion of the programme ] Fried Frailty Index includes: i) an unintentional loss of 10% of body weight in the past year; ii) exhaustion: by answering 'Yes' to either 'I felt that everything I did was an effort', or 'I could not get going in the last week'; iii) a slow walk time: with an average walking speed in the lowest quintile (...) that their mobility and balance is good enough to join the exercise training; and in a frail state with exhaustion as determined using the Fried Frailty Index (FFI), including: i) an unintentional loss of 10% of body weight in the past year; ii) exhaustion: by answering 'Yes' to either 'I felt that everything I did was an effort', or 'I could not get going in the last week'; iii) a slow walk time: with an average walking speed in the lowest quintile stratified by median body height; iv) reduced grip strength

2017 Clinical Trials

184. Protocol GELLC-7: Ibrutinib Followed by Ibrutinib Consolidation in Combination With Ofatumumab

margin) or progressive or symptomatic splenomegaly. Massive nodes (i.e. > 10 cm in longest diameter) or progressive or symptomatic lymphadenopathy. Progressive lymphocytosis with an increase of > 50% over a 2-month period, or lymphocyte doubling time (LDT) of less than 6 months. A minimum of any one of the following disease-related symptoms: unintentional weight loss ≥ 10% within the previous 6 months, significant fatigue (i.e., ECOG PS 2; cannot work or unable to perform usual activities), fevers (...) . Females of child bearing potential are defined as sexually mature women without prior hysterectomy or who have had any evidence of menses in the past 12 months. However, women who have been amenorrheic for 12 or more months are still considered to be of childbearing potential if the amenorrhea is possibly due to other causes, including prior chemotherapy, anti-estrogens, or ovarian suppression Exclusion Criteria: Prior treatment for CLL or SLL. Any serious medical condition, laboratory abnormality

2017 Clinical Trials

186. The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty. (PubMed)

recommendations were developed: strong, conditional, and no recommendation.Strong recommendations were (1) use a validated measurement tool to identify frailty; (2) prescribe physical activity with a resistance training component; and (3) address polypharmacy by reducing or deprescribing any inappropriate/superfluous medications. Conditional recommendations were (1) screen for, and address modifiable causes of fatigue; (2) for persons exhibiting unintentional weight loss, screen for reversible causes

2017 Journal of the American Medical Directors Association

187. Metabolic syndrome and insulin resistance are associated with frailty in older adults: a prospective cohort study. (PubMed)

individuals aged ≥60, who were free of diabetes at 2008-10 and were followed up for 3.5 years. At baseline, MS was ascertained according to the harmonised definition, and IR with the Homoeostatic Model Assessment for IR index (HOMA-IR). Frailty was defined as having three or more of the Fried's criteria: exhaustion, low physical activity, slow walking, unintentional weight loss and low grip strength. Statistical analyses were performed with logistic regression, and adjusted for the main confounders.in (...) Metabolic syndrome and insulin resistance are associated with frailty in older adults: a prospective cohort study. diabetes increases the risk of frailty that is a leading cause of disability and premature mortality in older people. Metabolic syndrome (MS) and insulin resistance (IR) are strong risk factors for diabetes and could, thus, lead to frailty. However, the association between MS or IR and frailty has barely been investigated.data were obtained from a cohort of 1,499 community-dwelling

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2017 Age and ageing

188. Primary Care Corner with Geoffrey Modest MD: SPRINT Trial: Elderly Subgroup Study of Lower Blood Pressure Goal

or LVEF <35%, clinical dementia, prevalent stroke , unintentional weight loss of >10%, an SBP of <110 mmHg after standing for 1 minute , or residing in a nursing home Not surprisingly, the NNT was much lower in this trial than the overall SPRINT trial, given the higher event rate of this older group And, reassuringly re: orthostatic hypotension, this subgroup analysis is pretty convincing that there was no increase, but they did exclude anyone with a standing SBP <110 But, a few caveats here (...) patients had SBP difference of 10.8 mm Hg, less fit 11.3 and fit 13.5 mmHg) Primary composite outcome (nonfatal MI, acute coronary syndrome, nonfatal stroke, nonfatal acute decompensated heart failure, death from cardiovascular cause): 102 events in intensive group (2.59%/yr) vs 148 (3.85%/yr) on standard therapy, a 34% reduction [HR 0.66 (0.51-0.85)]. Number-needed-to-treat for 3.14 years was 27 Secondary outcome (all-cause mortality): 73 deathsin intensive group vs 107 on standard therapy, a 33

2016 Evidence-Based Medicine blog

189. First Line Therapy of Advanced Stage Follicular Lymphoma in Patients Not Eligible for Standard Immunochemotherapy

, drenching night sweats, or unintentional weight loss of >10% of normal body weight over a period of 6 months or less) Hematopoietic insufficiency (at least one of the following: granulocytopenia <1500 cells/μl, Hb < 10 g/dl, thrombocytopenia <100.000 cells/μl) Compressive syndrome Pleural/peritoneal effusion Symptomatic nodal or extranodal manifestations At least one bi-dimensionally measurable lesion (> 1.5 cm in its largest dimension by CT scan or MRI) Adequate hematologic function (unless (...) is superior to single agent OBINUTUZUMAB in medically non-fit, 'compromised' patients in terms of anti-lymphoma activity (primary objective), side effects, and quality of life. For the assessment of the anti-lymphoma activity the "event free survival (EFS)" will be applied as primary endpoint. EFS is defined as the time from the day of randomization to the date of first documented disease progression, death by any cause, or institution of a new anti-lymphoma treatment. Condition or disease Intervention

2017 Clinical Trials

190. Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)

and Cognitive Frailty) [ Time Frame: 20 years - once every 3-4 years ] Physical frailty was assessed by scores (1 = present, 0 = absent) for five components (shrinking, weakness, slowness, exhaustion, and low Physical Activity (PA)) proposed by Fried et al (3), with the following operational modifications: (i) Shrinking was defined by unintentional weight loss of 4 kg or more in the past 6 months, or BMI less than 18.5 kg/m2, or calf circumference of 31 cm or less. (ii) Weakness was assessed by knee (...) /learning, visuospatial ability, language, attention, and executive functioning. All domains are calculated by weighted averages of age and education adjusted scores. Tests: (i) Digit Span forward and backwards tasks (9); (ii) Rey's Auditory Verbal Learning Test (10); (iii) Story Memory Test (11); (iv) Brief Visuospatial Memory Test - Revised (12); (v) Boston Naming Test (13); (vi) Clock Reading Test; (viii) Colour Trials 1 and 2 (14); (ix) Block Design task (9). Frailty (Measuring the physical

2017 Clinical Trials

191. Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments

-directed exercise (walks around the block, climbing stairs) is acceptable for inclusion, with subjects encouraged to continue such activity throughout the program. Eligible participants must be able to provide informed consent independently and also speak and read English at the 8th grade level. EXCLUSION CRITERIA: Medical condition, including recent unintentional weight loss, that might prohibit safe participation in the intervention Diagnosis of diabetes mellitus by self-report Fasting blood glucose (...) hormonal changes during pregnancy that affect study variables and potential pregnancy-related restrictions on exercise. Currently participating in a structured exercise or weight-loss program (e.g., Weight Watchers, NutriSystem, or fitness training) Have undergone weight loss (bariatric) surgery Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided

2017 Clinical Trials

192. Moderate Alcohol and Cardiovascular Health Trial

of any organ transplant Unintentional weight loss >10% in last 6 months Currently participating in another clinical trial (intervention trial) with CVD outcomes. Note: Participant must wait until the completion of his/her activities or the completion of the other trial before being screened for MACH15. Local restrictions for entry by participants can be more conservative if mandated. Not willing or able to provide a name and contact information for at least one additional contact person other than (...) : ethanol, beer, wine, spirits No Intervention: Abstention Abstention from alcohol Outcome Measures Go to Primary Outcome Measures : Cardiovascular Disease or Death [ Time Frame: Every 3 months for up to 90 months or close out, or until date of death ] Time from baseline to a composite endpoint comprised of the first occurrence of a non-fatal myocardial infarction, non-fatal ischemic stroke, hospitalization for angina, coronary/carotid revascularization, or all-cause mortality. Secondary Outcome

2017 Clinical Trials

193. Lemmel Syndrome Secondary to Duodenal Diverticulitis: A Case Report (PubMed)

to become inflamed. We report the case of a 25-year-old female presenting with unintentional weight loss and fatigue. Since her initial labs were concerning for possible infection with hepatobiliary abnormalities, a contrast-enhanced CT was obtained. This study revealed a large periampullary diverticulum with mucosal enhancement and fat stranding consistent with diverticulitis. (...) Lemmel Syndrome Secondary to Duodenal Diverticulitis: A Case Report Lemmel syndrome occurs when a duodenal diverticulum causes obstructive jaundice due to a mechanical obstruction of the common bile duct. Additional pathophysiologic processes may also contribute to the development of Lemmel syndrome. These include duodenal diverticula causing dysfunction of the sphincter of Oddi as well as compression of the common bile duct by duodenal diverticula. It is uncommon for duodenal diverticulum

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2017 Cureus

194. A Rare Case of Fusobacterium Necrophorum Liver Abscesses (PubMed)

A Rare Case of Fusobacterium Necrophorum Liver Abscesses Liver abscesses are an uncommon disease that can present with vague symptoms. Fusobacterium necrophorum causing liver abscesses is a rare condition and only a few cases have been reported. An 88-year-old female presented to her primary care physician with one week of fevers, night sweats, chills, fatigue and vague right upper quadrant abdominal pain. She denied nausea, vomiting, constipation, diarrhea and unintentional weight loss

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2017 Clinics and practice

195. Dilated Thoracic Esophagus Presenting with Painful Progressive Persistent Dysphagia and Leukocytosis of Unknown Origin (PubMed)

and a dilated thoracic esophagus with painful, progressive, and persistent dysphagia and leukocytosis of unknown origin. A 77-year-old man with a past medical history of hypertension and colonic cancer status post right hemicolectomy (surveillance negative) presented to the emergency department with painful, progressive, persistent, and worsening dysphagia for the past three weeks. It was associated with an unintentional weight loss of ten pounds in one month and nausea with non-bilious and non-bloody (...) Dilated Thoracic Esophagus Presenting with Painful Progressive Persistent Dysphagia and Leukocytosis of Unknown Origin Esophageal cancer is the eighth-most common cause of cancer-related mortality worldwide. The most common presenting symptom in advanced distal esophageal cancer is the sensation of sticking food, but it may sometimes present with bleeding and related complications, or asymptomatic leukocytosis. We present the case of a 77-year-old afebrile man with chronic alcoholism

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2017 Cureus

196. Cytomegalovirus-mononucleosis-induced thyroiditis in an immunocompetent patient (PubMed)

weight loss over the same time course Physical examination revealed mild tachycardia, an intention tremor and a normal-sized, nontender thyroid gland without palpable nodules. The remainder of the physical examination was unremarkable and without stigmata of Graves' disease. Her initial blood tests revealed overt thyrotoxicosis, elevated liver enzymes, an elevated C-reactive protein, a negative monospot and a positive CMV IgM antibody. Thyroid sonography revealed areas of hypoechogenicity (...) Cytomegalovirus-mononucleosis-induced thyroiditis in an immunocompetent patient Enteroviruses, including coxsackieviruses and Echovirus, are well known pathogens responsible for the development of thyroiditis. We describe the case of a 49-year-old woman with no personal or family history of thyroid disease who presented to the emergency room with a two-week history of daily fevers up to 39°C, a sore throat, occasional palpitations and diaphoresis, decreased appetite and an unintentional 10 kg

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2017 Endocrinology, diabetes & metabolism case reports

197. Sialanar (glycopyrronium) - for treating severe drooling of saliva in children and adolescents (aged 3 years and above) with conditions affecting the nervous system, such as cerebral palsy, epilepsy and neurodegenerative diseases

IPC in-process control IR Infrared i.v. intravenous(ly) kg kilogram(s) ?z terminal elimination rate constant L litre(s) LD 50 lethal dose 50% LDPE low density polyethylene LLOQ Lower Limit of Quantification LoA Letter of Access LOD loss on drying LoD limit of detection LoQ limit of quantitation M muscarinic (receptor) MA Marketing Authorisation MAA Marketing Authorisation Application MAH Marketing Authorisation Holder mBMRS Modified Behavioural and Medical Rating Scale mg milligram(s) MHRA (...) ) No 1901/2006. The eligibility to the centralised procedure was agreed upon by the EMA/CHMP on 24 October 2013. The applicant applied for the following indication: Treatment of sialorrhoea (chronic pathological drooling) in children aged 2 to M3 > M2/M4 > M5. GP is 2-4 times more selective for the M3 and M1 subtypes than M2, making it one of the most potent M3 blockers available (Bird et al. 2011). The applied dose is based on the weight of the child, starting with approximately 0.02 mg/kg per dose

2016 European Medicines Agency - EPARs

198. Coping with Common GI Symptoms in the Community: A Global Perspective on Heartburn, Constipation, Bloating, and Abdominal Pain/Discomfort

• Dysphonia, recurrent cough • GI bleeding • Evidence of iron-deficiency anemia • Progressive unintentional weight loss • Lymphadenopathy • Epigastric mass WGO Global Guidelines Common GI symptoms (long version) 14 © World Gastroenterology Organisation, 2013 • New-onset heartburn at age > 50–55 years • Family history of esophageal adenocarcinoma [46] 3.6 Heartburn—management cascade • Occasional/intermittent heartburn usually has no long-lasting effects. • Pain and discomfort caused by heartburn (...) , and prominent weight loss; diarrhea may be present. • Gynecological pathology—pain associated with, and worsened by, menses; it should be remembered that IBS is often worse with menstruation. Gynecologic causes of chronic/recurrent abdominal pain/discomfort are: endometriosis, dysfunctional uterine bleeding, pelvic inflammatory disease, and ovarian cancer (may mimic IBS or dyspepsia and be difficult to detect). Ruptured ovarian cyst and ectopic pregnancy present with acute abdominal pain. A pelvic

2013 World Gastroenterology Organisation

199. Clinical Practice Guidelines for Healthy Eating for the Prevention and Treatment of Metabolic and Endocrine Diseases in Adults: Cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology and The Obesity Society

Professor of Medicine and Director, Metabolic Support, Division of Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, 8 Director, Bone Densitometry Unit and Osteoporosis Center, Texas Institute for Reproductive Medicine and Endocrinology, 9 Medical Director, Weight Loss and Diabetes Center, Endocrinology, Northeast Medical Group, Greenwich Hospital/Yale New Haven Health, and Clinical Associate Professor of Medicine, Drexel University College (...) adipose tissue dysfunction (adiposopathy) (Grade A, BEL 1). Adult feeding behavior is solidly rooted from childhood, so it is important to counsel adult patients to include their families, especially their children, in healthy eat- ing behavior changes (Grade B, BEL 2). Nutrition counseling should be culturally, linguistically, and educationally provided to meet individual patient needs (Grade D, BEL 4). • R9. The weight-loss goal for overweight or obese patients is 5 to 10% of current body weight

2013 American Association of Clinical Endocrinologists

200. Localized Nodal Indolent Lymphoma

, or unintentional weight loss of >10% in the 6 months before presentation, occur in about 20% of patients. 1 University of Florida Proton Therapy Institute, Jacksonville, Florida. 2 Panel Chair, University of Rochester Medical Center, Rochester, New York. 3 Panel Vice-chair, Princess Margaret Hospital, Toronto, Ontario, Canada. 4 Stanford Cancer Center, Stanford, California, American Society of Clinical Oncology. 5 MD Anderson Cancer Center, Houston, Texas. 6 Emory University, Atlanta, Georgia, American Society (...) ) to doses of 35 Gy to 50 Gy at 1.5 Gy to 2.5 Gy per fraction. With a median follow-up of 7.7 years, the median OS time was 13.8 years with a 10- year freedom from recurrence rate of 44% and an OS rate of 64%. In the experience of Princess Margaret Hospital (Toronto, Ontario) [24] treating 190 patients with stage I or II follicular lymphoma, definitive treatment with RT (with variations in radiation field designs and doses) led to a 12-year relapse-free survival rate of 53%, a cause- specific survival

2013 American College of Radiology

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