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Unintentional Weight Loss Causes

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1. Assessment of unintentional weight loss

conditions for which early diagnosis may lead to better outcomes. There is a broad range of causes of unintentional weight loss including medical diseases, psychiatric illnesses, and social factors. These conditions may occur in isolation or in combination. Classification There is no formal consensus definition of unintentional weight loss; however, the weight loss must be considered unintentional by the patient and treating practitioner. The degree of weight loss has been defined in case series as being (...) =716098 http://www.ncbi.nlm.nih.gov/pubmed/12614090?tool=bestpractice.com and in older patients with unintentional (but not intentional) weight loss. Wijnhoven HA, van Zon SK, Twisk J, et al. Attribution of causes of weight loss and weight gain to 3-year mortality in older adults: results from the Longitudinal Aging Study Amsterdam. J Gerontol A Biol Sci Med Sci. 2014;69:1236-1243. http://www.ncbi.nlm.nih.gov/pubmed/24522392?tool=bestpractice.com In patients with recent (i.e., within 6 months

2018 BMJ Best Practice

2. Unintentional Weight Loss Causes

Unintentional Weight Loss Causes Unintentional Weight Loss Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Unintentional Weight (...) Loss Causes Unintentional Weight Loss Causes Aka: Unintentional Weight Loss Causes , Meals on Wheels Mnemonic From Related Chapters II. Causes: "Meals on Wheels" Mnemonic Medication Effects Emotional Problems ( ) or Late-life paranoia Swallowing disorders (See ) Oral factors (e.g. Poorly fitting dentures) No Money Wandering ( related behavior) , Hyperparaythyroidism, Hypoadrenalism Enteric problems (e.g. Malabsorption) Eating problems (e.g. difficult self-feeding) Low salt diet or low diet Stones

2018 FP Notebook

3. Unintentional weight loss: Clinical characteristics and outcomes in a prospective cohort of 2677 patients. Full Text available with Trip Pro

Unintentional weight loss: Clinical characteristics and outcomes in a prospective cohort of 2677 patients. Whereas there are numerous studies on unintentional weight loss (UWL), these have been limited by small sample sizes, short or variable follow-up, and focus on older patients. Although some case series have revealed that malignancies escaping early detection and uncovered subsequently are exceptional, reported follow-ups have been too short or unspecified and necropsies seldom made. Our (...) objective was to examine the etiologies, characteristics, and long-term outcome of UWL in a large cohort of outpatients.We prospectively enrolled patients referred to an outpatient diagnosis unit for evaluation of UWL as a dominant or isolated feature of disease. Eligible patients underwent a standard baseline evaluation with laboratory tests and chest X-ray. Patients without identifiable causes 6 months after presentation underwent a systematic follow-up lasting for 60 further months. Subjects aged ≥65

2017 PLoS ONE

4. Unintentional Weight Loss

Unintentional Weight Loss Aka: Unintentional Weight Loss , Geriatric Failure to Thrive , Cachexia , Wasting Syndrome , Malnutrition , Anorexia From Related Chapters II. Epidemiology: Incidence residents: 25-40% Overall over age 64 years: 13% III. Definition Unintentional Weight Loss of >5% of body weight within 6-12 months IV. Causes See V. Precautions Substantial weight loss should not be attributed to aging alone See VI. History How much weight loss over how much time? Patients down play weight changes (...) Unintentional Weight Loss Unintentional Weight Loss Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Unintentional Weight Loss

2018 FP Notebook

5. Medications Associated with Unintentional Weight Loss

Cancer Administration 4 Medications Associated with Unintentional Weight Loss Medications Associated with Unintentional Weight Loss Aka: Medications Associated with Unintentional Weight Loss , Unintentional Weight Loss due to Medications , Drug Induced Unintentional Weight Loss From Related Chapters II. Mechanisms Altered taste or smell See (includes ) s s ( ) See s (e.g. s) ( ) s (medications suppressing appetite) Anticonvulsants (e.g. ) (e.g. ) ( ) ( ) s s (e.g. , ) See s or See s ( ) s III. Causes (...) Medications Associated with Unintentional Weight Loss Medications Associated with Unintentional Weight Loss Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse

2018 FP Notebook

6. Unintentional Weight Loss Causes

Unintentional Weight Loss Causes Unintentional Weight Loss Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Unintentional Weight (...) Loss Causes Unintentional Weight Loss Causes Aka: Unintentional Weight Loss Causes , Meals on Wheels Mnemonic From Related Chapters II. Causes: "Meals on Wheels" Mnemonic Medication Effects Emotional Problems ( ) or Late-life paranoia Swallowing disorders (See ) Oral factors (e.g. Poorly fitting dentures) No Money Wandering ( related behavior) , Hyperparaythyroidism, Hypoadrenalism Enteric problems (e.g. Malabsorption) Eating problems (e.g. difficult self-feeding) Low salt diet or low diet Stones

2015 FP Notebook

7. Self-reported Intentional Weight Loss and Risk of Death in Moderate Chronic Kidney Disease in the United States. Full Text available with Trip Pro

prior and current weights and the intent to lose weight. We examined the association of self-reported intentional versus unintentional weight loss with all-cause mortality. Participants with no intent to lose weight and no change in weight were the reference group. A multivariable Cox regression model was used to relate mortality with intentional and unintentional weight losses after adjustment for demographics and comorbidity.There were 446 deaths over 6271 years of follow-up. Compared (...) Self-reported Intentional Weight Loss and Risk of Death in Moderate Chronic Kidney Disease in the United States. We hypothesized that intentional weight loss is associated with lower mortality risk, whereas unintentional weight loss is associated with higher mortality risk in chronic kidney disease (CKD).We examined this hypothesis in 872 participants with age >20 years, body mass index ≥ 25 kg/m2 and CKD from 1999-2004 National Health and Nutrition Examination Survey who reported their 1 year

2018 Journal of Renal Nutrition

8. A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

) or any other prescription medication or off-label products intended to increase appetite or treat unintentional weight loss Patient with pleural effusion requiring thoracentesis, pericardial effusion requiring drainage, edema or evidence of ascites Patient with uncontrolled or significant cardiovascular disease, including: History of myocardial infarction within the past 3 months A-V block of second or third degree (may be eligible if currently have a pacemaker) Unstable angina Congestive heart (...) A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2018 Clinical Trials

9. A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

period Patient currently taking androgenic compounds (including but not limited to testosterone, testosterone-like agents, oxandrolone, megestrol acetate, corticosteroids, olanzapine, mirtazapine (however, long-term use of mirtazapine for depression for at least four weeks prior to screening is allowed), dronabinol or marijuana (cannabis) or any other prescription medication or off-label products intended to increase appetite or treat unintentional weight loss Patient with pleural effusion requiring (...) A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2018 Clinical Trials

10. Medications Associated with Unintentional Weight Loss

Cancer Administration 4 Medications Associated with Unintentional Weight Loss Medications Associated with Unintentional Weight Loss Aka: Medications Associated with Unintentional Weight Loss , Unintentional Weight Loss due to Medications , Drug Induced Unintentional Weight Loss From Related Chapters II. Mechanisms Altered taste or smell See (includes ) s s ( ) See s (e.g. s) ( ) s (medications suppressing appetite) Anticonvulsants (e.g. ) (e.g. ) ( ) ( ) s s (e.g. , ) See s or See s ( ) s III. Causes (...) Medications Associated with Unintentional Weight Loss Medications Associated with Unintentional Weight Loss Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse

2015 FP Notebook

11. Unintentional Weight Loss

Unintentional Weight Loss Aka: Unintentional Weight Loss , Geriatric Failure to Thrive , Cachexia , Wasting Syndrome , Malnutrition , Anorexia From Related Chapters II. Epidemiology: Incidence residents: 25-40% Overall over age 64 years: 13% III. Definition Unintentional Weight Loss of >5% of body weight within 6-12 months IV. Causes See V. Precautions Substantial weight loss should not be attributed to aging alone See VI. History How much weight loss over how much time? Patients down play weight changes (...) Unintentional Weight Loss Unintentional Weight Loss Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Unintentional Weight Loss

2015 FP Notebook

12. Attribution of Causes of Weight Loss and Weight Gain to 3-Year Mortality in Older Adults: Results From the Longitudinal Aging Study Amsterdam. Full Text available with Trip Pro

Attribution of Causes of Weight Loss and Weight Gain to 3-Year Mortality in Older Adults: Results From the Longitudinal Aging Study Amsterdam. Weight loss is associated with a higher mortality risk in old age, but the underlying cause may impact this association. We examined associations between causes of intentional and unintentional weight loss and weight gain and mortality.We used data of five triannual examination rounds of the Longitudinal Aging Study Amsterdam (age ≥ 55 years, n = 2,645 (...) ) and two examination rounds of a new cohort (n = 909). Self-reported weight loss or gain and causes were measured during a personal interview. Time-dependent Cox regression was used to model the association between weight loss and gain causes and subsequent 3-year mortality.At baseline, 16% reported weight loss (mean = 4.7 kg, SD = 3.7) in 6 months. After adjustment for potential confounders, an increased mortality risk was observed for unintentional weight loss due to medical reasons (<72 years

2014 Biological Sciences and Medical Sciences

13. Weight Loss Caused by Visceral Artery Disease Full Text available with Trip Pro

Weight Loss Caused by Visceral Artery Disease Dramatic unintentional weight loss can be caused by a spectrum of diseases ranging from very serious to benign and treatable. We describe the case of a 70-year-old woman with an extensive history of cardiovascular disease who presented with unintentional weight loss. Although she was diagnosed and treated for colitis, the patient continued to lose 50 pounds over 8 months, which prompted an angiogram. The angiogram revealed occlusion of her superior (...) and inferior mesenteric arteries just distal to their origins, together with high-grade (80%-90%) stenosis at the origin of the celiac axis. After a stent was placed in the ostium of the celiac axis, the patient immediately began to regain weight. We suggest that clinicians consider chronic mesenteric ischemia when treating patients with undiagnosed unintentional weight loss and a history of atherosclerotic disease.

2013 Texas Heart Institute Journal

14. The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE. Full Text available with Trip Pro

The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE. Weight loss is strongly recommended for overweight and obese adults with type 2 diabetes. Unintentional weight loss is associated with increased risk of all-cause mortality, but few studies have examined its association with cardiovascular outcomes in patients with diabetes.To evaluate 2-year weight change and subsequent risk of cardiovascular events and mortality (...) , average age was 66 years. By the 2-year exam, 4.3% had >10% weight loss, 18.4% had 4-10% weight loss, and 5.3% had >10% weight gain. Over the following 3 years of the trial >10% weight loss was strongly associated with major macrovascular events (HR 1.75, 95% CI: 1.26, 2.44), cardiovascular mortality (HR 2.76, 1.87, 4.09), all-cause mortality (HR 2.79, 2.10, 3.79), but not major microvascular events (HR 0.91, 0.61, 1.36), compared to stable weight. There was no evidence of effect modification

2019 Journal of Clinical Endocrinology and Metabolism

15. Does weight loss reduce risk of early mortality?

, triglycerides, etc). However, the literature has been much more complicated in terms of the effect of weight loss on risk of early mortality. Adding to that literature is a study by Ingram and Mussolino published in The International Journal of Obesity. In essence this study showed that weight loss of 15% or more was associated with an increased risk of death from all causes among overweight men and among overweight and obese women. In the study, a sample of 6117 adults above 50 years of age from (...) or no weight loss (<5%, reference category), there was greater risk of early all-cause mortality among those who lost >15% of their maximum body weight, a finding which was statistically significant in overweight men, and in women of all weight categories (normal, overweight, and obese). While these results may shock some of our readers, similar findings have been reported in numerous other studies. However, many such studies are confounded by various issues making the interpretation of their results

2016 PLOS Blogs Network

16. Incidence and predictors of all-cause mortality within one year after adult spinal deformity surgery Full Text available with Trip Pro

surgery and 61 (0.99%) died within one year of surgery. Preoperative factors: controlling for age, gender, American Society of Anesthesiologists (ASA) score and postoperative complications, four independent risk factors were associated with all-cause mortality within 1 year of ASD surgery: increased age (OR =1.03; 95% CI, 1.01-1.06; P=0.012), ASA score (OR =4.32; 95% CI, 2.68-6.94; P<0.001), cancer history (OR =7.91; 95% CI, 4.23-14.78; P<0.001) and unintentional weight loss (OR =4.65; 95% CI, 1.68 (...) score, cancer history, and unexpected weight loss, along with postoperative complications of pneumonia, DVT, and unplanned intubation were independently associated with all-cause mortality within 1 year of ASD surgery. Interestingly, the potentially more severe complications of sepsis, PE, and MI did not independently predict death.

2018 Journal of Spine Surgery

17. Longitudinal Weight Change During CKD Progression and Its Association With Subsequent Mortality. Full Text available with Trip Pro

observed in the AASK.Inclusion of research participants only; inability to distinguish intentional versus unintentional weight loss.Significant weight loss began relatively early during the course of CKD and was associated with a substantially higher risk for death after dialysis therapy initiation. Further studies are needed to determine whether interventions to optimize weight and nutritional status before the initiation of dialysis therapy will improve outcomes after end-stage renal (...) , a longitudinal cohort of patients with CKD. We also performed similar analyses among 1,067 participants of the African American Study of Kidney Disease and Hypertension (AASK).Estimated glomerular filtration rate (eGFR) and weight change during CKD.Weight and all-cause mortality after dialysis therapy initiation.During a median follow-up of 5.7 years in CRIC, weight change was not linear. Weight was stable until cystatin C-based eGFR (eGFRcys) decreased to <35mL/min/1.73m2; thereafter, weight declined

2017 American Journal of Kidney Diseases

18. Endogenous endophthalmitis caused by Cryptococcus neoformans Var. Gattii mimicking choroidal tumor: From positron-emission tomography/computed tomography to histopathology Full Text available with Trip Pro

Endogenous endophthalmitis caused by Cryptococcus neoformans Var. Gattii mimicking choroidal tumor: From positron-emission tomography/computed tomography to histopathology A 60-year-old immunocompetent female with pneumonia history about 10 years ago suffered from blurred vision overall survival for 3 weeks. Common cold with headache and unintentional body weight loss was also noted recently. Choroidal detachment simulating choroidal tumor was observed in the temporal quadrant. The 18F-fluoro-2 (...) . Systemic and topical voriconazole eliminated the infection. In the literature, endogenous endophthalmitis caused by C. neoformans var. gattii has not been reported in detail. The key to successful management lies in early diagnosis. If clinical improvement could not be achieved after conventional management and imaging studies have failed to yield a definite diagnosis, retinal biopsy can be considered.

2017 Indian journal of ophthalmology

19. The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial. Full Text available with Trip Pro

The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial. Despite the reported benefits, weight loss is not always advised for older adults because some observational studies have associated weight loss with increased mortality. However, the distinction between intentional and unintentional weight loss is difficult to make in an observational context, so the effect of intentional weight loss on mortality may be clarified (...) in the setting of a randomized controlled trial.The objective was to determine the effect of intentional weight loss on all-cause mortality by using follow-up data from a randomized trial completed in 1995 that included a weight-loss arm.The Trial of Nonpharmacologic Intervention in the Elderly (TONE) used a 2 × 2 factorial design to determine the effect of dietary weight loss, sodium restriction, or both on blood pressure control in 585 overweight or obese older adults being treated for hypertension (mean

2011 The American journal of clinical nutrition Controlled trial quality: predicted high

20. Unusual cause of chest pain: empyema necessitans and tubercular osteomyelitis of the rib in an immunocompetent man Full Text available with Trip Pro

Unusual cause of chest pain: empyema necessitans and tubercular osteomyelitis of the rib in an immunocompetent man A 33-year-old man, born in India but resident in the UK for 5 years, presented to the emergency department with a 4-week history of a dry cough and right-sided pleuritic chest pain. He reported systemic features, including fever and unintentional weight loss. His medical history included vitamin D deficiency. He had travelled to India 10 months previously and denied any exposure

2016 BMJ case reports

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