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Unintentional Weight Loss

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1. Assessment of unintentional weight loss

Assessment of unintentional weight loss Assessment of unintentional weight loss - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of unintentional weight loss Last reviewed: February 2019 Last updated: June 2018 Summary Unintentional weight loss is often defined as weight loss of at least 5% of the patient’s usual body weight that occurs within the preceding 6 to 12 months, and that is not the expected (...) conditions for which early diagnosis may lead to better outcomes. There is a broad range of causes of unintentional weight loss including medical diseases, psychiatric illnesses, and social factors. These conditions may occur in isolation or in combination. Classification There is no formal consensus definition of unintentional weight loss; however, the weight loss must be considered unintentional by the patient and treating practitioner. The degree of weight loss has been defined in case series as being

2018 BMJ Best Practice

2. Associations of medical conditions, lifestyle and unintentional weight loss in early old age: The 1946 British Birth Cohort. (PubMed)

Associations of medical conditions, lifestyle and unintentional weight loss in early old age: The 1946 British Birth Cohort. Unintentional weight loss in older people has been linked to increased risk of mortality. We aimed to investigate common medical conditions and lifestyle factors, including body fat distribution, as potential determinants of recent and prospective unintentional weight loss in early old age.From the Medical Research Council (MRC) National Survey of Health and Development (...) (NSHD), we included a total of 2234 study members aged 60-64 with information on unintentional weight loss in 2006-2010. Of these, 2136 also had information on unintentional weight loss recorded in 2015. Logistic regression was conducted to examine the associations between medical conditions, lifestyle, and body fat distribution at age 60-64 and unintentional weight loss at age 60-64 and 69.A total of 109 of 2234 study members had unintentional weight loss at ages 60-64, and 166 of 2136 at age 69

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2019 PLoS ONE

3. Predicting unintentional weight loss in patients with gastrointestinal cancer. (PubMed)

Predicting unintentional weight loss in patients with gastrointestinal cancer. Unintentional weight loss is a major problem for patients with gastrointestinal (GI) cancers because it affects treatment, survival outcomes, and quality of life. To date, little is known about the trajectory of weight loss and the relationship between baseline body mass index (BMI), location of the cancer, and outcomes. The aims of this study were to investigate patterns of weight loss over time in patients with GI (...) cancer according to BMI groups (low, normal, and high) and location of cancer.We examined de-identified electronic medical record data of 801 adults (>21 years) with GI cancer using ICD-9 codes (150-159). Descriptive statistics and linear mixed models were used to examine unintentional weight loss over time by BMI group (low, normal, and high) and to determine the effect of primary cancer site and patient characteristics on weight loss.The mean age of patients was 66.5 ± 11.9 years (21-95 years

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2019 Journal of cachexia, sarcopenia and muscle

4. Observational Evidence for Unintentional Weight Loss in All-Cause Mortality and Major Cardiovascular Events: A Systematic Review and Meta-Analysis (PubMed)

Observational Evidence for Unintentional Weight Loss in All-Cause Mortality and Major Cardiovascular Events: A Systematic Review and Meta-Analysis The obesity paradox has been described in several observational cohorts and meta-analysis. However, evidence of the intentionality of weight loss in all-cause deaths and major cardiovascular events (MACE) in prospective cohorts is unclear. We analysed whether involuntary weight loss is associated with increased cardiovascular events and mortality (...) . In a systematic review, we searched multiple electronic databases for observational studies published up to October 2016. Studies reporting risk estimates for unintentional weight loss compared with stable weight in MACE and mortality were included. Fifteen studies met the selection criteria, with a total of 178,644 participants. For unintentional weight loss, we found adjusted risk ratios (RRs) with confidence intervals (CIs) of 1.38 (95% CI: 1.23, 1.53) and 1.17 (95% CI: 0.98, 1.37) for all-cause mortality

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2018 Scientific reports

5. Prognostic significance of unintentional body weight loss in colon cancer patients (PubMed)

Prognostic significance of unintentional body weight loss in colon cancer patients The aim of the present study was to investigate whether unintentional body weight loss (BWL) provides additional clinical information in terms of tumor progression and prognosis in non-metastatic colon cancer. In the present study, a total of 2,406 consecutive colon cancer patients without metastasis were retrospectively enrolled. Unintentional BWL was defined as loss of >5% of body weight within the last 6-12 (...) months, or defined subjectively upon fulfillment of at least two of the following: Evidence of change in clothing size and corroboration of the reported weight loss by family or friend. This category was recorded as present ('with') or absent ('without'). Logistic regression analysis was performed to determine the correlation between BWL and the tumor characteristics and post-operative outcomes of patients with colon cancer. The Cox regression model was used to determine the association of BWL

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2018 Molecular and clinical oncology

6. Nausea/vomiting · tachycardia · unintentional weight loss · Dx? (PubMed)

Nausea/vomiting · tachycardia · unintentional weight loss · Dx? A 22-year-old woman presented to the emergency department (ED) with a 24-hour history of nausea, vomiting, diarrhea, generalized abdominal pain, and mild headache. She denied shortness of breath, chest pain, or anxiety, and didn't have a history of cardiac problems. The physical examination revealed tachycardia (heart rate, 135 beats/min) and a respiratory rate of 24 breaths per minute.

2017 Journal of Family Practice

7. Medications Associated with Unintentional Weight Loss

Medications Associated with Unintentional Weight Loss Medications Associated with Unintentional Weight Loss Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse (...) Cancer Administration 4 Medications Associated with Unintentional Weight Loss Medications Associated with Unintentional Weight Loss Aka: Medications Associated with Unintentional Weight Loss , Unintentional Weight Loss due to Medications , Drug Induced Unintentional Weight Loss From Related Chapters II. Mechanisms Altered taste or smell See (includes ) s s ( ) See s (e.g. s) ( ) s (medications suppressing appetite) Anticonvulsants (e.g. ) (e.g. ) ( ) ( ) s s (e.g. , ) See s or See s ( ) s III. Causes

2018 FP Notebook

8. Unintentional Weight Loss Causes

Unintentional Weight Loss Causes Unintentional Weight Loss Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Unintentional Weight (...) Loss Causes Unintentional Weight Loss Causes Aka: Unintentional Weight Loss Causes , Meals on Wheels Mnemonic From Related Chapters II. Causes: "Meals on Wheels" Mnemonic Medication Effects Emotional Problems ( ) or Late-life paranoia Swallowing disorders (See ) Oral factors (e.g. Poorly fitting dentures) No Money Wandering ( related behavior) , Hyperparaythyroidism, Hypoadrenalism Enteric problems (e.g. Malabsorption) Eating problems (e.g. difficult self-feeding) Low salt diet or low diet Stones

2018 FP Notebook

9. Unintentional Weight Loss

Unintentional Weight Loss Unintentional Weight Loss Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Unintentional Weight Loss (...) Unintentional Weight Loss Aka: Unintentional Weight Loss , Geriatric Failure to Thrive , Cachexia , Wasting Syndrome , Malnutrition , Anorexia From Related Chapters II. Epidemiology: Incidence residents: 25-40% Overall over age 64 years: 13% III. Definition Unintentional Weight Loss of >5% of body weight within 6-12 months IV. Causes See V. Precautions Substantial weight loss should not be attributed to aging alone See VI. History How much weight loss over how much time? Patients down play weight changes

2018 FP Notebook

10. Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women. (PubMed)

Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women. Increased fracture risk has been associated with weight loss in postmenopausal women, but the time course over which this occurs has not been established. The aim of this study was to examine the effects of unintentional weight loss of ≥10 lb (4.5 kg) in postmenopausal women on fracture risk at multiple sites up to 5 years after weight loss. Using data (...) from the Global Longitudinal Study of Osteoporosis in Women (GLOW), we analyzed the relationships between self-reported unintentional weight loss of ≥10 lb at baseline, year 2, or year 3 and incident clinical fracture in the years after weight loss. Complete data were available in 40,179 women (mean age ± SD 68 ± 8.3 years). Five-year cumulative fracture rate was estimated using the Kaplan-Meier method, and adjusted hazard ratios for weight loss as a time-varying covariate were calculated from Cox

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2016 Journal of Bone and Mineral Research

11. Acupuncture for Unintentional Weight Loss and Anorexia With GI Cancer

Acupuncture for Unintentional Weight Loss and Anorexia With GI Cancer Acupuncture for Unintentional Weight Loss and Anorexia With GI Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Acupuncture (...) for Unintentional Weight Loss and Anorexia With GI Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02148159 Recruitment Status : Completed First Posted : May 28, 2014 Last Update Posted : January 17, 2019 Sponsor: University of Florida Information provided by (Responsible Party): University of Florida

2014 Clinical Trials

12. Unintentional weight loss in older adults (PubMed)

Unintentional weight loss in older adults 21324857 2011 06 02 2018 11 13 1488-2329 183 4 2011 Mar 08 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Unintentional weight loss in older adults. 443-9 10.1503/cmaj.101471 Stajkovic Svetlana S Department of Medicine, University of Calgary, Calgary, Alta. Aitken Elizabeth M EM Holroyd-Leduc Jayna J eng Case Reports Journal Article Review 2011 02 07 Canada CMAJ 9711805 0820-3946 AIM IM CMAJ. 2011 May (...) 17;183(8):935 Activities of Daily Living Aged Aging physiology Appetite drug effects physiology Body Mass Index Diagnosis, Differential Female Geriatric Assessment Humans Malnutrition etiology prevention & control Prognosis Risk Factors Weight Loss drug effects physiology 2011 2 18 6 0 2011 2 18 6 0 2011 6 3 6 0 ppublish 21324857 cmaj.101471 10.1503/cmaj.101471 PMC3050948 CMAJ. 2005 Mar 15;172(6):773-80 15767612 J Nutr Health Aging. 2000;4(4):246-51 11115810 Geriatr Nurs. 1993 May-Jun;14(3):156-9

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2011 EvidenceUpdates

13. Health-Smart for Weight Loss at UF Jax Clinics

renal disease or cancer Prior bariatric surgery within the last 5 years or plans for this surgery in the next 2 years Use of prescription or over-the-counter weight-loss medication within the last 6 months Pregnant or plan to get pregnant within the next 2 years Plan to relocate from the area within the next 2 years Having had unintentional weight loss (>or = to 5% of body weight) within 6 months prior to enrollment Taking a daily dose of oral corticosteroid antipsychotic (clozapine, olanzapine (...) Health-Smart for Weight Loss at UF Jax Clinics Health-Smart for Weight Loss at UF Jax Clinics - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Health-Smart for Weight Loss at UF Jax Clinics The safety

2018 Clinical Trials

14. A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

) or any other prescription medication or off-label products intended to increase appetite or treat unintentional weight loss Patient with pleural effusion requiring thoracentesis, pericardial effusion requiring drainage, edema or evidence of ascites Patient with uncontrolled or significant cardiovascular disease, including: History of myocardial infarction within the past 3 months A-V block of second or third degree (may be eligible if currently have a pacemaker) Unstable angina Congestive heart (...) A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2018 Clinical Trials

15. A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

period Patient currently taking androgenic compounds (including but not limited to testosterone, testosterone-like agents, oxandrolone, megestrol acetate, corticosteroids, olanzapine, mirtazapine (however, long-term use of mirtazapine for depression for at least four weeks prior to screening is allowed), dronabinol or marijuana (cannabis) or any other prescription medication or off-label products intended to increase appetite or treat unintentional weight loss Patient with pleural effusion requiring (...) A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) A Study to Evaluate the Efficacy and Safety of Anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer

2018 Clinical Trials

16. A 68-Year-Old Lung Transplant Recipient With Shortness of Breath, Weight Loss, and Abnormal Chest CT. (PubMed)

A 68-Year-Old Lung Transplant Recipient With Shortness of Breath, Weight Loss, and Abnormal Chest CT. A 68-year-old man presented to our ED with shortness of breath, weakness, and a 25-lb unintentional weight loss. He had undergone bilateral lung transplantation (cytomegalovirus [CMV]: donor+, recipient+; Epstein-Barr virus: donor+; recipient+) for idiopathic pulmonary fibrosis (IPF) 18 months prior. His posttransplant course was fairly unremarkable until 1 month earlier, when he was admitted (...) -sulfamethoxazole for antimicrobial prophylaxis. His 25-lb weight loss occurred over the span of just one month.Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

2018 Chest

17. Association between involuntary weight loss with low muscle mass and health-related quality of life in community-dwelling older adults: Nationwide surveys (KNHANES 2008-2011). (PubMed)

included 2249 individuals aged ≥70 years. The participants reported an unintentional weight loss >3 kg in the past year. Appendicular lean mass was measured using dual-energy X-ray absorptiometry and calculated with the appendicular lean mass index. Health-related quality of life was measured using the EuroQol-5 dimension (EQ-5D) instrument. Univariate and multivariate survey logistic regression models were used to calculate odds ratios (OR) with 95% confidence intervals (95% CI) for the lowest (...) Association between involuntary weight loss with low muscle mass and health-related quality of life in community-dwelling older adults: Nationwide surveys (KNHANES 2008-2011). To investigate the relationship between involuntary weight loss with low muscle mass and health-related quality of life in a large representative sample of older adults.A nationwide cross-sectional study based on data from the Korea National Health and Nutritional Examination Survey, 2008 to 2011. Study participants

2018 Experimental Gerontology

18. Determination of Factors Associated with Critical Weight Loss in Oral Cavity Carcinoma Patients: A Retrospective Cohort Study (PubMed)

Determination of Factors Associated with Critical Weight Loss in Oral Cavity Carcinoma Patients: A Retrospective Cohort Study Introduction  Critical weight loss is defined as an unintentional weight loss of ≥ 5% at 1 month or ≥ 10% at 6 months from the start of treatment. Critical weight loss leads to deterioration of the immune function and reduced tolerance to treatment (surgery ± radiochemotherapy) as well as increased complication rates. Objective  Critical weight loss, defined as a weight (...) loss of ≥ 5% after 1 month or ≥ 10% after 6 months from the start of treatment, is not uncommon in head and neck cancer patients. We aimed to assess the factors associated with critical weight loss during the treatment of oral cavity squamous cell carcinoma patients. Methods  A retrospective cohort study was performed at the Aga Khan University Hospital, in Karachi, Pakistan, on 125 patients. Patients receiving adjuvant therapy were considered exposed, and the outcome was critical weight loss

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2018 International archives of otorhinolaryngology

19. Weight loss has an additive effect on the proteinuria reduction of angiotensin II receptor blockers in hypertensive patients with chronic kidney disease (PubMed)

groups, but mean differences in weight and percent changes in urinary sodium excretion over the period were statistically different (P < 0.001 and P = 0.017). Over the study period, unintentional weight loss independently increased the probability of reduced albuminuria (group 1, relative risk 6.234, 95% confidence interval 1.913-20.315, P = 0.002). Among urinary cytokines, only podocalyxin level decreased significantly in participants who lost weight (P = 0.013).We observed that weight loss had (...) Weight loss has an additive effect on the proteinuria reduction of angiotensin II receptor blockers in hypertensive patients with chronic kidney disease Weight reduction is a lifestyle intervention that has been introduced for prevention and management of chronic kidney disease (CKD). We investigate the additive anti-proteinuric effect of weight reduction on the usage of angiotensin II receptor blockers (ARBs) and its potential mechanisms in hypertensive CKD patients.This study is a subanalysis

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2018 Kidney research and clinical practice

20. Promoting Weight Loss and Stress Reduction in Overweight and Obese Patients With Type 2 Diabetes

in the study difficult and/or unsafe; Presence of any medical condition associated with unintentional weight loss or gain; Presence of untreated, severe and/or recently diagnosed (≤ 6 months) mental illness and/or presence of a severe personality disorder; History of eating disorders and/or substance abuse; Use of drugs for weight loss; Participation in another weight loss program or in any other trial; Participation in an individual or group psychological intervention; Weight loss surgery within the year (...) Promoting Weight Loss and Stress Reduction in Overweight and Obese Patients With Type 2 Diabetes Promoting Weight Loss and Stress Reduction in Overweight and Obese Patients With Type 2 Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

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